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BGLAP Gene Record

  • Summary
  • Interactions
  • Claims
  • BGLAP 632 Druggable Genome

    Alternate Names:

    632
    BONE GAMMA-CARBOXYGLUTAMATE PROTEIN
    BGLAP
    BGP
    OC
    OCN
    112260
    1043
    ENSG00000242252
    OTTHUMG00000014819

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Vámos et al., 1997, [Bone metabolism markers in patients with Basedow-Graves disease]., Orv Hetil
    Hodsman et al., 1991, Differential effects of inhaled budesonide and oral prednisolone on serum osteocalcin., J. Clin. Endocrinol. Metab.
    Boissy et al., 2005, Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation., Cancer Res.
    Kim et al., 2007, A 6-month longitudinal study of bone mineral density with antiepileptic drug monotherapy., Epilepsy Behav
    Ongphiphadhanakul et al., 1993, Etidronate inhibits the thyroid hormone-induced bone loss in rats assessed by bone mineral density and messenger ribonucleic acid markers of osteoblast and osteoclast function., Endocrinology
    Kuo et al., 2005, Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells., J. Pharmacol. Exp. Ther.
    Kołaczkowska et al., 1998, [The effect of chemotherapy on bone metabolism in patients with non-small cell lung cancer]., Pneumonol Alergol Pol
    Na et al., 2003, [Study of the effects of isoflavone on serum lipid and bone biochemical markers in ovariectomized rats]., Wei Sheng Yan Jiu
    Itoh et al., 2003, Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures., Eur. J. Pharmacol.
    Reid et al., 2005, Effects of a beta-blocker on bone turnover in normal postmenopausal women: a randomized controlled trial., J. Clin. Endocrinol. Metab.
    Satomura et al., 2007, Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo., J. Pineal Res.
    Miheller et al., 2005, [Improvement of bone metabolism after infliximab therapy in Crohn's disease]., Orv Hetil
    Deeks et al., 2006, Oral paricalcitol., Treat Endocrinol
    Evans et al., 1989, The effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on human osteoblast-like cells., Biochem. Biophys. Res. Commun.
    Osman et al., 2006, Role of human valve interstitial cells in valve calcification and their response to atorvastatin., Circulation
    Kudo et al., 1998, Evidence for modulation of osteocalcin containing gamma-carboxyglutamic acid residues synthesis by insulin-like growth factor-I and vitamin K2 in human osteosarcoma cell line MG-63., Eur. J. Endocrinol.
    Love et al., 2005, Endocrine effects of tamoxifen plus exemestane in postmenopausal women with breast cancer., Clin. Cancer Res.
    Mason et al., 1997, Effects of dihydrotestosterone on bone biochemical markers in sham and oophorectomized rats., J. Bone Miner. Res.
    Vandenput et al., 2002, Evidence from the aged orchidectomized male rat model that 17beta-estradiol is a more effective bone-sparing and anabolic agent than 5alpha-dihydrotestosterone., J. Bone Miner. Res.
    Gruber et al., BMP-6-induced osteogenic differentiation of mesenchymal cell lines is not modulated by sex steroids and resveratrol., Cytokine
    Uchiyama et al., 2007, Genistein and zinc synergistically enhance gene expression and mineralization in osteoblastic MC3T3-E1 cells., Int. J. Mol. Med.
    Li et al., 2003, [The beneficial effect of genistein on mandible bone metabolism in ovariectomized rats]., Zhonghua Kou Qiang Yi Xue Za Zhi
    Li et al., 2003, Genistein prevents bone resorption diseases by inhibiting bone resorption and stimulating bone formation., Biol. Pharm. Bull.
    Deftos et al., 1982, Changes in plasma bone GLA protein during treatment of bone disease., Calcif. Tissue Int.
    Marttunen et al., 1998, Comparison of effects of tamoxifen and toremifene on bone biochemistry and bone mineral density in postmenopausal breast cancer patients., J. Clin. Endocrinol. Metab.
    Vardar-Sengül et al., 2006, Effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats., J. Periodontol.
  • PARICALCITOL   BGLAP

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17002490


    Sources:
    NCI

  • ISOFLAVONE   BGLAP

    Interaction Score: 1.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12793001


    Sources:
    NCI

  • CALCITONIN   BGLAP

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6805917


    Sources:
    NCI

  • ETIDRONIC ACID   BGLAP

    Interaction Score: 0.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8243271


    Sources:
    NCI

  • CLODRONIC ACID   BGLAP

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14512092


    Sources:
    NCI

  • ANDROSTANOLONE   BGLAP

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9286759 12412816 12967649


    Sources:
    NCI

  • COUMARIN   BGLAP

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9578515


    Sources:
    NCI

  • MITOMYCIN   BGLAP

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9857648


    Sources:
    NCI

  • EXEMESTANE   BGLAP

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15746052


    Sources:
    NCI

  • REGRAMOSTIM   BGLAP

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2655592


    Sources:
    NCI

  • PROPRANOLOL   BGLAP

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15998769


    Sources:
    NCI

  • METHIMAZOLE   BGLAP

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9380378


    Sources:
    NCI

  • INFLIXIMAB   BGLAP

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16130441


    Sources:
    NCI

  • GENISTEIN   BGLAP

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17203194 14680578 12808286


    Sources:
    NCI

  • PREDNISOLONE   BGLAP

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1997509


    Sources:
    NCI

  • MELATONIN   BGLAP

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17349020


    Sources:
    NCI

  • WARFARIN   BGLAP

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9578515


    Sources:
    NCI

  • CHEMBL35482   BGLAP

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15956019


    Sources:
    NCI

  • CARBAMAZEPINE   BGLAP

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17224308


    Sources:
    NCI

  • RESVERATROL   BGLAP

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16267019


    Sources:
    NCI

  • TAMOXIFEN   BGLAP

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9543133


    Sources:
    NCI

  • ATORVASTATIN   BGLAP

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16820635


    Sources:
    NCI

  • CELECOXIB   BGLAP

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16584347


    Sources:
    NCI

  • Ensembl: ENSG00000242252

    • Version: 101_38

    Alternate Names:
    BGLAP Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: BGLAP

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Vámos et al., 1997, [Bone metabolism markers in patients with Basedow-Graves disease]., Orv Hetil
    Kim et al., 2007, A 6-month longitudinal study of bone mineral density with antiepileptic drug monotherapy., Epilepsy Behav
    Kołaczkowska et al., 1998, [The effect of chemotherapy on bone metabolism in patients with non-small cell lung cancer]., Pneumonol Alergol Pol

  • HingoraniCasas: ENSG00000242252

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000242252 Gene Symbol
    BGLAP Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21