DGIdb - CA7 Gene Record

CA7 766 Druggable Genome

Alternate Names:

766
CARBONIC ANHYDRASE 7
CA7
CAVII
114770
1381
ENSG00000168748
OTTHUMG00000137524
2749
P43166
BE0003629
CARBONIC ANHYDRASE VII (EC 4.2.1.1) (CARBONATE DEHYDRATASE VII) (CA- VII). [SOURCE:UNIPROT/SWISSPROT;ACC:P43166]
CA-VII
Carbonic anhydrase VII
Carbonate dehydratase VII
CAH7_HUMAN
NM_005182
NP_005173

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Carbonic_anhydrase_a
Uniprot Status	Swiss-Prot
Interpro Name	Alpha carbonic anhydrase
Interpro Acc	IPR001148
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Domain
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Carbonic anhydrases
GuideToPharmacology Gene Category ID	842

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol
Supuran et al., 2008, Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity., Expert Opin Emerg Drugs
De Simone et al., 2009, Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?, Chem Biol Drug Des
Farooq et al., 2008, Therapeutic role of zonisamide in neuropsychiatric disorders., Mini Rev Med Chem
2007, Zonisamide: new drug. No advantage in refractory partial epilepsy., Prescrire Int
Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.
Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.
Innocenti et al., 2010, Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids., Bioorg. Med. Chem.

METHAZOLAMIDE CA7

Interaction Score: 1.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
18336310

Sources:
DrugBank GuideToPharmacology ChemblInteractions
DICHLORPHENAMIDE CA7

Interaction Score: 1.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18336310

Sources:
DrugBank
INDISULAM CA7

Interaction Score: 1.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
ETHOXZOLAMIDE CA7

Interaction Score: 1.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
18336310

Sources:
DrugBank GuideToPharmacology ChemblInteractions
ACETAZOLAMIDE CA7

Interaction Score: 0.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
18336310

Sources:
DrugBank GuideToPharmacology
ZONISAMIDE CA7

Interaction Score: 0.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
17762320 18537527 19703035 18782051 17582922

Sources:
DrugBank GuideToPharmacology
HYDROFLUMETHIAZIDE CA7

Interaction Score: 0.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19119014

Sources:
DrugBank
DORZOLAMIDE CA7

Interaction Score: 0.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
BRINZOLAMIDE CA7

Interaction Score: 0.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
HISTIDINE CA7

Interaction Score: 0.39

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Specific Action of the Ligand Activation

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHLORTHALIDONE CA7

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
HISTAMINE CA7

Interaction Score: 0.3

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Specific Action of the Ligand Activation

Details of Interaction K<sub>A</sub> 37500 nM.

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SULPIRIDE CA7

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
AMPHETAMINE CA7

Interaction Score: 0.18

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Details of Interaction K<sub>A</sub> 910 nM.

PMIDs:
None found

Sources:
GuideToPharmacology
ELLAGIC ACID CA7

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
20185318

Sources:
DrugBank
TOPIRAMATE CA7

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Ensembl: ENSG00000168748
- Version: 101_38
Alternate Names:

CA7 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000168748
- Version: 26-July-2011
Alternate Names:

CARBONIC ANHYDRASE VII (EC 4.2.1.1) (CARBONATE DEHYDRATASE VII) (CA- VII). [SOURCE:UNIPROT/SWISSPROT;ACC:P43166] Description

CA7 Display Id

ENSG00000168748 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P43166
- Version: 11-September-2012
Alternate Names:

766 Entrez Gene Id

ENSG00000168748 Ensembl Gene Id

CARBONIC ANHYDRASE 7 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Carbonic_anhydrase_a

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 766
- Version: 29-September-2020
Alternate Names:

1381 HUGO Gene ID

1381 HUGO Gene Symbol

carbonic anhydrase 7 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Carbonic anhydrases

GuideToPharmacology Gene Category ID 842

Gene Categories:

ENZYME

Publications:

DrugBank: BE0003629

Version: 5.1.7

Alternate Names:

CA7 DrugBank Gene Name

P43166 UniProt Accession

766 Entrez Gene Id

Gene Info:

Publications:

Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.

Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.

Innocenti et al., 2010, Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids., Bioorg. Med. Chem.

ChemblInteractions: CA7
- Version: chembl_23
Alternate Names:

CA7 GENE_SYMBOL

Carbonic anhydrase 7 UNIPROT

Carbonate dehydratase VII UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000168748
- Version: 31-May-2017
Alternate Names:

ENSG00000168748 Gene Symbol

CA7 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Specific Action of the Ligand	Activation
Endogenous Drug?	False
Direct Interaction?	False

Specific Action of the Ligand	Activation
Details of Interaction	K<sub>A</sub> 37500 nM.
Endogenous Drug?	False

CARBONIC ANHYDRASE VII (EC 4.2.1.1) (CARBONATE DEHYDRATASE VII) (CA- VII). [SOURCE:UNIPROT/SWISSPROT;ACC:P43166]	Description
CA7	Display Id
ENSG00000168748	Ensembl Gene Id

766	Entrez Gene Id
ENSG00000168748	Ensembl Gene Id
CARBONIC ANHYDRASE 7	Uniprot Protein Name

1381	HUGO Gene ID
1381	HUGO Gene Symbol
carbonic anhydrase 7	HUGO Gene Name

CA7	DrugBank Gene Name
P43166	UniProt Accession
766	Entrez Gene Id

CA7	GENE_SYMBOL
Carbonic anhydrase 7	UNIPROT
Carbonate dehydratase VII	UNIPROT

CA7 Gene Record

CA7 766 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 18336310

Sources: DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 18336310

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 18336310

Sources: DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 18336310

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 17762320 18537527 19703035 18782051 17582922

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19119014

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: activator (activating)

Interaction Info: Specific Action of the Ligand Activation Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: activator (activating)

Interaction Info: Specific Action of the Ligand Activation Details of Interaction K<sub>A</sub> 37500 nM. Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Inhibition Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: activator (activating)

Interaction Info: Direct Interaction? False Endogenous Drug? False Details of Interaction K<sub>A</sub> 910 nM.

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 20185318

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Ensembl: ENSG00000168748

Alternate Names: CA7 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000168748

Alternate Names: CARBONIC ANHYDRASE VII (EC 4.2.1.1) (CARBONATE DEHYDRATASE VII) (CA- VII). [SOURCE:UNIPROT/SWISSPROT;ACC:P43166] Description CA7 Display Id ENSG00000168748 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P43166

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
18336310

Sources:
DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
18336310

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
18336310

Sources:
DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
18336310

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
17762320 18537527 19703035 18782051 17582922

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19119014

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Specific Action of the Ligand Activation

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Specific Action of the Ligand Activation

Details of Interaction K<sub>A</sub> 37500 nM.

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Details of Interaction K<sub>A</sub> 910 nM.

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
20185318

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Alternate Names:

CA7 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CARBONIC ANHYDRASE VII (EC 4.2.1.1) (CARBONATE DEHYDRATASE VII) (CA- VII). [SOURCE:UNIPROT/SWISSPROT;ACC:P43166] Description

CA7 Display Id

ENSG00000168748 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

766 Entrez Gene Id

ENSG00000168748 Ensembl Gene Id

CARBONIC ANHYDRASE 7 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Carbonic_anhydrase_a

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

1381 HUGO Gene ID

1381 HUGO Gene Symbol

carbonic anhydrase 7 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Carbonic anhydrases

GuideToPharmacology Gene Category ID 842

Gene Categories:

ENZYME

Alternate Names:

CA7 DrugBank Gene Name

P43166 UniProt Accession

766 Entrez Gene Id

Alternate Names:

CA7 GENE_SYMBOL

Carbonic anhydrase 7 UNIPROT

Carbonate dehydratase VII UNIPROT

Alternate Names:

ENSG00000168748 Gene Symbol

CA7 Ensembl Id

Gene Categories:

DRUGGABLE GENOME