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ATP7B Gene Record

  • Summary
  • Interactions
  • Claims
  • ATP7B 540 Druggable Genome

    Alternate Names:

    540
    ATPASE COPPER TRANSPORTING BETA
    ATP7B
    PWD
    WC1
    WD
    WND
    606882
    870
    ENSG00000123191
    OTTHUMG00000017406
    P35670
    PA73
    Copper-transporting ATPase 2

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Samimi et al., 2004, Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B., Mol. Pharmacol.
    He YJ et al., 2016, Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial., Pharmacogenomics J
    Miyashita et al., 2003, Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a chemoresistance marker in human oral squamous cell carcinoma treated with cisplatin., Oral Oncol.
    Nakayama et al., Expression and cisplatin sensitivity of copper-transporting P-type adenosine triphosphatase (ATP7B) in human solid carcinoma cell lines., Oncol. Rep.
    Thompson P et al., 2014, Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group., Cancer Chemother Pharmacol
  • PLATINUM   ATP7B

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15213293


    Sources:
    NCI

  • OXALIPLATIN   ATP7B

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15213293


    Sources:
    NCI

  • CARBOPLATIN   ATP7B

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15213293 26194361


    Sources:
    NCI PharmGKB

  • DAUNORUBICIN   ATP7B

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25119182


    Sources:
    PharmGKB

  • CISPLATIN   ATP7B

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15213293 12509969 11605050


    Sources:
    NCI

  • Ensembl: ENSG00000123191

    • Version: 101_38

    Alternate Names:
    ATP7B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: ATP7B

    • Version: 18-August-2020

    Alternate Names:
    PA73 PharmGKB ID

    Gene Info:

    Publications:
    He YJ et al., 2016, Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial., Pharmacogenomics J
    Thompson P et al., 2014, Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group., Cancer Chemother Pharmacol
    Li XP et al., 2014, The ATP7B genetic polymorphisms predict clinical outcome to platinum-based chemotherapy in lung cancer patients., Tumour Biol

  • NCI: ATP7B

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Samimi et al., 2004, Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B., Mol. Pharmacol.
    Miyashita et al., 2003, Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a chemoresistance marker in human oral squamous cell carcinoma treated with cisplatin., Oral Oncol.
    Nakayama et al., Expression and cisplatin sensitivity of copper-transporting P-type adenosine triphosphatase (ATP7B) in human solid carcinoma cell lines., Oncol. Rep.

  • HingoraniCasas: ENSG00000123191

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000123191 Gene Symbol
    ATP7B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: ATP7B

    • Version: 19.3

    Alternate Names:
    ENSG00000123191 Ensembl Gene ID
    WND Human Protein Atlas Gene Synonym
    ATPase copper transporting beta Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    TRANSPORTER, ENZYME

    Publications:

  • Tempus: ATP7B

    • Version: 11-November-2018

    Alternate Names:
    ATP7B Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: ATP7B

    • Version: 01-February-2022

    Alternate Names:
    Copper-transporting ATPase 2 Gene Name
    P35670 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21