DGIdb - BCL2L1 Gene Record

BCL2L1 598 Druggable GenomeClinically Actionable

Alternate Names:

598
BCL2 LIKE 1
BCL2L1
BCL-XL/S
BCL2L
BCLX
Bcl-X
PPP1R52
600039
992
ENSG00000171552
OTTHUMG00000032192
Bcl-2-like protein 1
Apoptosis regulator Bcl-X
Bcl2-L-1
APOPTOSIS REGULATOR BCL-X (BCL-2-LIKE 1 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07817]
Q07817
B2CL1_HUMAN
BCL-XL
Apoptosis regulator Bcl-xL
T56510

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000712
Interpro Name	Apoptosis regulator, Bcl-2, BH
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Bcl2_BH
Interpro Type	Domain
Target Class	Miscellaneous
Target Subclass	regulator of apoptosis
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Wei J et al., 2009, Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins., J Med Chem
Bauer et al., 2005, Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL., Mol. Cancer Ther.
Zhou H et al., 2012, Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity., J Med Chem
Rajule R et al., 2012, Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study., Bioorg Med Chem
Lee SA et al., 2007, The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation., J Biol Chem

APOGOSSYPOL BCL2L1

Interaction Score: 17.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19555126

Sources:
DTC
SANGIVAMYCIN BCL2L1

Interaction Score: 8.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17371872

Sources:
DTC
ABT 737 BCL2L1

Interaction Score: 5.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
22747598 22386982

Sources:
DTC
NAVITOCLAX BCL2L1

Interaction Score: 2.21

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Apoptosis regulator Bcl-X inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC ChemblInteractions TTD
OBATOCLAX BCL2L1

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
OBATOCLAX MESYLATE BCL2L1

Interaction Score: 1.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Apoptosis regulator Bcl-X inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GOSSYPOL BCL2L1

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19555126 16020667

Sources:
DTC

Ensembl: ENSG00000171552
- Version: 101_38
Alternate Names:

BCL2L1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000171552
- Version: 26-July-2011
Alternate Names:

BCL2L1 Display Id

APOPTOSIS REGULATOR BCL-X (BCL-2-LIKE 1 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07817] Description

ENSG00000171552 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: Q07817
- Version: 11-September-2012
Alternate Names:

BCL2L1 Uniprot Gene Name

598 Entrez Gene Id

Q07817 Uniprot Accession

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR000712

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q07817
- Version: January-2014
Alternate Names:

BCL2L1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass regulator of apoptosis

Publications:

DTC: BCL2L1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Wei J et al., 2009, Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins., J Med Chem

Lee SA et al., 2007, The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation., J Biol Chem

Rajule R et al., 2012, Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study., Bioorg Med Chem

TALC: BCL-XL
- Version: 12-May-2016
Alternate Names:

BCL-XL Gene Symbol

Gene Info:

Publications:
HingoraniCasas: ENSG00000171552
- Version: 31-May-2017
Alternate Names:

ENSG00000171552 Gene Symbol

BCL2L1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: BCL2L
- Version: chembl_23
Alternate Names:

BCLX GENE_SYMBOL

BCL2L1 GENE_SYMBOL

BCL2L GENE_SYMBOL

Gene Info:

Publications:
Tempus: BCL2L1
- Version: 11-November-2018
Alternate Names:

BCL2L1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Apoptosis regulator Bcl-xL
- Version: 2020.06.01
Alternate Names:

BCL-xL TTD Gene Abbreviation

T56510 TTD Target ID

Gene Info:

Publications:
MskImpact: BCL2L1
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: BCL2L1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Apoptosis regulator Bcl-X inhibitor
Direct Interaction	yes
Notes

BCL2L1	Display Id
APOPTOSIS REGULATOR BCL-X (BCL-2-LIKE 1 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07817]	Description
ENSG00000171552	Ensembl Gene Id

BCL2L1	Uniprot Gene Name
598	Entrez Gene Id
Q07817	Uniprot Accession

antagonist (inhibitory)
inhibitor (inhibitory)

BCL2L1 Gene Record

BCL2L1 598 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

APOGOSSYPOL BCL2L1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19555126

Sources: DTC

SANGIVAMYCIN BCL2L1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17371872

Sources: DTC

ABT 737 BCL2L1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 22747598 22386982

Sources: DTC

NAVITOCLAX BCL2L1

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Apoptosis regulator Bcl-X inhibitor Direct Interaction yes Notes

PMIDs: None found

Sources: TALC ChemblInteractions TTD

OBATOCLAX BCL2L1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

OBATOCLAX MESYLATE BCL2L1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Apoptosis regulator Bcl-X inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

GOSSYPOL BCL2L1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19555126 16020667

Sources: DTC

Ensembl: ENSG00000171552

Alternate Names: BCL2L1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000171552

Alternate Names: BCL2L1 Display Id APOPTOSIS REGULATOR BCL-X (BCL-2-LIKE 1 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07817] Description ENSG00000171552 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: Q07817

Alternate Names: BCL2L1 Uniprot Gene Name 598 Entrez Gene Id Q07817 Uniprot Accession

Gene Info: Uniprot Status Swiss-Prot Human Readable Name DRUGGABLE GENOME Interpro Acc IPR000712

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q07817

Alternate Names: BCL2L1 Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass regulator of apoptosis

Publications:

DTC: BCL2L1

Alternate Names:

Gene Info:

TALC: BCL-XL

Alternate Names: BCL-XL Gene Symbol

Gene Info:

Publications:

HingoraniCasas: ENSG00000171552

Alternate Names: ENSG00000171552 Gene Symbol BCL2L1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: BCL2L

Alternate Names: BCLX GENE_SYMBOL BCL2L1 GENE_SYMBOL BCL2L GENE_SYMBOL

Gene Info:

Publications:

Tempus: BCL2L1

Alternate Names: BCL2L1 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
19555126

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17371872

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
22747598 22386982

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Apoptosis regulator Bcl-X inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Apoptosis regulator Bcl-X inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
19555126 16020667

Sources:
DTC

Alternate Names:

BCL2L1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

BCL2L1 Display Id

APOPTOSIS REGULATOR BCL-X (BCL-2-LIKE 1 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07817] Description

ENSG00000171552 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

BCL2L1 Uniprot Gene Name

598 Entrez Gene Id

Q07817 Uniprot Accession

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR000712

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

BCL2L1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass regulator of apoptosis

Alternate Names:

BCL-XL Gene Symbol

Alternate Names:

ENSG00000171552 Gene Symbol

BCL2L1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

BCLX GENE_SYMBOL

BCL2L1 GENE_SYMBOL

BCL2L GENE_SYMBOL

Alternate Names:

BCL2L1 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

BCL-xL TTD Gene Abbreviation

T56510 TTD Target ID

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE