6790 |
AURORA KINASE A |
AURKA |
AIK |
ARK1 |
AURA |
BTAK |
PPP1R47 |
STK15 |
STK6 |
STK7 |
603072 |
11393 |
ENSG00000087586 |
OTTHUMG00000032796 |
O14965 |
AURKA_HUMAN |
Aurora 2 |
hARK1 |
Serine/threonine-protein kinase 6 |
Serine/threonine-protein kinase 15 |
AYK1 |
Breast tumor-amplified kinase |
Aurora/IPL1-related kinase 1 |
ARK-1 |
IAK1 |
Serine/threonine-protein kinase aurora-A |
AIRK1 |
Aurora-related kinase 1 |
61 |
O14695 |
Aurora A/B/C |
Aurora A |
SERINE/THREONINE-PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE KINASE 15) (AURORA/IPL1-RELATED KINASE 1) (AURORA-RELATED KINASE 1) (HARK1) (AURORA-A) (BREAST-TUMOR-AMPLIFIED KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:O14965] |
T87675 |
AURORA2 |
Interpro Name | Serine/threonine- / dual-specificity protein kinase, catalytic domain |
Interpro Type | Domain |
Human Readable Name | KINASE |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Status | Swiss-Prot |
Interpro Short Name | Ser/Thr_dual-sp_kinase_dom |
Interpro Acc | IPR002290 |
Uniprot Evidence | 1: Evidence at protein level |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.1 |
CancerCommons Reported Gene Name | Aurora Kinase |
Gene Biotype | PROTEIN_CODING |
KINASE |
SERINE THREONINE KINASE |
DRUG RESISTANCE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora-A inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora-A inhibitor |
Direct Interaction | yes |
Notes |
inhibitor (inhibitory) |
Notes | |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora-A inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora inhibitor |
Notes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora inhibitor |
Direct Interaction | yes |
Notes |
inhibitor (inhibitory) |
Notes | |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora-A inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora inhibitor |
inhibitor (inhibitory) |
Novel drug target | Novel Target |
Trial Name | ENMD-2076 |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora-A inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora-A inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora-A inhibitor |
Notes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora-A inhibitor |
inhibitor (inhibitory) |
Trial Name | SNS-314 |
Novel drug target | Novel Target |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora inhibitor |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Notes | |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora inhibitor |
Direct Interaction | yes |
n/a |
Trial Name | XL228 |
Novel drug target | Novel Target |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora-A inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Notes | |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase Aurora-A inhibitor |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
AURKA | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000087586 | Ensembl Gene Id |
AURKA_HUMAN | Uniprot Id |
O14965 | Uniprot Accession |
Interpro Name | Serine/threonine- / dual-specificity protein kinase, catalytic domain |
Interpro Type | Domain |
Human Readable Name | KINASE |
KINASE, DRUGGABLE GENOME |
AURKA | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.1 |
6790 | Entrez Gene ID |
CancerCommons Reported Gene Name | Aurora Kinase |
AURKA | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.1 |
ENSG00000087586 | Ensembl Gene Id |
SERINE/THREONINE-PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE KINASE 15) (AURORA/IPL1-RELATED KINASE 1) (AURORA-RELATED KINASE 1) (HARK1) (AURORA-A) (BREAST-TUMOR-AMPLIFIED KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:O14965] | Description |
AURKA | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
6790 | Entrez Gene ID |
61 | CIViC Gene ID |
DRUG RESISTANCE |
AURORA A | Gene Symbol |
6790 | Entrez Gene Id |
AURKA | MyCancerGenome Gene Symbol |
Aurora A | MyCancerGenome Reported Gene Name |
ENSG00000087586 | Gene Symbol |
AURKA | Ensembl Id |
DRUGGABLE GENOME |
AIRK1 | GENE_SYMBOL |
ARK1 | GENE_SYMBOL |
AURA | GENE_SYMBOL |
AIK | GO Gene Synonym |
AIRK1 | GO Gene Synonym |
ARK1 | GO Gene Synonym |
SERINE THREONINE KINASE |
AURKA | Gene Symbol |
CLINICALLY ACTIONABLE |
6790 | Gene ID |
AIK | dGene Synonym |
ARK1 | dGene Synonym |
KINASE, SERINE THREONINE KINASE |
AURKA | TTD Gene Abbreviation |
T87675 | TTD Target ID |
Aurora kinase A | Gene Name |
O14965 | UniProt ID |
KINASE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |