• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

CA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CA1 759 Druggable Genome

    Alternate Names:

    759
    CARBONIC ANHYDRASE 1
    CA1
    CA-I
    CAB
    Car1
    HEL-S-11
    114800
    1368
    ENSG00000133742
    OTTHUMG00000164941
    Carbonic anhydrase B
    Carbonate dehydratase I
    Carbonic anhydrase I
    P00915
    CAH1_HUMAN
    CARBONIC ANHYDRASE I (EC 4.2.1.1) (CARBONATE DEHYDRATASE I) (CA-I) (CARBONIC ANHYDRASE B). [SOURCE:UNIPROT/SWISSPROT;ACC:P00915]
    T13201

    Gene Info:

    Interpro Name Alpha carbonic anhydrase
    Interpro Acc IPR001148
    Interpro Type Domain
    Interpro Short Name Carbonic_anhydrase_a
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Target Main Class Enzymes
    Target Subclass 4.2.1.1
    Target Class Enzymes
    Target Subclass EC:4.2.1.1
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Lindskog, 1997, Structure and mechanism of carbonic anhydrase., Pharmacol. Ther.
    Winum et al., 2004, Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits., Bioorg. Med. Chem. Lett.
    Nishimori et al., 2007, Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors., J. Med. Chem.
    Giacomotto et al., 2009, Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy., Hum. Mol. Genet.
    Cleland et al., 2008, Treatment of neuromuscular channelopathies: current concepts and future prospects., Neurotherapeutics
    Temperini et al., 2008, Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies., Bioorg. Med. Chem. Lett.
    Supuran et al., 2008, Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity., Expert Opin Emerg Drugs
    Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol
    Farooq et al., 2008, Therapeutic role of zonisamide in neuropsychiatric disorders., Mini Rev Med Chem
    Masuda et al., 1993, Inhibitory effect of zonisamide on human carbonic anhydrase in vitro., Arzneimittelforschung
    De Simone et al., 2005, Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies., Bioorg. Med. Chem. Lett.
    2007, Zonisamide: new drug. No advantage in refractory partial epilepsy., Prescrire Int
    Shank et al., 2008, Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate., J Enzyme Inhib Med Chem
    Scozzafava et al., 2000, Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes., J. Med. Chem.
    Köhling et al., 2000, Ictal epileptiform activity is facilitated by hippocampal GABAA receptor-mediated oscillations., J. Neurosci.
    Heck et al., 1994, Catalytic properties of mouse carbonic anhydrase V., J. Biol. Chem.
    Bertucci et al., 2009, Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides., Bioorg. Med. Chem.
    Siffert et al., 1982, Carbonic anhydrase C in white-skeletal-muscle tissue., Biochem. J.
    Perez Velazquez, 2003, Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity., Eur. J. Neurosci.
    Iyer et al., 1999, In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics., J Pharmacokinet Biopharm
    Ilies et al., 2004, Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity., Bioorg. Med. Chem.
    Puscas et al., 1996, Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action., J. Pharmacol. Exp. Ther.
    Meierkord et al., 2000, Sodium bromide: effects on different patterns of epileptiform activity, extracellular pH changes and GABAergic inhibition., Naunyn Schmiedebergs Arch. Pharmacol.
    Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.
    Puscas et al., 2001, Indomethacin activates carbonic anhydrase and antagonizes the effect of the specific carbonic anhydrase inhibitor acetazolamide, by a direct mechanism of action., Int J Clin Pharmacol Ther
    Puscas et al., 1999, Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action., Drugs Exp Clin Res
    Puscas et al., 1999, The inhibitory effect of diuretics on carbonic anhydrases., Res. Commun. Mol. Pathol. Pharmacol.
    Güney M et al., 2015, Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives., Bioorg Med Chem Lett
    Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Parr et al., 1992, Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters., J. Biol. Chem.
    Tauro M et al., 2014, Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors., Bioorg Med Chem Lett
  • DICHLORPHENAMIDE   CA1

    Interaction Score: 7.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    9336012 14684332 17228881 19648295 19019313


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • METHAZOLAMIDE   CA1

    Interaction Score: 3.86

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Carbonic anhydrase I inhibitor
    Direct Interaction yes
    Trial Name -

    PMIDs:
    10533697 15110853 14684332 10649985 9336012


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • RESORCINOL   CA1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26073005


    Sources:
    DTC

  • POLMACOXIB   CA1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Carbonic anhydrase I inhibitor
    Direct Interaction yes
    Trial Name CG100649

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • ACETAZOLAMIDE   CA1

    Interaction Score: 3.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Carbonic anhydrase I inhibitor

    PMIDs:
    8667211 10651143 18336310 11430635 12956733 10713865


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • TRICHLORMETHIAZIDE   CA1

    Interaction Score: 2.86

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    19119014 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • ETHOXZOLAMIDE   CA1

    Interaction Score: 2.64

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Carbonic anhydrase inhibitor
    Trial Name -

    PMIDs:
    10649985 10995826 7929150 19520577 6816217 12956733


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • CHLOROTHIAZIDE   CA1

    Interaction Score: 2.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10713865 10954127


    Sources:
    TdgClinicalTrial TEND

  • MEDRONIC ACID   CA1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24813742


    Sources:
    DTC

  • PHENOL   CA1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26073005


    Sources:
    DTC TTD

  • ZONISAMIDE   CA1

    Interaction Score: 1.41

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    18162396 18537527 17762320 18782051 8494570 15837316 17582922 18343915


    Sources:
    TEND

  • METHOCARBAMOL   CA1

    Interaction Score: 1.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Carbonic anhydrase I inhibitor
    Direct Interaction yes

    PMIDs:
    1460006


    Sources:
    ChemblInteractions

  • SULFAMIDE   CA1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ACETAZOLAMIDE SODIUM   CA1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Carbonic anhydrase I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PARABEN   CA1

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LEVETIRACETAM   CA1

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • CATECHOL   CA1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26073005


    Sources:
    DTC

  • CURCUMIN   CA1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000133742

    • Version: 101_38

    Alternate Names:
    CA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P00915

    • Version: 01-August-2011

    Alternate Names:
    CAH1_HUMAN Uniprot Id
    P00915 Uniprot Accession
    CA1 Gene Symbol

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 4.2.1.1

    Publications:

  • HopkinsGroom: P00915

    • Version: 11-September-2012

    Alternate Names:
    CARBONIC ANHYDRASE 1 Uniprot Protein Name
    759 Entrez Gene Id
    P00915 Uniprot Accession

    Gene Info:
    Interpro Name Alpha carbonic anhydrase
    Interpro Acc IPR001148
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P00915

    • Version: January-2014

    Alternate Names:
    CA1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:4.2.1.1

    Publications:

  • RussLampel: ENSG00000133742

    • Version: 26-July-2011

    Alternate Names:
    CARBONIC ANHYDRASE I (EC 4.2.1.1) (CARBONATE DEHYDRATASE I) (CA-I) (CARBONIC ANHYDRASE B). [SOURCE:UNIPROT/SWISSPROT;ACC:P00915] Description
    CA1 Display Id
    ENSG00000133742 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • DTC: CA1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Güney M et al., 2015, Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives., Bioorg Med Chem Lett
    Tauro M et al., 2014, Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors., Bioorg Med Chem Lett

  • ChemblInteractions: CA1

    • Version: chembl_23

    Alternate Names:
    CA1 GENE_SYMBOL
    Carbonic anhydrase 1 UNIPROT
    Carbonate dehydratase I UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000133742

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000133742 Gene Symbol
    CA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Carbonic anhydrase I

    • Version: 2020.06.01

    Alternate Names:
    CA-I TTD Gene Abbreviation
    T13201 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21