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BCL2L1 Gene Record

  • Summary
  • Interactions
  • Claims
  • BCL2L1 598 Druggable GenomeClinically Actionable

    Alternate Names:

    598
    BCL2 LIKE 1
    BCL2L1
    BCL-XL/S
    BCL2L
    BCLX
    Bcl-X
    PPP1R52
    600039
    992
    ENSG00000171552
    OTTHUMG00000032192
    Bcl-2-like protein 1
    Apoptosis regulator Bcl-X
    Bcl2-L-1
    APOPTOSIS REGULATOR BCL-X (BCL-2-LIKE 1 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07817]
    Q07817
    B2CL1_HUMAN
    BCL-XL
    Apoptosis regulator Bcl-xL
    T56510

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000712
    Interpro Name Apoptosis regulator, Bcl-2, BH
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Bcl2_BH
    Interpro Type Domain
    Target Class Miscellaneous
    Target Subclass regulator of apoptosis
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Wei J et al., 2009, Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins., J Med Chem
    Bauer et al., 2005, Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL., Mol. Cancer Ther.
    Zhou H et al., 2012, Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity., J Med Chem
    Rajule R et al., 2012, Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study., Bioorg Med Chem
    Lee SA et al., 2007, The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation., J Biol Chem
  • APOGOSSYPOL   BCL2L1

    Interaction Score: 17.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19555126


    Sources:
    DTC

  • SANGIVAMYCIN   BCL2L1

    Interaction Score: 8.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17371872


    Sources:
    DTC

  • ABT 737   BCL2L1

    Interaction Score: 5.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    22747598 22386982


    Sources:
    DTC

  • NAVITOCLAX   BCL2L1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Apoptosis regulator Bcl-X inhibitor
    Direct Interaction yes
    Notes

    PMIDs:
    None found


    Sources:
    TALC ChemblInteractions TTD

  • OBATOCLAX   BCL2L1

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OBATOCLAX MESYLATE   BCL2L1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Apoptosis regulator Bcl-X inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GOSSYPOL   BCL2L1

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19555126 16020667


    Sources:
    DTC

  • Ensembl: ENSG00000171552

    • Version: 101_38

    Alternate Names:
    BCL2L1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000171552

    • Version: 26-July-2011

    Alternate Names:
    BCL2L1 Display Id
    APOPTOSIS REGULATOR BCL-X (BCL-2-LIKE 1 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07817] Description
    ENSG00000171552 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q07817

    • Version: 11-September-2012

    Alternate Names:
    BCL2L1 Uniprot Gene Name
    598 Entrez Gene Id
    Q07817 Uniprot Accession

    Gene Info:
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000712

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q07817

    • Version: January-2014

    Alternate Names:
    BCL2L1 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass regulator of apoptosis

    Publications:

  • DTC: BCL2L1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Wei J et al., 2009, Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins., J Med Chem
    Lee SA et al., 2007, The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation., J Biol Chem
    Rajule R et al., 2012, Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study., Bioorg Med Chem

  • TALC: BCL-XL

    • Version: 12-May-2016

    Alternate Names:
    BCL-XL Gene Symbol

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000171552

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000171552 Gene Symbol
    BCL2L1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: BCL2L

    • Version: chembl_23

    Alternate Names:
    BCLX GENE_SYMBOL
    BCL2L1 GENE_SYMBOL
    BCL2L GENE_SYMBOL

    Gene Info:

    Publications:

  • Tempus: BCL2L1

    • Version: 11-November-2018

    Alternate Names:
    BCL2L1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Apoptosis regulator Bcl-xL

    • Version: 2020.06.01

    Alternate Names:
    BCL-xL TTD Gene Abbreviation
    T56510 TTD Target ID

    Gene Info:

    Publications:

  • MskImpact: BCL2L1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: BCL2L1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21