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ATP7A Gene Record

  • Summary
  • Interactions
  • Claims
  • ATP7A 538 Druggable Genome

    Alternate Names:

    538
    ATPASE COPPER TRANSPORTING ALPHA
    ATP7A
    DSMAX
    MK
    MNK
    SMAX3
    300011
    869
    ENSG00000165240
    OTTHUMG00000021885
    Q04656
    PA72
    Copper-transporting ATPase 1

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Samimi et al., 2003, Increase in expression of the copper transporter ATP7A during platinum drug-based treatment is associated with poor survival in ovarian cancer patients., Clin. Cancer Res.
    Samimi et al., 2004, Increased expression of the copper efflux transporter ATP7A mediates resistance to cisplatin, carboplatin, and oxaliplatin in ovarian cancer cells., Clin. Cancer Res.
    Ackland et al., 1997, Expression of Menkes disease gene in mammary carcinoma cells., Biochem. J.
    Deeken JF et al., 2010, A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform., Pharmacogenomics J
    Samimi et al., 2004, Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B., Mol. Pharmacol.
  • PLATINUM   ATP7A

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15213293 14676106


    Sources:
    NCI

  • THALIDOMIDE   ATP7A

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20038957


    Sources:
    PharmGKB

  • OXALIPLATIN   ATP7A

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15269138


    Sources:
    NCI

  • PROGESTERONE   ATP7A

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9359859


    Sources:
    NCI

  • DOCETAXEL   ATP7A

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20038957


    Sources:
    PharmGKB

  • CARBOPLATIN   ATP7A

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14676106


    Sources:
    NCI

  • Ensembl: ENSG00000165240

    • Version: 101_38

    Alternate Names:
    ATP7A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: ATP7A

    • Version: 18-August-2020

    Alternate Names:
    PA72 PharmGKB ID

    Gene Info:

    Publications:
    Marsh S et al., 2009, Platinum pathway., Pharmacogenet Genomics
    Deeken JF et al., 2010, A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform., Pharmacogenomics J

  • NCI: ATP7A

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Samimi et al., 2003, Increase in expression of the copper transporter ATP7A during platinum drug-based treatment is associated with poor survival in ovarian cancer patients., Clin. Cancer Res.
    Samimi et al., 2004, Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B., Mol. Pharmacol.
    Ackland et al., 1999, Expression of menkes copper-transporting ATPase, MNK, in the lactating human breast: possible role in copper transport into milk., J. Histochem. Cytochem.

  • HingoraniCasas: ENSG00000165240

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000165240 Gene Symbol
    ATP7A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: ATP7A

    • Version: 19.3

    Alternate Names:
    ENSG00000165240 Ensembl Gene ID
    MNK Human Protein Atlas Gene Synonym
    ATPase copper transporting alpha Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    TRANSPORTER, ENZYME

    Publications:

  • Pharos: ATP7A

    • Version: 01-February-2022

    Alternate Names:
    Copper-transporting ATPase 1 Gene Name
    Q04656 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21