• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

ASS1 Gene Record

  • Summary
  • Interactions
  • Claims
  • ASS1 445 Drug Resistance

    Alternate Names:

    445
    ARGININOSUCCINATE SYNTHASE 1
    ASS1
    ASS
    CTLN1
    603470
    758
    ENSG00000130707
    OTTHUMG00000020806
    BE0000671
    P00966
    PA162376926
    BE0000788
    Q5T6L4
    450
    Argininosuccinate synthase

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUG RESISTANCE
    ENZYME

    Publications:

    Bean GR et al., 2016, A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas., Cell Death Dis
    Shen et al., 2005, Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway., Biochem. Pharmacol.
    Flam et al., Endothelial nitric oxide production is tightly coupled to the citrulline-NO cycle., Nitric Oxide
    Ben-Yoseph et al., 1989, Detection of kinetically abnormal argininosuccinate synthase in neonatal citrullinemia by conversion of citrulline to arginine in intact fibroblasts., Clin. Chim. Acta
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Takahashi et al., 2006, A case of adult-onset type II citrullinemia--deterioration of clinical course after infusion of hyperosmotic and high sugar solutions., Med. Sci. Monit.
    Zhang et al., 2000, Stable expression of varied levels of inducible nitric oxide synthase in primary cultures of endothelial cells., Anal. Biochem.
    Braissant et al., 1999, Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain., Neurosci. Lett.
    Husson et al., 2003, Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle., Eur. J. Biochem.
    Zandvliet et al., Transient hyperammonemia due to urea cycle enzyme deficiency in Irish wolfhounds., J. Vet. Intern. Med.
    Zhang et al., 2000, Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide., Brain Res. Mol. Brain Res.
    Keilhoff et al., 2000, Citrulline immunohistochemistry for demonstration of NOS activity in vivo and in vitro., Nitric Oxide
    Van Geldre et al., 2002, L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus., Eur. J. Pharmacol.
    Braissant et al., 1999, L-arginine uptake, the citrulline-NO cycle and arginase II in the rat brain: an in situ hybridization study., Brain Res. Mol. Brain Res.
    Hammermann et al., 1998, Inability of rat alveolar macrophages to recycle L-citrulline to L-arginine despite induction of argininosuccinate synthetase mRNA and protein, and inhibition of nitric oxide synthesis by exogenous L-citrulline., Naunyn Schmiedebergs Arch. Pharmacol.
    Moradi et al., 2006, Effect of chronic renal failure on arginase and argininosuccinate synthetase expression., Am. J. Nephrol.
    Feun et al., 2006, Pegylated arginine deiminase: a novel anticancer enzyme agent., Expert Opin Investig Drugs
    Cheng et al., 2007, Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion., Cancer Res.
    Szlosarek et al., 2007, Aberrant regulation of argininosuccinate synthetase by TNF-alpha in human epithelial ovarian cancer., Int. J. Cancer
  • PEGARGIMINASE   ASS1

    Interaction Score: 18.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27735949


    Sources:
    CIViC

  • L-CITRULLINE   ASS1

    Interaction Score: 8.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16449956 11067741 10353334 12709047 17427379 11072090 10944418 12445581 10407171 9879717


    Sources:
    DrugBank

  • ARGININE   ASS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16809898 16787144 17210712 17354225


    Sources:
    DrugBank

  • ASPARTIC ACID   ASS1

    Interaction Score: 3.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15588718 17869551 2791302 17139284 17016423


    Sources:
    DrugBank

  • CHLOROQUINE   ASS1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27735949


    Sources:
    CIViC

  • ADENOSINE TRIPHOSPHATE   ASS1

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • Ensembl: ENSG00000130707

    • Version: 101_38

    Alternate Names:
    ASS1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: ASS1

    • Version: 14-September-2020

    Alternate Names:
    445 Entrez Gene ID
    450 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Nicholson LJ et al., 2009, Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer., Int J Cancer
    Bean GR et al., 2016, A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas., Cell Death Dis

  • DrugBank: BE0000671

    • Version: 5.1.7

    Alternate Names:
    ASS1 DrugBank Gene Name
    P00966 UniProt Accession
    445 Entrez Gene Id

    Gene Info:

    Publications:
    Shen et al., 2005, Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway., Biochem. Pharmacol.
    Flam et al., Endothelial nitric oxide production is tightly coupled to the citrulline-NO cycle., Nitric Oxide
    Ben-Yoseph et al., 1989, Detection of kinetically abnormal argininosuccinate synthase in neonatal citrullinemia by conversion of citrulline to arginine in intact fibroblasts., Clin. Chim. Acta

  • DrugBank: BE0000788

    • Version: 5.1.7

    Alternate Names:
    ASS DrugBank Gene Name
    Q5T6L4 UniProt Accession

    Gene Info:

    Publications:
    Takahashi et al., 2006, A case of adult-onset type II citrullinemia--deterioration of clinical course after infusion of hyperosmotic and high sugar solutions., Med. Sci. Monit.
    Husson et al., 2003, Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle., Eur. J. Biochem.
    Zandvliet et al., Transient hyperammonemia due to urea cycle enzyme deficiency in Irish wolfhounds., J. Vet. Intern. Med.

  • PharmGKB: ASS1

    • Version: 18-August-2020

    Alternate Names:
    PA162376926 PharmGKB ID

    Gene Info:

    Publications:

  • HumanProteinAtlas: ASS1

    • Version: 19.3

    Alternate Names:
    ENSG00000130707 Ensembl Gene ID
    ASS Human Protein Atlas Gene Synonym
    CTLN1 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: ASS1

    • Version: 03-September-2020

    Alternate Names:
    Argininosuccinate synthase Gene Name
    P00966 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: ASS1

    • Version: 05-September-2020

    Alternate Names:
    ASS GO Gene Synonym

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:

  • FDA: ASS1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21