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CA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CA1 759 Druggable Genome

    Alternate Names:

    759
    CARBONIC ANHYDRASE 1
    CA1
    CA-I
    CAB
    Car1
    HEL-S-11
    114800
    1368
    ENSG00000133742
    OTTHUMG00000164941
    Carbonic anhydrase B
    Carbonate dehydratase I
    Carbonic anhydrase I
    BE0000267
    P00915
    CAH1_HUMAN
    CARBONIC ANHYDRASE I (EC 4.2.1.1) (CARBONATE DEHYDRATASE I) (CA-I) (CARBONIC ANHYDRASE B). [SOURCE:UNIPROT/SWISSPROT;ACC:P00915]
    2597
    ENSG00000137731
    T13201
    NM_001128830
    NP_001122302
    BE0009965

    Gene Info:

    Interpro Name Alpha carbonic anhydrase
    Interpro Acc IPR001148
    Interpro Type Domain
    Interpro Short Name Carbonic_anhydrase_a
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Target Main Class Enzymes
    Target Subclass 4.2.1.1
    Target Class Enzymes
    Target Subclass EC:4.2.1.1
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Carbonic anhydrases
    GuideToPharmacology Gene Category ID 842
    (8 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Cleland et al., 2008, Treatment of neuromuscular channelopathies: current concepts and future prospects., Neurotherapeutics
    Lindskog, 1997, Structure and mechanism of carbonic anhydrase., Pharmacol. Ther.
    Winum et al., 2004, Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits., Bioorg. Med. Chem. Lett.
    Giacomotto et al., 2009, Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy., Hum. Mol. Genet.
    Nishimori et al., 2007, Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors., J. Med. Chem.
    De Simone et al., 2005, Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies., Bioorg. Med. Chem. Lett.
    Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol
    Supuran et al., 2008, Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity., Expert Opin Emerg Drugs
    Shank et al., 2008, Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate., J Enzyme Inhib Med Chem
    Farooq et al., 2008, Therapeutic role of zonisamide in neuropsychiatric disorders., Mini Rev Med Chem
    2007, Zonisamide: new drug. No advantage in refractory partial epilepsy., Prescrire Int
    Masuda et al., 1993, Inhibitory effect of zonisamide on human carbonic anhydrase in vitro., Arzneimittelforschung
    Temperini et al., 2008, Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies., Bioorg. Med. Chem. Lett.
    Herkel et al., 2001, Update on topical carbonic anhydrase inhibitors., Curr Opin Ophthalmol
    Maren et al., 1997, Ocular absorption, blood levels, and excretion of dorzolamide, a topically active carbonic anhydrase inhibitor., J Ocul Pharmacol Ther
    Hasegawa et al., Binding of dorzolamide and its metabolite, N-deethylated dorzolamide, to human erythrocytes in vitro., Drug Metab. Dispos.
    Sugrue, 1996, The preclinical pharmacology of dorzolamide hydrochloride, a topical carbonic anhydrase inhibitor., J Ocul Pharmacol Ther
    Perez Velazquez, 2003, Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity., Eur. J. Neurosci.
    Scozzafava et al., 2000, Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes., J. Med. Chem.
    Heck et al., 1994, Catalytic properties of mouse carbonic anhydrase V., J. Biol. Chem.
    Bertucci et al., 2009, Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides., Bioorg. Med. Chem.
    Siffert et al., 1982, Carbonic anhydrase C in white-skeletal-muscle tissue., Biochem. J.
    Köhling et al., 2000, Ictal epileptiform activity is facilitated by hippocampal GABAA receptor-mediated oscillations., J. Neurosci.
    Iyer et al., 1999, In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics., J Pharmacokinet Biopharm
    Ilies et al., 2004, Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity., Bioorg. Med. Chem.
    Puscas et al., 2000, Hypotensive effect of calcium channel blockers is parallel with carbonic anhydrase I inhibition., Clin. Pharmacol. Ther.
    Puscas et al., 2001, Vasoconstrictive drugs increase carbonic anhydrase I in vascular smooth muscle while vasodilating drugs reduce the activity of this isozyme by a direct mechanism of action., Drugs Exp Clin Res
    Puscas et al., 2000, Calcium channel blockers reduce blood pressure in part by inhibiting vascular smooth muscle carbonic anhydrase I., Cardiovasc Drugs Ther
    Parr et al., 1992, Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters., J. Biol. Chem.
    Puscas et al., 1999, Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action., Drugs Exp Clin Res
    Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.
    Puscas et al., 1996, Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action., J. Pharmacol. Exp. Ther.
    Meierkord et al., 2000, Sodium bromide: effects on different patterns of epileptiform activity, extracellular pH changes and GABAergic inhibition., Naunyn Schmiedebergs Arch. Pharmacol.
    Puscas et al., 2001, Indomethacin activates carbonic anhydrase and antagonizes the effect of the specific carbonic anhydrase inhibitor acetazolamide, by a direct mechanism of action., Int J Clin Pharmacol Ther
    Puscas et al., 1999, The inhibitory effect of diuretics on carbonic anhydrases., Res. Commun. Mol. Pathol. Pharmacol.
    Berg et al., 2004, Carbonic anhydrase in mammalian vascular smooth muscle., J. Histochem. Cytochem.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Tricarico D et al., 2006, Carbonic anhydrase inhibitors ameliorate the symptoms of hypokalaemic periodic paralysis in rats by opening the muscular Ca2+-activated-K+ channels., Neuromuscul Disord
    Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.
    Couloigner et al., 1998, Effect of locally applied drugs on the endolymphatic sac potential., Laryngoscope
    Supuran, 2008, Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides., Curr. Pharm. Des.
    Temperini et al., 2008, Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct., Bioorg. Med. Chem. Lett.
    Temperini et al., 2008, Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?, Org. Biomol. Chem.
    Woodman R et al., 2010, Chlorthalidone decreases platelet aggregation and vascular permeability and promotes angiogenesis., Hypertension
    Güney M et al., 2015, Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives., Bioorg Med Chem Lett
    Temperini C et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference., J Med Chem
    Larson et al., 1994, Effects of cyclothiazide on synaptic responses in slices of adult and neonatal rat hippocampus., Neuroreport
    Rammes et al., 1999, Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide., Pflugers Arch.
    Fleck et al., 1996, AMPA receptor heterogeneity in rat hippocampal neurons revealed by differential sensitivity to cyclothiazide., J. Neurophysiol.
    Pirotte et al., 1998, 4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships., J. Med. Chem.
    Rammes et al., 1996, Interactions of 2,3-benzodiazepines and cyclothiazide at AMPA receptors: patch clamp recordings in cultured neurones and area CA1 in hippocampal slices., Br. J. Pharmacol.
    Erdemli et al., 1993, Diazoxide suppresses slowly-inactivating outward and inward currents in CA1 hippocampal neurones., Neuroreport
    Domoki et al., 2004, Diazoxide prevents mitochondrial swelling and Ca2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs., Brain Res.
    Crépel et al., 1993, The K+ channel opener diazoxide enhances glutamatergic currents and reduces GABAergic currents in hippocampal neurons., J. Neurophysiol.
    Scuvée-Moreau et al., 1997, Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro., Arch. Physiol. Biochem.
    Erdemli et al., 1995, Actions of diazoxide on CA1 neurons in hippocampal slices from rats., Can. J. Physiol. Pharmacol.
    Dodgson et al., 2000, Topiramate as an inhibitor of carbonic anhydrase isoenzymes., Epilepsia
    Nishimori I et al., 2007, Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides., Bioorg Med Chem
    LEIBMAN KC et al., 1961, Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide., J Pharmacol Exp Ther
    Tauro M et al., 2014, Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors., Bioorg Med Chem Lett
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Innocenti et al., 2010, Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids., Bioorg. Med. Chem.
  • DICHLORPHENAMIDE   CA1

    Interaction Score: 2.67

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    19019313 9336012 14684332 19648295 17228881


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • METHAZOLAMIDE   CA1

    Interaction Score: 1.6

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    10533697 15110853 9336012 14684332 10649985


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • CHEMBL451332   CA1

    Interaction Score: 1.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • ETHINAMATE   CA1

    Interaction Score: 1.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    1460006


    Sources:
    DrugBank

  • POLMACOXIB   CA1

    Interaction Score: 1.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Carbonic anhydrase I inhibitor
    Direct Interaction yes
    Trial Name CG100649

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD ChemblInteractions

  • ACETAZOLAMIDE   CA1

    Interaction Score: 1.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    10713865 12956733 18336310 8667211 10651143 11430635


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • ETHOXZOLAMIDE   CA1

    Interaction Score: 1.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    12956733 10649985 7929150 19520577 6816217 10995826


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • TRICHLORMETHIAZIDE   CA1

    Interaction Score: 1.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    19119014 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • BENDROFLUMETHIAZIDE   CA1

    Interaction Score: 1.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    15258186 17139284 17016423 16368240


    Sources:
    DrugBank

  • CHLOROTHIAZIDE   CA1

    Interaction Score: 1.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10713865 10954127


    Sources:
    TEND TdgClinicalTrial DrugBank

  • METHOCARBAMOL   CA1

    Interaction Score: 1.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Carbonic anhydrase I inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

    PMIDs:
    1460006


    Sources:
    DrugBank GuideToPharmacology ChemblInteractions

  • CYCLOTHIAZIDE   CA1

    Interaction Score: 1.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19119014 19115843 8003661 9929558 8793745 9685234 8882618


    Sources:
    DrugBank

  • QUINETHAZONE   CA1

    Interaction Score: 1.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    18336309 18374572 18600270


    Sources:
    DrugBank

  • DORZOLAMIDE   CA1

    Interaction Score: 1.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    9029437 8070313 8875343


    Sources:
    DrugBank GuideToPharmacology

  • RESORCINOL   CA1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26073005


    Sources:
    DTC

  • METHYCLOTHIAZIDE   CA1

    Interaction Score: 0.97

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19119014 10713865 9546276


    Sources:
    DrugBank

  • BRINZOLAMIDE   CA1

    Interaction Score: 0.83

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    14684332 11224713


    Sources:
    DrugBank GuideToPharmacology

  • SODIUM CARBONATE   CA1

    Interaction Score: 0.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17139284


    Sources:
    DrugBank

  • MEDRONIC ACID   CA1

    Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24813742


    Sources:
    DTC

  • BENZTHIAZIDE   CA1

    Interaction Score: 0.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    13760527 17139284 17016423


    Sources:
    DrugBank

  • BENZOLAMIDE   CA1

    Interaction Score: 0.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PHENOL   CA1

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26073005


    Sources:
    DTC TTD

  • HYDROFLUMETHIAZIDE   CA1

    Interaction Score: 0.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19119014 17139284 17016423


    Sources:
    DrugBank

  • DIAZOXIDE   CA1

    Interaction Score: 0.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    8298083 15306243 7681475 9439778 7585327


    Sources:
    DrugBank

  • INDISULAM   CA1

    Interaction Score: 0.49

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHLORTHALIDONE   CA1

    Interaction Score: 0.44

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    20625077


    Sources:
    DrugBank GuideToPharmacology

  • ZONISAMIDE   CA1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    15837316 17762320 18537527 18343915 18782051 17582922 8494570 18162396


    Sources:
    TEND DrugBank GuideToPharmacology

  • SULFAMIDE   CA1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ACETAZOLAMIDE SODIUM   CA1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Carbonic anhydrase I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMLODIPINE   CA1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11061585 11392054 11101200


    Sources:
    DrugBank

  • PARABEN   CA1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LEVETIRACETAM   CA1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • HISTIDINE   CA1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand Activation
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CATECHOL   CA1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26073005


    Sources:
    DTC

  • TOPIRAMATE   CA1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    10768298 17826101


    Sources:
    DrugBank GuideToPharmacology

  • HISTAMINE   CA1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand Activation
    Details of Interaction K<sub>A</sub> of 2100 nM.
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • SULPIRIDE   CA1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ELLAGIC ACID   CA1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    20185318


    Sources:
    DrugBank

  • CURCUMIN   CA1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000133742

    • Version: 101_38

    Alternate Names:
    CA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P00915

    • Version: 01-August-2011

    Alternate Names:
    CAH1_HUMAN Uniprot Id
    P00915 Uniprot Accession
    CA1 Gene Symbol

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 4.2.1.1

    Publications:

  • HopkinsGroom: P00915

    • Version: 11-September-2012

    Alternate Names:
    CARBONIC ANHYDRASE 1 Uniprot Protein Name
    759 Entrez Gene Id
    P00915 Uniprot Accession

    Gene Info:
    Interpro Name Alpha carbonic anhydrase
    Interpro Acc IPR001148
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P00915

    • Version: January-2014

    Alternate Names:
    CA1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:4.2.1.1

    Publications:

  • RussLampel: ENSG00000133742

    • Version: 26-July-2011

    Alternate Names:
    CARBONIC ANHYDRASE I (EC 4.2.1.1) (CARBONATE DEHYDRATASE I) (CA-I) (CARBONIC ANHYDRASE B). [SOURCE:UNIPROT/SWISSPROT;ACC:P00915] Description
    CA1 Display Id
    ENSG00000133742 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 759

    • Version: 29-September-2020

    Alternate Names:
    1368 HUGO Gene ID
    1368 HUGO Gene Symbol
    carbonic anhydrase 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Carbonic anhydrases
    GuideToPharmacology Gene Category ID 842

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0000267

    • Version: 5.1.7

    Alternate Names:
    CA1 DrugBank Gene Name
    P00915 UniProt Accession
    759 Entrez Gene Id

    Gene Info:

    Publications:
    Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.
    Puscas et al., 1999, Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action., Drugs Exp Clin Res
    Couloigner et al., 1998, Effect of locally applied drugs on the endolymphatic sac potential., Laryngoscope

  • DrugBank: BE0009965

    • Version: 5.1.7

    Alternate Names:
    CA1 DrugBank Gene Name
    P00915 UniProt Accession
    759 Entrez Gene Id

    Gene Info:

    Publications:
    Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.
    Temperini C et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference., J Med Chem
    LEIBMAN KC et al., 1961, Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide., J Pharmacol Exp Ther

  • DTC: CA1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Güney M et al., 2015, Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives., Bioorg Med Chem Lett
    Tauro M et al., 2014, Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors., Bioorg Med Chem Lett

  • ChemblInteractions: CA1

    • Version: chembl_23

    Alternate Names:
    CA1 GENE_SYMBOL
    Carbonic anhydrase 1 UNIPROT
    Carbonate dehydratase I UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000133742

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000133742 Gene Symbol
    CA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Carbonic anhydrase I

    • Version: 2020.06.01

    Alternate Names:
    CA-I TTD Gene Abbreviation
    T13201 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21