DGIdb - BCR Gene Record

BCR 613 Druggable GenomeClinically Actionable

Alternate Names:

613
BCR, RHOGEF AND GTPASE ACTIVATING PROTEIN
BCR
ALL
BCR1
CML
D22S11
D22S662
PHL
151410
1014
ENSG00000186716
OTTHUMG00000150655
P11274
PA25321
2755
NP_004318
NM_004327
Renal carcinoma antigen NY-REN-26
Breakpoint cluster region protein
BCR activator of RhoGEF and GTPase

Gene Info:

GuideToPharmacology Gene Category Name	BCR family
GuideToPharmacology Gene Category ID	874
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Iqbal et al., 2013, Sensitive detection of pre-existing BCR-ABL kinase domain mutations in CD34+ cells of newly diagnosed chronic-phase chronic myeloid leukemia patients is associated with imatinib resistance: implications in the post-imatinib era., PLoS ONE
Mojzych M et al., 2014, Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines., Eur J Med Chem
Page BD et al., 2012, Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity., J Med Chem
Croom et al., 2003, Imatinib mesylate: in the treatment of gastrointestinal stromal tumours., Drugs
Waller, 2010, Imatinib mesylate., Recent Results Cancer Res.
Nadal et al., 2004, Imatinib mesylate (Gleevec/Glivec) a molecular-targeted therapy for chronic myeloid leukaemia and other malignancies., Int. J. Clin. Pract.
Reddy EP et al., 2012, The ins and outs of bcr-abl inhibition., Genes Cancer
Adrián FJ et al., 2006, Allosteric inhibitors of Bcr-abl-dependent cell proliferation., Nat Chem Biol
Shah NP et al., 2004, Overriding imatinib resistance with a novel ABL kinase inhibitor., Science

CHEMBL483847 BCR

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16415863

Sources:
DTC
PONATINIB HYDROCHLORIDE BCR

Interaction Score: 2.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Breakpoint cluster region protein inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BLINATUMOMAB BCR

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

Fusion protein BCR:ABL1

PMIDs:
None found

Sources:
PharmGKB FDA
OMACETAXINE MEPESUCCINATE BCR

Interaction Score: 1.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
NILOTINIB BCR

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

Fusion protein BCR:ABL1

PMIDs:
None found

Sources:
PharmGKB FDA
PONATINIB BCR

Interaction Score: 0.79

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Fusion protein BCR:ABL1

Notes Pan-BCR-ABL

PMIDs:
23409026

Sources:
TALC PharmGKB FDA
IMATINIB BCR

Interaction Score: 0.78

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Fusion protein BCR:ABL1

Notes Targets BCR-ABL fusion protein

PMIDs:
24681986 22148584 12600228 20072827 15206509 23226582

Sources:
TALC DTC PharmGKB FDA
BUSULFAN BCR

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

Fusion protein BCR:ABL1

PMIDs:
None found

Sources:
PharmGKB FDA
BOSUTINIB BCR

Interaction Score: 0.56

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Fusion protein BCR:ABL1

PMIDs:
None found

Sources:
PharmGKB FDA
SARACATINIB BCR

Interaction Score: 0.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes Targets BCR-ABL fusion protein

PMIDs:
None found

Sources:
TALC
DASATINIB BCR

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes Targets BCR-ABL fusion protein

Fusion protein BCR:ABL1

PMIDs:
15256671

Sources:
TALC PharmGKB FDA
VINCRISTINE BCR

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Fusion protein BCR:ABL1

PMIDs:
None found

Sources:
PharmGKB FDA

Ensembl: ENSG00000186716
- Version: 101_38
Alternate Names:

BCR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 613
- Version: 29-September-2020
Alternate Names:

1014 HUGO Gene ID

1014 HUGO Gene Symbol

BCR activator of RhoGEF and GTPase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name BCR family

GuideToPharmacology Gene Category ID 874

Gene Categories:

ENZYME

Publications:

NCI: BCR

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Okabe et al., 1992, Effect of herbimycin A, an antagonist of tyrosine kinase, on bcr/abl oncoprotein-associated cell proliferations: abrogative effect on the transformation of murine hematopoietic cells by transfection of a retroviral vector expressing oncoprotein P210bcr/abl and preferential inhibition on Ph1-positive leukemia cell growth., Blood

DTC: BCR

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Page BD et al., 2012, Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity., J Med Chem

Mojzych M et al., 2014, Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines., Eur J Med Chem

Adrián FJ et al., 2006, Allosteric inhibitors of Bcr-abl-dependent cell proliferation., Nat Chem Biol

HingoraniCasas: ENSG00000186716
- Version: 31-May-2017
Alternate Names:

ENSG00000186716 Gene Symbol

BCR Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: BCR
- Version: 12-May-2016
Alternate Names:

BCR Gene Symbol

Gene Info:

Publications:
ChemblInteractions: BCR1
- Version: chembl_23
Alternate Names:

D22S11 GENE_SYMBOL

BCR GENE_SYMBOL

Breakpoint cluster region protein UNIPROT

Gene Info:

Publications:
PharmGKB: BCR
- Version: 18-August-2020
Alternate Names:

PA25321 PharmGKB ID

Gene Info:

Publications:
Tempus: BCR
- Version: 11-November-2018
Alternate Names:

BCR Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: BCR
- Version: 27-Jun-2013
Alternate Names:

613 Gene ID

ALL dGene Synonym

BCR1 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
GO: BCR
- Version: 01-May-2021
Alternate Names:

BCR1 GO Gene Synonym

D22S11 GO Gene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
Pharos: BCR
- Version: 01-May-2021
Alternate Names:

Breakpoint cluster region protein Gene Name

P11274 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
FoundationOneGenes: BCR
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: BCR
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FDA: BCR
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:

Mechanism of Interaction	Breakpoint cluster region protein inhibitor
Direct Interaction	yes

1014	HUGO Gene ID
1014	HUGO Gene Symbol
BCR activator of RhoGEF and GTPase	HUGO Gene Name

D22S11	GENE_SYMBOL
BCR	GENE_SYMBOL
Breakpoint cluster region protein	UNIPROT

Fusion protein	BCR:ABL1
Notes	Pan-BCR-ABL

Fusion protein	BCR:ABL1
Notes	Targets BCR-ABL fusion protein

Notes	Targets BCR-ABL fusion protein
Fusion protein	BCR:ABL1

BCR Gene Record

BCR 613 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16415863

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Breakpoint cluster region protein inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Fusion protein BCR:ABL1

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Fusion protein BCR:ABL1

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Fusion protein BCR:ABL1 Notes Pan-BCR-ABL

PMIDs: 23409026

Sources: TALC PharmGKB FDA

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Fusion protein BCR:ABL1 Notes Targets BCR-ABL fusion protein

PMIDs: 24681986 22148584 12600228 20072827 15206509 23226582

Sources: TALC DTC PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info: Fusion protein BCR:ABL1

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Fusion protein BCR:ABL1

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Targets BCR-ABL fusion protein

PMIDs: None found

Sources: TALC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Targets BCR-ABL fusion protein Fusion protein BCR:ABL1

PMIDs: 15256671

Sources: TALC PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info: Fusion protein BCR:ABL1

PMIDs: None found

Sources: PharmGKB FDA

Ensembl: ENSG00000186716

Alternate Names: BCR Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 613

Alternate Names: 1014 HUGO Gene ID 1014 HUGO Gene Symbol BCR activator of RhoGEF and GTPase HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name BCR family GuideToPharmacology Gene Category ID 874

Gene Categories: ENZYME

Publications:

NCI: BCR

Alternate Names:

Gene Info:

DTC: BCR

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000186716

Alternate Names: ENSG00000186716 Gene Symbol BCR Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TALC: BCR

Alternate Names: BCR Gene Symbol

Gene Info:

Publications:

ChemblInteractions: BCR1

Alternate Names: D22S11 GENE_SYMBOL BCR GENE_SYMBOL Breakpoint cluster region protein UNIPROT

Interaction Types & Directionality:

n/a

PMIDs:
16415863

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Breakpoint cluster region protein inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Fusion protein BCR:ABL1

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Fusion protein BCR:ABL1

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Fusion protein BCR:ABL1

Notes Pan-BCR-ABL

PMIDs:
23409026

Sources:
TALC PharmGKB FDA

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Fusion protein BCR:ABL1

Notes Targets BCR-ABL fusion protein

PMIDs:
24681986 22148584 12600228 20072827 15206509 23226582

Sources:
TALC DTC PharmGKB FDA

Interaction Types & Directionality:

n/a

Interaction Info:

Fusion protein BCR:ABL1

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Fusion protein BCR:ABL1

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes Targets BCR-ABL fusion protein

PMIDs:
None found

Sources:
TALC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes Targets BCR-ABL fusion protein

Fusion protein BCR:ABL1

PMIDs:
15256671

Sources:
TALC PharmGKB FDA

Interaction Types & Directionality:

n/a

Interaction Info:

Fusion protein BCR:ABL1

PMIDs:
None found

Sources:
PharmGKB FDA

Alternate Names:

BCR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

1014 HUGO Gene ID

1014 HUGO Gene Symbol

BCR activator of RhoGEF and GTPase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name BCR family

GuideToPharmacology Gene Category ID 874

Gene Categories:

ENZYME

Alternate Names:

ENSG00000186716 Gene Symbol

BCR Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

BCR Gene Symbol

Alternate Names:

D22S11 GENE_SYMBOL

BCR GENE_SYMBOL

Breakpoint cluster region protein UNIPROT

Alternate Names:

PA25321 PharmGKB ID

Alternate Names:

BCR Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

613 Gene ID

ALL dGene Synonym

BCR1 dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Alternate Names:

BCR1 GO Gene Synonym

D22S11 GO Gene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Alternate Names:

Breakpoint cluster region protein Gene Name

P11274 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE