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AVPR2 554 Druggable Genome
Alternate Names:
554 ARGININE VASOPRESSIN RECEPTOR 2 AVPR2 ADHR DI1 DIR DIR3 NDI V2R 300538 897 ENSG00000126895 OTTHUMG00000024227 P30518 V2R_HUMAN Renal-type arginine vasopressin receptor Vasopressin V2 receptor Antidiuretic hormone receptor AVPR V2 368 V<sub>2</sub> receptor VASOPRESSIN V2 RECEPTOR (RENAL-TYPE ARGININE VASOPRESSIN RECEPTOR) (ANTIDIURETIC HORMONE RECEPTOR) (AVPR V2). [SOURCE:UNIPROT/SWISSPROT;ACC:P30518] NP_000045 NM_000054 T66237 Gene Info:
Human Readable Name G PROTEIN COUPLED RECEPTOR Transmembrane Helix Count 7 Target Subclass Rhodopsin Target Main Class Receptors Target Subclass GPCR Uniprot Status Swiss-Prot Interpro Name GPCR, rhodopsin-like, 7TM Interpro Type Family Interpro Short Name 7TM_GPCR_Rhodpsn Interpro Acc IPR000276 Uniprot Evidence 1: Evidence at protein level Human Readable Name DRUGGABLE GENOME Target Class Receptors GuideToPharmacology Gene Category Name Vasopressin and oxytocin receptors GuideToPharmacology Gene Category ID 66 Gene Biotype PROTEIN_CODING Gene Categories: Category Details
G PROTEIN COUPLED RECEPTOR DRUGGABLE GENOME Publications:
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Interaction Score: 20.41
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Novel drug target Established target Trial Name conivaptan, YM-087,Vaprisol Specific Action of the Ligand Antagonist -
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Vasopressin V2 receptor antagonist Trial Name tolvaptan, OPC-41061,Samsca -
Interaction Score: 5.1
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Interaction Score: 5.1
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Interaction Score: 5.1
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Vasopressin V2 receptor antagonist Direct Interaction yes Novel drug target Established target -
Interaction Score: 3.83
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Endogenous Drug? False Specific Action of the Ligand Full agonist Trial Name OX 19, sublingual desmopressin -
Interaction Score: 2.55
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Endogenous Drug? False Specific Action of the Ligand Antagonist Direct Interaction? False -
Interaction Score: 2.55
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Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False -
Interaction Score: 1.7
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inverse agonist -
Interaction Score: 1.5
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Specific Action of the Ligand Full agonist Endogenous Drug? True Direct Interaction? True
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Interaction Score: 1.28
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Vasopressin V2 receptor antagonist -
Interaction Score: 0.85
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.85
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Mechanism of Interaction Vasopressin receptor agonist Direct Interaction yes -
Interaction Score: 0.85
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Specific Action of the Ligand Full agonist Endogenous Drug? False -
Interaction Score: 0.85
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False -
Interaction Score: 0.85
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Mechanism of Interaction Vasopressin V2 receptor agonist Direct Interaction yes -
Interaction Score: 0.64
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False -
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Specific Action of the Ligand Full agonist Endogenous Drug? True -
Interaction Score: 0.51
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False -
Interaction Score: 0.51
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Interaction Score: 0.36
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False -
Interaction Score: 0.15
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- Version: 101_38
Alternate Names:
AVPR2 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: January-2014
Alternate Names:
AVPR2 Gene Symbol Gene Info:
Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin Publications:
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- Version: 26-July-2011
Alternate Names:
VASOPRESSIN V2 RECEPTOR (RENAL-TYPE ARGININE VASOPRESSIN RECEPTOR) (ANTIDIURETIC HORMONE RECEPTOR) (AVPR V2). [SOURCE:UNIPROT/SWISSPROT;ACC:P30518] Description ENSG00000126895 Ensembl Gene Id AVPR2 Display Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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Alternate Names:
ENSG00000126895 Ensembl Gene Id AVPR2 Gene Symbol V2R_HUMAN Uniprot Id Gene Info:
Transmembrane Helix Count 7 Target Subclass Rhodopsin Target Main Class Receptors Publications:
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- Version: 11-September-2012
Alternate Names:
V2R_HUMAN Uniprot Id P30518 Uniprot Accession ENSG00000126895 Ensembl Gene Id Gene Info:
Interpro Name GPCR, rhodopsin-like, 7TM Interpro Type Family Human Readable Name G PROTEIN COUPLED RECEPTOR Gene Categories:
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME Publications:
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- Version: 29-September-2020
Alternate Names:
897 HUGO Gene ID 897 HUGO Gene Symbol arginine vasopressin receptor 2 HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name Vasopressin and oxytocin receptors GuideToPharmacology Gene Category ID 66 Gene Categories:
G PROTEIN COUPLED RECEPTOR Publications:
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Alternate Names:
Gene Info:
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- Version: 31-May-2017
Alternate Names:
ENSG00000126895 Gene Symbol AVPR2 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: chembl_23
Alternate Names:
DIR GENE_SYMBOL DIR3 GENE_SYMBOL V2R GENE_SYMBOL Gene Info:
Publications:
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Alternate Names:
554 Gene ID ADHR dGene Synonym DI1 dGene Synonym Gene Info:
Gene Categories:
G PROTEIN COUPLED RECEPTOR Publications:
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- Version: 2020.06.01
Alternate Names:
V2R TTD Gene Abbreviation T66237 TTD Target ID Gene Info:
Publications:
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Alternate Names:
ADHR GO Gene Synonym DIR GO Gene Synonym DIR3 GO Gene Synonym Gene Info:
Gene Categories:
G PROTEIN COUPLED RECEPTOR Publications:
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Alternate Names:
Vasopressin V2 receptor Gene Name P30518 UniProt ID Gene Info:
Gene Categories:
G PROTEIN COUPLED RECEPTOR Publications: