• Interaction Score: 1.67

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Recombinant Cav1.3 calcium channel complexes expressed in tsA201-cells
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 1.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Trial Name Clevelox
    Novel drug target Established target
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

  • Interaction Score: 0.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    30645721


    Sources:
    DrugBank

  • Interaction Score: 0.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)
    blocker (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Recombinant Ca<sub>v</sub>1.3 calcium channel complexes expressed in tsA201-cells
    Specific Action of the Ligand None
    Endogenous Drug? False

  • Interaction Score: 0.64

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

  • Interaction Score: 0.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

  • Interaction Score: 0.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19029287


    Sources:
    DrugBank

  • Interaction Score: 0.42

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.42

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    None found


  • Interaction Score: 0.33

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.33

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.32

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name enalapril + felodipine,Lexxel
    Novel drug target Established target
    Trial Name felodipine ,Plendil

  • Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    3530295 1281221


    Sources:
    DrugBank

  • Interaction Score: 0.29

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

  • Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

  • Interaction Score: 0.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

  • Interaction Score: 0.28

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.24

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    None found


  • Interaction Score: 0.21

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.19

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)
    blocker (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

  • Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    23997577


    Sources:
    DrugBank

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11160515


    Sources:
    DrugBank

  • Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12970385


    Sources:
    DrugBank