DGIdb - CA1 Gene Record

CA1 759 Druggable Genome

Alternate Names:

759
CARBONIC ANHYDRASE 1
CA1
CA-I
CAB
Car1
HEL-S-11
114800
1368
ENSG00000133742
OTTHUMG00000164941
Carbonic anhydrase B
Carbonate dehydratase I
Carbonic anhydrase I
P00915
CAH1_HUMAN
CARBONIC ANHYDRASE I (EC 4.2.1.1) (CARBONATE DEHYDRATASE I) (CA-I) (CARBONIC ANHYDRASE B). [SOURCE:UNIPROT/SWISSPROT;ACC:P00915]
T13201

Gene Info:

Interpro Name	Alpha carbonic anhydrase
Interpro Acc	IPR001148
Interpro Type	Domain
Interpro Short Name	Carbonic_anhydrase_a
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Target Main Class	Enzymes
Target Subclass	4.2.1.1
Target Class	Enzymes
Target Subclass	EC:4.2.1.1
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Lindskog, 1997, Structure and mechanism of carbonic anhydrase., Pharmacol. Ther.
Winum et al., 2004, Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits., Bioorg. Med. Chem. Lett.
Nishimori et al., 2007, Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors., J. Med. Chem.
Giacomotto et al., 2009, Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy., Hum. Mol. Genet.
Cleland et al., 2008, Treatment of neuromuscular channelopathies: current concepts and future prospects., Neurotherapeutics
Temperini et al., 2008, Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies., Bioorg. Med. Chem. Lett.
Supuran et al., 2008, Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity., Expert Opin Emerg Drugs
Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol
Farooq et al., 2008, Therapeutic role of zonisamide in neuropsychiatric disorders., Mini Rev Med Chem
Masuda et al., 1993, Inhibitory effect of zonisamide on human carbonic anhydrase in vitro., Arzneimittelforschung
De Simone et al., 2005, Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies., Bioorg. Med. Chem. Lett.
2007, Zonisamide: new drug. No advantage in refractory partial epilepsy., Prescrire Int
Shank et al., 2008, Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate., J Enzyme Inhib Med Chem
Scozzafava et al., 2000, Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes., J. Med. Chem.
Köhling et al., 2000, Ictal epileptiform activity is facilitated by hippocampal GABAA receptor-mediated oscillations., J. Neurosci.
Heck et al., 1994, Catalytic properties of mouse carbonic anhydrase V., J. Biol. Chem.
Bertucci et al., 2009, Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides., Bioorg. Med. Chem.
Siffert et al., 1982, Carbonic anhydrase C in white-skeletal-muscle tissue., Biochem. J.
Perez Velazquez, 2003, Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity., Eur. J. Neurosci.
Iyer et al., 1999, In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics., J Pharmacokinet Biopharm
Ilies et al., 2004, Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity., Bioorg. Med. Chem.
Puscas et al., 1996, Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action., J. Pharmacol. Exp. Ther.
Meierkord et al., 2000, Sodium bromide: effects on different patterns of epileptiform activity, extracellular pH changes and GABAergic inhibition., Naunyn Schmiedebergs Arch. Pharmacol.
Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.
Puscas et al., 2001, Indomethacin activates carbonic anhydrase and antagonizes the effect of the specific carbonic anhydrase inhibitor acetazolamide, by a direct mechanism of action., Int J Clin Pharmacol Ther
Puscas et al., 1999, Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action., Drugs Exp Clin Res
Puscas et al., 1999, The inhibitory effect of diuretics on carbonic anhydrases., Res. Commun. Mol. Pathol. Pharmacol.
Güney M et al., 2015, Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives., Bioorg Med Chem Lett
Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Parr et al., 1992, Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters., J. Biol. Chem.
Tauro M et al., 2014, Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors., Bioorg Med Chem Lett

DICHLORPHENAMIDE CA1

Interaction Score: 7.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
9336012 14684332 17228881 19648295 19019313

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
METHAZOLAMIDE CA1

Interaction Score: 3.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
10533697 15110853 14684332 10649985 9336012

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
RESORCINOL CA1

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26073005

Sources:
DTC
POLMACOXIB CA1

Interaction Score: 3.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

Trial Name CG100649

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
ACETAZOLAMIDE CA1

Interaction Score: 3.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Carbonic anhydrase I inhibitor

PMIDs:
8667211 10651143 18336310 11430635 12956733 10713865

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
TRICHLORMETHIAZIDE CA1

Interaction Score: 2.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19119014 17016423 17139284

Sources:
TdgClinicalTrial TEND
ETHOXZOLAMIDE CA1

Interaction Score: 2.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Carbonic anhydrase inhibitor

Trial Name -

PMIDs:
10649985 10995826 7929150 19520577 6816217 12956733

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
CHLOROTHIAZIDE CA1

Interaction Score: 2.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10713865 10954127

Sources:
TdgClinicalTrial TEND
MEDRONIC ACID CA1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24813742

Sources:
DTC
PHENOL CA1

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26073005

Sources:
DTC TTD
ZONISAMIDE CA1

Interaction Score: 1.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18162396 18537527 17762320 18782051 8494570 15837316 17582922 18343915

Sources:
TEND
METHOCARBAMOL CA1

Interaction Score: 1.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

PMIDs:
1460006

Sources:
ChemblInteractions
SULFAMIDE CA1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ACETAZOLAMIDE SODIUM CA1

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PARABEN CA1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LEVETIRACETAM CA1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
CATECHOL CA1

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26073005

Sources:
DTC
CURCUMIN CA1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000133742
- Version: 101_38
Alternate Names:

CA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P00915
- Version: 01-August-2011
Alternate Names:

CAH1_HUMAN Uniprot Id

P00915 Uniprot Accession

CA1 Gene Symbol

Gene Info:

Target Main Class Enzymes

Target Subclass 4.2.1.1

Publications:
HopkinsGroom: P00915
- Version: 11-September-2012
Alternate Names:

CARBONIC ANHYDRASE 1 Uniprot Protein Name

759 Entrez Gene Id

P00915 Uniprot Accession

Gene Info:

Interpro Name Alpha carbonic anhydrase

Interpro Acc IPR001148

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P00915
- Version: January-2014
Alternate Names:

CA1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:4.2.1.1

Publications:

RussLampel: ENSG00000133742

Version: 26-July-2011

Alternate Names:

CARBONIC ANHYDRASE I (EC 4.2.1.1) (CARBONATE DEHYDRATASE I) (CA-I) (CARBONIC ANHYDRASE B). [SOURCE:UNIPROT/SWISSPROT;ACC:P00915] Description

CA1 Display Id

ENSG00000133742 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

DTC: CA1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Güney M et al., 2015, Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives., Bioorg Med Chem Lett

Tauro M et al., 2014, Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors., Bioorg Med Chem Lett

ChemblInteractions: CA1
- Version: chembl_23
Alternate Names:

CA1 GENE_SYMBOL

Carbonic anhydrase 1 UNIPROT

Carbonate dehydratase I UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000133742
- Version: 31-May-2017
Alternate Names:

ENSG00000133742 Gene Symbol

CA1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Carbonic anhydrase I
- Version: 2020.06.01
Alternate Names:

CA-I TTD Gene Abbreviation

T13201 TTD Target ID

Gene Info:

Publications:

Trial Name	-
Novel drug target	Established target
Direct Interaction	yes

Mechanism of Interaction	Carbonic anhydrase I inhibitor
Direct Interaction	yes
Trial Name	-

Direct Interaction	yes
Mechanism of Interaction	Carbonic anhydrase inhibitor
Trial Name	-

CARBONIC ANHYDRASE 1	Uniprot Protein Name
759	Entrez Gene Id
P00915	Uniprot Accession

CARBONIC ANHYDRASE I (EC 4.2.1.1) (CARBONATE DEHYDRATASE I) (CA-I) (CARBONIC ANHYDRASE B). [SOURCE:UNIPROT/SWISSPROT;ACC:P00915]	Description
CA1	Display Id
ENSG00000133742	Ensembl Gene Id

CA1	GENE_SYMBOL
Carbonic anhydrase 1	UNIPROT
Carbonate dehydratase I	UNIPROT

CA1 Gene Record

CA1 759 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Direct Interaction yes

PMIDs: 9336012 14684332 17228881 19648295 19019313

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase I inhibitor Direct Interaction yes Trial Name -

PMIDs: 10533697 15110853 14684332 10649985 9336012

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26073005

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase I inhibitor Direct Interaction yes Trial Name CG100649

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Carbonic anhydrase I inhibitor

PMIDs: 8667211 10651143 18336310 11430635 12956733 10713865

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 19119014 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Carbonic anhydrase inhibitor Trial Name -

PMIDs: 10649985 10995826 7929150 19520577 6816217 12956733

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10713865 10954127

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24813742

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26073005

Sources: DTC TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 18162396 18537527 17762320 18782051 8494570 15837316 17582922 18343915

Sources: TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase I inhibitor Direct Interaction yes

PMIDs: 1460006

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase I inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26073005

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Ensembl: ENSG00000133742

Alternate Names: CA1 Ensembl Gene Name

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
9336012 14684332 17228881 19648295 19019313

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
10533697 15110853 14684332 10649985 9336012

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
26073005

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

Trial Name CG100649

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Carbonic anhydrase I inhibitor

PMIDs:
8667211 10651143 18336310 11430635 12956733 10713865

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19119014 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Carbonic anhydrase inhibitor

Trial Name -

PMIDs:
10649985 10995826 7929150 19520577 6816217 12956733

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10713865 10954127

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
24813742

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26073005

Sources:
DTC TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
18162396 18537527 17762320 18782051 8494570 15837316 17582922 18343915

Sources:
TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

PMIDs:
1460006

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
26073005

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

CA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CAH1_HUMAN Uniprot Id

P00915 Uniprot Accession

CA1 Gene Symbol

Gene Info:

Target Main Class Enzymes

Target Subclass 4.2.1.1

Alternate Names:

CARBONIC ANHYDRASE 1 Uniprot Protein Name

759 Entrez Gene Id

P00915 Uniprot Accession

Gene Info:

Interpro Name Alpha carbonic anhydrase

Interpro Acc IPR001148

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CA1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:4.2.1.1

Alternate Names:

CARBONIC ANHYDRASE I (EC 4.2.1.1) (CARBONATE DEHYDRATASE I) (CA-I) (CARBONIC ANHYDRASE B). [SOURCE:UNIPROT/SWISSPROT;ACC:P00915] Description

CA1 Display Id

ENSG00000133742 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CA1 GENE_SYMBOL

Carbonic anhydrase 1 UNIPROT

Carbonate dehydratase I UNIPROT

Alternate Names:

ENSG00000133742 Gene Symbol

CA1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CA-I TTD Gene Abbreviation

T13201 TTD Target ID