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CACNA1G Gene Record

  • Summary
  • Interactions
  • Claims
  • CACNA1G 8913 Druggable Genome

    Alternate Names:

    8913
    CALCIUM VOLTAGE-GATED CHANNEL SUBUNIT ALPHA1 G
    CACNA1G
    Ca(V)T.1
    Cav3.1
    NBR13
    SCA42
    604065
    1394
    ENSG00000006283
    OTTHUMG00000162180
    O43497
    KIAA1123
    CAC1G_HUMAN
    BE0000483
    VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
    VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL ALPHA-1G SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV3.1) (CAV3.1C) (NBR13). [SOURCE:UNIPROT/SWISSPROT;ACC:O43497]
    PA381
    Voltage-gated calcium channel subunit alpha Cav3.1
    Cav3.1c
    535
    Ca<sub>v</sub>3.1
    NP_938190|NP_938192|NP_938201|NP_938193|NP_061496
    Voltage-gated calcium channel alpha Cav3.1
    T64795
    NM_198378|NM_198387|NM_198379|NM_198376
    BE0008716

    Gene Info:

    Interpro Name Ion transport domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR005821
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Ion_trans_dom
    Uniprot Evidence 2: Evidence at transcript level
    Human Readable Name ION CHANNEL
    Target Subclass Voltage_gated_ion_channels
    Target Subclass CalciumChannels
    Target Main Class Transporters
    Target Subclass Channels
    Transmembrane Helix Count 22
    GuideToPharmacology Gene Category Name Voltage-gated calcium channels
    GuideToPharmacology Gene Category ID 80
    Initial Gene Query Cav3.1
    Counted Citations from 1950-2000 413
    Target Class Transporters
    Target Subclass TC:1.A.1.11
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

    Gomora et al., 2001, Block of cloned human T-type calcium channels by succinimide antiepileptic drugs., Mol. Pharmacol.
    Matthews et al., 2001, Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats., Eur. J. Pharmacol.
    Wang et al., 2008, Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions., J. Neurosci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Singh, 1986, The mechanism of action of calcium antagonists relative to their clinical applications., Br J Clin Pharmacol
    Cohen et al., 1992, Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists., J. Gen. Physiol.
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Coulter et al., 1989, Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons., Ann. Neurol.
    Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.
    Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol
    Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure
    Murata, 2010, Zonisamide: a new drug for Parkinson's disease., Drugs Today
    Sobieszek et al., Zonisamide: a new antiepileptic drug., Pol J Pharmacol
    Kothare et al., 2008, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety., Expert Opin Drug Metab Toxicol
    Schulze-Bonhage, 2010, Zonisamide in the treatment of epilepsy., Expert Opin Pharmacother
    Janszky, 2009, [Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases]., Ideggyogy Sz
    Zaccara et al., 2009, Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature., Neuropsychiatr Dis Treat
    Murata, 2004, Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease., Curr. Pharm. Des.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Barton et al., 2005, The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil., Eur. J. Pharmacol.
    Shen et al., 2007, Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss., Hear. Res.
    Lee et al., 2006, Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms., Pharmacology
    Monteil et al., 2000, Molecular and functional properties of the human alpha(1G) subunit that forms T-type calcium channels., J. Biol. Chem.
    Clozel et al., 1997, Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker., J Hypertens Suppl
    McNulty et al., 2004, State-dependent mibefradil block of Na+ channels., Mol. Pharmacol.
    Massie, 1997, Mibefradil: a selective T-type calcium antagonist., Am. J. Cardiol.
    Freeze et al., 2006, State-dependent verapamil block of the cloned human Ca(v)3.1 T-type Ca(2+) channel., Mol. Pharmacol.
    Tfelt-Hansen et al., 2009, Verapamil for cluster headache. Clinical pharmacology and possible mode of action., Headache
    Bergson P et al., 2011, Verapamil block of T-type calcium channels., Mol Pharmacol
    Santi et al., 2002, Differential inhibition of T-type calcium channels by neuroleptics., J. Neurosci.
    Uebele et al., 2009, Positive allosteric interaction of structurally diverse T-type calcium channel antagonists., Cell Biochem. Biophys.
    Hildebrand ME et al., 2004, Mammalian voltage-gated calcium channels are potently blocked by the pyrethroid insecticide allethrin., J Pharmacol Exp Ther
    McKeage K et al., 2004, Manidipine: a review of its use in the management of hypertension., Drugs
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
    Yao K et al., 2006, Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker., J Pharmacol Sci
    Radulovic M et al., 2015, Targeting Ion Channels: An Important Therapeutic Implication in Gastrointestinal Dysmotility in Patients With Spinal Cord Injury., J Neurogastroenterol Motil
    Godfraind T, 2017, Discovery and Development of Calcium Channel Blockers., Front Pharmacol
  • TRIMETHADIONE   CACNA1G

    Interaction Score: 5.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)
    blocker (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Voltage-gated T-type calcium channel blocker

    PMIDs:
    11752352 16171802 17016423 17139284 17291698


    Sources:
    DrugBank TdgClinicalTrial ChemblInteractions TEND TTD

  • METHSUXIMIDE   CACNA1G

    Interaction Score: 4.73

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated T-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    11274992 2545161 19005061 11641441


    Sources:
    DrugBank ChemblInteractions TTD

  • ETHOSUXIMIDE   CACNA1G

    Interaction Score: 3.65

    Interaction Types & Directionality:
    inhibitor (inhibitory)
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated T-type calcium channel blocker
    Trial Name -

    PMIDs:
    11641441 11274992 19005061 11752352


    Sources:
    DrugBank TdgClinicalTrial ChemblInteractions TEND TTD

  • MANIDIPINE 6300   CACNA1G

    Interaction Score: 2.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:

    PMIDs:
    15329044


    Sources:
    DrugBank

  • FLUNARIZINE   CACNA1G

    Interaction Score: 1.58

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11784784 19582593 17016423 17139284


    Sources:
    DrugBank TdgClinicalTrial TEND

  • BENIDIPINE   CACNA1G

    Interaction Score: 1.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    16565579


    Sources:
    DrugBank

  • PARAMETHADIONE   CACNA1G

    Interaction Score: 1.35

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated T-type calcium channel blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ZONISAMIDE   CACNA1G

    Interaction Score: 0.82

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name zonisamide,Zonegran, Trerief
    Novel drug target Established target
    Trial Name Empatic

    PMIDs:
    19948168 17762320 15511691 20502722 14704463 18433351 20001433 20025128 19557119 14965331 17016423 17139284


    Sources:
    DrugBank TdgClinicalTrial TEND

  • BIOALLETHRIN   CACNA1G

    Interaction Score: 0.81

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:

    PMIDs:
    14634047


    Sources:
    DrugBank

  • PENFLURIDOL   CACNA1G

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ABT-639   CACNA1G

    Interaction Score: 0.68

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Pore blocker
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PHENSUXIMIDE   CACNA1G

    Interaction Score: 0.68

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated T-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MIBEFRADIL   CACNA1G

    Interaction Score: 0.68

    Interaction Types & Directionality:
    inhibitor (inhibitory)
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    16899990 10692398 9481612 15562257 11752352 9375939


    Sources:
    DrugBank GuideToPharmacology

  • TRIMEBUTINE   CACNA1G

    Interaction Score: 0.51

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    26424038


    Sources:
    DrugBank

  • CINNARIZINE   CACNA1G

    Interaction Score: 0.36

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    3530295 1281221


    Sources:
    DrugBank

  • MIBEFRADIL DIHYDROCHLORIDE   CACNA1G

    Interaction Score: 0.29

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated T-type calcium channel blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VERAPAMIL   CACNA1G

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16699084 19125880 11752352 21149638


    Sources:
    DrugBank TEND TTD

  • ANANDAMIDE   CACNA1G

    Interaction Score: 0.13

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Endogenous Drug? True
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • NIFEDIPINE   CACNA1G

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    28611661 16899990


    Sources:
    DrugBank

  • CANNABIDIOL   CACNA1G

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   CACNA1G

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • IMAGABALIN   CACNA1G

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GABAPENTIN ENACARBIL   CACNA1G

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PREGABALIN   CACNA1G

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ATAGABALIN   CACNA1G

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated calcium channel modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BEPRIDIL HYDROCHLORIDE   CACNA1G

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GABAPENTIN   CACNA1G

    Interaction Score: 0.07

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CELECOXIB   CACNA1G

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

  • Ensembl: ENSG00000006283

    • Version: 101_38

    Alternate Names:
    CACNA1G Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: O43497

    • Version: January-2014

    Alternate Names:
    CACNA1G Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.11

    Publications:

  • RussLampel: ENSG00000006283

    • Version: 26-July-2011

    Alternate Names:
    CACNA1G Display Id
    ENSG00000006283 Ensembl Gene Id
    VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL ALPHA-1G SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV3.1) (CAV3.1C) (NBR13). [SOURCE:UNIPROT/SWISSPROT;ACC:O43497] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: O43497

    • Version: 01-August-2011

    Alternate Names:
    8913 Entrez Gene Id
    O43497 Uniprot Accession
    ENSG00000006283 Ensembl Gene Id

    Gene Info:
    Target Subclass Voltage_gated_ion_channels
    Target Subclass CalciumChannels
    Target Main Class Transporters

    Publications:

  • BaderLabGenes: CACNA1G

    • Version: February-2014

    Alternate Names:
    8913 Entrez Gene ID

    Gene Info:
    Initial Gene Query Cav3.1
    Counted Citations from 1950-2000 413

    Gene Categories:
    ION CHANNEL

    Publications:

  • HopkinsGroom: O43497

    • Version: 11-September-2012

    Alternate Names:
    8913 Entrez Gene Id
    VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G Uniprot Protein Name
    O43497 Uniprot Accession

    Gene Info:
    Interpro Name Ion transport domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR005821

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 8913

    • Version: 29-September-2020

    Alternate Names:
    1394 HUGO Gene ID
    1394 HUGO Gene Symbol
    calcium voltage-gated channel subunit alpha1 G HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Voltage-gated calcium channels
    GuideToPharmacology Gene Category ID 80

    Gene Categories:
    ION CHANNEL

    Publications:

  • PharmGKB: CACNA1G

    • Version: 18-August-2020

    Alternate Names:
    PA381 PharmGKB ID

    Gene Info:

    Publications:
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

  • DrugBank: BE0008716

    • Version: 5.1.7

    Alternate Names:
    CACNA1G DrugBank Gene Name
    O43497 UniProt Accession
    8913 Entrez Gene Id

    Gene Info:

    Publications:
    Radulovic M et al., 2015, Targeting Ion Channels: An Important Therapeutic Implication in Gastrointestinal Dysmotility in Patients With Spinal Cord Injury., J Neurogastroenterol Motil
    McKeage K et al., 2004, Manidipine: a review of its use in the management of hypertension., Drugs
    Yao K et al., 2006, Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker., J Pharmacol Sci

  • DrugBank: BE0000483

    • Version: 5.1.7

    Alternate Names:
    CACNA1G DrugBank Gene Name
    O43497 UniProt Accession
    8913 Entrez Gene Id

    Gene Info:

    Publications:
    Singh, 1986, The mechanism of action of calcium antagonists relative to their clinical applications., Br J Clin Pharmacol
    Cohen et al., 1992, Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists., J. Gen. Physiol.
    Matthews et al., 2001, Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats., Eur. J. Pharmacol.

  • HingoraniCasas: ENSG00000006283

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000006283 Gene Symbol
    CACNA1G Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: KIAA1123

    • Version: chembl_23

    Alternate Names:
    KIAA1123 GENE_SYMBOL
    CACNA1G GENE_SYMBOL
    Voltage-dependent T-type calcium channel subunit alpha-1G UNIPROT

    Gene Info:

    Publications:

  • Pharos: CACNA1G

    • Version: 03-September-2020

    Alternate Names:
    Voltage-dependent T-type calcium channel subunit alpha-1G Gene Name
    O43497 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

  • TTD: Voltage-gated calcium channel alpha Cav3.1

    • Version: 2020.06.01

    Alternate Names:
    CACNA1G TTD Gene Abbreviation
    T64795 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21