554 |
ARGININE VASOPRESSIN RECEPTOR 2 |
AVPR2 |
ADHR |
DI1 |
DIR |
DIR3 |
NDI |
V2R |
300538 |
897 |
ENSG00000126895 |
OTTHUMG00000024227 |
P30518 |
V2R_HUMAN |
Renal-type arginine vasopressin receptor |
Vasopressin V2 receptor |
Antidiuretic hormone receptor |
AVPR V2 |
BE0000293 |
368 |
V<sub>2</sub> receptor |
VASOPRESSIN V2 RECEPTOR (RENAL-TYPE ARGININE VASOPRESSIN RECEPTOR) (ANTIDIURETIC HORMONE RECEPTOR) (AVPR V2). [SOURCE:UNIPROT/SWISSPROT;ACC:P30518] |
NP_000045 |
NM_000054 |
T66237 |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Transmembrane Helix Count | 7 |
Target Subclass | Rhodopsin |
Target Main Class | Receptors |
Target Subclass | GPCR |
Uniprot Status | Swiss-Prot |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Interpro Type | Family |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Interpro Acc | IPR000276 |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | DRUGGABLE GENOME |
Target Class | Receptors |
GuideToPharmacology Gene Category Name | Vasopressin and oxytocin receptors |
GuideToPharmacology Gene Category ID | 66 |
Gene Biotype | PROTEIN_CODING |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | conivaptan, YM-087,Vaprisol |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Vasopressin V2 receptor antagonist |
Trial Name | tolvaptan, OPC-41061,Samsca |
antagonist (inhibitory) |
Mechanism of Interaction | Vasopressin V2 receptor antagonist |
Direct Interaction | yes |
Novel drug target | Established target |
agonist (activating) |
Endogenous Drug? | False |
Specific Action of the Ligand | Full agonist |
Trial Name | OX 19, sublingual desmopressin |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
Direct Interaction? | False |
antagonist (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inverse agonist |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | True |
Direct Interaction? | True |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Vasopressin V2 receptor antagonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Mechanism of Interaction | Vasopressin receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Mechanism of Interaction | Vasopressin V2 receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | True |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
AVPR2 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
AVPR2 | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
VASOPRESSIN V2 RECEPTOR (RENAL-TYPE ARGININE VASOPRESSIN RECEPTOR) (ANTIDIURETIC HORMONE RECEPTOR) (AVPR V2). [SOURCE:UNIPROT/SWISSPROT;ACC:P30518] | Description |
ENSG00000126895 | Ensembl Gene Id |
AVPR2 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ENSG00000126895 | Ensembl Gene Id |
AVPR2 | Gene Symbol |
V2R_HUMAN | Uniprot Id |
Transmembrane Helix Count | 7 |
Target Subclass | Rhodopsin |
Target Main Class | Receptors |
V2R_HUMAN | Uniprot Id |
P30518 | Uniprot Accession |
ENSG00000126895 | Ensembl Gene Id |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Interpro Type | Family |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
897 | HUGO Gene ID |
897 | HUGO Gene Symbol |
arginine vasopressin receptor 2 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | Vasopressin and oxytocin receptors |
GuideToPharmacology Gene Category ID | 66 |
G PROTEIN COUPLED RECEPTOR |
AVPR2 | DrugBank Gene Name |
P30518 | UniProt Accession |
554 | Entrez Gene Id |
ENSG00000126895 | Gene Symbol |
AVPR2 | Ensembl Id |
DRUGGABLE GENOME |
DIR | GENE_SYMBOL |
DIR3 | GENE_SYMBOL |
V2R | GENE_SYMBOL |
Vasopressin V2 receptor | Gene Name |
P30518 | UniProt ID |
G PROTEIN COUPLED RECEPTOR |
ADHR | GO Gene Synonym |
DIR | GO Gene Synonym |
DIR3 | GO Gene Synonym |
G PROTEIN COUPLED RECEPTOR |
554 | Gene ID |
ADHR | dGene Synonym |
DI1 | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |
V2R | TTD Gene Abbreviation |
T66237 | TTD Target ID |