DGIdb - BCHE Gene Record

BCHE 590 Druggable GenomeDrug Resistance

Alternate Names:

590
BUTYRYLCHOLINESTERASE
BCHE
CHE1
CHE2
E1
177400
983
ENSG00000114200
OTTHUMG00000158131
CHOLINESTERASE
BUTYRYLCHOLINE ESTERASE
PSEUDOCHOLINESTERASE
CHOLINE ESTERASE II
P06276
ACYLCHOLINE ACYLHYDROLASE
CHLE_HUMAN
CHOLINESTERASE PRECURSOR (EC 3.1.1.8) (ACYLCHOLINE ACYLHYDROLASE) (CHOLINE ESTERASE II) (BUTYRYLCHOLINE ESTERASE) (PSEUDOCHOLINESTERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P06276]
2471
PA25294
T99799
NM_000055
NP_000046
BCHED

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.1.1.8
Target Main Class	Enzymes
Target Subclass	3.1.1.8
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Acc	IPR002018
Interpro Type	Domain
Interpro Name	Carboxylesterase, type B
Interpro Short Name	CarbesteraseB
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Acetylcholine turnover
GuideToPharmacology Gene Category ID	765
GuideToPharmacology Gene Category Name	Hydrolases
GuideToPharmacology Gene Category ID	799

(11 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
DRUGGABLE GENOME
ENZYME

Publications:

Han HJ et al., 2015, Effect of rivastigmine or memantine add-on therapy is affected by butyrylcholinesterase genotype in patients with probable Alzheimer's disease., Eur Neurol
Scacchi R et al., 2009, Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine., Am J Med Genet B Neuropsychiatr Genet
Blesa R et al., 2006, Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease., Pharmacogenet Genomics
O'Brien KK et al., 2003, Regulation of attention and response to therapy in dementia by butyrylcholinesterase., Pharmacogenetics
Greig et al., 2002, Butyrylcholinesterase: an important new target in Alzheimer's disease therapy., Int Psychogeriatr
Birks, 2006, Cholinesterase inhibitors for Alzheimer's disease., Cochrane Database Syst Rev
Stahl, 2000, The new cholinesterase inhibitors for Alzheimer's disease, Part 1: their similarities are different., J Clin Psychiatry
Smith, 2009, Treatment of Alzheimer's disease in the long-term-care setting., Am J Health Syst Pharm
Gottwald et al., 1999, Rivastigmine, a brain-region selective acetylcholinesterase inhibitor for treating Alzheimer's disease: review and current status., Expert Opin Investig Drugs
Lalli et al., 2008, Rivastigmine in Parkinson's disease dementia., Expert Rev Neurother
Bassil et al., 2009, Novel regimens and delivery systems in the pharmacological treatment of Alzheimer's disease., CNS Drugs
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Farlow, 2003, Update on rivastigmine., Neurologist
Birks et al., 2009, Rivastigmine for Alzheimer's disease., Cochrane Database Syst Rev
Naik et al., 2009, Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice., J Pharm Pharm Sci
Onor et al., 2007, Rivastigmine in the treatment of Alzheimer's disease: an update., Clin Interv Aging
Kamata et al., 2001, Correlation of binding sites for diisopropyl phosphorofluoridate with cholinesterase and neuropathy target esterase in membrane and cytosol preparations from hen., Neurotoxicology
Kelly et al., 1990, The effects of anticholinesterases on the latencies of action potentials in mouse skeletal muscles., Br. J. Pharmacol.
Acey et al., 2002, A butyrylcholinesterase in the early development of the brine shrimp (Artemia salina) larvae: a target for phthalate ester embryotoxicity?, Biochem. Biophys. Res. Commun.
Pittel et al., 1992, Differential long-term effect of AF64A on [3H]ACh synthesis and release in rat hippocampal synaptosomes., Brain Res.
Miller et al., 1991, Determination of serum cholinesterase activity by liquid chromatography with electrochemical detection., Anal. Biochem.
McGuire MC et al., 1989, Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase., Proc Natl Acad Sci U S A
Alvarellos ML et al., 2015, PharmGKB summary: succinylcholine pathway, pharmacokinetics/pharmacodynamics., Pharmacogenet Genomics
Delacour H et al., 2014, Characterization of a novel BCHE "silent" allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium., PLoS One
Zavorotnyy M et al., 2011, Prolonged apnea during electroconvulsive therapy in monozygotic twins: case reports., Ann Gen Psychiatry
Garcia DF et al., 2011, Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine., Genet Mol Biol
Parnas ML et al., 2011, Concordance of butyrylcholinesterase phenotype with genotype: implications for biochemical reporting., Am J Clin Pathol
Mollerup HM et al., 2011, Butyrylcholinesterase gene mutations in patients with prolonged apnea after succinylcholine for electroconvulsive therapy., Acta Anaesthesiol Scand
Gätke MR et al., 2007, Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia., Pharmacogenet Genomics
Levano S et al., 2005, Genotyping the butyrylcholinesterase in patients with prolonged neuromuscular block after succinylcholine., Anesthesiology
Nogueira CP et al., 1992, Identification of two different point mutations associated with the fluoride-resistant phenotype for human butyrylcholinesterase., Am J Hum Genet
Yen T et al., 2003, Butyrylcholinesterase (BCHE) genotyping for post-succinylcholine apnea in an Australian population., Clin Chem
Lando G et al., 2003, Frequency of butyrylcholinesterase gene mutations in individuals with abnormal inhibition numbers: an Italian-population study., Pharmacogenetics
Negrão AB et al., 2013, Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes., PLoS One
Wichmann S et al., 2016, Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene., Pharmacogenet Genomics
Kao et al., 1996, The reversal of profound mivacurium-induced neuromuscular blockade., Can J Anaesth
Somani et al., Interactive and delayed effects of pyridostigmine and physical stress on biochemical and histological changes in peripheral tissues of mice., J Appl Toxicol
Servatius et al., 2000, Effects of inescapable stress and treatment with pyridostigmine bromide on plasma butyrylcholinesterase and the acoustic startle response in rats., Physiol. Behav.
Abou-Donia et al., 1996, Increased neurotoxicity following concurrent exposure to pyridostigmine bromide, DEET, and chlorpyrifos., Fundam Appl Toxicol
Guemei et al., 2001, Human plasma carboxylesterase and butyrylcholinesterase enzyme activity: correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan., Cancer Chemother. Pharmacol.
Ahmed et al., 2006, Inhibition of two different cholinesterases by tacrine., Chem. Biol. Interact.
Marco et al., 2003, Recent developments in the synthesis of acetylcholinesterase inhibitors., Mini Rev Med Chem
Wang et al., 1998, Anticholinesterase effects of huperzine A, E2020, and tacrine in rats., Zhongguo Yao Li Xue Bao
Krustev et al., 2006, Calcium-independent tacrine-induced relaxation of rat gastric corpus smooth muscles., Can. J. Physiol. Pharmacol.
Debord et al., 2002, Inhibition of butyrylcholinesterase by phenothiazine derivatives., J Enzyme Inhib Med Chem
Hahn et al., 1994, Effects of the synthetic glucocorticoid triamcinolone acetonide on vasoactive hydrolases of the human placenta in vitro., Placenta
Bullock et al., 2005, Rivastigmine and donepezil treatment in moderate to moderately-severe Alzheimer's disease over a 2-year period., Curr Med Res Opin
Heydorn, 1997, Donepezil (E2020): a new acetylcholinesterase inhibitor. Review of its pharmacology, pharmacokinetics, and utility in the treatment of Alzheimer's disease., Expert Opin Investig Drugs
Sokolow S et al., 2017, Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment., J Alzheimers Dis
De Beaumont L et al., 2016, Butyrylcholinesterase K and Apolipoprotein E-ɛ4 Reduce the Age of Onset of Alzheimer's Disease, Accelerate Cognitive Decline, and Modulate Donepezil Response in Mild Cognitively Impaired Subjects., J Alzheimers Dis
Liston DR et al., 2004, Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease., Eur J Pharmacol
Seltzer B, 2005, Donepezil: a review., Expert Opin Drug Metab Toxicol
Nordberg A et al., 2013, A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer's disease., Prim Care Companion CNS Disord
Ogura H et al., 2000, Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro., Methods Find Exp Clin Pharmacol
Giacobini, 2001, Selective inhibitors of butyrylcholinesterase: a valid alternative for therapy of Alzheimer's disease?, Drugs Aging
Svoboda et al., 2006, Effect of galantamine on acetylcholinesterase and butyrylcholinesterase activities in the presence of L-carnitine in rat selected brain and peripheral tissues., Neuro Endocrinol. Lett.
Wilkinson, 2001, Galantamine: a new treatment for Alzheimer's disease., Expert Rev Neurother
Bag S et al., 2013, Design, synthesis and biological activity of multifunctional α,β-unsaturated carbonyl scaffolds for Alzheimer's disease., Bioorg Med Chem Lett
Lilienfeld, 2002, Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease., CNS Drug Rev
Galenko-Yaroshevskii et al., 2003, Pharmacokinetics and pharmacodynamics of a new local anesthetic agent., Bull. Exp. Biol. Med.

RIVASTIGMINE BCHE

Interaction Score: 15.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
25376930 18780301 17047484 12668920 12636181 16437532 11078030 19420308 11139819 18671661 19374459 11752352 14587496 19370562 19470293 18044073

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB
ISOFLUROPHATE BCHE

Interaction Score: 10.63

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11405252 2361169 12459190 1511344 1776688

Sources:
TdgClinicalTrial TEND
SUXAMETHONIUM BCHE

Interaction Score: 7.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2915989 26398623 25054547 22053728 21637541 21228368 21029050 18075469 15731589 1415224 12881446 12724618

Sources:
PharmGKB FDA
DONEPEZIL BCHE

Interaction Score: 5.21

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

PMIDs:
16083542 15989517 27911294 27567841 18780301 17047484 14751402 16863459 23930233 11256231

Sources:
NCI PharmGKB
MIVACURIUM BCHE

Interaction Score: 4.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27031121 8922768

Sources:
PharmGKB FDA
GALANTAMINE BCHE

Interaction Score: 3.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11888344 17159811 19811027 23540646 12177686

Sources:
DTC
VOLANESORSEN BCHE

Interaction Score: 3.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MEPTAZINOL BCHE

Interaction Score: 3.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TACRINE BCHE

Interaction Score: 2.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16860785 12871155 10375753 17218977

Sources:
GuideToPharmacology
PYRIDOSTIGMINE BCHE

Interaction Score: 1.74

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of human plasma BCHE activity by a modified Ellman assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
10942908 10869589 8954750

Sources:
GuideToPharmacology
RIVASTIGMINE TARTRATE BCHE

Interaction Score: 1.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
TACRINE HYDROCHLORIDE BCHE

Interaction Score: 1.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
BAMBUTEROL BCHE

Interaction Score: 1.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
EPTASTIGMINE BCHE

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PHYSOSTIGMINE BCHE

Interaction Score: 0.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
BUPIVACAINE BCHE

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14631501

Sources:
NCI
PHENOTHIAZINE BCHE

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12443046

Sources:
NCI
COCAINE BCHE

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24312228

Sources:
PharmGKB
TRIAMCINOLONE BCHE

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7937594

Sources:
NCI
IRINOTECAN BCHE

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11345644

Sources:
NCI PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN BCHE

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000114200
- Version: 101_38
Alternate Names:

BCHE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000114200

Version: 26-July-2011

Alternate Names:

CHOLINESTERASE PRECURSOR (EC 3.1.1.8) (ACYLCHOLINE ACYLHYDROLASE) (CHOLINE ESTERASE II) (BUTYRYLCHOLINE ESTERASE) (PSEUDOCHOLINESTERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P06276] Description

ENSG00000114200 Ensembl Gene Id

BCHE Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: P06276
- Version: 01-August-2011
Alternate Names:

590 Entrez Gene Id

ENSG00000114200 Ensembl Gene Id

P06276 Uniprot Accession

Gene Info:

Target Main Class Enzymes

Target Subclass 3.1.1.8

Publications:
HopkinsGroom: P06276
- Version: 11-September-2012
Alternate Names:

ENSG00000114200 Ensembl Gene Id

CHLE_HUMAN Uniprot Id

590 Entrez Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P06276
- Version: January-2014
Alternate Names:

BCHE Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.1.8

Publications:
GuideToPharmacology: 590
- Version: 29-September-2020
Alternate Names:

983 HUGO Gene ID

983 HUGO Gene Symbol

butyrylcholinesterase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Acetylcholine turnover

GuideToPharmacology Gene Category ID 765

GuideToPharmacology Gene Category Name Hydrolases

Gene Categories:

ENZYME

Publications:

PharmGKB: BCHE

Version: 18-August-2020

Alternate Names:

PA25294 PharmGKB ID

Gene Info:

Publications:

Negrão AB et al., 2013, Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes., PLoS One

Scacchi R et al., 2009, Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine., Am J Med Genet B Neuropsychiatr Genet

De Beaumont L et al., 2016, Butyrylcholinesterase K and Apolipoprotein E-ɛ4 Reduce the Age of Onset of Alzheimer's Disease, Accelerate Cognitive Decline, and Modulate Donepezil Response in Mild Cognitively Impaired Subjects., J Alzheimers Dis

NCI: BCHE

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Debord et al., 2002, Inhibition of butyrylcholinesterase by phenothiazine derivatives., J Enzyme Inhib Med Chem

Galenko-Yaroshevskii et al., 2003, Pharmacokinetics and pharmacodynamics of a new local anesthetic agent., Bull. Exp. Biol. Med.

Galli et al., 1996, Reversible inhibition of cholinesterases by opioids: possible pharmacological consequences., J. Pharm. Pharmacol.

DTC: BCHE
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Bag S et al., 2013, Design, synthesis and biological activity of multifunctional α,β-unsaturated carbonyl scaffolds for Alzheimer's disease., Bioorg Med Chem Lett
HingoraniCasas: ENSG00000114200
- Version: 31-May-2017
Alternate Names:

ENSG00000114200 Gene Symbol

BCHE Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CHE1
- Version: chembl_23
Alternate Names:

CHE1 GENE_SYMBOL

BCHE GENE_SYMBOL

Cholinesterase UNIPROT

Gene Info:

Publications:
TTD: Cholinesterase
- Version: 2020.06.01
Alternate Names:

BCHE TTD Gene Abbreviation

T99799 TTD Target ID

Gene Info:

Publications:
GO: BCHE
- Version: 01-May-2021
Alternate Names:

CHE1 GO Gene Synonym

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:
Pharos: BCHE
- Version: 01-May-2021
Alternate Names:

Cholinesterase Gene Name

P06276 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
FDA: BCHE
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Details of the Assay for Interaction	Inhibition of human plasma BCHE activity by a modified Ellman assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Direct Interaction	yes
Mechanism of Interaction	Cholinesterases; ACHE & BCHE inhibitor

CHOLINESTERASE PRECURSOR (EC 3.1.1.8) (ACYLCHOLINE ACYLHYDROLASE) (CHOLINE ESTERASE II) (BUTYRYLCHOLINE ESTERASE) (PSEUDOCHOLINESTERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P06276]	Description
ENSG00000114200	Ensembl Gene Id
BCHE	Display Id

590	Entrez Gene Id
ENSG00000114200	Ensembl Gene Id
P06276	Uniprot Accession

983	HUGO Gene ID
983	HUGO Gene Symbol
butyrylcholinesterase	HUGO Gene Name

antagonist (inhibitory)
inhibitor (inhibitory)

BCHE Gene Record

BCHE 590 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 25376930 18780301 17047484 12668920 12636181 16437532 11078030 19420308 11139819 18671661 19374459 11752352 14587496 19370562 19470293 18044073

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 11405252 2361169 12459190 1511344 1776688

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2915989 26398623 25054547 22053728 21637541 21228368 21029050 18075469 15731589 1415224 12881446 12724618

Sources: PharmGKB FDA

Interaction Types & Directionality: inducer (activating)

Interaction Info:

PMIDs: 16083542 15989517 27911294 27567841 18780301 17047484 14751402 16863459 23930233 11256231

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27031121 8922768

Sources: PharmGKB FDA

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 11888344 17159811 19811027 23540646 12177686

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 16860785 12871155 10375753 17218977

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of human plasma BCHE activity by a modified Ellman assay. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 10942908 10869589 8954750

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14631501

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12443046

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24312228

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
25376930 18780301 17047484 12668920 12636181 16437532 11078030 19420308 11139819 18671661 19374459 11752352 14587496 19370562 19470293 18044073

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
11405252 2361169 12459190 1511344 1776688

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
2915989 26398623 25054547 22053728 21637541 21228368 21029050 18075469 15731589 1415224 12881446 12724618

Sources:
PharmGKB FDA

Interaction Types & Directionality:

inducer (activating)

PMIDs:
16083542 15989517 27911294 27567841 18780301 17047484 14751402 16863459 23930233 11256231

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27031121 8922768

Sources:
PharmGKB FDA

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
11888344 17159811 19811027 23540646 12177686

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16860785 12871155 10375753 17218977

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of human plasma BCHE activity by a modified Ellman assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
10942908 10869589 8954750

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
14631501

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12443046

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24312228

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
7937594

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11345644

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

BCHE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CHOLINESTERASE PRECURSOR (EC 3.1.1.8) (ACYLCHOLINE ACYLHYDROLASE) (CHOLINE ESTERASE II) (BUTYRYLCHOLINE ESTERASE) (PSEUDOCHOLINESTERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P06276] Description

ENSG00000114200 Ensembl Gene Id

BCHE Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

590 Entrez Gene Id

ENSG00000114200 Ensembl Gene Id

P06276 Uniprot Accession

Gene Info:

Target Main Class Enzymes

Target Subclass 3.1.1.8

Alternate Names:

ENSG00000114200 Ensembl Gene Id

CHLE_HUMAN Uniprot Id

590 Entrez Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot