DGIdb - AXL Gene Record

AXL 558 Druggable GenomeClinically Actionable

Alternate Names:

558
AXL RECEPTOR TYROSINE KINASE
AXL
ARK
JTK11
Tyro7
UFO
109135
905
ENSG00000167601
OTTHUMG00000182727
AXL oncogene
Tyrosine-protein kinase receptor UFO
P30530
UFO_HUMAN
TYROSINE-PROTEIN KINASE RECEPTOR UFO PRECURSOR (EC 2.7.1.112) (AXL ONCOGENE). [SOURCE:UNIPROT/SWISSPROT;ACC:P30530]
1835
NP_001690
NM_001699
Tyrosine-protein kinase UFO
T82383
BE0009412

Gene Info:

Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR001245
Human Readable Name	KINASE
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
GuideToPharmacology Gene Category Name	Type XI RTKs: TAM (TYRO3-, AXL- and MER-TK) receptor family
GuideToPharmacology Gene Category ID	328
GuideToPharmacology Gene Type	catalytic_receptor
Human Readable Name	TYROSINE KINASE
Target Class	Receptors
Target Subclass	EC:2.7.10.1
Source Reported Gene Name	AXL
Gene Biotype	PROTEIN_CODING

(16 More Sources)

Gene Categories: Category Details

CELL SURFACE
KINASE
TYROSINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Mori M et al., 2017, Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia., Invest New Drugs
Antar A et al., 2017, Inhibition of FLT3 in AML: a focus on sorafenib., Bone Marrow Transplant
Thom C, 2015, Preliminary data on ASP2215: tolerability and efficacy in acute myeloid leukemia patients., Future Oncol
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem
Barcelos RC et al., 2014, A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness., Eur J Med Chem
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

GILTERITINIB AXL

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Publications:

Mori M et al., 2017, Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia., Invest New Drugs

Antar A et al., 2017, Inhibition of FLT3 in AML: a focus on sorafenib., Bone Marrow Transplant

Thom C, 2015, Preliminary data on ASP2215: tolerability and efficacy in acute myeloid leukemia patients., Future Oncol

DUBERMATINIB AXL

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Direct Interaction? False

Publications:
R428 AXL

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tyrosine-protein kinase receptor UFO inhibitor

Publications:
BEMCENTINIB AXL

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Publications:
BPI-9016 AXL

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase receptor UFO inhibitor

Direct Interaction yes

Publications:
SITRAVATINIB AXL

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical enzyme activity assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Publications:
MERESTINIB AXL

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of <i>in vitro</i> biochemical activity by EMD Millipore assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Publications:
BMS-777607 AXL

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Publications:
HESPERADIN AXL

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
FOSTAMATINIB AXL

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

BMS-754807 AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem

GONIOTHALAMIN AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Barcelos RC et al., 2014, A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness., Eur J Med Chem

DASATINIB AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PF-00562271 AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GLESATINIB AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CEDIRANIB AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GW843682X AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
LINIFANIB AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
SORAFENIB AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
OSI-632 AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ILORASERTIB AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
BI-505 AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
DOVITINIB AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
VANDETANIB AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GEFITINIB AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TAE-684 AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CENISERTIB AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ENTRECTINIB AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TOZASERTIB AXL

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000167601
- Version: 101_38
Alternate Names:

AXL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacologyGenes: 1835

Version: 4-March-2015

Alternate Names:

AXL receptor tyrosine kinase HUGO Gene Name

905 HUGO Gene ID

AXL Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name Type XI RTKs: TAM (TYRO3-, AXL- and MER-TK) receptor family

GuideToPharmacology Gene Category ID 328

GuideToPharmacology Gene Type catalytic_receptor

Gene Categories:

KINASE, TYROSINE KINASE

Publications:

RussLampel: ENSG00000167601
- Version: 26-July-2011
Alternate Names:

ENSG00000167601 Ensembl Gene Id

TYROSINE-PROTEIN KINASE RECEPTOR UFO PRECURSOR (EC 2.7.1.112) (AXL ONCOGENE). [SOURCE:UNIPROT/SWISSPROT;ACC:P30530] Description

AXL Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P30530
- Version: January-2014
Alternate Names:

AXL Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass EC:2.7.10.1

Publications:
HopkinsGroom: P30530
- Version: 11-September-2012
Alternate Names:

P30530 Uniprot Accession

AXL Uniprot Gene Name

UFO_HUMAN Uniprot Id

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR001245

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

DrugBank: BE0009412

Version: 5.1.7

Alternate Names:

AXL DrugBank Gene Name

P30530 UniProt Accession

558 Entrez Gene Id

Gene Info:

Publications:

Thom C, 2015, Preliminary data on ASP2215: tolerability and efficacy in acute myeloid leukemia patients., Future Oncol

Antar A et al., 2017, Inhibition of FLT3 in AML: a focus on sorafenib., Bone Marrow Transplant

Mori M et al., 2017, Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia., Invest New Drugs

DTC: AXL

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Barcelos RC et al., 2014, A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness., Eur J Med Chem

Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem

HingoraniCasas: ENSG00000167601
- Version: 31-May-2017
Alternate Names:

ENSG00000167601 Gene Symbol

AXL Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: UFO
- Version: chembl_23
Alternate Names:

UFO GENE_SYMBOL

AXL GENE_SYMBOL

Tyrosine-protein kinase receptor UFO UNIPROT

Gene Info:

Publications:
GuideToPharmacologyInteractions: ENSG00000167601
- Version: 20-July-2020
Alternate Names:

AXL receptor tyrosine kinase GuideToPharmacology Name

P30530 UniProtKB ID

Gene Info:

Publications:
TTD: Tyrosine-protein kinase UFO
- Version: 2020.06.01
Alternate Names:

AXL TTD Gene Abbreviation

T82383 TTD Target ID

Gene Info:

Publications:
HumanProteinAtlas: AXL
- Version: 19.3
Alternate Names:

ENSG00000167601 Ensembl Gene ID

ARK Human Protein Atlas Gene Synonym

JTK11 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: AXL
- Version: 03-September-2020
Alternate Names:

Tyrosine-protein kinase receptor UFO Gene Name

P30530 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: AXL
- Version: 05-September-2020
Alternate Names:

UFO GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, TYROSINE KINASE

Publications:
Tempus: AXL
- Version: 11-November-2018
Alternate Names:

AXL Gene Symbol

Gene Info:

Publications:
dGene: AXL
- Version: 27-Jun-2013
Alternate Names:

558 Gene ID

JTK11 dGene Synonym

UFO dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
MskImpact: AXL
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: AXL
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: AXL
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: AXL
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Direct Interaction	yes
Mechanism of Interaction	Tyrosine-protein kinase receptor UFO inhibitor

Details of the Assay for Interaction	In a biochemical enzyme activity assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Details of the Assay for Interaction	Inhibition of <i>in vitro</i> biochemical activity by EMD Millipore assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

AXL receptor tyrosine kinase	HUGO Gene Name
905	HUGO Gene ID
AXL	Gene Symbol

ENSG00000167601	Ensembl Gene Id
TYROSINE-PROTEIN KINASE RECEPTOR UFO PRECURSOR (EC 2.7.1.112) (AXL ONCOGENE). [SOURCE:UNIPROT/SWISSPROT;ACC:P30530]	Description
AXL	Display Id

P30530	Uniprot Accession
AXL	Uniprot Gene Name
UFO_HUMAN	Uniprot Id

AXL	DrugBank Gene Name
P30530	UniProt Accession
558	Entrez Gene Id

UFO	GENE_SYMBOL
AXL	GENE_SYMBOL
Tyrosine-protein kinase receptor UFO	UNIPROT

AXL receptor tyrosine kinase	GuideToPharmacology Name
P30530	UniProtKB ID

ENSG00000167601	Ensembl Gene ID
ARK	Human Protein Atlas Gene Synonym
JTK11	Human Protein Atlas Gene Synonym

Tyrosine-protein kinase receptor UFO	Gene Name
P30530	UniProt ID

AXL Gene Record

AXL 558 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Inhibition Direct Interaction? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tyrosine-protein kinase receptor UFO inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosine-protein kinase receptor UFO inhibitor Direct Interaction yes

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction In a biochemical enzyme activity assay. Specific Action of the Ligand Inhibition Endogenous Drug? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of <i>in vitro</i> biochemical activity by EMD Millipore assay. Specific Action of the Ligand Inhibition Endogenous Drug? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Barcelos RC et al., 2014, A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness., Eur J Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Direct Interaction? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tyrosine-protein kinase receptor UFO inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase receptor UFO inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical enzyme activity assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of <i>in vitro</i> biochemical activity by EMD Millipore assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

Interaction Types & Directionality:

n/a

Publications:

Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Barcelos RC et al., 2014, A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness., Eur J Med Chem

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Alternate Names:

AXL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

AXL receptor tyrosine kinase HUGO Gene Name

905 HUGO Gene ID

AXL Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name Type XI RTKs: TAM (TYRO3-, AXL- and MER-TK) receptor family

GuideToPharmacology Gene Category ID 328

GuideToPharmacology Gene Type catalytic_receptor

Gene Categories:

KINASE, TYROSINE KINASE

Alternate Names:

ENSG00000167601 Ensembl Gene Id

TYROSINE-PROTEIN KINASE RECEPTOR UFO PRECURSOR (EC 2.7.1.112) (AXL ONCOGENE). [SOURCE:UNIPROT/SWISSPROT;ACC:P30530] Description

AXL Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

AXL Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass EC:2.7.10.1

Alternate Names:

P30530 Uniprot Accession

AXL Uniprot Gene Name

UFO_HUMAN Uniprot Id

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR001245

Gene Categories:

KINASE, DRUGGABLE GENOME

Alternate Names:

AXL DrugBank Gene Name

P30530 UniProt Accession

558 Entrez Gene Id