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CALR Gene Record

  • Summary
  • Interactions
  • Claims
  • CALR 811 Druggable GenomeClinically Actionable

    Alternate Names:

    811
    CALRETICULIN
    CALR
    CRT
    HEL-S-99n
    RO
    SSA
    cC1qR
    109091
    1455
    ENSG00000179218
    OTTHUMG00000180574
    732
    CRTC
    P27797

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    NUCLEAR HORMONE RECEPTOR
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Bae et al., 2005, Enhanced CCAAT/enhancer-binding protein beta-liver-enriched inhibitory protein production by Oltipraz, which accompanies CUG repeat-binding protein-1 (CUGBP1) RNA-binding protein activation, leads to inhibition of preadipocyte differentiation., Mol. Pharmacol.
    Horibe et al., 2004, Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity., Biochem. Biophys. Res. Commun.
  • OLTIPRAZ   CALR

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15961673


    Sources:
    NCI

  • GENTAMICIN   CALR

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15351734


    Sources:
    NCI

  • Ensembl: ENSG00000179218

    • Version: 101_38

    Alternate Names:
    CALR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • JAX-CKB: CALR

    • Version: 27-September-2017

    Alternate Names:
    811 CKB Entrez Id
    CALR CKB Gene Synonym
    cC1qR CKB Gene Synonym

    Gene Info:

    Publications:
    Verger et al., 2015, Clinical and molecular response to interferon-α therapy in essential thrombocythemia patients with CALR mutations., Blood
    Saeidi, 2016, Myeloproliferative neoplasms: Current molecular biology and genetics., Crit. Rev. Oncol. Hematol.
    Kim et al., 2015, CALR, JAK2, and MPL mutation profiles in patients with four different subtypes of myeloproliferative neoplasms: primary myelofibrosis, essential thrombocythemia, polycythemia vera, and myeloproliferative neoplasm, unclassifiable., Am. J. Clin. Pathol.

  • CIViC: CALR

    • Version: 14-September-2020

    Alternate Names:
    811 Entrez Gene ID
    732 CIViC Gene ID

    Gene Info:

    Publications:
    Verger et al., 2015, Clinical and molecular response to interferon-α therapy in essential thrombocythemia patients with CALR mutations., Blood

  • NCI: CALR

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Pike et al., 1999, Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth., Blood
    Michalak et al., 1996, Endoplasmic reticulum form of calreticulin modulates glucocorticoid-sensitive gene expression., J. Biol. Chem.
    Burns et al., 1994, Modulation of gene expression by calreticulin binding to the glucocorticoid receptor., Nature

  • HingoraniCasas: ENSG00000179218

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000179218 Gene Symbol
    CALR Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: CALR

    • Version: 01-February-2022

    Alternate Names:
    CRTC GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • Tempus: CALR

    • Version: 11-November-2018

    Alternate Names:
    CALR Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: CALR

    • Version: 01-February-2022

    Alternate Names:
    Calreticulin Gene Name
    P27797 UniProt ID

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • FoundationOneGenes: CALR

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: CALR

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21