DGIdb - CA1 Gene Record

CA1 759 Druggable Genome

Alternate Names:

759
CARBONIC ANHYDRASE 1
CA1
CA-I
CAB
Car1
HEL-S-11
114800
1368
ENSG00000133742
OTTHUMG00000164941
Carbonic anhydrase B
Carbonate dehydratase I
Carbonic anhydrase I
BE0000267
P00915
CAH1_HUMAN
CARBONIC ANHYDRASE I (EC 4.2.1.1) (CARBONATE DEHYDRATASE I) (CA-I) (CARBONIC ANHYDRASE B). [SOURCE:UNIPROT/SWISSPROT;ACC:P00915]
2597
ENSG00000137731
T13201
NM_001128830
NP_001122302
BE0009965

Gene Info:

Interpro Name	Alpha carbonic anhydrase
Interpro Acc	IPR001148
Interpro Type	Domain
Interpro Short Name	Carbonic_anhydrase_a
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Target Main Class	Enzymes
Target Subclass	4.2.1.1
Target Class	Enzymes
Target Subclass	EC:4.2.1.1
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Carbonic anhydrases
GuideToPharmacology Gene Category ID	842

(8 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Cleland et al., 2008, Treatment of neuromuscular channelopathies: current concepts and future prospects., Neurotherapeutics
Lindskog, 1997, Structure and mechanism of carbonic anhydrase., Pharmacol. Ther.
Winum et al., 2004, Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits., Bioorg. Med. Chem. Lett.
Giacomotto et al., 2009, Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy., Hum. Mol. Genet.
Nishimori et al., 2007, Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors., J. Med. Chem.
De Simone et al., 2005, Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies., Bioorg. Med. Chem. Lett.
Biton, Clinical pharmacology and mechanism of action of zonisamide., Clin Neuropharmacol
Supuran et al., 2008, Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity., Expert Opin Emerg Drugs
Shank et al., 2008, Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate., J Enzyme Inhib Med Chem
Farooq et al., 2008, Therapeutic role of zonisamide in neuropsychiatric disorders., Mini Rev Med Chem
2007, Zonisamide: new drug. No advantage in refractory partial epilepsy., Prescrire Int
Masuda et al., 1993, Inhibitory effect of zonisamide on human carbonic anhydrase in vitro., Arzneimittelforschung
Temperini et al., 2008, Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies., Bioorg. Med. Chem. Lett.
Herkel et al., 2001, Update on topical carbonic anhydrase inhibitors., Curr Opin Ophthalmol
Maren et al., 1997, Ocular absorption, blood levels, and excretion of dorzolamide, a topically active carbonic anhydrase inhibitor., J Ocul Pharmacol Ther
Hasegawa et al., Binding of dorzolamide and its metabolite, N-deethylated dorzolamide, to human erythrocytes in vitro., Drug Metab. Dispos.
Sugrue, 1996, The preclinical pharmacology of dorzolamide hydrochloride, a topical carbonic anhydrase inhibitor., J Ocul Pharmacol Ther
Perez Velazquez, 2003, Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity., Eur. J. Neurosci.
Scozzafava et al., 2000, Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes., J. Med. Chem.
Heck et al., 1994, Catalytic properties of mouse carbonic anhydrase V., J. Biol. Chem.
Bertucci et al., 2009, Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides., Bioorg. Med. Chem.
Siffert et al., 1982, Carbonic anhydrase C in white-skeletal-muscle tissue., Biochem. J.
Köhling et al., 2000, Ictal epileptiform activity is facilitated by hippocampal GABAA receptor-mediated oscillations., J. Neurosci.
Iyer et al., 1999, In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics., J Pharmacokinet Biopharm
Ilies et al., 2004, Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity., Bioorg. Med. Chem.
Puscas et al., 2000, Hypotensive effect of calcium channel blockers is parallel with carbonic anhydrase I inhibition., Clin. Pharmacol. Ther.
Puscas et al., 2001, Vasoconstrictive drugs increase carbonic anhydrase I in vascular smooth muscle while vasodilating drugs reduce the activity of this isozyme by a direct mechanism of action., Drugs Exp Clin Res
Puscas et al., 2000, Calcium channel blockers reduce blood pressure in part by inhibiting vascular smooth muscle carbonic anhydrase I., Cardiovasc Drugs Ther
Parr et al., 1992, Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters., J. Biol. Chem.
Puscas et al., 1999, Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action., Drugs Exp Clin Res
Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.
Puscas et al., 1996, Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action., J. Pharmacol. Exp. Ther.
Meierkord et al., 2000, Sodium bromide: effects on different patterns of epileptiform activity, extracellular pH changes and GABAergic inhibition., Naunyn Schmiedebergs Arch. Pharmacol.
Puscas et al., 2001, Indomethacin activates carbonic anhydrase and antagonizes the effect of the specific carbonic anhydrase inhibitor acetazolamide, by a direct mechanism of action., Int J Clin Pharmacol Ther
Puscas et al., 1999, The inhibitory effect of diuretics on carbonic anhydrases., Res. Commun. Mol. Pathol. Pharmacol.
Berg et al., 2004, Carbonic anhydrase in mammalian vascular smooth muscle., J. Histochem. Cytochem.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Tricarico D et al., 2006, Carbonic anhydrase inhibitors ameliorate the symptoms of hypokalaemic periodic paralysis in rats by opening the muscular Ca2+-activated-K+ channels., Neuromuscul Disord
Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.
Couloigner et al., 1998, Effect of locally applied drugs on the endolymphatic sac potential., Laryngoscope
Supuran, 2008, Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides., Curr. Pharm. Des.
Temperini et al., 2008, Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct., Bioorg. Med. Chem. Lett.
Temperini et al., 2008, Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?, Org. Biomol. Chem.
Woodman R et al., 2010, Chlorthalidone decreases platelet aggregation and vascular permeability and promotes angiogenesis., Hypertension
Güney M et al., 2015, Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives., Bioorg Med Chem Lett
Temperini C et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference., J Med Chem
Larson et al., 1994, Effects of cyclothiazide on synaptic responses in slices of adult and neonatal rat hippocampus., Neuroreport
Rammes et al., 1999, Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide., Pflugers Arch.
Fleck et al., 1996, AMPA receptor heterogeneity in rat hippocampal neurons revealed by differential sensitivity to cyclothiazide., J. Neurophysiol.
Pirotte et al., 1998, 4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships., J. Med. Chem.
Rammes et al., 1996, Interactions of 2,3-benzodiazepines and cyclothiazide at AMPA receptors: patch clamp recordings in cultured neurones and area CA1 in hippocampal slices., Br. J. Pharmacol.
Erdemli et al., 1993, Diazoxide suppresses slowly-inactivating outward and inward currents in CA1 hippocampal neurones., Neuroreport
Domoki et al., 2004, Diazoxide prevents mitochondrial swelling and Ca2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs., Brain Res.
Crépel et al., 1993, The K+ channel opener diazoxide enhances glutamatergic currents and reduces GABAergic currents in hippocampal neurons., J. Neurophysiol.
Scuvée-Moreau et al., 1997, Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro., Arch. Physiol. Biochem.
Erdemli et al., 1995, Actions of diazoxide on CA1 neurons in hippocampal slices from rats., Can. J. Physiol. Pharmacol.
Dodgson et al., 2000, Topiramate as an inhibitor of carbonic anhydrase isoenzymes., Epilepsia
Nishimori I et al., 2007, Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides., Bioorg Med Chem
LEIBMAN KC et al., 1961, Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide., J Pharmacol Exp Ther
Tauro M et al., 2014, Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors., Bioorg Med Chem Lett
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Innocenti et al., 2010, Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids., Bioorg. Med. Chem.

DICHLORPHENAMIDE CA1

Interaction Score: 2.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
19019313 9336012 14684332 19648295 17228881

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
METHAZOLAMIDE CA1

Interaction Score: 1.6

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10533697 15110853 9336012 14684332 10649985

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
CHEMBL451332 CA1

Interaction Score: 1.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
ETHINAMATE CA1

Interaction Score: 1.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
1460006

Sources:
DrugBank
POLMACOXIB CA1

Interaction Score: 1.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

Trial Name CG100649

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions
ACETAZOLAMIDE CA1

Interaction Score: 1.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10713865 12956733 18336310 8667211 10651143 11430635

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
ETHOXZOLAMIDE CA1

Interaction Score: 1.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
12956733 10649985 7929150 19520577 6816217 10995826

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
TRICHLORMETHIAZIDE CA1

Interaction Score: 1.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19119014 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank
BENDROFLUMETHIAZIDE CA1

Interaction Score: 1.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15258186 17139284 17016423 16368240

Sources:
DrugBank
CHLOROTHIAZIDE CA1

Interaction Score: 1.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10713865 10954127

Sources:
TEND TdgClinicalTrial DrugBank
METHOCARBAMOL CA1

Interaction Score: 1.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
1460006

Sources:
DrugBank GuideToPharmacology ChemblInteractions
CYCLOTHIAZIDE CA1

Interaction Score: 1.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19119014 19115843 8003661 9929558 8793745 9685234 8882618

Sources:
DrugBank
QUINETHAZONE CA1

Interaction Score: 1.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18336309 18374572 18600270

Sources:
DrugBank
DORZOLAMIDE CA1

Interaction Score: 1.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
9029437 8070313 8875343

Sources:
DrugBank GuideToPharmacology
RESORCINOL CA1

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26073005

Sources:
DTC
METHYCLOTHIAZIDE CA1

Interaction Score: 0.97

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19119014 10713865 9546276

Sources:
DrugBank
BRINZOLAMIDE CA1

Interaction Score: 0.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
14684332 11224713

Sources:
DrugBank GuideToPharmacology
SODIUM CARBONATE CA1

Interaction Score: 0.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17139284

Sources:
DrugBank
MEDRONIC ACID CA1

Interaction Score: 0.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24813742

Sources:
DTC
BENZTHIAZIDE CA1

Interaction Score: 0.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
13760527 17139284 17016423

Sources:
DrugBank
BENZOLAMIDE CA1

Interaction Score: 0.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PHENOL CA1

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26073005

Sources:
DTC TTD
HYDROFLUMETHIAZIDE CA1

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19119014 17139284 17016423

Sources:
DrugBank
DIAZOXIDE CA1

Interaction Score: 0.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8298083 15306243 7681475 9439778 7585327

Sources:
DrugBank
INDISULAM CA1

Interaction Score: 0.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHLORTHALIDONE CA1

Interaction Score: 0.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
20625077

Sources:
DrugBank GuideToPharmacology
ZONISAMIDE CA1

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
15837316 17762320 18537527 18343915 18782051 17582922 8494570 18162396

Sources:
TEND DrugBank GuideToPharmacology
SULFAMIDE CA1

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ACETAZOLAMIDE SODIUM CA1

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMLODIPINE CA1

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11061585 11392054 11101200

Sources:
DrugBank
PARABEN CA1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LEVETIRACETAM CA1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
HISTIDINE CA1

Interaction Score: 0.16

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Specific Action of the Ligand Activation

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CATECHOL CA1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26073005

Sources:
DTC
TOPIRAMATE CA1

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
10768298 17826101

Sources:
DrugBank GuideToPharmacology
HISTAMINE CA1

Interaction Score: 0.12

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Specific Action of the Ligand Activation

Details of Interaction K<sub>A</sub> of 2100 nM.

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SULPIRIDE CA1

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
ELLAGIC ACID CA1

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
20185318

Sources:
DrugBank
CURCUMIN CA1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000133742
- Version: 101_38
Alternate Names:

CA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P00915
- Version: 01-August-2011
Alternate Names:

CAH1_HUMAN Uniprot Id

P00915 Uniprot Accession

CA1 Gene Symbol

Gene Info:

Target Main Class Enzymes

Target Subclass 4.2.1.1

Publications:
HopkinsGroom: P00915
- Version: 11-September-2012
Alternate Names:

CARBONIC ANHYDRASE 1 Uniprot Protein Name

759 Entrez Gene Id

P00915 Uniprot Accession

Gene Info:

Interpro Name Alpha carbonic anhydrase

Interpro Acc IPR001148

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P00915
- Version: January-2014
Alternate Names:

CA1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:4.2.1.1

Publications:

RussLampel: ENSG00000133742

Version: 26-July-2011

Alternate Names:

CARBONIC ANHYDRASE I (EC 4.2.1.1) (CARBONATE DEHYDRATASE I) (CA-I) (CARBONIC ANHYDRASE B). [SOURCE:UNIPROT/SWISSPROT;ACC:P00915] Description

CA1 Display Id

ENSG00000133742 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 759
- Version: 29-September-2020
Alternate Names:

1368 HUGO Gene ID

1368 HUGO Gene Symbol

carbonic anhydrase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Carbonic anhydrases

GuideToPharmacology Gene Category ID 842

Gene Categories:

ENZYME

Publications:

DrugBank: BE0000267

Version: 5.1.7

Alternate Names:

CA1 DrugBank Gene Name

P00915 UniProt Accession

759 Entrez Gene Id

Gene Info:

Publications:

Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.

Puscas et al., 1999, Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action., Drugs Exp Clin Res

Couloigner et al., 1998, Effect of locally applied drugs on the endolymphatic sac potential., Laryngoscope

DrugBank: BE0009965

Version: 5.1.7

Alternate Names:

CA1 DrugBank Gene Name

P00915 UniProt Accession

759 Entrez Gene Id

Gene Info:

Publications:

Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.

Temperini C et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference., J Med Chem

LEIBMAN KC et al., 1961, Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide., J Pharmacol Exp Ther

DTC: CA1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Güney M et al., 2015, Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives., Bioorg Med Chem Lett

Tauro M et al., 2014, Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors., Bioorg Med Chem Lett

ChemblInteractions: CA1
- Version: chembl_23
Alternate Names:

CA1 GENE_SYMBOL

Carbonic anhydrase 1 UNIPROT

Carbonate dehydratase I UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000133742
- Version: 31-May-2017
Alternate Names:

ENSG00000133742 Gene Symbol

CA1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Carbonic anhydrase I
- Version: 2020.06.01
Alternate Names:

CA-I TTD Gene Abbreviation

T13201 TTD Target ID

Gene Info:

Publications:

Trial Name	-
Novel drug target	Established target
Direct Interaction	yes

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Mechanism of Interaction	Carbonic anhydrase I inhibitor
Direct Interaction	yes
Trial Name	CG100649

Specific Action of the Ligand	Activation
Endogenous Drug?	False
Direct Interaction?	False

Specific Action of the Ligand	Activation
Details of Interaction	K<sub>A</sub> of 2100 nM.
Endogenous Drug?	False

CARBONIC ANHYDRASE 1	Uniprot Protein Name
759	Entrez Gene Id
P00915	Uniprot Accession

CARBONIC ANHYDRASE I (EC 4.2.1.1) (CARBONATE DEHYDRATASE I) (CA-I) (CARBONIC ANHYDRASE B). [SOURCE:UNIPROT/SWISSPROT;ACC:P00915]	Description
CA1	Display Id
ENSG00000133742	Ensembl Gene Id

1368	HUGO Gene ID
1368	HUGO Gene Symbol
carbonic anhydrase 1	HUGO Gene Name

CA1	DrugBank Gene Name
P00915	UniProt Accession
759	Entrez Gene Id

CA1	GENE_SYMBOL
Carbonic anhydrase 1	UNIPROT
Carbonate dehydratase I	UNIPROT

CA1 Gene Record

CA1 759 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Direct Interaction yes

PMIDs: 19019313 9336012 14684332 19648295 17228881

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 10533697 15110853 9336012 14684332 10649985

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 1460006

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase I inhibitor Direct Interaction yes Trial Name CG100649

PMIDs: None found

Sources: TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 10713865 12956733 18336310 8667211 10651143 11430635

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 12956733 10649985 7929150 19520577 6816217 10995826

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 19119014 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15258186 17139284 17016423 16368240

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10713865 10954127

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase I inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 1460006

Sources: DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19119014 19115843 8003661 9929558 8793745 9685234 8882618

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 18336309 18374572 18600270

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 9029437 8070313 8875343

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26073005

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19119014 10713865 9546276

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 14684332 11224713

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 17139284

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
19019313 9336012 14684332 19648295 17228881

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10533697 15110853 9336012 14684332 10649985

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
1460006

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

Trial Name CG100649

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10713865 12956733 18336310 8667211 10651143 11430635

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
12956733 10649985 7929150 19520577 6816217 10995826

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19119014 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15258186 17139284 17016423 16368240

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10713865 10954127

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase I inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
1460006

Sources:
DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19119014 19115843 8003661 9929558 8793745 9685234 8882618

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
18336309 18374572 18600270

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
9029437 8070313 8875343

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
26073005

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19119014 10713865 9546276

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
14684332 11224713

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17139284

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
24813742

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
13760527 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
26073005

Sources:
DTC TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19119014 17139284 17016423

Sources:
DrugBank