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C1QB Gene Record

  • Summary
  • Interactions
  • Claims
  • C1QB 713 Druggable Genome

    Alternate Names:

    713
    COMPLEMENT C1Q B CHAIN
    C1QB
    120570
    1242
    ENSG00000173369
    OTTHUMG00000002896
    P02746
    BE0002095

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    DRUGGABLE GENOME

    Publications:

    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Wang Y et al., 2004, Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro., Angiogenesis
    Deveuve Q et al., 2020, The Proteolytic Cleavage of Therapeutic Monoclonal Antibody Hinge Region: More Than a Matter of Subclass., Front Immunol
    Hiatt A et al., 2014, Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy., Proc Natl Acad Sci U S A
    Wang F et al., 2013, Immobilized metal affinity chromatography and human serum proteomics., J Chromatogr B Analyt Technol Biomed Life Sci
    Boyle MD, 1981, Inhibition by zinc of the binding of C1 to antigen-antibody complexes., Biochem Biophys Res Commun
  • PALIVIZUMAB   C1QB

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423 24711420


    Sources:
    DrugBank

  • DACLIZUMAB   C1QB

    Interaction Score: 2.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • BEVACIZUMAB   C1QB

    Interaction Score: 0.92

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423 15886877


    Sources:
    DrugBank

  • CETUXIMAB   C1QB

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32117299 17139284 17016423


    Sources:
    DrugBank

  • ZINC CHLORIDE   C1QB

    Interaction Score: 0.2

    Interaction Types & Directionality:
    modulator

    Interaction Info:

    PMIDs:
    7332580


    Sources:
    DrugBank

  • METHYLDOPA   C1QB

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • Ensembl: ENSG00000173369

    • Version: 101_38

    Alternate Names:
    C1QB Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • DrugBank: BE0002095

    • Version: 5.1.7

    Alternate Names:
    C1QB DrugBank Gene Name
    P02746 UniProt Accession
    713 Entrez Gene Id

    Gene Info:

    Publications:
    Deveuve Q et al., 2020, The Proteolytic Cleavage of Therapeutic Monoclonal Antibody Hinge Region: More Than a Matter of Subclass., Front Immunol
    Hiatt A et al., 2014, Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy., Proc Natl Acad Sci U S A
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

  • HingoraniCasas: ENSG00000173369

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000173369 Gene Symbol
    C1QB Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: C1QB

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21