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CCL11 Gene Record

  • Summary
  • Interactions
  • Claims
  • CCL11 6356 Druggable Genome

    Alternate Names:

    6356
    C-C MOTIF CHEMOKINE LIGAND 11
    CCL11
    SCYA11
    601156
    10610
    ENSG00000172156
    OTTHUMG00000132884
    C-C motif chemokine 11
    Small-inducible cytokine A11
    Eotaxin
    Eosinophil chemotactic protein
    PA35543
    T16888

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Cui et al., 2001, Effect of roxithromycin on eotaxin-primed reactive oxygen species from eosinophils., Int. Arch. Allergy Immunol.
    Kuo HW et al., 2018, Inflammatory chemokine eotaxin-1 is correlated with age in heroin dependent patients under methadone maintenance therapy., Drug Alcohol Depend
  • BERTILIMUMAB   CCL11

    Interaction Score: 41.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Eotaxin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ROXITHROMYCIN   CCL11

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11408771


    Sources:
    NCI

  • METHADONE   CCL11

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29222992


    Sources:
    PharmGKB

  • Ensembl: ENSG00000172156

    • Version: 101_38

    Alternate Names:
    CCL11 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: CCL11

    • Version: 18-August-2020

    Alternate Names:
    PA35543 PharmGKB ID

    Gene Info:

    Publications:
    Kuo HW et al., 2018, Inflammatory chemokine eotaxin-1 is correlated with age in heroin dependent patients under methadone maintenance therapy., Drug Alcohol Depend

  • NCI: CCL11

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    El-Shazly et al., 1999, Novel association of the src family kinases, hck and c-fgr, with CCR3 receptor stimulation: A possible mechanism for eotaxin-induced human eosinophil chemotaxis., Biochem. Biophys. Res. Commun.
    Sabatini et al., 2003, Concentration-dependent effects of mometasone furoate and dexamethasone on foetal lung fibroblast functions involved in airway inflammation and remodeling., Pulm Pharmacol Ther
    Nie et al., 2005, beta2-Adrenoceptor agonists, like glucocorticoids, repress eotaxin gene transcription by selective inhibition of histone H4 acetylation., J. Immunol.

  • HingoraniCasas: ENSG00000172156

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000172156 Gene Symbol
    CCL11 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: SCYA11

    • Version: chembl_23

    Alternate Names:
    SCYA11 GENE_SYMBOL
    CCL11 GENE_SYMBOL
    Eotaxin UNIPROT

    Gene Info:

    Publications:

  • TTD: Small-inducible cytokine A11

    • Version: 2020.06.01

    Alternate Names:
    CCL11 TTD Gene Abbreviation
    T16888 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21