695 |
BRUTON TYROSINE KINASE |
BTK |
AGMX1 |
AT |
ATK |
BPK |
IMD1 |
PSCTK1 |
XLA |
300300 |
1133 |
ENSG00000010671 |
OTTHUMG00000022022 |
Q06187 |
TYROSINE-PROTEIN KINASE BTK |
BTK_HUMAN |
B-cell progenitor kinase |
Agammaglobulinemia tyrosine kinase |
65 |
TYROSINE-PROTEIN KINASE BTK (EC 2.7.1.112) (BRUTON'S TYROSINE KINASE) (AGAMMAGLOBULINAEMIA TYROSINE KINASE) (ATK) (B CELL PROGENITOR KINASE) (BPK). [SOURCE:UNIPROT/SWISSPROT;ACC:Q06187] |
PA25454 |
T25005 |
IGHD3 |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Uniprot Status | Swiss-Prot |
Human Readable Name | KINASE |
Interpro Type | Domain |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR001245 |
Target Class | Enzymes |
Target Subclass | EC:2.7.10.2 |
Initial Gene Query | BTK |
Counted Citations from 1950-2000 | 808 |
Gene Biotype | PROTEIN_CODING |
KINASE |
TYROSINE KINASE |
DRUG RESISTANCE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
TRANSCRIPTION FACTOR |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Tyrosine-protein kinase BTK inhibitor |
Trial Name | AVL-292 |
inhibitor (inhibitory) |
Mechanism of Interaction | Tyrosine-protein kinase BTK inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Clinical Status | early trials |
Pathway | activation |
Variant Effect | gain-of-function |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Tyrosine-protein kinase BTK inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Tyrosine-protein kinase BTK inhibitor |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Notes |
BTK | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
695 | Entrez Gene Id |
BTK_HUMAN | Uniprot Id |
Q06187 | Uniprot Accession |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Uniprot Status | Swiss-Prot |
Human Readable Name | KINASE |
KINASE, DRUGGABLE GENOME |
695 | Entrez Gene ID |
Initial Gene Query | BTK |
Counted Citations from 1950-2000 | 808 |
KINASE |
BTK | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.10.2 |
ENSG00000010671 | Ensembl Gene Id |
TYROSINE-PROTEIN KINASE BTK (EC 2.7.1.112) (BRUTON'S TYROSINE KINASE) (AGAMMAGLOBULINAEMIA TYROSINE KINASE) (ATK) (B CELL PROGENITOR KINASE) (BPK). [SOURCE:UNIPROT/SWISSPROT;ACC:Q06187] | Description |
BTK | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
PA25454 | PharmGKB ID |
695 | Entrez Gene ID |
65 | CIViC Gene ID |
DRUG RESISTANCE |
ATK | TTD Gene Abbreviation |
T25005 | TTD Target ID |
ENSG00000010671 | Gene Symbol |
BTK | Ensembl Id |
DRUGGABLE GENOME |
BTK | Gene Symbol |
ATK | GENE_SYMBOL |
BPK | GENE_SYMBOL |
BTK | GENE_SYMBOL |
695 | Entrez Gene Id |
BTK | MyCancerGenome Gene Symbol |
BTK | MyCancerGenome Reported Gene Name |
AGMX1 | GO Gene Synonym |
ATK | GO Gene Synonym |
BPK | GO Gene Synonym |
TYROSINE KINASE |
BTK | Gene Symbol |
CLINICALLY ACTIONABLE |
695 | Gene ID |
AGMX1 | dGene Synonym |
AT | dGene Synonym |
KINASE, TYROSINE KINASE |
Tyrosine-protein kinase BTK | Gene Name |
Q06187 | UniProt ID |
KINASE, TRANSCRIPTION FACTOR |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
DRUG RESISTANCE |