DGIdb - ASS1 Gene Record

ASS1 445 Drug Resistance

Alternate Names:

445
ARGININOSUCCINATE SYNTHASE 1
ASS1
ASS
CTLN1
603470
758
ENSG00000130707
OTTHUMG00000020806
BE0000671
P00966
PA162376926
BE0000788
Q5T6L4
450
Argininosuccinate synthase

Gene Info:

Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
ENZYME

Publications:

Bean GR et al., 2016, A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas., Cell Death Dis
Shen et al., 2005, Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway., Biochem. Pharmacol.
Flam et al., Endothelial nitric oxide production is tightly coupled to the citrulline-NO cycle., Nitric Oxide
Ben-Yoseph et al., 1989, Detection of kinetically abnormal argininosuccinate synthase in neonatal citrullinemia by conversion of citrulline to arginine in intact fibroblasts., Clin. Chim. Acta
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Takahashi et al., 2006, A case of adult-onset type II citrullinemia--deterioration of clinical course after infusion of hyperosmotic and high sugar solutions., Med. Sci. Monit.
Zhang et al., 2000, Stable expression of varied levels of inducible nitric oxide synthase in primary cultures of endothelial cells., Anal. Biochem.
Braissant et al., 1999, Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain., Neurosci. Lett.
Husson et al., 2003, Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle., Eur. J. Biochem.
Zandvliet et al., Transient hyperammonemia due to urea cycle enzyme deficiency in Irish wolfhounds., J. Vet. Intern. Med.
Zhang et al., 2000, Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide., Brain Res. Mol. Brain Res.
Keilhoff et al., 2000, Citrulline immunohistochemistry for demonstration of NOS activity in vivo and in vitro., Nitric Oxide
Van Geldre et al., 2002, L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus., Eur. J. Pharmacol.
Braissant et al., 1999, L-arginine uptake, the citrulline-NO cycle and arginase II in the rat brain: an in situ hybridization study., Brain Res. Mol. Brain Res.
Hammermann et al., 1998, Inability of rat alveolar macrophages to recycle L-citrulline to L-arginine despite induction of argininosuccinate synthetase mRNA and protein, and inhibition of nitric oxide synthesis by exogenous L-citrulline., Naunyn Schmiedebergs Arch. Pharmacol.
Moradi et al., 2006, Effect of chronic renal failure on arginase and argininosuccinate synthetase expression., Am. J. Nephrol.
Feun et al., 2006, Pegylated arginine deiminase: a novel anticancer enzyme agent., Expert Opin Investig Drugs
Cheng et al., 2007, Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion., Cancer Res.
Szlosarek et al., 2007, Aberrant regulation of argininosuccinate synthetase by TNF-alpha in human epithelial ovarian cancer., Int. J. Cancer

PEGARGIMINASE ASS1

Interaction Score: 18.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27735949

Sources:
CIViC
L-CITRULLINE ASS1

Interaction Score: 8.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16449956 11067741 10353334 12709047 17427379 11072090 10944418 12445581 10407171 9879717

Sources:
DrugBank
ARGININE ASS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16809898 16787144 17210712 17354225

Sources:
DrugBank
ASPARTIC ACID ASS1

Interaction Score: 3.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15588718 17869551 2791302 17139284 17016423

Sources:
DrugBank
CHLOROQUINE ASS1

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27735949

Sources:
CIViC
ADENOSINE TRIPHOSPHATE ASS1

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank

Ensembl: ENSG00000130707
- Version: 101_38
Alternate Names:

ASS1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

CIViC: ASS1

Version: 14-September-2020

Alternate Names:

445 Entrez Gene ID

450 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Nicholson LJ et al., 2009, Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer., Int J Cancer

Bean GR et al., 2016, A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas., Cell Death Dis

DrugBank: BE0000671

Version: 5.1.7

Alternate Names:

ASS1 DrugBank Gene Name

P00966 UniProt Accession

445 Entrez Gene Id

Gene Info:

Publications:

Shen et al., 2005, Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway., Biochem. Pharmacol.

Flam et al., Endothelial nitric oxide production is tightly coupled to the citrulline-NO cycle., Nitric Oxide

Ben-Yoseph et al., 1989, Detection of kinetically abnormal argininosuccinate synthase in neonatal citrullinemia by conversion of citrulline to arginine in intact fibroblasts., Clin. Chim. Acta

DrugBank: BE0000788

Version: 5.1.7

Alternate Names:

ASS DrugBank Gene Name

Q5T6L4 UniProt Accession

Gene Info:

Publications:

Takahashi et al., 2006, A case of adult-onset type II citrullinemia--deterioration of clinical course after infusion of hyperosmotic and high sugar solutions., Med. Sci. Monit.

Husson et al., 2003, Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle., Eur. J. Biochem.

Zandvliet et al., Transient hyperammonemia due to urea cycle enzyme deficiency in Irish wolfhounds., J. Vet. Intern. Med.

PharmGKB: ASS1
- Version: 18-August-2020
Alternate Names:

PA162376926 PharmGKB ID

Gene Info:

Publications:
HumanProteinAtlas: ASS1
- Version: 19.3
Alternate Names:

ENSG00000130707 Ensembl Gene ID

ASS Human Protein Atlas Gene Synonym

CTLN1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: ASS1
- Version: 03-September-2020
Alternate Names:

Argininosuccinate synthase Gene Name

P00966 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: ASS1
- Version: 05-September-2020
Alternate Names:

ASS GO Gene Synonym

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:
FDA: ASS1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:

ASS1	DrugBank Gene Name
P00966	UniProt Accession
445	Entrez Gene Id

ENSG00000130707	Ensembl Gene ID
ASS	Human Protein Atlas Gene Synonym
CTLN1	Human Protein Atlas Gene Synonym

ASS1 Gene Record

ASS1 445 Drug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PEGARGIMINASE ASS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27735949

Sources: CIViC

L-CITRULLINE ASS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16449956 11067741 10353334 12709047 17427379 11072090 10944418 12445581 10407171 9879717

Sources: DrugBank

ARGININE ASS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16809898 16787144 17210712 17354225

Sources: DrugBank

ASPARTIC ACID ASS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15588718 17869551 2791302 17139284 17016423

Sources: DrugBank

CHLOROQUINE ASS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27735949

Sources: CIViC

ADENOSINE TRIPHOSPHATE ASS1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Ensembl: ENSG00000130707

Alternate Names: ASS1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

CIViC: ASS1

Alternate Names: 445 Entrez Gene ID 450 CIViC Gene ID

Gene Info:

Gene Categories: DRUG RESISTANCE

DrugBank: BE0000671

Alternate Names: ASS1 DrugBank Gene Name P00966 UniProt Accession 445 Entrez Gene Id

Gene Info:

DrugBank: BE0000788

Alternate Names: ASS DrugBank Gene Name Q5T6L4 UniProt Accession

Gene Info:

PharmGKB: ASS1

Alternate Names: PA162376926 PharmGKB ID

Gene Info:

Publications:

HumanProteinAtlas: ASS1

Alternate Names: ENSG00000130707 Ensembl Gene ID ASS Human Protein Atlas Gene Synonym CTLN1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

Pharos: ASS1

Alternate Names: Argininosuccinate synthase Gene Name P00966 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

GO: ASS1

Alternate Names: ASS GO Gene Synonym

Gene Info:

Gene Categories: DRUG RESISTANCE

Publications:

FDA: ASS1

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
27735949

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
16449956 11067741 10353334 12709047 17427379 11072090 10944418 12445581 10407171 9879717

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16809898 16787144 17210712 17354225

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15588718 17869551 2791302 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
27735949

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Alternate Names:

ASS1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

445 Entrez Gene ID

450 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Alternate Names:

ASS1 DrugBank Gene Name

P00966 UniProt Accession

445 Entrez Gene Id

Alternate Names:

ASS DrugBank Gene Name

Q5T6L4 UniProt Accession

Alternate Names:

PA162376926 PharmGKB ID

Alternate Names:

ENSG00000130707 Ensembl Gene ID

ASS Human Protein Atlas Gene Synonym

CTLN1 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

Argininosuccinate synthase Gene Name

P00966 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

ASS GO Gene Synonym

Gene Categories:

DRUG RESISTANCE