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ARG2 Gene Record

  • Summary
  • Interactions
  • Claims
  • ARG2 384

    Alternate Names:

    384
    ARGINASE 2
    ARG2
    107830
    664
    ENSG00000081181
    OTTHUMG00000171807
    BE0000758
    P78540
    1245
    Arginase II
    Kidney-type arginase
    T36806

    Gene Info:

    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Arginase
    GuideToPharmacology Gene Category ID 250
    (0 More Sources)

    Gene Categories: Category Details

    ENZYME

    Publications:

    Hood et al., 2007, Evolutionary changes in the fungal carbamoyl-phosphate synthetase small subunit gene and its associated upstream open reading frame., Fungal Genet. Biol.
    Topal et al., 2006, Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells., J. Pharmacol. Exp. Ther.
    Rodriguez et al., 2003, L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes., J. Immunol.
    Bussière et al., 2005, Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation., J. Biol. Chem.
    Nissim et al., 2005, The role of mitochondrially bound arginase in the regulation of urea synthesis: studies with [U-15N4]arginine, isolated mitochondria, and perfused rat liver., J. Biol. Chem.
    Levillain et al., 2005, Testosterone down-regulates ornithine aminotransferase gene and up-regulates arginase II and ornithine decarboxylase genes for polyamines synthesis in the murine kidney., Endocrinology
    Levillain et al., 2004, Ornithine metabolism in male and female rat kidney: mitochondrial expression of ornithine aminotransferase and arginase II., Am. J. Physiol. Renal Physiol.
  • ORNITHINE   ARG2

    Interaction Score: 15.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12874210 15548540 15753084 15539552 14871882


    Sources:
    DrugBank

  • ARGININE   ARG2

    Interaction Score: 8.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16979358 16801455


    Sources:
    DrugBank

  • Ensembl: ENSG00000081181

    • Version: 101_38

    Alternate Names:
    ARG2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • GuideToPharmacology: 384

    • Version: 29-September-2020

    Alternate Names:
    664 HUGO Gene ID
    664 HUGO Gene Symbol
    arginase 2 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Arginase
    GuideToPharmacology Gene Category ID 250

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0000758

    • Version: 5.1.7

    Alternate Names:
    ARG2 DrugBank Gene Name
    P78540 UniProt Accession
    384 Entrez Gene Id

    Gene Info:

    Publications:
    Rodriguez et al., 2003, L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes., J. Immunol.
    Bussière et al., 2005, Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation., J. Biol. Chem.
    Nissim et al., 2005, The role of mitochondrially bound arginase in the regulation of urea synthesis: studies with [U-15N4]arginine, isolated mitochondria, and perfused rat liver., J. Biol. Chem.

  • TTD: Kidney-type arginase

    • Version: 2020.06.01

    Alternate Names:
    ARG2 TTD Gene Abbreviation
    T36806 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21