DGIdb - BCHE Gene Record

BCHE 590 Druggable GenomeDrug Resistance

Alternate Names:

590
BUTYRYLCHOLINESTERASE
BCHE
CHE1
CHE2
E1
177400
983
ENSG00000114200
OTTHUMG00000158131
CHOLINESTERASE
BUTYRYLCHOLINE ESTERASE
PSEUDOCHOLINESTERASE
CHOLINE ESTERASE II
P06276
ACYLCHOLINE ACYLHYDROLASE
CHLE_HUMAN
CHOLINESTERASE PRECURSOR (EC 3.1.1.8) (ACYLCHOLINE ACYLHYDROLASE) (CHOLINE ESTERASE II) (BUTYRYLCHOLINE ESTERASE) (PSEUDOCHOLINESTERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P06276]
BE0002180
2471
PA25294
T99799
NM_000055
NP_000046

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.1.1.8
Target Main Class	Enzymes
Target Subclass	3.1.1.8
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Acc	IPR002018
Interpro Type	Domain
Interpro Name	Carboxylesterase, type B
Interpro Short Name	CarbesteraseB
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Acetylcholine turnover
GuideToPharmacology Gene Category ID	765
GuideToPharmacology Gene Category Name	Hydrolases
GuideToPharmacology Gene Category ID	799

(12 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
DRUGGABLE GENOME
DRUG METABOLISM
ENZYME

Publications:

Han HJ et al., 2015, Effect of rivastigmine or memantine add-on therapy is affected by butyrylcholinesterase genotype in patients with probable Alzheimer's disease., Eur Neurol
Scacchi R et al., 2009, Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine., Am J Med Genet B Neuropsychiatr Genet
Blesa R et al., 2006, Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease., Pharmacogenet Genomics
O'Brien KK et al., 2003, Regulation of attention and response to therapy in dementia by butyrylcholinesterase., Pharmacogenetics
Greig et al., 2002, Butyrylcholinesterase: an important new target in Alzheimer's disease therapy., Int Psychogeriatr
Birks, 2006, Cholinesterase inhibitors for Alzheimer's disease., Cochrane Database Syst Rev
Stahl, 2000, The new cholinesterase inhibitors for Alzheimer's disease, Part 1: their similarities are different., J Clin Psychiatry
Smith, 2009, Treatment of Alzheimer's disease in the long-term-care setting., Am J Health Syst Pharm
Gottwald et al., 1999, Rivastigmine, a brain-region selective acetylcholinesterase inhibitor for treating Alzheimer's disease: review and current status., Expert Opin Investig Drugs
Lalli et al., 2008, Rivastigmine in Parkinson's disease dementia., Expert Rev Neurother
Bassil et al., 2009, Novel regimens and delivery systems in the pharmacological treatment of Alzheimer's disease., CNS Drugs
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Farlow, 2003, Update on rivastigmine., Neurologist
Birks et al., 2009, Rivastigmine for Alzheimer's disease., Cochrane Database Syst Rev
Naik et al., 2009, Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice., J Pharm Pharm Sci
Onor et al., 2007, Rivastigmine in the treatment of Alzheimer's disease: an update., Clin Interv Aging
Kamata et al., 2001, Correlation of binding sites for diisopropyl phosphorofluoridate with cholinesterase and neuropathy target esterase in membrane and cytosol preparations from hen., Neurotoxicology
Kelly et al., 1990, The effects of anticholinesterases on the latencies of action potentials in mouse skeletal muscles., Br. J. Pharmacol.
Acey et al., 2002, A butyrylcholinesterase in the early development of the brine shrimp (Artemia salina) larvae: a target for phthalate ester embryotoxicity?, Biochem. Biophys. Res. Commun.
Pittel et al., 1992, Differential long-term effect of AF64A on [3H]ACh synthesis and release in rat hippocampal synaptosomes., Brain Res.
Miller et al., 1991, Determination of serum cholinesterase activity by liquid chromatography with electrochemical detection., Anal. Biochem.
McGuire MC et al., 1989, Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase., Proc Natl Acad Sci U S A
Alvarellos ML et al., 2015, PharmGKB summary: succinylcholine pathway, pharmacokinetics/pharmacodynamics., Pharmacogenet Genomics
Delacour H et al., 2014, Characterization of a novel BCHE "silent" allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium., PLoS One
Zavorotnyy M et al., 2011, Prolonged apnea during electroconvulsive therapy in monozygotic twins: case reports., Ann Gen Psychiatry
Garcia DF et al., 2011, Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine., Genet Mol Biol
Parnas ML et al., 2011, Concordance of butyrylcholinesterase phenotype with genotype: implications for biochemical reporting., Am J Clin Pathol
Mollerup HM et al., 2011, Butyrylcholinesterase gene mutations in patients with prolonged apnea after succinylcholine for electroconvulsive therapy., Acta Anaesthesiol Scand
Gätke MR et al., 2007, Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia., Pharmacogenet Genomics
Levano S et al., 2005, Genotyping the butyrylcholinesterase in patients with prolonged neuromuscular block after succinylcholine., Anesthesiology
Nogueira CP et al., 1992, Identification of two different point mutations associated with the fluoride-resistant phenotype for human butyrylcholinesterase., Am J Hum Genet
Yen T et al., 2003, Butyrylcholinesterase (BCHE) genotyping for post-succinylcholine apnea in an Australian population., Clin Chem
Lando G et al., 2003, Frequency of butyrylcholinesterase gene mutations in individuals with abnormal inhibition numbers: an Italian-population study., Pharmacogenetics
Janas et al., 2005, The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats., Life Sci.
Gum et al., 1993, Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma., Am. J. Vet. Res.
Meiniel, 1981, Neuromuscular blocking agents and axial teratogenesis in the avian embryo. Can axial morphogenetic disorders by explained by pharmacological action upon muscle tissue?, Teratology
Negrão AB et al., 2013, Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes., PLoS One
Wichmann S et al., 2016, Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene., Pharmacogenet Genomics
Kao et al., 1996, The reversal of profound mivacurium-induced neuromuscular blockade., Can J Anaesth
Harel et al., 1992, Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis., Proc. Natl. Acad. Sci. U.S.A.
Saxena et al., 1997, Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase., Biochemistry
Somani et al., Interactive and delayed effects of pyridostigmine and physical stress on biochemical and histological changes in peripheral tissues of mice., J Appl Toxicol
Servatius et al., 2000, Effects of inescapable stress and treatment with pyridostigmine bromide on plasma butyrylcholinesterase and the acoustic startle response in rats., Physiol. Behav.
Abou-Donia et al., 1996, Increased neurotoxicity following concurrent exposure to pyridostigmine bromide, DEET, and chlorpyrifos., Fundam Appl Toxicol
Guemei et al., 2001, Human plasma carboxylesterase and butyrylcholinesterase enzyme activity: correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan., Cancer Chemother. Pharmacol.
Ahmed et al., 2006, Inhibition of two different cholinesterases by tacrine., Chem. Biol. Interact.
Marco et al., 2003, Recent developments in the synthesis of acetylcholinesterase inhibitors., Mini Rev Med Chem
Wang et al., 1998, Anticholinesterase effects of huperzine A, E2020, and tacrine in rats., Zhongguo Yao Li Xue Bao
Krustev et al., 2006, Calcium-independent tacrine-induced relaxation of rat gastric corpus smooth muscles., Can. J. Physiol. Pharmacol.
Stoytcheva et al., 2006, Electrochemical sensor based on Arthrobacter globiformis for cholinesterase activity determination., Biosens Bioelectron
Lurie et al., 2007, Reduced pseudocholinesterase activity in patients with HELLP syndrome., Reprod Sci
Amenta et al., 2006, Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission., Mech. Ageing Dev.
Hsieh et al., 2007, Choline biosensor constructed with chitinous membrane from soldier crab and its application in measuring cholinesterase inhibitory activities., J Pharm Biomed Anal
Calaf et al., 2007, Gene expression signature of parathion-transformed human breast epithelial cells., Int. J. Mol. Med.
Ramos et al., 2006, Influence of malathion on acetylcholinesterase activity in rats submitted to a forced swimming test., Neurotox Res
da Silva et al., 2006, Lactational exposure to malathion inhibits brain acetylcholinesterase in mice., Neurotoxicology
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Ahmed et al., 2007, Malathion, carbofuran and paraquat inhibit Bungarus sindanus (krait) venom acetylcholinesterase and human serum butyrylcholinesterase in vitro., Ecotoxicology
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Henderson et al., 1989, Echothiophate and cogeners decrease the voltage dependence of end-plate current decay in frog skeletal muscle., J. Pharmacol. Exp. Ther.
Debord et al., 2002, Inhibition of butyrylcholinesterase by phenothiazine derivatives., J Enzyme Inhib Med Chem
Hahn et al., 1994, Effects of the synthetic glucocorticoid triamcinolone acetonide on vasoactive hydrolases of the human placenta in vitro., Placenta
Khan et al., 2001, Neuroparalysis and oxime efficacy in organophosphate poisoning: a study of butyrylcholinesterase., Hum Exp Toxicol
Pohanka et al., 2009, In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048., J Enzyme Inhib Med Chem
Bullock et al., 2005, Rivastigmine and donepezil treatment in moderate to moderately-severe Alzheimer's disease over a 2-year period., Curr Med Res Opin
Heydorn, 1997, Donepezil (E2020): a new acetylcholinesterase inhibitor. Review of its pharmacology, pharmacokinetics, and utility in the treatment of Alzheimer's disease., Expert Opin Investig Drugs
Sokolow S et al., 2017, Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment., J Alzheimers Dis
De Beaumont L et al., 2016, Butyrylcholinesterase K and Apolipoprotein E-ɛ4 Reduce the Age of Onset of Alzheimer's Disease, Accelerate Cognitive Decline, and Modulate Donepezil Response in Mild Cognitively Impaired Subjects., J Alzheimers Dis
Liston DR et al., 2004, Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease., Eur J Pharmacol
Seltzer B, 2005, Donepezil: a review., Expert Opin Drug Metab Toxicol
Nordberg A et al., 2013, A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer's disease., Prim Care Companion CNS Disord
Ogura H et al., 2000, Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro., Methods Find Exp Clin Pharmacol
Schuh, 1976, Interaction of hexafluorenium with human plasma cholinesterase in comparison with hexamethonium., Naunyn Schmiedebergs Arch. Pharmacol.
Nakamura et al., 1993, Characterization of esterases involved in the hydrolysis of dipivefrin hydrochloride., Ophthalmic Res.
Giacobini, 2001, Selective inhibitors of butyrylcholinesterase: a valid alternative for therapy of Alzheimer's disease?, Drugs Aging
Svoboda et al., 2006, Effect of galantamine on acetylcholinesterase and butyrylcholinesterase activities in the presence of L-carnitine in rat selected brain and peripheral tissues., Neuro Endocrinol. Lett.
Wilkinson, 2001, Galantamine: a new treatment for Alzheimer's disease., Expert Rev Neurother
Bag S et al., 2013, Design, synthesis and biological activity of multifunctional α,β-unsaturated carbonyl scaffolds for Alzheimer's disease., Bioorg Med Chem Lett
Lilienfeld, 2002, Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease., CNS Drug Rev
Galenko-Yaroshevskii et al., 2003, Pharmacokinetics and pharmacodynamics of a new local anesthetic agent., Bull. Exp. Biol. Med.
Tacal O et al., 2010, Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry., J Appl Toxicol
Kohrs R et al., 1998, Ketamine: teaching an old drug new tricks., Anesth Analg
Bourne Y et al., 2006, Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding., J Biol Chem

BAMBUTEROL BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Publications:
TACRINE HYDROCHLORIDE BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Publications:
RIVASTIGMINE TARTRATE BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Publications:
PHYSOSTIGMINE BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Publications:

RIVASTIGMINE BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Publications:

Han HJ et al., 2015, Effect of rivastigmine or memantine add-on therapy is affected by butyrylcholinesterase genotype in patients with probable Alzheimer's disease., Eur Neurol

Scacchi R et al., 2009, Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine., Am J Med Genet B Neuropsychiatr Genet

Blesa R et al., 2006, Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease., Pharmacogenet Genomics

ISOFLUROPHATE BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Publications:

Kamata et al., 2001, Correlation of binding sites for diisopropyl phosphorofluoridate with cholinesterase and neuropathy target esterase in membrane and cytosol preparations from hen., Neurotoxicology

Kelly et al., 1990, The effects of anticholinesterases on the latencies of action potentials in mouse skeletal muscles., Br. J. Pharmacol.

Acey et al., 2002, A butyrylcholinesterase in the early development of the brine shrimp (Artemia salina) larvae: a target for phthalate ester embryotoxicity?, Biochem. Biophys. Res. Commun.

PHENSERINE BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Janas et al., 2005, The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats., Life Sci.

DEMECARIUM BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Gum et al., 1993, Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma., Am. J. Vet. Res.

Meiniel, 1981, Neuromuscular blocking agents and axial teratogenesis in the avian embryo. Can axial morphogenetic disorders by explained by pharmacological action upon muscle tissue?, Teratology

EDROPHONIUM BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Harel et al., 1992, Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis., Proc. Natl. Acad. Sci. U.S.A.

Saxena et al., 1997, Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase., Biochemistry

PYRIDOSTIGMINE BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of human plasma BCHE activity by a modified Ellman assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Publications:

Somani et al., Interactive and delayed effects of pyridostigmine and physical stress on biochemical and histological changes in peripheral tissues of mice., J Appl Toxicol

Servatius et al., 2000, Effects of inescapable stress and treatment with pyridostigmine bromide on plasma butyrylcholinesterase and the acoustic startle response in rats., Physiol. Behav.

Abou-Donia et al., 1996, Increased neurotoxicity following concurrent exposure to pyridostigmine bromide, DEET, and chlorpyrifos., Fundam Appl Toxicol

TACRINE BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Publications:

Ahmed et al., 2006, Inhibition of two different cholinesterases by tacrine., Chem. Biol. Interact.

Marco et al., 2003, Recent developments in the synthesis of acetylcholinesterase inhibitors., Mini Rev Med Chem

Wang et al., 1998, Anticholinesterase effects of huperzine A, E2020, and tacrine in rats., Zhongguo Yao Li Xue Bao

CHOLINE BCHE

Interaction Types & Directionality:

product of

Interaction Info:

Publications:

Stoytcheva et al., 2006, Electrochemical sensor based on Arthrobacter globiformis for cholinesterase activity determination., Biosens Bioelectron

Lurie et al., 2007, Reduced pseudocholinesterase activity in patients with HELLP syndrome., Reprod Sci

Amenta et al., 2006, Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission., Mech. Ageing Dev.

MALATHION BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Ramos et al., 2006, Influence of malathion on acetylcholinesterase activity in rats submitted to a forced swimming test., Neurotox Res

da Silva et al., 2006, Lactational exposure to malathion inhibits brain acetylcholinesterase in mice., Neurotoxicology

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

ECHOTHIOPHATE BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Henderson et al., 1989, Echothiophate and cogeners decrease the voltage dependence of end-plate current decay in frog skeletal muscle., J. Pharmacol. Exp. Ther.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

PRALIDOXIME BCHE

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Publications:

Khan et al., 2001, Neuroparalysis and oxime efficacy in organophosphate poisoning: a study of butyrylcholinesterase., Hum Exp Toxicol

Pohanka et al., 2009, In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048., J Enzyme Inhib Med Chem

DONEPEZIL BCHE

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Publications:

Bullock et al., 2005, Rivastigmine and donepezil treatment in moderate to moderately-severe Alzheimer's disease over a 2-year period., Curr Med Res Opin

Heydorn, 1997, Donepezil (E2020): a new acetylcholinesterase inhibitor. Review of its pharmacology, pharmacokinetics, and utility in the treatment of Alzheimer's disease., Expert Opin Investig Drugs

Sokolow S et al., 2017, Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment., J Alzheimers Dis

HEXAFLURONIUM BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Schuh, 1976, Interaction of hexafluorenium with human plasma cholinesterase in comparison with hexamethonium., Naunyn Schmiedebergs Arch. Pharmacol.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

DIPIVEFRIN BCHE

Interaction Types & Directionality:

potentiator

substrate

Interaction Info:

Publications:

Nakamura et al., 1993, Characterization of esterases involved in the hydrolysis of dipivefrin hydrochloride., Ophthalmic Res.

GALANTAMINE BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Giacobini, 2001, Selective inhibitors of butyrylcholinesterase: a valid alternative for therapy of Alzheimer's disease?, Drugs Aging

Svoboda et al., 2006, Effect of galantamine on acetylcholinesterase and butyrylcholinesterase activities in the presence of L-carnitine in rat selected brain and peripheral tissues., Neuro Endocrinol. Lett.

Wilkinson, 2001, Galantamine: a new treatment for Alzheimer's disease., Expert Rev Neurother

KETAMINE BCHE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Kohrs R et al., 1998, Ketamine: teaching an old drug new tricks., Anesth Analg

CHOLINE SALICYLATE BCHE

Interaction Types & Directionality:

product of

Interaction Info:

Publications:

Lurie et al., 2007, Reduced pseudocholinesterase activity in patients with HELLP syndrome., Reprod Sci

Stoytcheva et al., 2006, Electrochemical sensor based on Arthrobacter globiformis for cholinesterase activity determination., Biosens Bioelectron

Amenta et al., 2006, Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission., Mech. Ageing Dev.

CHEMBL139908 BCHE

Interaction Types & Directionality:

substrate

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Bourne Y et al., 2006, Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding., J Biol Chem

SUXAMETHONIUM BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

McGuire MC et al., 1989, Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase., Proc Natl Acad Sci U S A

Alvarellos ML et al., 2015, PharmGKB summary: succinylcholine pathway, pharmacokinetics/pharmacodynamics., Pharmacogenet Genomics

Delacour H et al., 2014, Characterization of a novel BCHE "silent" allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium., PLoS One

COCAINE BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Negrão AB et al., 2013, Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes., PLoS One

MIVACURIUM BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wichmann S et al., 2016, Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene., Pharmacogenet Genomics

Kao et al., 1996, The reversal of profound mivacurium-induced neuromuscular blockade., Can J Anaesth

IRINOTECAN BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Guemei et al., 2001, Human plasma carboxylesterase and butyrylcholinesterase enzyme activity: correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan., Cancer Chemother. Pharmacol.

PHENOTHIAZINE BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Debord et al., 2002, Inhibition of butyrylcholinesterase by phenothiazine derivatives., J Enzyme Inhib Med Chem
TRIAMCINOLONE BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hahn et al., 1994, Effects of the synthetic glucocorticoid triamcinolone acetonide on vasoactive hydrolases of the human placenta in vitro., Placenta
BUPIVACAINE BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Galenko-Yaroshevskii et al., 2003, Pharmacokinetics and pharmacodynamics of a new local anesthetic agent., Bull. Exp. Biol. Med.

DICHLORVOS BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Tacal O et al., 2010, Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry., J Appl Toxicol

CHEMBL215344 BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

EPTASTIGMINE BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MEPTAZINOL BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
7-ETHYL-10-HYDROXYCAMPTOTHECIN BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
VOLANESORSEN BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
BUTANOIC ACID BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL1234276 BCHE

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000114200
- Version: 101_38
Alternate Names:

BCHE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000114200

Version: 26-July-2011

Alternate Names:

CHOLINESTERASE PRECURSOR (EC 3.1.1.8) (ACYLCHOLINE ACYLHYDROLASE) (CHOLINE ESTERASE II) (BUTYRYLCHOLINE ESTERASE) (PSEUDOCHOLINESTERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P06276] Description

ENSG00000114200 Ensembl Gene Id

BCHE Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: P06276
- Version: 01-August-2011
Alternate Names:

590 Entrez Gene Id

ENSG00000114200 Ensembl Gene Id

P06276 Uniprot Accession

Gene Info:

Target Main Class Enzymes

Target Subclass 3.1.1.8

Publications:
HopkinsGroom: P06276
- Version: 11-September-2012
Alternate Names:

ENSG00000114200 Ensembl Gene Id

CHLE_HUMAN Uniprot Id

590 Entrez Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P06276
- Version: January-2014
Alternate Names:

BCHE Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.1.8

Publications:
GuideToPharmacology: 590
- Version: 29-September-2020
Alternate Names:

983 HUGO Gene ID

983 HUGO Gene Symbol

butyrylcholinesterase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Acetylcholine turnover

GuideToPharmacology Gene Category ID 765

GuideToPharmacology Gene Category Name Hydrolases

Gene Categories:

ENZYME

Publications:

PharmGKB: BCHE

Version: 18-August-2020

Alternate Names:

PA25294 PharmGKB ID

Gene Info:

Publications:

Negrão AB et al., 2013, Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes., PLoS One

Blesa R et al., 2006, Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease., Pharmacogenet Genomics

Scacchi R et al., 2009, Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine., Am J Med Genet B Neuropsychiatr Genet

DrugBank: BE0002180

Version: 5.1.7

Alternate Names:

BCHE DrugBank Gene Name

P06276 UniProt Accession

590 Entrez Gene Id

Gene Info:

Publications:

Hsieh et al., 2007, Choline biosensor constructed with chitinous membrane from soldier crab and its application in measuring cholinesterase inhibitory activities., J Pharm Biomed Anal

Calaf et al., 2007, Gene expression signature of parathion-transformed human breast epithelial cells., Int. J. Mol. Med.

Amenta et al., 2006, Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission., Mech. Ageing Dev.

NCI: BCHE

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Debord et al., 2002, Inhibition of butyrylcholinesterase by phenothiazine derivatives., J Enzyme Inhib Med Chem

Galenko-Yaroshevskii et al., 2003, Pharmacokinetics and pharmacodynamics of a new local anesthetic agent., Bull. Exp. Biol. Med.

Galli et al., 1996, Reversible inhibition of cholinesterases by opioids: possible pharmacological consequences., J. Pharm. Pharmacol.

DTC: BCHE
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Bag S et al., 2013, Design, synthesis and biological activity of multifunctional α,β-unsaturated carbonyl scaffolds for Alzheimer's disease., Bioorg Med Chem Lett
HingoraniCasas: ENSG00000114200
- Version: 31-May-2017
Alternate Names:

ENSG00000114200 Gene Symbol

BCHE Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CHE1
- Version: chembl_23
Alternate Names:

CHE1 GENE_SYMBOL

BCHE GENE_SYMBOL

Cholinesterase UNIPROT

Gene Info:

Publications:
Pharos: BCHE
- Version: 03-September-2020
Alternate Names:

Cholinesterase Gene Name

P06276 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: BCHE
- Version: 05-September-2020
Alternate Names:

CHE1 GO Gene Synonym

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:
TTD: Cholinesterase
- Version: 2020.06.01
Alternate Names:

BCHE TTD Gene Abbreviation

T99799 TTD Target ID

Gene Info:

Publications:
FDA: BCHE
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Direct Interaction	yes
Mechanism of Interaction	Cholinesterases; ACHE & BCHE inhibitor

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Details of the Assay for Interaction	Inhibition of human plasma BCHE activity by a modified Ellman assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

CHOLINESTERASE PRECURSOR (EC 3.1.1.8) (ACYLCHOLINE ACYLHYDROLASE) (CHOLINE ESTERASE II) (BUTYRYLCHOLINE ESTERASE) (PSEUDOCHOLINESTERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P06276]	Description
ENSG00000114200	Ensembl Gene Id
BCHE	Display Id

590	Entrez Gene Id
ENSG00000114200	Ensembl Gene Id
P06276	Uniprot Accession

983	HUGO Gene ID
983	HUGO Gene Symbol
butyrylcholinesterase	HUGO Gene Name

BCHE	DrugBank Gene Name
P06276	UniProt Accession
590	Entrez Gene Id

BCHE Gene Record

BCHE 590 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Janas et al., 2005, The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats., Life Sci.

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality: inhibitor (inhibitory) antagonist (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of human plasma BCHE activity by a modified Ellman assay. Specific Action of the Ligand Inhibition Endogenous Drug? False

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

Interaction Types & Directionality: product of

Interaction Info:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Henderson et al., 1989, Echothiophate and cogeners decrease the voltage dependence of end-plate current decay in frog skeletal muscle., J. Pharmacol. Exp. Ther. Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality: activator (activating)

Interaction Info:

Interaction Types & Directionality: inducer (activating)

Interaction Info:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Schuh, 1976, Interaction of hexafluorenium with human plasma cholinesterase in comparison with hexamethonium., Naunyn Schmiedebergs Arch. Pharmacol. Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality: potentiator substrate

Interaction Info:

Publications: Nakamura et al., 1993, Characterization of esterases involved in the hydrolysis of dipivefrin hydrochloride., Ophthalmic Res.

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Kohrs R et al., 1998, Ketamine: teaching an old drug new tricks., Anesth Analg

Interaction Types & Directionality: product of

Interaction Info:

Interaction Types & Directionality: substrate

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Bourne Y et al., 2006, Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding., J Biol Chem

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Negrão AB et al., 2013, Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes., PLoS One

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Wichmann S et al., 2016, Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene., Pharmacogenet Genomics Kao et al., 1996, The reversal of profound mivacurium-induced neuromuscular blockade., Can J Anaesth

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Guemei et al., 2001, Human plasma carboxylesterase and butyrylcholinesterase enzyme activity: correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan., Cancer Chemother. Pharmacol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Debord et al., 2002, Inhibition of butyrylcholinesterase by phenothiazine derivatives., J Enzyme Inhib Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Hahn et al., 1994, Effects of the synthetic glucocorticoid triamcinolone acetonide on vasoactive hydrolases of the human placenta in vitro., Placenta

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Galenko-Yaroshevskii et al., 2003, Pharmacokinetics and pharmacodynamics of a new local anesthetic agent., Bull. Exp. Biol. Med.

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Janas et al., 2005, The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats., Life Sci.

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of human plasma BCHE activity by a modified Ellman assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Interaction Types & Directionality:

product of

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Henderson et al., 1989, Echothiophate and cogeners decrease the voltage dependence of end-plate current decay in frog skeletal muscle., J. Pharmacol. Exp. Ther.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality:

activator (activating)

Interaction Types & Directionality:

inducer (activating)

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Schuh, 1976, Interaction of hexafluorenium with human plasma cholinesterase in comparison with hexamethonium., Naunyn Schmiedebergs Arch. Pharmacol.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality:

potentiator

substrate

Publications:

Nakamura et al., 1993, Characterization of esterases involved in the hydrolysis of dipivefrin hydrochloride., Ophthalmic Res.

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Kohrs R et al., 1998, Ketamine: teaching an old drug new tricks., Anesth Analg

Interaction Types & Directionality:

product of

Interaction Types & Directionality:

substrate

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Bourne Y et al., 2006, Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding., J Biol Chem

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Negrão AB et al., 2013, Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes., PLoS One

Interaction Types & Directionality:

n/a

Publications:

Wichmann S et al., 2016, Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene., Pharmacogenet Genomics

Kao et al., 1996, The reversal of profound mivacurium-induced neuromuscular blockade., Can J Anaesth

Interaction Types & Directionality:

n/a

Publications:

Guemei et al., 2001, Human plasma carboxylesterase and butyrylcholinesterase enzyme activity: correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan., Cancer Chemother. Pharmacol.

Interaction Types & Directionality:

n/a

Publications:

Debord et al., 2002, Inhibition of butyrylcholinesterase by phenothiazine derivatives., J Enzyme Inhib Med Chem

Interaction Types & Directionality:

n/a

Publications:

Hahn et al., 1994, Effects of the synthetic glucocorticoid triamcinolone acetonide on vasoactive hydrolases of the human placenta in vitro., Placenta

Interaction Types & Directionality:

n/a

Publications:

Galenko-Yaroshevskii et al., 2003, Pharmacokinetics and pharmacodynamics of a new local anesthetic agent., Bull. Exp. Biol. Med.

Interaction Types & Directionality:

n/a

Publications:

Tacal O et al., 2010, Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry., J Appl Toxicol

Interaction Types & Directionality:

n/a

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a