• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

CCKBR Gene Record

  • Summary
  • Interactions
  • Claims
  • CCKBR 887 Druggable Genome

    Alternate Names:

    887
    CHOLECYSTOKININ B RECEPTOR
    CCKBR
    CCK-B
    CCK2R
    GASR
    118445
    1571
    ENSG00000110148
    OTTHUMG00000133380
    CCKRB
    Gastrin/cholecystokinin type B receptor
    Cholecystokinin-2 receptor
    CCK-B receptor
    CCK-BR
    CCK2-R
    P32239
    GASR_HUMAN
    GASTRIN/CHOLECYSTOKININ TYPE B RECEPTOR (CCK-B RECEPTOR) (CCK-BR) (CHOLECYSTOKININ-2 RECEPTOR) (CCK2-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P32239]
    PA26143
    T05849

    Gene Info:

    Interpro Acc IPR000276
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Name GPCR, rhodopsin-like, 7TM
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Target Main Class Receptors
    Transmembrane Helix Count 7
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Tiwari AK et al., 2010, Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients., Prog Neuropsychopharmacol Biol Psychiatry
    Bock et al., 1994, Selective non-peptide ligands for an accommodating peptide receptor. Imidazobenzodiazepines as potent cholecystokinin type B receptor antagonists., Bioorg. Med. Chem.
    Håkanson et al., 1999, CCK2 receptor antagonists: pharmacological tools to study the gastrin-ECL cell-parietal cell axis., Regul. Pept.
    Harikumar KG et al., 2010, Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization., J Med Chem
    Scott et al., 2012, Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017)., J. Med. Chem.
    Khan et al., 2004, Effect of repeat exposure on neuroendocrine and symptom responses to pentagastrin., Psychiatry Res
    Nishida et al., 1995, Gastrin receptor antagonist YM022 prevents hypersecretion after long-term acid suppression., Am. J. Physiol.
    Singh et al., 1986, Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC-26) in BALB/c mice., Cancer Res.
    Radu et al., 2002, Anxiogenic effects of the CCK(B) agonist pentagastrin in humans and dose-dependent increase in plasma C-peptide levels., Psychopharmacology (Berl.)
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Makovec et al., 1992, Structure-antigastrin activity relationships of new (R)-4-benzamido-5-oxopentanoic acid derivatives., J. Med. Chem.
    Xu et al., 1996, L-740,093, a new antagonist of the CCK-B receptor, potentiates the antinociceptive effect of morphine: electrophysiological and behavioural studies., Neuropeptides
    Costall et al., 1991, Anxiolytic effects of CCK-B antagonists., Neuropeptides
    Berna MJ et al., 2007, Role of CCK/gastrin receptors in gastrointestinal/metabolic diseases and results of human studies using gastrin/CCK receptor agonists/antagonists in these diseases., Curr Top Med Chem
    Weng et al., 1996, Novel CCK-B receptor agonists: diketopiperazine analogues derived for CCK4 bioactive conformation., Regul. Pept.
    Olszewska-Pazdrak et al., 2004, Epidermal growth factor potentiates cholecystokinin/gastrin receptor-mediated Ca2+ release by activation of mitogen-activated protein kinases., J. Biol. Chem.
  • PENTAGASTRIN   CCKBR

    Interaction Score: 37.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    15157745 7491961 3004700 12073167 11752352 1732532


    Sources:
    TdgClinicalTrial TEND TTD

  • ITRIGLUMIDE   CCKBR

    Interaction Score: 12.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cholecystokinin B receptor antagonist
    Direct Interaction yes

    PMIDs:
    17584143


    Sources:
    ChemblInteractions TTD

  • L-365260   CCKBR

    Interaction Score: 8.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    20235611


    Sources:
    DTC

  • NETAZEPIDE   CCKBR

    Interaction Score: 8.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cholecystokinin B receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CI-988   CCKBR

    Interaction Score: 4.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cholecystokinin B receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AZD-4017   CCKBR

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22691057


    Sources:
    DTC

  • BENZODIAZEPINE   CCKBR

    Interaction Score: 2.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7712133 10235629


    Sources:
    NCI

  • PD-170292   CCKBR

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CERULETIDE   CCKBR

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SPIROGLUMIDE   CCKBR

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • INOSITOL   CCKBR

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8876029 14602717


    Sources:
    NCI

  • DIAZEPAM   CCKBR

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1679211


    Sources:
    NCI

  • MORPHINE   CCKBR

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8771563


    Sources:
    NCI

  • CLOZAPINE   CCKBR

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20732371


    Sources:
    PharmGKB

  • OLANZAPINE   CCKBR

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20732371


    Sources:
    PharmGKB

  • Ensembl: ENSG00000110148

    • Version: 101_38

    Alternate Names:
    CCKBR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000110148

    • Version: 26-July-2011

    Alternate Names:
    GASTRIN/CHOLECYSTOKININ TYPE B RECEPTOR (CCK-B RECEPTOR) (CCK-BR) (CHOLECYSTOKININ-2 RECEPTOR) (CCK2-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P32239] Description
    CCKBR Display Id
    ENSG00000110148 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P32239

    • Version: 11-September-2012

    Alternate Names:
    GASTRIN/CHOLECYSTOKININ TYPE B RECEPTOR Uniprot Protein Name
    P32239 Uniprot Accession
    ENSG00000110148 Ensembl Gene Id

    Gene Info:
    Interpro Acc IPR000276
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Uniprot Status Swiss-Prot

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TEND: P32239

    • Version: 01-August-2011

    Alternate Names:
    CCKBR Gene Symbol
    P32239 Uniprot Accession
    ENSG00000110148 Ensembl Gene Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass Rhodopsin
    Target Subclass GPCR

    Publications:

  • TdgClinicalTrial: P32239

    • Version: January-2014

    Alternate Names:
    CCKBR Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • PharmGKB: CCKBR

    • Version: 18-August-2020

    Alternate Names:
    PA26143 PharmGKB ID

    Gene Info:

    Publications:
    Tiwari AK et al., 2010, Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients., Prog Neuropsychopharmacol Biol Psychiatry

  • TTD: Gastrin/cholecystokinin type B receptor

    • Version: 2020.06.01

    Alternate Names:
    CCKBR TTD Gene Abbreviation
    T05849 TTD Target ID

    Gene Info:

    Publications:
    Chau I et al., 2006, Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials., Br J Cancer
    Berna MJ et al., 2007, Role of CCK/gastrin receptors in gastrointestinal/metabolic diseases and results of human studies using gastrin/CCK receptor agonists/antagonists in these diseases., Curr Top Med Chem

  • NCI: CCKBR

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Håkanson et al., 1999, CCK2 receptor antagonists: pharmacological tools to study the gastrin-ECL cell-parietal cell axis., Regul. Pept.
    Bock et al., 1994, Selective non-peptide ligands for an accommodating peptide receptor. Imidazobenzodiazepines as potent cholecystokinin type B receptor antagonists., Bioorg. Med. Chem.
    Costall et al., 1991, Anxiolytic effects of CCK-B antagonists., Neuropeptides

  • DTC: CCKBR

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Harikumar KG et al., 2010, Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization., J Med Chem
    Scott et al., 2012, Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017)., J. Med. Chem.

  • HingoraniCasas: ENSG00000110148

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000110148 Gene Symbol
    CCKBR Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CCKRB

    • Version: chembl_23

    Alternate Names:
    CCKRB GENE_SYMBOL
    CCKBR GENE_SYMBOL
    Gastrin/cholecystokinin type B receptor UNIPROT

    Gene Info:

    Publications:

  • GO: CCKBR

    • Version: 01-February-2022

    Alternate Names:
    CCKRB GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: CCKBR

    • Version: 27-Jun-2013

    Alternate Names:
    887 Gene ID
    CCK-B dGene Synonym
    CCK2R dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21