DGIdb - CA12 Gene Record

CA12 771 Druggable Genome

Alternate Names:

771
CARBONIC ANHYDRASE 12
CA12
CA-XII
CAXII
HsT18816
T18816
603263
1371
ENSG00000074410
OTTHUMG00000132881
PA25987
carbonic anhydrase XII
O43570
CARBONIC ANHYDRASE XII PRECURSOR (EC 4.2.1.1) (CARBONATE DEHYDRATASE XII) (CA-XII) (TUMOR ANTIGEN HOM-RCC-3.1.3). [SOURCE:UNIPROT/SWISSPROT;ACC:O43570]
Tumor antigen HOM-RCC-3.1.3
Carbonate dehydratase XII
CAH12_HUMAN
BE0001653
T16987

Gene Info:

Target Class	Enzymes
Target Subclass	EC:4.2.1
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Name	Alpha carbonic anhydrase
Interpro Short Name	Carbonic_anhydrase_a
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR001148
Target Subclass	4.2.1
Transmembrane Helix Count	1
Target Main Class	Enzymes
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.
Jogaitė V et al., 2013, Characterization of human carbonic anhydrase XII stability and inhibitor binding., Bioorg Med Chem
Mirza NS et al., 2011, Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors., Pharmacogenet Genomics
Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.
Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol
Supuran et al., 2008, Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity., Expert Opin Emerg Drugs
De Simone et al., 2009, Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?, Chem Biol Drug Des
Farooq et al., 2008, Therapeutic role of zonisamide in neuropsychiatric disorders., Mini Rev Med Chem
2007, Zonisamide: new drug. No advantage in refractory partial epilepsy., Prescrire Int
Innocenti et al., 2010, Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids., Bioorg. Med. Chem.

TRIFLUOROMETHANESULFONAMIDE CA12

Interaction Score: 7.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23159038

Sources:
DTC
ACETAZOLAMIDE CA12

Interaction Score: 1.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Carbonic anhydrase XII inhibitor

PMIDs:
18336310

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions
BENZTHIAZIDE CA12

Interaction Score: 0.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19119014

Sources:
DrugBank
ACETAZOLAMIDE SODIUM CA12

Interaction Score: 0.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase XII inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOXZOLAMIDE CA12

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
23159038

Sources:
DTC ChemblInteractions
ZONISAMIDE CA12

Interaction Score: 0.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17762320 18537527 21278619 19703035 18782051 17582922

Sources:
PharmGKB DrugBank
SULFAMYLON CA12

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
HYDROFLUMETHIAZIDE CA12

Interaction Score: 0.69

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19119014

Sources:
DrugBank
DICHLORPHENAMIDE CA12

Interaction Score: 0.63

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase XII inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PARABEN CA12

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PHENOL CA12

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ELLAGIC ACID CA12

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
20185318

Sources:
DrugBank
TOPIRAMATE CA12

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
21278619

Sources:
PharmGKB
CELECOXIB CA12

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CURCUMIN CA12

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000074410
- Version: 101_38
Alternate Names:

CA12 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: O43570
- Version: January-2014
Alternate Names:

CA12 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:4.2.1

Publications:

RussLampel: ENSG00000074410

Version: 26-July-2011

Alternate Names:

CARBONIC ANHYDRASE XII PRECURSOR (EC 4.2.1.1) (CARBONATE DEHYDRATASE XII) (CA-XII) (TUMOR ANTIGEN HOM-RCC-3.1.3). [SOURCE:UNIPROT/SWISSPROT;ACC:O43570] Description

ENSG00000074410 Ensembl Gene Id

CA12 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: O43570
- Version: 01-August-2011
Alternate Names:

771 Entrez Gene Id

O43570 Uniprot Accession

CA12 Gene Symbol

Gene Info:

Target Subclass 4.2.1

Transmembrane Helix Count 1

Target Main Class Enzymes

Publications:
HopkinsGroom: O43570
- Version: 11-September-2012
Alternate Names:

CARBONIC ANHYDRASE 12 Uniprot Protein Name

CA12 Uniprot Gene Name

ENSG00000074410 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: CA12

Version: 18-August-2020

Alternate Names:

PA25987 PharmGKB ID

Gene Info:

Publications:

Mirza NS et al., 2011, Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors., Pharmacogenet Genomics

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

DrugBank: BE0001653

Version: 5.1.7

Alternate Names:

CA12 DrugBank Gene Name

O43570 UniProt Accession

771 Entrez Gene Id

Gene Info:

Publications:

Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.

Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.

Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol

DTC: CA12
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Jogaitė V et al., 2013, Characterization of human carbonic anhydrase XII stability and inhibitor binding., Bioorg Med Chem
ChemblInteractions: CA12
- Version: chembl_23
Alternate Names:

CA12 GENE_SYMBOL

Carbonic anhydrase 12 UNIPROT

Carbonate dehydratase XII UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000074410
- Version: 31-May-2017
Alternate Names:

ENSG00000074410 Gene Symbol

CA12 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Carbonic anhydrase XII
- Version: 2020.06.01
Alternate Names:

CA-XII TTD Gene Abbreviation

T16987 TTD Target ID

Gene Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Carbonic anhydrase XII inhibitor

Mechanism of Interaction	Carbonic anhydrase XII inhibitor
Direct Interaction	yes

Mechanism of Interaction	Carbonic anhydrase inhibitor
Direct Interaction	yes

CARBONIC ANHYDRASE XII PRECURSOR (EC 4.2.1.1) (CARBONATE DEHYDRATASE XII) (CA-XII) (TUMOR ANTIGEN HOM-RCC-3.1.3). [SOURCE:UNIPROT/SWISSPROT;ACC:O43570]	Description
ENSG00000074410	Ensembl Gene Id
CA12	Display Id

CARBONIC ANHYDRASE 12	Uniprot Protein Name
CA12	Uniprot Gene Name
ENSG00000074410	Ensembl Gene Id

CA12	DrugBank Gene Name
O43570	UniProt Accession
771	Entrez Gene Id

CA12	GENE_SYMBOL
Carbonic anhydrase 12	UNIPROT
Carbonate dehydratase XII	UNIPROT

CA12 Gene Record

CA12 771 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23159038

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Carbonic anhydrase XII inhibitor

PMIDs: 18336310

Sources: TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19119014

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase XII inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase inhibitor Direct Interaction yes

PMIDs: 23159038

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 17762320 18537527 21278619 19703035 18782051 17582922

Sources: PharmGKB DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19119014

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase XII inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 20185318

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 21278619

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Ensembl: ENSG00000074410

Alternate Names: CA12 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: O43570

Alternate Names: CA12 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:4.2.1

Publications:

RussLampel: ENSG00000074410

Alternate Names: CARBONIC ANHYDRASE XII PRECURSOR (EC 4.2.1.1) (CARBONATE DEHYDRATASE XII) (CA-XII) (TUMOR ANTIGEN HOM-RCC-3.1.3). [SOURCE:UNIPROT/SWISSPROT;ACC:O43570] Description ENSG00000074410 Ensembl Gene Id CA12 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: O43570

Interaction Types & Directionality:

n/a

PMIDs:
23159038

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Carbonic anhydrase XII inhibitor

PMIDs:
18336310

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19119014

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase XII inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase inhibitor

Direct Interaction yes

PMIDs:
23159038

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17762320 18537527 21278619 19703035 18782051 17582922

Sources:
PharmGKB DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19119014

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase XII inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
20185318

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
21278619

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

CA12 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CA12 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:4.2.1

Alternate Names:

CARBONIC ANHYDRASE XII PRECURSOR (EC 4.2.1.1) (CARBONATE DEHYDRATASE XII) (CA-XII) (TUMOR ANTIGEN HOM-RCC-3.1.3). [SOURCE:UNIPROT/SWISSPROT;ACC:O43570] Description

ENSG00000074410 Ensembl Gene Id

CA12 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

771 Entrez Gene Id

O43570 Uniprot Accession

CA12 Gene Symbol

Gene Info:

Target Subclass 4.2.1

Transmembrane Helix Count 1

Target Main Class Enzymes

Alternate Names:

CARBONIC ANHYDRASE 12 Uniprot Protein Name

CA12 Uniprot Gene Name

ENSG00000074410 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA25987 PharmGKB ID

Publications:

Mirza NS et al., 2011, Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors., Pharmacogenet Genomics

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

Alternate Names:

CA12 DrugBank Gene Name

O43570 UniProt Accession

771 Entrez Gene Id

Publications:

Jogaitė V et al., 2013, Characterization of human carbonic anhydrase XII stability and inhibitor binding., Bioorg Med Chem

Alternate Names:

CA12 GENE_SYMBOL

Carbonic anhydrase 12 UNIPROT

Carbonate dehydratase XII UNIPROT

Alternate Names:

ENSG00000074410 Gene Symbol

CA12 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CA-XII TTD Gene Abbreviation

T16987 TTD Target ID