DGIdb - CACNA1G Gene Record

CACNA1G 8913 Druggable Genome

Alternate Names:

8913
CALCIUM VOLTAGE-GATED CHANNEL SUBUNIT ALPHA1 G
CACNA1G
Ca(V)T.1
Cav3.1
NBR13
SCA42
604065
1394
ENSG00000006283
OTTHUMG00000162180
O43497
KIAA1123
CAC1G_HUMAN
BE0000483
VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G
VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL ALPHA-1G SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV3.1) (CAV3.1C) (NBR13). [SOURCE:UNIPROT/SWISSPROT;ACC:O43497]
PA381
Voltage-gated calcium channel subunit alpha Cav3.1
Cav3.1c
535
Ca<sub>v</sub>3.1
NP_938190\|NP_938192\|NP_938201\|NP_938193\|NP_061496
Voltage-gated calcium channel alpha Cav3.1
T64795
NM_198378\|NM_198387\|NM_198379\|NM_198376
BE0008716

Gene Info:

Interpro Name	Ion transport domain
Uniprot Status	Swiss-Prot
Interpro Acc	IPR005821
Interpro Type	Domain
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ion_trans_dom
Uniprot Evidence	2: Evidence at transcript level
Human Readable Name	ION CHANNEL
Target Subclass	Voltage_gated_ion_channels
Target Subclass	CalciumChannels
Target Main Class	Transporters
Target Subclass	Channels
Transmembrane Helix Count	22
GuideToPharmacology Gene Category Name	Voltage-gated calcium channels
GuideToPharmacology Gene Category ID	80
Initial Gene Query	Cav3.1
Counted Citations from 1950-2000	413
Target Class	Transporters
Target Subclass	TC:1.A.1.11
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Gomora et al., 2001, Block of cloned human T-type calcium channels by succinimide antiepileptic drugs., Mol. Pharmacol.
Matthews et al., 2001, Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats., Eur. J. Pharmacol.
Wang et al., 2008, Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions., J. Neurosci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Singh, 1986, The mechanism of action of calcium antagonists relative to their clinical applications., Br J Clin Pharmacol
Cohen et al., 1992, Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists., J. Gen. Physiol.
Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Coulter et al., 1989, Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons., Ann. Neurol.
Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.
Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol
Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure
Murata, 2010, Zonisamide: a new drug for Parkinson's disease., Drugs Today
Sobieszek et al., Zonisamide: a new antiepileptic drug., Pol J Pharmacol
Kothare et al., 2008, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety., Expert Opin Drug Metab Toxicol
Schulze-Bonhage, 2010, Zonisamide in the treatment of epilepsy., Expert Opin Pharmacother
Janszky, 2009, [Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases]., Ideggyogy Sz
Zaccara et al., 2009, Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature., Neuropsychiatr Dis Treat
Murata, 2004, Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease., Curr. Pharm. Des.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Barton et al., 2005, The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil., Eur. J. Pharmacol.
Shen et al., 2007, Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss., Hear. Res.
Lee et al., 2006, Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms., Pharmacology
Monteil et al., 2000, Molecular and functional properties of the human alpha(1G) subunit that forms T-type calcium channels., J. Biol. Chem.
Clozel et al., 1997, Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker., J Hypertens Suppl
McNulty et al., 2004, State-dependent mibefradil block of Na+ channels., Mol. Pharmacol.
Massie, 1997, Mibefradil: a selective T-type calcium antagonist., Am. J. Cardiol.
Freeze et al., 2006, State-dependent verapamil block of the cloned human Ca(v)3.1 T-type Ca(2+) channel., Mol. Pharmacol.
Tfelt-Hansen et al., 2009, Verapamil for cluster headache. Clinical pharmacology and possible mode of action., Headache
Bergson P et al., 2011, Verapamil block of T-type calcium channels., Mol Pharmacol
Santi et al., 2002, Differential inhibition of T-type calcium channels by neuroleptics., J. Neurosci.
Uebele et al., 2009, Positive allosteric interaction of structurally diverse T-type calcium channel antagonists., Cell Biochem. Biophys.
Hildebrand ME et al., 2004, Mammalian voltage-gated calcium channels are potently blocked by the pyrethroid insecticide allethrin., J Pharmacol Exp Ther
McKeage K et al., 2004, Manidipine: a review of its use in the management of hypertension., Drugs
Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
Yao K et al., 2006, Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker., J Pharmacol Sci
Radulovic M et al., 2015, Targeting Ion Channels: An Important Therapeutic Implication in Gastrointestinal Dysmotility in Patients With Spinal Cord Injury., J Neurogastroenterol Motil
Godfraind T, 2017, Discovery and Development of Calcium Channel Blockers., Front Pharmacol

TRIMETHADIONE CACNA1G

Interaction Score: 5.07

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

PMIDs:
11752352 16171802 17016423 17139284 17291698

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND TTD
METHSUXIMIDE CACNA1G

Interaction Score: 4.73

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

Direct Interaction yes

PMIDs:
11274992 2545161 19005061 11641441

Sources:
DrugBank ChemblInteractions TTD
ETHOSUXIMIDE CACNA1G

Interaction Score: 3.65

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

Trial Name -

PMIDs:
11641441 11274992 19005061 11752352

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND TTD
MANIDIPINE 6300 CACNA1G

Interaction Score: 2.03

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

PMIDs:
15329044

Sources:
DrugBank
FLUNARIZINE CACNA1G

Interaction Score: 1.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11784784 19582593 17016423 17139284

Sources:
DrugBank TdgClinicalTrial TEND
BENIDIPINE CACNA1G

Interaction Score: 1.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
16565579

Sources:
DrugBank
PARAMETHADIONE CACNA1G

Interaction Score: 1.35

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions TTD
ZONISAMIDE CACNA1G

Interaction Score: 0.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Novel drug target Established target

Trial Name Empatic

PMIDs:
19948168 17762320 15511691 20502722 14704463 18433351 20001433 20025128 19557119 14965331 17016423 17139284

Sources:
DrugBank TdgClinicalTrial TEND
BIOALLETHRIN CACNA1G

Interaction Score: 0.81

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

PMIDs:
14634047

Sources:
DrugBank
PENFLURIDOL CACNA1G

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ABT-639 CACNA1G

Interaction Score: 0.68

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Pore blocker

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PHENSUXIMIDE CACNA1G

Interaction Score: 0.68

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MIBEFRADIL CACNA1G

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
16899990 10692398 9481612 15562257 11752352 9375939

Sources:
DrugBank GuideToPharmacology
TRIMEBUTINE CACNA1G

Interaction Score: 0.51

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
26424038

Sources:
DrugBank
CINNARIZINE CACNA1G

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
3530295 1281221

Sources:
DrugBank
MIBEFRADIL DIHYDROCHLORIDE CACNA1G

Interaction Score: 0.29

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions
VERAPAMIL CACNA1G

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
16699084 19125880 11752352 21149638

Sources:
DrugBank TEND TTD
ANANDAMIDE CACNA1G

Interaction Score: 0.13

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Endogenous Drug? True

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
NIFEDIPINE CACNA1G

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
28611661 16899990

Sources:
DrugBank
CANNABIDIOL CACNA1G

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26264914

Sources:
DrugBank
NABIXIMOLS CACNA1G

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26264914

Sources:
DrugBank
IMAGABALIN CACNA1G

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN ENACARBIL CACNA1G

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA1G

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ATAGABALIN CACNA1G

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions
BEPRIDIL HYDROCHLORIDE CACNA1G

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA1G

Interaction Score: 0.07

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CELECOXIB CACNA1G

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB

Ensembl: ENSG00000006283
- Version: 101_38
Alternate Names:

CACNA1G Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: O43497
- Version: January-2014
Alternate Names:

CACNA1G Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.11

Publications:

RussLampel: ENSG00000006283

Version: 26-July-2011

Alternate Names:

CACNA1G Display Id

ENSG00000006283 Ensembl Gene Id

VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL ALPHA-1G SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV3.1) (CAV3.1C) (NBR13). [SOURCE:UNIPROT/SWISSPROT;ACC:O43497] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: O43497
- Version: 01-August-2011
Alternate Names:

8913 Entrez Gene Id

O43497 Uniprot Accession

ENSG00000006283 Ensembl Gene Id

Gene Info:

Target Subclass Voltage_gated_ion_channels

Target Subclass CalciumChannels

Target Main Class Transporters

Publications:
BaderLabGenes: CACNA1G
- Version: February-2014
Alternate Names:

8913 Entrez Gene ID

Gene Info:

Initial Gene Query Cav3.1

Counted Citations from 1950-2000 413

Gene Categories:

ION CHANNEL

Publications:
HopkinsGroom: O43497
- Version: 11-September-2012
Alternate Names:

8913 Entrez Gene Id

VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G Uniprot Protein Name

O43497 Uniprot Accession

Gene Info:

Interpro Name Ion transport domain

Uniprot Status Swiss-Prot

Interpro Acc IPR005821

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 8913
- Version: 29-September-2020
Alternate Names:

1394 HUGO Gene ID

1394 HUGO Gene Symbol

calcium voltage-gated channel subunit alpha1 G HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Voltage-gated calcium channels

GuideToPharmacology Gene Category ID 80

Gene Categories:

ION CHANNEL

Publications:
PharmGKB: CACNA1G
- Version: 18-August-2020
Alternate Names:

PA381 PharmGKB ID

Gene Info:

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

DrugBank: BE0008716

Version: 5.1.7

Alternate Names:

CACNA1G DrugBank Gene Name

O43497 UniProt Accession

8913 Entrez Gene Id

Gene Info:

Publications:

Radulovic M et al., 2015, Targeting Ion Channels: An Important Therapeutic Implication in Gastrointestinal Dysmotility in Patients With Spinal Cord Injury., J Neurogastroenterol Motil

McKeage K et al., 2004, Manidipine: a review of its use in the management of hypertension., Drugs

Yao K et al., 2006, Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker., J Pharmacol Sci

DrugBank: BE0000483

Version: 5.1.7

Alternate Names:

CACNA1G DrugBank Gene Name

O43497 UniProt Accession

8913 Entrez Gene Id

Gene Info:

Publications:

Singh, 1986, The mechanism of action of calcium antagonists relative to their clinical applications., Br J Clin Pharmacol

Cohen et al., 1992, Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists., J. Gen. Physiol.

Matthews et al., 2001, Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats., Eur. J. Pharmacol.

HingoraniCasas: ENSG00000006283
- Version: 31-May-2017
Alternate Names:

ENSG00000006283 Gene Symbol

CACNA1G Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: KIAA1123
- Version: chembl_23
Alternate Names:

KIAA1123 GENE_SYMBOL

CACNA1G GENE_SYMBOL

Voltage-dependent T-type calcium channel subunit alpha-1G UNIPROT

Gene Info:

Publications:
Pharos: CACNA1G
- Version: 03-September-2020
Alternate Names:

Voltage-dependent T-type calcium channel subunit alpha-1G Gene Name

O43497 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:
TTD: Voltage-gated calcium channel alpha Cav3.1
- Version: 2020.06.01
Alternate Names:

CACNA1G TTD Gene Abbreviation

T64795 TTD Target ID

Gene Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Voltage-gated T-type calcium channel blocker

Mechanism of Interaction	Voltage-gated T-type calcium channel blocker
Direct Interaction	yes

Trial Name	zonisamide,Zonegran, Trerief
Novel drug target	Established target
Trial Name	Empatic

Specific Action of the Ligand	Pore blocker
Endogenous Drug?	False
Direct Interaction?	False

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	False

Mechanism of Interaction	Voltage-gated calcium channel modulator
Direct Interaction	yes

Mechanism of Interaction	Voltage-gated calcium channel blocker
Direct Interaction	yes

CACNA1G	Display Id
ENSG00000006283	Ensembl Gene Id
VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL ALPHA-1G SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV3.1) (CAV3.1C) (NBR13). [SOURCE:UNIPROT/SWISSPROT;ACC:O43497]	Description

8913	Entrez Gene Id
O43497	Uniprot Accession
ENSG00000006283	Ensembl Gene Id

1394	HUGO Gene ID
1394	HUGO Gene Symbol
calcium voltage-gated channel subunit alpha1 G	HUGO Gene Name

inhibitor (inhibitory)
blocker (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

inhibitor (inhibitory)
blocker (inhibitory)

inhibitor (inhibitory)
blocker (inhibitory)

CACNA1G	DrugBank Gene Name
O43497	UniProt Accession
8913	Entrez Gene Id

KIAA1123	GENE_SYMBOL
CACNA1G	GENE_SYMBOL
Voltage-dependent T-type calcium channel subunit alpha-1G	UNIPROT

Voltage-dependent T-type calcium channel subunit alpha-1G	Gene Name
O43497	UniProt ID

CACNA1G Gene Record

CACNA1G 8913 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory) blocker (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Voltage-gated T-type calcium channel blocker

PMIDs: 11752352 16171802 17016423 17139284 17291698

Sources: DrugBank TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated T-type calcium channel blocker Direct Interaction yes

PMIDs: 11274992 2545161 19005061 11641441

Sources: DrugBank ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory) blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated T-type calcium channel blocker Trial Name -

PMIDs: 11641441 11274992 19005061 11752352

Sources: DrugBank TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info:

PMIDs: 15329044

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11784784 19582593 17016423 17139284

Sources: DrugBank TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 16565579

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated T-type calcium channel blocker

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name zonisamide,Zonegran, Trerief Novel drug target Established target Trial Name Empatic

PMIDs: 19948168 17762320 15511691 20502722 14704463 18433351 20001433 20025128 19557119 14965331 17016423 17139284

Sources: DrugBank TdgClinicalTrial TEND

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info:

PMIDs: 14634047

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand Pore blocker Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated T-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory) blocker (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

PMIDs: 16899990 10692398 9481612 15562257 11752352 9375939

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 26424038

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 3530295 1281221

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated T-type calcium channel blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 16699084 19125880 11752352 21149638

Sources: DrugBank TEND TTD

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Endogenous Drug? True Specific Action of the Ligand Antagonist

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

PMIDs:
11752352 16171802 17016423 17139284 17291698

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

Direct Interaction yes

PMIDs:
11274992 2545161 19005061 11641441

Sources:
DrugBank ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

Trial Name -

PMIDs:
11641441 11274992 19005061 11752352

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

blocker (inhibitory)

PMIDs:
15329044

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11784784 19582593 17016423 17139284

Sources:
DrugBank TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
16565579

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Novel drug target Established target

Trial Name Empatic

PMIDs:
19948168 17762320 15511691 20502722 14704463 18433351 20001433 20025128 19557119 14965331 17016423 17139284

Sources:
DrugBank TdgClinicalTrial TEND

Interaction Types & Directionality:

blocker (inhibitory)

PMIDs:
14634047

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Pore blocker

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
16899990 10692398 9481612 15562257 11752352 9375939

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

activator (activating)

PMIDs:
26424038

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
3530295 1281221

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated T-type calcium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
16699084 19125880 11752352 21149638

Sources:
DrugBank TEND TTD

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Endogenous Drug? True

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
28611661 16899990

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
26264914

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
26264914

Sources:
DrugBank

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes