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BIRC5 Gene Record

  • Summary
  • Interactions
  • Claims
  • BIRC5 332 Druggable GenomeDrug Resistance

    Alternate Names:

    332
    BACULOVIRAL IAP REPEAT CONTAINING 5
    BIRC5
    API4
    EPR-1
    603352
    593
    ENSG00000089685
    OTTHUMG00000177505
    O15392
    355
    APOPTOSIS INHIBITOR SURVIVIN
    T02677
    IAP4

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Inhibitor of apoptosis
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    DRUG RESISTANCE
    PROTEASE INHIBITOR
    DRUGGABLE GENOME

    Publications:

    Qiu et al., 2005, Targeted inhibition of transient activation of the EGFR-mediated cell survival pathway enhances paclitaxel-induced ovarian cancer cell death., Int. J. Oncol.
    Zhang et al., 2004, [Alteration of survivin gene expression in ovarian cancer cell line CAOV3 after chemotherapy in vitro]., Zhonghua Fu Chan Ke Za Zhi
    Zhang et al., 2005, Survivin mediates resistance to antiandrogen therapy in prostate cancer., Oncogene
    Thomas et al., 2005, Calcitonin induces apoptosis resistance in prostate cancer cell lines against cytotoxic drugs via the Akt/survivin pathway., Cancer Biol. Ther.
    Meng, 2005, [Sensitivity of survivin-positive primary leukemia cells to chemotherapy]., Zhongguo Shi Yan Xue Ye Xue Za Zhi
    Carter et al., 2001, Cytokine-regulated expression of survivin in myeloid leukemia., Blood
    Peñuelas et al., 2005, Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells., FEBS J.
    Yamaguchi et al., 2005, Targeting of X-linked inhibitor of apoptosis protein or survivin by short interfering RNAs sensitize hepatoma cells to TNF-related apoptosis-inducing ligand- and chemotherapeutic agent-induced cell death., Oncol. Rep.
    He et al., 2006, Expression of survivin gene in apoptosis induced by dexamethasone in CEM cells., Zhongguo Dang Dai Er Ke Za Zhi
    Pyrko et al., 2006, Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo., Mol. Cancer
    Konturek et al., 2003, Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients., Dig. Dis. Sci.
    Shankar et al., 2004, UCN-01 alters phosphorylation of Akt and GSK3beta and induces apoptosis in six independent human neuroblastoma cell lines., J. Neurochem.
    Ozisik et al., 2006, Expression of antiapoptotic survivin and aven genes in rat heart tissue after traumatic brain injury., Transplant. Proc.
    Blanc-Brude et al., 2007, IAP survivin regulates atherosclerotic macrophage survival., Arterioscler. Thromb. Vasc. Biol.
    Estève et al., 2007, Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells., J. Biol. Chem.
    Minderman et al., 2005, In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells., Mol. Cancer Ther.
    Xue et al., 2005, [Factors regulating expression of antiapoptosis gene survivin]., Zhongguo Shi Yan Xue Ye Xue Za Zhi
    Guan et al., 2006, [siRNA against survivin coupling with epirubicin enhances to induce breast cancer cell MCF-7 to apoptosis]., Sichuan Da Xue Xue Bao Yi Xue Ban
    Pratt et al., 2003, Differential regulation of protein expression, growth and apoptosis by natural and synthetic retinoids., J. Cell. Biochem.
    Xia et al., 2006, Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers., Cancer Res.
    Jin et al., 2006, Synergistic induction of apoptosis by sulindac and arsenic trioxide in human lung cancer A549 cells via reactive oxygen species-dependent down-regulation of survivin., Biochem. Pharmacol.
    Sakoguchi-Okada et al., 2007, Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells., Biochem. Pharmacol.
    Sato et al., 2004, FR901228, a novel histone deacetylase inhibitor, induces cell cycle arrest and subsequent apoptosis in refractory human pancreatic cancer cells., Int. J. Oncol.
    Morgillo et al., 2006, Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib., Cancer Res.
    Hayun et al., 2006, The immunomodulator AS101 induces growth arrest and apoptosis in multiple myeloma: association with the Akt/survivin pathway., Biochem. Pharmacol.
    Taguchi et al., 2006, Suppressive effects of dehydroepiandrosterone and the nuclear factor-kappaB inhibitor parthenolide on corticotroph tumor cell growth and function in vitro and in vivo., J. Endocrinol.
    Ma et al., 2007, [Effects of Genistein on the proliferation and expression of survivin in salivary adenoid cystic carcinoma cell line SACC-83]., Hua Xi Kou Qiang Yi Xue Za Zhi
    Kirkiles-Smith et al., 2004, IL-11 protects human microvascular endothelium from alloinjury in vivo by induction of survivin expression., J. Immunol.
    Kulp et al., 2006, Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer., Clin. Cancer Res.
    Chakrabarty et al., 2013, Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors., Cancer Res.
    Aziz et al., 2005, Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?, FASEB J.
    Fulda et al., 2004, Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol., Cancer Res.
    Carter et al., 2006, Regulation of survivin expression through Bcr-Abl/MAPK cascade: targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells., Blood
    de Angelis et al., 2004, Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil., Int. J. Oncol.
  • GATAPARSEN   BIRC5

    Interaction Score: 3.43

    Interaction Types & Directionality:
    antisense oligonucleotide (inhibitory)

    Interaction Info:
    Novel drug target Novel Target
    Trial Name LY2181308
    Notes

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial

  • VALDECOXIB   BIRC5

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16707021


    Sources:
    NCI

  • AMMONIUM TRICHLOROTELLURATE   BIRC5

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16889755


    Sources:
    NCI

  • OMACETAXINE MEPESUCCINATE   BIRC5

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15854289


    Sources:
    NCI

  • ROFECOXIB   BIRC5

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16707021 14627349


    Sources:
    NCI

  • OPRELVEKIN   BIRC5

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14734714


    Sources:
    NCI

  • PLICAMYCIN   BIRC5

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17124180


    Sources:
    NCI

  • CALCITONIN   BIRC5

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16222118


    Sources:
    NCI

  • IRINOTECAN HYDROCHLORIDE   BIRC5

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15956246


    Sources:
    NCI

  • TRASTUZUMAB   BIRC5

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23204226 16452223


    Sources:
    NCI CIViC

  • SULINDAC   BIRC5

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16950207 16707021


    Sources:
    NCI

  • REGRAMOSTIM   BIRC5

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16403261


    Sources:
    NCI

  • PRASTERONE   BIRC5

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16461558


    Sources:
    NCI

  • ROMIDEPSIN   BIRC5

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14767553


    Sources:
    NCI

  • EPOETIN ALFA   BIRC5

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17112829


    Sources:
    NCI

  • FLUTAMIDE   BIRC5

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15735703


    Sources:
    NCI

  • TRETINOIN   BIRC5

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16403261 14587026


    Sources:
    NCI

  • UCN-01   BIRC5

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15255949


    Sources:
    NCI

  • RESVERATROL   BIRC5

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17270149 15837718 14729643


    Sources:
    NCI

  • LAPATINIB   BIRC5

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16452223


    Sources:
    NCI

  • STAUROSPORINE   BIRC5

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17255535


    Sources:
    NCI

  • EPIRUBICIN   BIRC5

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16608080


    Sources:
    NCI

  • INDOMETHACIN   BIRC5

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17270149


    Sources:
    NCI

  • CAMPTOTHECIN   BIRC5

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16211302


    Sources:
    NCI

  • CHEMBL35482   BIRC5

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11313272


    Sources:
    NCI

  • VORINOSTAT   BIRC5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16951239


    Sources:
    NCI

  • ERLOTINIB   BIRC5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17047074


    Sources:
    NCI

  • PACLITAXEL   BIRC5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16211241 15347474


    Sources:
    ClearityFoundationBiomarkers NCI

  • GENISTEIN   BIRC5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17375591


    Sources:
    NCI

  • IMATINIB   BIRC5

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16254145


    Sources:
    NCI

  • CARBOPLATIN   BIRC5

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15347474


    Sources:
    NCI

  • DEXAMETHASONE   BIRC5

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16787583


    Sources:
    NCI

  • DOXORUBICIN   BIRC5

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16211302


    Sources:
    NCI

  • FLUOROURACIL   BIRC5

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15067352


    Sources:
    NCI

  • METHOTREXATE   BIRC5

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15670151


    Sources:
    NCI

  • DOCETAXEL   BIRC5

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers

  • Ensembl: ENSG00000089685

    • Version: 101_38

    Alternate Names:
    BIRC5 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: O15392

    • Version: January-2014

    Alternate Names:
    BIRC5 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Inhibitor of apoptosis

    Publications:

  • CIViC: BIRC5

    • Version: 14-September-2020

    Alternate Names:
    332 Entrez Gene ID
    355 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Wu et al., 2014, Nuclear survivin expression: a prognostic factor for the response to taxane-platinum chemotherapy in patients with advanced non-small cell lung cancer., Med. Oncol.
    Chakrabarty et al., 2013, Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors., Cancer Res.

  • NCI: BIRC5

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Thomas et al., 2005, Calcitonin induces apoptosis resistance in prostate cancer cell lines against cytotoxic drugs via the Akt/survivin pathway., Cancer Biol. Ther.
    Peñuelas et al., 2005, Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells., FEBS J.
    Ozisik et al., 2006, Expression of antiapoptotic survivin and aven genes in rat heart tissue after traumatic brain injury., Transplant. Proc.

  • TALC: BIRC5

    • Version: 12-May-2016

    Alternate Names:
    BIRC5 Gene Symbol

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000089685

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000089685 Gene Symbol
    BIRC5 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: BIRC5

    • Version: 01-February-2022

    Alternate Names:
    API4 GO Gene Synonym
    IAP4 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR

    Publications:

  • dGene: BIRC5

    • Version: 27-Jun-2013

    Alternate Names:
    332 Gene ID
    API4 dGene Synonym
    EPR-1 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE INHIBITOR

    Publications:

  • TTD: Apoptosis inhibitor survivin

    • Version: 2020.06.01

    Alternate Names:
    BIRC5 TTD Gene Abbreviation
    T02677 TTD Target ID

    Gene Info:

    Publications:

  • ClearityFoundationBiomarkers: BIRC5

    • Version: 26-July-2013

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21