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AVPR1A Gene Record

  • Summary
  • Interactions
  • Claims
  • AVPR1A 552 Druggable Genome

    Alternate Names:

    552
    ARGININE VASOPRESSIN RECEPTOR 1A
    AVPR1A
    AVPR V1a
    AVPR1
    V1aR
    600821
    895
    ENSG00000166148
    OTTHUMG00000169980
    P37288
    V1AR_HUMAN
    VASOPRESSIN V1A RECEPTOR (V1AR) (VASCULAR/HEPATIC-TYPE ARGININE VASOPRESSIN RECEPTOR) (ANTIDIURETIC HORMONE RECEPTOR 1A) (AVPR V1A). [SOURCE:UNIPROT/SWISSPROT;ACC:P37288]
    ANTIDIURETIC HORMONE RECEPTOR 1A
    VASOPRESSIN V1A RECEPTOR
    VASCULAR/HEPATIC-TYPE ARGININE VASOPRESSIN RECEPTOR
    T79232

    Gene Info:

    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Human Readable Name DRUGGABLE GENOME
    Transmembrane Helix Count 7
    Target Main Class Receptors
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Name GPCR, rhodopsin-like, 7TM
    Interpro Type Family
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Adikesavan et al., 2005, A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein., Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
    Liedman et al., 2006, Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea., Acta Obstet Gynecol Scand
    Aoyagi et al., 2007, Alteration of glucose homeostasis in V1a vasopressin receptor-deficient mice., Endocrinology
    Hammock et al., 2005, Association of vasopressin 1a receptor levels with a regulatory microsatellite and behavior., Genes Brain Behav.
    Hiroyama et al., 2007, Vasopressin promotes cardiomyocyte hypertrophy via the vasopressin V1A receptor in neonatal mice., Eur. J. Pharmacol.
    Méchaly et al., 1999, Vasopressin V2 (SR121463A) and V1a (SR49059) receptor antagonists both inhibit desmopressin vasorelaxing activity., Eur. J. Pharmacol.
    Péqueux et al., 2004, Oxytocin- and vasopressin-induced growth of human small-cell lung cancer is mediated by the mitogen-activated protein kinase pathway., Endocr. Relat. Cancer
    Barthelmebs et al., 1996, Vascular effects of [Arg8]vasopressin in the isolated perfused rat kidney., Eur. J. Pharmacol.
    Loichot et al., 2000, Nitric oxide, but not vasopressin V2 receptor-mediated vasodilation, modulates vasopressin-induced renal vasoconstriction in rats., Naunyn Schmiedebergs Arch. Pharmacol.
    Akerlund et al., 1999, Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women., Br J Obstet Gynaecol
    Pierzynski P, 2011, Oxytocin and vasopressin V(1A) receptors as new therapeutic targets in assisted reproduction., Reprod Biomed Online
    Wiśniewski K et al., 2014, New, potent, and selective peptidic oxytocin receptor agonists., J Med Chem
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Manning et al., 2008, Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents., Prog. Brain Res.
    Annane et al., 2009, Efficacy and safety of oral conivaptan, a vasopressin-receptor antagonist, evaluated in a randomized, controlled trial in patients with euvolemic or hypervolemic hyponatremia., Am. J. Med. Sci.
    Ali et al., 2007, Therapeutic potential of vasopressin receptor antagonists., Drugs
    Ghali et al., 2009, Conivaptan and its role in the treatment of hyponatremia., Drug Des Devel Ther
    Hoque et al., 2009, Conivaptan: promise of treatment in heart failure., Expert Opin Pharmacother
    Ali et al., 2007, Conivaptan: a dual vasopressin receptor v1a/v2 antagonist [corrected]., Cardiovasc Drug Rev
    Wada et al., 2007, A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH)., Biol. Pharm. Bull.
    Walter, 2007, Conivaptan: new treatment for hyponatremia., Am J Health Syst Pharm
    Mao et al., 2009, Pharmacokinetics of conivaptan hydrochloride, a vasopressin V(1A)/V(2)-receptor antagonist, in patients with euvolemic or hypervolemic hyponatremia and with or without congestive heart failure from a prospective, 4-day open-label study., Clin Ther
    Ghali et al., 2006, Efficacy and safety of oral conivaptan: a V1A/V2 vasopressin receptor antagonist, assessed in a randomized, placebo-controlled trial in patients with euvolemic or hypervolemic hyponatremia., J. Clin. Endocrinol. Metab.
  • FELYPRESSIN   AVPR1A

    Interaction Score: 25.46

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 11752352 18655903


    Sources:
    TdgClinicalTrial TEND TTD

  • CONIVAPTAN   AVPR1A

    Interaction Score: 23.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name conivaptan, YM-087,Vaprisol
    Novel drug target Established target

    PMIDs:
    19057376 17428103 20054444 19663609 17919259 17202666 11752352 17592003 19695403 16522696


    Sources:
    TdgClinicalTrial TEND TTD

  • TERLIPRESSIN   AVPR1A

    Interaction Score: 10.91

    Interaction Types & Directionality:
    stimulator (activating)

    Interaction Info:
    Trial Name terlipressin,Lucassin
    Novel drug target Established target

    PMIDs:
    17275806 16511036 16532916 17303660 11752352 16011575


    Sources:
    TdgClinicalTrial TEND TTD

  • SRX246   AVPR1A

    Interaction Score: 7.27

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Vasopressin V1a receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • LYPRESSIN   AVPR1A

    Interaction Score: 7.27

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Vasopressin receptor agonist

    PMIDs:
    17303660 16511036 16532916 16011575 17275806


    Sources:
    ChemblInteractions

  • SELEPRESSIN   AVPR1A

    Interaction Score: 7.27

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Vasopressin V1a receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • SRX251   AVPR1A

    Interaction Score: 7.27

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Vasopressin V1a receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • DESMOPRESSIN   AVPR1A

    Interaction Score: 6.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name OX 19, sublingual desmopressin
    Novel drug target Established target

    PMIDs:
    10594321 15613460 8957254 10731046


    Sources:
    TdgClinicalTrial TEND TTD

  • CARBETOCIN   AVPR1A

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24874785


    Sources:
    DTC

  • RELCOVAPTAN   AVPR1A

    Interaction Score: 2.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Vasopressin V1a receptor antagonist

    PMIDs:
    10519430 21130036


    Sources:
    ChemblInteractions

  • ATOSIBAN   AVPR1A

    Interaction Score: 1.82

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    10519430


    Sources:
    TTD

  • CONIVAPTAN HYDROCHLORIDE   AVPR1A

    Interaction Score: 1.82

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Vasopressin V1a receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VASOPRESSIN   AVPR1A

    Interaction Score: 1.82

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction Vasopressin receptor agonist

    PMIDs:
    16511036 16532916 17303660 16011575 17275806


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • MOZAVAPTAN   AVPR1A

    Interaction Score: 1.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • VASOPRESSIN TANNATE   AVPR1A

    Interaction Score: 1.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Vasopressin V1a receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DESMOPRESSIN ACETATE   AVPR1A

    Interaction Score: 1.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Vasopressin receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OXYTOCIN   AVPR1A

    Interaction Score: 0.4

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000166148

    • Version: 101_38

    Alternate Names:
    AVPR1A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000166148

    • Version: 26-July-2011

    Alternate Names:
    VASOPRESSIN V1A RECEPTOR (V1AR) (VASCULAR/HEPATIC-TYPE ARGININE VASOPRESSIN RECEPTOR) (ANTIDIURETIC HORMONE RECEPTOR 1A) (AVPR V1A). [SOURCE:UNIPROT/SWISSPROT;ACC:P37288] Description
    AVPR1A Display Id
    ENSG00000166148 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P37288

    • Version: January-2014

    Alternate Names:
    AVPR1A Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • TEND: P37288

    • Version: 01-August-2011

    Alternate Names:
    AVPR1A Gene Symbol
    552 Entrez Gene Id
    ENSG00000166148 Ensembl Gene Id

    Gene Info:
    Target Subclass GPCR
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin

    Publications:

  • HopkinsGroom: P37288

    • Version: 11-September-2012

    Alternate Names:
    AVPR1A Uniprot Gene Name
    P37288 Uniprot Accession
    552 Entrez Gene Id

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TTD: Vasopressin V1a receptor

    • Version: 2020.06.01

    Alternate Names:
    V1AR TTD Gene Abbreviation
    T79232 TTD Target ID

    Gene Info:

    Publications:
    Baribeau DA et al., 2014, Social Communication is an Emerging Target for Pharmacotherapy in Autism Spectrum Disorder - A Review of the Literature on Potential Agents., J Can Acad Child Adolesc Psychiatry

  • DTC: AVPR1A

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Wiśniewski K et al., 2014, New, potent, and selective peptidic oxytocin receptor agonists., J Med Chem

  • ChemblInteractions: AVPR1

    • Version: chembl_23

    Alternate Names:
    AVPR1 GENE_SYMBOL
    AVPR1A GENE_SYMBOL
    Vasopressin V1a receptor UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000166148

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000166148 Gene Symbol
    AVPR1A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: AVPR1A

    • Version: 01-February-2022

    Alternate Names:
    AVPR1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: AVPR1A

    • Version: 27-Jun-2013

    Alternate Names:
    552 Gene ID
    AVPR V1a dGene Synonym
    AVPR1 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21