BCL2L2 Gene Record

  • BCL2L2 599 Druggable GenomeClinically Actionable

    Alternate Names:

    599
    BCL2 LIKE 2
    BCL2L2
    BCL-W
    BCL2-L-2
    BCLW
    PPP1R51
    601931
    995
    ENSG00000129473
    OTTHUMG00000028738
    BE0003420
    Q92843
    B2CL2_HUMAN
    BCL-2-LIKE PROTEIN 2
    ENSG00000258643
    APOPTOSIS REGULATOR BCL-W
    KIAA0271
    APOPTOSIS REGULATOR BCL-W (BCL-2-LIKE 2 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92843]
    2846
    Bcl-2-like 2
    T03755
    NM_004050
    NP_004041

    Gene Info:

    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000712
    Interpro Short Name Bcl2_BH
    Interpro Name Apoptosis regulator, Bcl-2, BH
    Target Class Miscellaneous
    Target Subclass regulator of apoptosis
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name B-cell lymphoma 2 (Bcl-2) protein family
    GuideToPharmacology Gene Category ID 910
    (9 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

  • NAVITOCLAX   BCL2L2

    Interaction Score: 2.91

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Apoptosis regulator Bcl-W inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD DrugBank TALC ChemblInteractions

  • OBATOCLAX MESYLATE   BCL2L2

    Interaction Score: 1.58

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Apoptosis regulator Bcl-W inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ABT 737   BCL2L2

    Interaction Score: 1.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CLADRIBINE   BCL2L2

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15813915


    Sources:
    NCI

  • VENETOCLAX   BCL2L2

    Interaction Score: 0.63

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BORTEZOMIB   BCL2L2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15813915


    Sources:
    NCI

  • Ensembl: ENSG00000129473

    • Version: 101_38

    Alternate Names:
    BCL2L2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: Q92843

    • Version: 11-September-2012

    Alternate Names:
    B2CL2_HUMAN Uniprot Id
    BCL2L2 Uniprot Gene Name
    Q92843 Uniprot Accession

    Gene Info:
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q92843

    • Version: January-2014

    Alternate Names:
    BCL2L2 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass regulator of apoptosis

    Publications:

  • RussLampel: ENSG00000129473

    • Version: 26-July-2011

    Alternate Names:
    APOPTOSIS REGULATOR BCL-W (BCL-2-LIKE 2 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q92843] Description
    ENSG00000129473 Ensembl Gene Id
    BCL2L2 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 599

    • Version: 29-September-2020

    Alternate Names:
    995 HUGO Gene ID
    995 HUGO Gene Symbol
    BCL2 like 2 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name B-cell lymphoma 2 (Bcl-2) protein family
    GuideToPharmacology Gene Category ID 910

    Publications:

  • NCI: BCL2L2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Duechler et al., 2005, In vitro cytotoxic effect of proteasome inhibitor bortezomib in combination with purine nucleoside analogues on chronic lymphocytic leukaemia cells., Eur. J. Haematol.

  • TALC: BCL-W

    • Version: 12-May-2016

    Alternate Names:
    BCL-W Gene Symbol

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000129473

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000129473 Gene Symbol
    BCL2L2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: BCLW

    • Version: chembl_23

    Alternate Names:
    KIAA0271 GENE_SYMBOL
    BCL2L2 GENE_SYMBOL
    Bcl-2-like protein 2 UNIPROT

    Gene Info:

    Publications:

  • DrugBank: BE0003420

    • Version: 5.1.7

    Alternate Names:
    BCL2L2 DrugBank Gene Name
    Q92843 UniProt Accession
    599 Entrez Gene Id

    Gene Info:

    Publications:

  • TTD: Apoptosis regulator Bcl-W

    • Version: 2020.06.01

    Alternate Names:
    BCL-W TTD Gene Abbreviation
    T03755 TTD Target ID

    Gene Info:

    Publications:

  • FoundationOneGenes: BCL2L2

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: BCL2L2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: