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CA12 Gene Record

  • Summary
  • Interactions
  • Claims
  • CA12 771 Druggable Genome

    Alternate Names:

    771
    CARBONIC ANHYDRASE 12
    CA12
    CA-XII
    CAXII
    HsT18816
    T18816
    603263
    1371
    ENSG00000074410
    OTTHUMG00000132881
    PA25987
    carbonic anhydrase XII
    O43570
    CARBONIC ANHYDRASE XII PRECURSOR (EC 4.2.1.1) (CARBONATE DEHYDRATASE XII) (CA-XII) (TUMOR ANTIGEN HOM-RCC-3.1.3). [SOURCE:UNIPROT/SWISSPROT;ACC:O43570]
    Tumor antigen HOM-RCC-3.1.3
    Carbonate dehydratase XII
    CAH12_HUMAN
    BE0001653
    T16987

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:4.2.1
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Interpro Name Alpha carbonic anhydrase
    Interpro Short Name Carbonic_anhydrase_a
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001148
    Target Subclass 4.2.1
    Transmembrane Helix Count 1
    Target Main Class Enzymes
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.
    Jogaitė V et al., 2013, Characterization of human carbonic anhydrase XII stability and inhibitor binding., Bioorg Med Chem
    Mirza NS et al., 2011, Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors., Pharmacogenet Genomics
    Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.
    Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol
    Supuran et al., 2008, Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity., Expert Opin Emerg Drugs
    De Simone et al., 2009, Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?, Chem Biol Drug Des
    Farooq et al., 2008, Therapeutic role of zonisamide in neuropsychiatric disorders., Mini Rev Med Chem
    2007, Zonisamide: new drug. No advantage in refractory partial epilepsy., Prescrire Int
    Innocenti et al., 2010, Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids., Bioorg. Med. Chem.
  • TRIFLUOROMETHANESULFONAMIDE   CA12

    Interaction Score: 7.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23159038


    Sources:
    DTC

  • ACETAZOLAMIDE   CA12

    Interaction Score: 1.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Carbonic anhydrase XII inhibitor

    PMIDs:
    18336310


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • BENZTHIAZIDE   CA12

    Interaction Score: 0.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19119014


    Sources:
    DrugBank

  • ACETAZOLAMIDE SODIUM   CA12

    Interaction Score: 0.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Carbonic anhydrase XII inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETHOXZOLAMIDE   CA12

    Interaction Score: 0.87

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Carbonic anhydrase inhibitor
    Direct Interaction yes

    PMIDs:
    23159038


    Sources:
    DTC ChemblInteractions

  • ZONISAMIDE   CA12

    Interaction Score: 0.82

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17762320 18537527 21278619 19703035 18782051 17582922


    Sources:
    PharmGKB DrugBank

  • SULFAMYLON   CA12

    Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • HYDROFLUMETHIAZIDE   CA12

    Interaction Score: 0.69

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19119014


    Sources:
    DrugBank

  • DICHLORPHENAMIDE   CA12

    Interaction Score: 0.63

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Carbonic anhydrase XII inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PARABEN   CA12

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PHENOL   CA12

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ELLAGIC ACID   CA12

    Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    20185318


    Sources:
    DrugBank

  • TOPIRAMATE   CA12

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    21278619


    Sources:
    PharmGKB

  • CELECOXIB   CA12

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

  • CURCUMIN   CA12

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000074410

    • Version: 101_38

    Alternate Names:
    CA12 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: O43570

    • Version: January-2014

    Alternate Names:
    CA12 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:4.2.1

    Publications:

  • RussLampel: ENSG00000074410

    • Version: 26-July-2011

    Alternate Names:
    CARBONIC ANHYDRASE XII PRECURSOR (EC 4.2.1.1) (CARBONATE DEHYDRATASE XII) (CA-XII) (TUMOR ANTIGEN HOM-RCC-3.1.3). [SOURCE:UNIPROT/SWISSPROT;ACC:O43570] Description
    ENSG00000074410 Ensembl Gene Id
    CA12 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: O43570

    • Version: 01-August-2011

    Alternate Names:
    771 Entrez Gene Id
    O43570 Uniprot Accession
    CA12 Gene Symbol

    Gene Info:
    Target Subclass 4.2.1
    Transmembrane Helix Count 1
    Target Main Class Enzymes

    Publications:

  • HopkinsGroom: O43570

    • Version: 11-September-2012

    Alternate Names:
    CARBONIC ANHYDRASE 12 Uniprot Protein Name
    CA12 Uniprot Gene Name
    ENSG00000074410 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: CA12

    • Version: 18-August-2020

    Alternate Names:
    PA25987 PharmGKB ID

    Gene Info:

    Publications:
    Mirza NS et al., 2011, Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors., Pharmacogenet Genomics
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

  • DrugBank: BE0001653

    • Version: 5.1.7

    Alternate Names:
    CA12 DrugBank Gene Name
    O43570 UniProt Accession
    771 Entrez Gene Id

    Gene Info:

    Publications:
    Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.
    Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.
    Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol

  • DTC: CA12

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Jogaitė V et al., 2013, Characterization of human carbonic anhydrase XII stability and inhibitor binding., Bioorg Med Chem

  • ChemblInteractions: CA12

    • Version: chembl_23

    Alternate Names:
    CA12 GENE_SYMBOL
    Carbonic anhydrase 12 UNIPROT
    Carbonate dehydratase XII UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000074410

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000074410 Gene Symbol
    CA12 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Carbonic anhydrase XII

    • Version: 2020.06.01

    Alternate Names:
    CA-XII TTD Gene Abbreviation
    T16987 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21