DGIdb - ATP7A Gene Record

ATP7A 538 Druggable Genome

Alternate Names:

538
ATPASE COPPER TRANSPORTING ALPHA
ATP7A
DSMAX
MK
MNK
SMAX3
300011
869
ENSG00000165240
OTTHUMG00000021885
Q04656
852
PA72
Copper-transporting ATPase 1

Gene Info:

GuideToPharmacology Gene Category Name	Cu<sup>+</sup>-ATPases
GuideToPharmacology Gene Category ID	161
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

TRANSPORTER
DRUGGABLE GENOME
ENZYME

Publications:

Samimi et al., 2003, Increase in expression of the copper transporter ATP7A during platinum drug-based treatment is associated with poor survival in ovarian cancer patients., Clin. Cancer Res.
Samimi et al., 2004, Increased expression of the copper efflux transporter ATP7A mediates resistance to cisplatin, carboplatin, and oxaliplatin in ovarian cancer cells., Clin. Cancer Res.
Ackland et al., 1997, Expression of Menkes disease gene in mammary carcinoma cells., Biochem. J.
Deeken JF et al., 2010, A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform., Pharmacogenomics J
Samimi et al., 2004, Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B., Mol. Pharmacol.

PLATINUM ATP7A

Interaction Score: 2.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15213293 14676106

Sources:
NCI
THALIDOMIDE ATP7A

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20038957

Sources:
PharmGKB
OXALIPLATIN ATP7A

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15269138

Sources:
NCI
PROGESTERONE ATP7A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9359859

Sources:
NCI
DOCETAXEL ATP7A

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20038957

Sources:
PharmGKB
CARBOPLATIN ATP7A

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14676106

Sources:
NCI

Ensembl: ENSG00000165240
- Version: 101_38
Alternate Names:

ATP7A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 538
- Version: 29-September-2020
Alternate Names:

869 HUGO Gene ID

869 HUGO Gene Symbol

ATPase copper transporting alpha HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Cu<sup>+</sup>-ATPases

GuideToPharmacology Gene Category ID 161

Gene Categories:

TRANSPORTER

Publications:

PharmGKB: ATP7A

Version: 18-August-2020

Alternate Names:

PA72 PharmGKB ID

Gene Info:

Publications:

Marsh S et al., 2009, Platinum pathway., Pharmacogenet Genomics

Deeken JF et al., 2010, A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform., Pharmacogenomics J

NCI: ATP7A

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Samimi et al., 2003, Increase in expression of the copper transporter ATP7A during platinum drug-based treatment is associated with poor survival in ovarian cancer patients., Clin. Cancer Res.

Samimi et al., 2004, Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B., Mol. Pharmacol.

Ackland et al., 1999, Expression of menkes copper-transporting ATPase, MNK, in the lactating human breast: possible role in copper transport into milk., J. Histochem. Cytochem.

HingoraniCasas: ENSG00000165240
- Version: 31-May-2017
Alternate Names:

ENSG00000165240 Gene Symbol

ATP7A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: ATP7A
- Version: 19.3
Alternate Names:

ENSG00000165240 Ensembl Gene ID

MNK Human Protein Atlas Gene Synonym

ATPase copper transporting alpha Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

TRANSPORTER, ENZYME

Publications:
Pharos: ATP7A
- Version: 01-May-2021
Alternate Names:

Copper-transporting ATPase 1 Gene Name

Q04656 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

869	HUGO Gene ID
869	HUGO Gene Symbol
ATPase copper transporting alpha	HUGO Gene Name

ENSG00000165240	Ensembl Gene ID
MNK	Human Protein Atlas Gene Synonym
ATPase copper transporting alpha	Human Protein Atlas Gene Description

ATP7A Gene Record

ATP7A 538 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PLATINUM ATP7A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15213293 14676106

Sources: NCI

THALIDOMIDE ATP7A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20038957

Sources: PharmGKB

OXALIPLATIN ATP7A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15269138

Sources: NCI

PROGESTERONE ATP7A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9359859

Sources: NCI

DOCETAXEL ATP7A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20038957

Sources: PharmGKB

CARBOPLATIN ATP7A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14676106

Sources: NCI

Ensembl: ENSG00000165240

Alternate Names: ATP7A Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 538

Alternate Names: 869 HUGO Gene ID 869 HUGO Gene Symbol ATPase copper transporting alpha HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Cu<sup>+</sup>-ATPases GuideToPharmacology Gene Category ID 161

Gene Categories: TRANSPORTER

Publications:

PharmGKB: ATP7A

Alternate Names: PA72 PharmGKB ID

Gene Info:

Publications: Marsh S et al., 2009, Platinum pathway., Pharmacogenet Genomics Deeken JF et al., 2010, A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform., Pharmacogenomics J

NCI: ATP7A

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000165240

Alternate Names: ENSG00000165240 Gene Symbol ATP7A Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: ATP7A

Alternate Names: ENSG00000165240 Ensembl Gene ID MNK Human Protein Atlas Gene Synonym ATPase copper transporting alpha Human Protein Atlas Gene Description

Gene Info:

Gene Categories: TRANSPORTER, ENZYME

Publications:

Pharos: ATP7A

Alternate Names: Copper-transporting ATPase 1 Gene Name Q04656 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
15213293 14676106

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
20038957

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15269138

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9359859

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
20038957

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
14676106

Sources:
NCI

Alternate Names:

ATP7A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

869 HUGO Gene ID

869 HUGO Gene Symbol

ATPase copper transporting alpha HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Cu<sup>+</sup>-ATPases

GuideToPharmacology Gene Category ID 161

Gene Categories:

TRANSPORTER

Alternate Names:

PA72 PharmGKB ID

Publications:

Marsh S et al., 2009, Platinum pathway., Pharmacogenet Genomics

Deeken JF et al., 2010, A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform., Pharmacogenomics J

Alternate Names:

ENSG00000165240 Gene Symbol

ATP7A Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000165240 Ensembl Gene ID

MNK Human Protein Atlas Gene Synonym

ATPase copper transporting alpha Human Protein Atlas Gene Description

Gene Categories:

TRANSPORTER, ENZYME

Alternate Names:

Copper-transporting ATPase 1 Gene Name

Q04656 UniProt ID

Gene Categories:

ENZYME