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CCL2 Gene Record

  • Summary
  • Interactions
  • Claims
  • CCL2 6347 Druggable Genome

    Alternate Names:

    6347
    C-C MOTIF CHEMOKINE LIGAND 2
    CCL2
    GDCF-2
    HC11
    HSMCR30
    MCAF
    MCP-1
    MCP1
    SCYA2
    SMC-CF
    158105
    10618
    ENSG00000108691
    OTTHUMG00000132887
    C-C motif chemokine 2
    Monocyte chemoattractant protein 1
    Monocyte chemotactic and activating factor
    Monocyte chemotactic protein 1
    Monocyte secretory protein JE
    Small-inducible cytokine A2
    BE0001047
    P13500
    PA130413151
    T11309

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Ligand
    Target Subclass Cytokine
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Boucher et al., 2000, Effect of hormonal agents on monocyte chemotactic protein-1 expression by endometrial epithelial cells of women with endometriosis., Fertil. Steril.
    Jolicoeur et al., 2001, Comparative effect of danazol and a GnRH agonist on monocyte chemotactic protein-1 expression by endometriotic cells., Am. J. Reprod. Immunol.
    Conti et al., 2002, Inhibition of MCP-1 and MIP-2 transcription and translation by mimosine in muscle tissue infected with the parasite Trichinella spiralis., Mol. Cell. Biochem.
    Frydas et al., Inhibition of MCP-1 and MIP-2 chemokines in murine trichinellosis: effect of the anti-inflammatory compound L-mimosine., Int J Immunopathol Pharmacol
    Xiong Y et al., 2014, A pharmacogenetic study of risperidone on chemokine (C-C motif) ligand 2 (CCL2) in Chinese Han schizophrenia patients., Prog Neuropsychopharmacol Biol Psychiatry
    Distler JH et al., 2006, Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells., Arthritis Rheum
  • CARLUMAB   CCL2

    Interaction Score: 18.94

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction C-C motif chemokine 2 inhibitor

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • BINDARIT   CCL2

    Interaction Score: 9.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MIMOSINE   CCL2

    Interaction Score: 9.47

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11936838 15698514


    Sources:
    DrugBank

  • CHONDROITIN SULFATE   CCL2

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16385517


    Sources:
    DrugBank

  • DANAZOL   CCL2

    Interaction Score: 1.67

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11056242 11216879


    Sources:
    DrugBank

  • RISPERIDONE   CCL2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24495780


    Sources:
    PharmGKB

  • Ensembl: ENSG00000108691

    • Version: 101_38

    Alternate Names:
    CCL2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P13500

    • Version: January-2014

    Alternate Names:
    CCL2 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Ligand
    Target Subclass Cytokine

    Publications:

  • PharmGKB: CCL2

    • Version: 18-August-2020

    Alternate Names:
    PA130413151 PharmGKB ID

    Gene Info:

    Publications:
    Xiong Y et al., 2014, A pharmacogenetic study of risperidone on chemokine (C-C motif) ligand 2 (CCL2) in Chinese Han schizophrenia patients., Prog Neuropsychopharmacol Biol Psychiatry

  • DrugBank: BE0001047

    • Version: 5.1.7

    Alternate Names:
    CCL2 DrugBank Gene Name
    P13500 UniProt Accession
    6347 Entrez Gene Id

    Gene Info:

    Publications:
    Distler JH et al., 2006, Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells., Arthritis Rheum
    Conti et al., 2002, Inhibition of MCP-1 and MIP-2 transcription and translation by mimosine in muscle tissue infected with the parasite Trichinella spiralis., Mol. Cell. Biochem.
    Frydas et al., Inhibition of MCP-1 and MIP-2 chemokines in murine trichinellosis: effect of the anti-inflammatory compound L-mimosine., Int J Immunopathol Pharmacol

  • HingoraniCasas: ENSG00000108691

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000108691 Gene Symbol
    CCL2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: MCP1

    • Version: chembl_23

    Alternate Names:
    SCYA2 GENE_SYMBOL
    CCL2 GENE_SYMBOL
    C-C motif chemokine 2 UNIPROT

    Gene Info:

    Publications:

  • TTD: Monocyte chemotactic and activating factor

    • Version: 2020.06.01

    Alternate Names:
    CCL2 TTD Gene Abbreviation
    T11309 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21