DGIdb - C1QA Gene Record

C1QA 712 Druggable Genome

Alternate Names:

712
COMPLEMENT C1Q A CHAIN
C1QA
120550
1241
ENSG00000173372
OTTHUMG00000002893
C1QA_HUMAN
P02745
BE0002094
BE0009995

Gene Info:

Target Main Class	Other
Target Subclass	Complement system
Target Subclass	Immune response
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUGGABLE GENOME

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Deveuve Q et al., 2020, The Proteolytic Cleavage of Therapeutic Monoclonal Antibody Hinge Region: More Than a Matter of Subclass., Front Immunol
Wang Y et al., 2004, Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro., Angiogenesis
Hofmann HP et al., 2016, Characterization and non-clinical assessment of the proposed etanercept biosimilar GP2015 with originator etanercept (Enbrel(®))., Expert Opin Biol Ther
Hiatt A et al., 2014, Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy., Proc Natl Acad Sci U S A

PALIVIZUMAB C1QA

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 24711420

Sources:
DrugBank
DACLIZUMAB C1QA

Interaction Score: 2.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
ETANERCEPT C1QA

Interaction Score: 1.82

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
27463856 17139284 17016423

Sources:
DrugBank
BEVACIZUMAB C1QA

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 15886877

Sources:
DrugBank
CETUXIMAB C1QA

Interaction Score: 0.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
32117299 17139284 17016423

Sources:
DrugBank

Ensembl: ENSG00000173372
- Version: 101_38
Alternate Names:

C1QA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P02745
- Version: 01-August-2011
Alternate Names:

ENSG00000173372 Ensembl Gene Id

712 Entrez Gene Id

C1QA_HUMAN Uniprot Id

Gene Info:

Target Main Class Other

Target Subclass Complement system

Target Subclass Immune response

Publications:
DrugBank: BE0009995
- Version: 5.1.7
Alternate Names:

C1QA DrugBank Gene Name

P02745 UniProt Accession

712 Entrez Gene Id

Gene Info:

Publications:

Hofmann HP et al., 2016, Characterization and non-clinical assessment of the proposed etanercept biosimilar GP2015 with originator etanercept (Enbrel(®))., Expert Opin Biol Ther

DrugBank: BE0002094

Version: 5.1.7

Alternate Names:

C1QA DrugBank Gene Name

P02745 UniProt Accession

712 Entrez Gene Id

Gene Info:

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Deveuve Q et al., 2020, The Proteolytic Cleavage of Therapeutic Monoclonal Antibody Hinge Region: More Than a Matter of Subclass., Front Immunol

HingoraniCasas: ENSG00000173372
- Version: 31-May-2017
Alternate Names:

ENSG00000173372 Gene Symbol

C1QA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: C1QA
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE

Publications:

ENSG00000173372	Ensembl Gene Id
712	Entrez Gene Id
C1QA_HUMAN	Uniprot Id

C1QA	DrugBank Gene Name
P02745	UniProt Accession
712	Entrez Gene Id

C1QA Gene Record

C1QA 712 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PALIVIZUMAB C1QA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423 24711420

Sources: DrugBank

DACLIZUMAB C1QA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

ETANERCEPT C1QA

Interaction Types & Directionality: ligand

Interaction Info:

PMIDs: 27463856 17139284 17016423

Sources: DrugBank

BEVACIZUMAB C1QA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423 15886877

Sources: DrugBank

CETUXIMAB C1QA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 32117299 17139284 17016423

Sources: DrugBank

Ensembl: ENSG00000173372

Alternate Names: C1QA Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P02745

Alternate Names: ENSG00000173372 Ensembl Gene Id 712 Entrez Gene Id C1QA_HUMAN Uniprot Id

Gene Info: Target Main Class Other Target Subclass Complement system Target Subclass Immune response

Publications:

DrugBank: BE0009995

Alternate Names: C1QA DrugBank Gene Name P02745 UniProt Accession 712 Entrez Gene Id

Gene Info:

Publications: Hofmann HP et al., 2016, Characterization and non-clinical assessment of the proposed etanercept biosimilar GP2015 with originator etanercept (Enbrel(®))., Expert Opin Biol Ther

DrugBank: BE0002094

Alternate Names: C1QA DrugBank Gene Name P02745 UniProt Accession 712 Entrez Gene Id

Gene Info:

HingoraniCasas: ENSG00000173372

Alternate Names: ENSG00000173372 Gene Symbol C1QA Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: C1QA

Alternate Names:

Gene Info:

Gene Categories: CELL SURFACE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423 24711420

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

ligand

PMIDs:
27463856 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423 15886877

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
32117299 17139284 17016423

Sources:
DrugBank

Alternate Names:

C1QA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000173372 Ensembl Gene Id

712 Entrez Gene Id

C1QA_HUMAN Uniprot Id

Gene Info:

Target Main Class Other

Target Subclass Complement system

Target Subclass Immune response

Alternate Names:

C1QA DrugBank Gene Name

P02745 UniProt Accession

712 Entrez Gene Id

Publications:

Hofmann HP et al., 2016, Characterization and non-clinical assessment of the proposed etanercept biosimilar GP2015 with originator etanercept (Enbrel(®))., Expert Opin Biol Ther

Alternate Names:

C1QA DrugBank Gene Name

P02745 UniProt Accession

712 Entrez Gene Id

Alternate Names:

ENSG00000173372 Gene Symbol

C1QA Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Gene Categories:

CELL SURFACE