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AVPR2 Gene Record

  • Summary
  • Interactions
  • Claims
  • AVPR2 554 Druggable Genome

    Alternate Names:

    554
    ARGININE VASOPRESSIN RECEPTOR 2
    AVPR2
    ADHR
    DI1
    DIR
    DIR3
    NDI
    V2R
    300538
    897
    ENSG00000126895
    OTTHUMG00000024227
    P30518
    V2R_HUMAN
    Renal-type arginine vasopressin receptor
    Vasopressin V2 receptor
    Antidiuretic hormone receptor
    AVPR V2
    BE0000293
    368
    V<sub>2</sub> receptor
    VASOPRESSIN V2 RECEPTOR (RENAL-TYPE ARGININE VASOPRESSIN RECEPTOR) (ANTIDIURETIC HORMONE RECEPTOR) (AVPR V2). [SOURCE:UNIPROT/SWISSPROT;ACC:P30518]
    NP_000045
    NM_000054
    T66237

    Gene Info:

    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Main Class Receptors
    Target Subclass GPCR
    Uniprot Status Swiss-Prot
    Interpro Name GPCR, rhodopsin-like, 7TM
    Interpro Type Family
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Acc IPR000276
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Target Class Receptors
    GuideToPharmacology Gene Category Name Vasopressin and oxytocin receptors
    GuideToPharmacology Gene Category ID 66
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Dixon et al., 2008, Tolvaptan and its potential in the treatment of hyponatremia., Ther Clin Risk Manag
    Aperis et al., 2011, Tolvaptan: a new therapeutic agent., Rev Recent Clin Trials
    Slusarz et al., 2006, Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system., Biopolymers
    Del Tredici et al., 2008, Identification of novel selective V2 receptor non-peptide agonists., Biochem. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Boson et al., 2006, Novel vasopressin type 2 (AVPR2) gene mutations in Brazilian nephrogenic diabetes insipidus patients., Genet. Test.
    Yi et al., 2007, Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R., Am. J. Physiol. Renal Physiol.
    Bouley et al., 2006, Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment., Biol. Cell
    Annane et al., 2009, Efficacy and safety of oral conivaptan, a vasopressin-receptor antagonist, evaluated in a randomized, controlled trial in patients with euvolemic or hypervolemic hyponatremia., Am. J. Med. Sci.
    Ali et al., 2007, Conivaptan: a dual vasopressin receptor v1a/v2 antagonist [corrected]., Cardiovasc Drug Rev
    Ghali et al., 2006, Efficacy and safety of oral conivaptan: a V1A/V2 vasopressin receptor antagonist, assessed in a randomized, placebo-controlled trial in patients with euvolemic or hypervolemic hyponatremia., J. Clin. Endocrinol. Metab.
    Palm et al., 2006, Vasopressin antagonists as aquaretic agents for the treatment of hyponatremia., Am. J. Med.
    Ghali et al., 2009, Conivaptan and its role in the treatment of hyponatremia., Drug Des Devel Ther
    Wada et al., 2007, A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH)., Biol. Pharm. Bull.
    Ali et al., 2007, Therapeutic potential of vasopressin receptor antagonists., Drugs
    Hoque et al., 2009, Conivaptan: promise of treatment in heart failure., Expert Opin Pharmacother
    Walter, 2007, Conivaptan: new treatment for hyponatremia., Am J Health Syst Pharm
    Wada et al., 2005, Intravenous administration of conivaptan hydrochloride improves cardiac hemodynamics in rats with myocardial infarction-induced congestive heart failure., Eur. J. Pharmacol.
    Mao et al., 2009, Pharmacokinetics of conivaptan hydrochloride, a vasopressin V(1A)/V(2)-receptor antagonist, in patients with euvolemic or hypervolemic hyponatremia and with or without congestive heart failure from a prospective, 4-day open-label study., Clin Ther
    Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem
    Akerlund et al., 1999, Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women., Br J Obstet Gynaecol
    Narayen G et al., 2012, Vasopressin receptor antagonists and their role in clinical medicine., Indian J Endocrinol Metab
    Kortenoeven ML et al., 2013, Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla., Am J Physiol Renal Physiol
  • CONIVAPTAN   AVPR2

    Interaction Score: 17.88

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name conivaptan, YM-087,Vaprisol
    Specific Action of the Ligand Antagonist

    PMIDs:
    19057376 17919259 16522696 16843091 20054444 17202666 11752352 17428103 19663609 17592003 15659304 19695403


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • TOLVAPTAN   AVPR2

    Interaction Score: 5.61

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Vasopressin V2 receptor antagonist
    Trial Name tolvaptan, OPC-41061,Samsca

    PMIDs:
    19337422 20868352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • LYPRESSIN   AVPR2

    Interaction Score: 4.91

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Vasopressin receptor agonist
    Direct Interaction yes

    PMIDs:
    17020465 16333859 17287200 16563128 11752352


    Sources:
    DrugBank ChemblInteractions

  • TERLIPRESSIN   AVPR2

    Interaction Score: 4.91

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name terlipressin,Lucassin
    Novel drug target Established target

    PMIDs:
    17020465 16333859 17287200 16563128


    Sources:
    TEND TdgClinicalTrial DrugBank

  • TETRA-IODOPHENOLPHTHALEIN   AVPR2

    Interaction Score: 4.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23437772


    Sources:
    DTC

  • LIXIVAPTAN   AVPR2

    Interaction Score: 4.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Vasopressin V2 receptor antagonist
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD GuideToPharmacology ChemblInteractions

  • DESMOPRESSIN   AVPR2

    Interaction Score: 3.68

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist
    Trial Name OX 19, sublingual desmopressin

    PMIDs:
    16333859 18761325 11752352


    Sources:
    TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • CHEMBL332447   AVPR2

    Interaction Score: 2.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • DEMECLOCYCLINE   AVPR2

    Interaction Score: 2.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22470853 24154696


    Sources:
    DrugBank

  • ATOSIBAN   AVPR2

    Interaction Score: 2.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    10519430


    Sources:
    TTD DrugBank GuideToPharmacology

  • SATAVAPTAN   AVPR2

    Interaction Score: 2.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology ChemblInteractions

  • FEDOVAPAGON   AVPR2

    Interaction Score: 2.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MOZAVAPTAN   AVPR2

    Interaction Score: 1.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inverse agonist

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology

  • VASOPRESSIN   AVPR2

    Interaction Score: 1.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True
    Direct Interaction? True

    PMIDs:
    17020465 16333859 17287200 16563128 11752352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • CONIVAPTAN HYDROCHLORIDE   AVPR2

    Interaction Score: 1.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Vasopressin V2 receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RO-5028442   AVPR2

    Interaction Score: 0.7

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DESMOPRESSIN ACETATE   AVPR2

    Interaction Score: 0.7

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Vasopressin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL435323   AVPR2

    Interaction Score: 0.7

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL296908   AVPR2

    Interaction Score: 0.7

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • VASOPRESSIN TANNATE   AVPR2

    Interaction Score: 0.7

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Vasopressin V2 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BALOVAPTAN   AVPR2

    Interaction Score: 0.53

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • OXYTOCIN   AVPR2

    Interaction Score: 0.47

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology

  • NELIVAPTAN   AVPR2

    Interaction Score: 0.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ITRACONAZOLE   AVPR2

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23437772


    Sources:
    DTC

  • RELCOVAPTAN   AVPR2

    Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CLOTRIMAZOLE   AVPR2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23437772


    Sources:
    DTC

  • QUERCETIN   AVPR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23437772


    Sources:
    DTC

  • Ensembl: ENSG00000126895

    • Version: 101_38

    Alternate Names:
    AVPR2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P30518

    • Version: January-2014

    Alternate Names:
    AVPR2 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • RussLampel: ENSG00000126895

    • Version: 26-July-2011

    Alternate Names:
    VASOPRESSIN V2 RECEPTOR (RENAL-TYPE ARGININE VASOPRESSIN RECEPTOR) (ANTIDIURETIC HORMONE RECEPTOR) (AVPR V2). [SOURCE:UNIPROT/SWISSPROT;ACC:P30518] Description
    ENSG00000126895 Ensembl Gene Id
    AVPR2 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P30518

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000126895 Ensembl Gene Id
    AVPR2 Gene Symbol
    V2R_HUMAN Uniprot Id

    Gene Info:
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Main Class Receptors

    Publications:

  • HopkinsGroom: P30518

    • Version: 11-September-2012

    Alternate Names:
    V2R_HUMAN Uniprot Id
    P30518 Uniprot Accession
    ENSG00000126895 Ensembl Gene Id

    Gene Info:
    Interpro Name GPCR, rhodopsin-like, 7TM
    Interpro Type Family
    Human Readable Name G PROTEIN COUPLED RECEPTOR

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 554

    • Version: 29-September-2020

    Alternate Names:
    897 HUGO Gene ID
    897 HUGO Gene Symbol
    arginine vasopressin receptor 2 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Vasopressin and oxytocin receptors
    GuideToPharmacology Gene Category ID 66

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • DrugBank: BE0000293

    • Version: 5.1.7

    Alternate Names:
    AVPR2 DrugBank Gene Name
    P30518 UniProt Accession
    554 Entrez Gene Id

    Gene Info:

    Publications:
    Narayen G et al., 2012, Vasopressin receptor antagonists and their role in clinical medicine., Indian J Endocrinol Metab
    Kortenoeven ML et al., 2013, Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla., Am J Physiol Renal Physiol
    Boson et al., 2006, Novel vasopressin type 2 (AVPR2) gene mutations in Brazilian nephrogenic diabetes insipidus patients., Genet. Test.

  • DTC: AVPR2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem

  • HingoraniCasas: ENSG00000126895

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000126895 Gene Symbol
    AVPR2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ADHR

    • Version: chembl_23

    Alternate Names:
    DIR GENE_SYMBOL
    DIR3 GENE_SYMBOL
    V2R GENE_SYMBOL

    Gene Info:

    Publications:

  • Pharos: AVPR2

    • Version: 03-September-2020

    Alternate Names:
    Vasopressin V2 receptor Gene Name
    P30518 UniProt ID

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • GO: AVPR2

    • Version: 05-September-2020

    Alternate Names:
    ADHR GO Gene Synonym
    DIR GO Gene Synonym
    DIR3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: AVPR2

    • Version: 27-Jun-2013

    Alternate Names:
    554 Gene ID
    ADHR dGene Synonym
    DI1 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Vasopressin V2 receptor

    • Version: 2020.06.01

    Alternate Names:
    V2R TTD Gene Abbreviation
    T66237 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21