DGIdb - ATIC Gene Record

ATIC 471 Druggable GenomeClinically Actionable

Alternate Names:

471
5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE/IMP CYCLOHYDROLASE
ATIC
AICAR
AICARFT
HEL-S-70p
IMPCHASE
PURH
601731
794
ENSG00000138363
OTTHUMG00000133023
PA25094
Bifunctional purine biosynthesis protein PURH
P31939

Gene Info:

Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Allegra et al., 1985, Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates., Proc. Natl. Acad. Sci. U.S.A.
López-Rodríguez R et al., 2018, Evaluation of a clinical pharmacogenetics model to predict methotrexate response in patients with rheumatoid arthritis., Pharmacogenomics J
Kurzawski M et al., 2016, ATIC missense variant affects response to methotrexate treatment in rheumatoid arthritis patients., Pharmacogenomics
Lima A et al., 2016, Moving toward personalized medicine in rheumatoid arthritis: SNPs in methotrexate intracellular pathways are associated with methotrexate therapeutic outcome., Pharmacogenomics
Jenko B et al., 2017, Clinical-pharmacogenetic predictive models for MTX discontinuation due to adverse events in rheumatoid arthritis., Pharmacogenomics J
Muralidharan N et al., 2016, ATIC 347C>G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis., Pharmacogenomics
Salazar J et al., 2014, Polymorphisms in genes involved in the mechanism of action of methotrexate: are they associated with outcome in rheumatoid arthritis patients?, Pharmacogenomics
Iannaccone CK et al., 2011, Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study., Rheumatology (Oxford)
James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol
Wessels JA et al., 2006, Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis., Arthritis Rheum
Dervieux T et al., 2004, Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis., Arthritis Rheum
Inoue K et al., 2014, Molecular basis for pharmacokinetics and pharmacodynamics of methotrexate in rheumatoid arthritis therapy., Drug Metab Pharmacokinet
Mitchell-Ryan S et al., 2013, Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to ampk activation and antitumor activity., J Med Chem
Kindler, 2002, Pemetrexed in pancreatic cancer., Semin. Oncol.
Hanauske et al., 2001, Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors., Oncologist
Racanelli et al., 2009, Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition., Cancer Res.

PEMETREXED ATIC

Interaction Score: 11.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
24256410 12571811 11524555 19549896

Sources:
DTC
METHOTREXATE ATIC

Interaction Score: 4.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
3860829 29520081 27885916 27676277 27217051 26799664 25084201 20847201 18322994 16947783 15457444 24284432

Sources:
NCI PharmGKB

Ensembl: ENSG00000138363
- Version: 101_38
Alternate Names:

ATIC Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: ATIC

Version: 18-August-2020

Alternate Names:

PA25094 PharmGKB ID

Gene Info:

Publications:

Kurzawski M et al., 2016, ATIC missense variant affects response to methotrexate treatment in rheumatoid arthritis patients., Pharmacogenomics

James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol

Jenko B et al., 2017, Clinical-pharmacogenetic predictive models for MTX discontinuation due to adverse events in rheumatoid arthritis., Pharmacogenomics J

NCI: ATIC

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Faessel et al., 1998, Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: the critical role of polyglutamylation., Cancer Res.

Allegra et al., 1985, Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates., Proc. Natl. Acad. Sci. U.S.A.

DTC: ATIC

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Mitchell-Ryan S et al., 2013, Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to ampk activation and antitumor activity., J Med Chem

HingoraniCasas: ENSG00000138363
- Version: 31-May-2017
Alternate Names:

ENSG00000138363 Gene Symbol

ATIC Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: ATIC
- Version: 11-November-2018
Alternate Names:

ATIC Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: ATIC
- Version: 01-February-2022
Alternate Names:

Bifunctional purine biosynthesis protein PURH Gene Name

P31939 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
FoundationOneGenes: ATIC
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: ATIC
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Bifunctional purine biosynthesis protein PURH	Gene Name
P31939	UniProt ID

ATIC Gene Record

ATIC 471 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PEMETREXED ATIC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 24256410 12571811 11524555 19549896

Sources: DTC

METHOTREXATE ATIC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 3860829 29520081 27885916 27676277 27217051 26799664 25084201 20847201 18322994 16947783 15457444 24284432

Sources: NCI PharmGKB

Ensembl: ENSG00000138363

Alternate Names: ATIC Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: ATIC

Alternate Names: PA25094 PharmGKB ID

Gene Info:

NCI: ATIC

Alternate Names:

Gene Info:

DTC: ATIC

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000138363

Alternate Names: ENSG00000138363 Gene Symbol ATIC Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Tempus: ATIC

Alternate Names: ATIC Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Pharos: ATIC

Alternate Names: Bifunctional purine biosynthesis protein PURH Gene Name P31939 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

FoundationOneGenes: ATIC

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

CarisMolecularIntelligence: ATIC

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
24256410 12571811 11524555 19549896

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
3860829 29520081 27885916 27676277 27217051 26799664 25084201 20847201 18322994 16947783 15457444 24284432

Sources:
NCI PharmGKB

Alternate Names:

ATIC Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA25094 PharmGKB ID

Alternate Names:

ENSG00000138363 Gene Symbol

ATIC Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ATIC Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

Bifunctional purine biosynthesis protein PURH Gene Name

P31939 UniProt ID

Gene Categories:

ENZYME

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE