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AOX1 Gene Record

  • Summary
  • Interactions
  • Claims
  • AOX1 316 Druggable Genome

    Alternate Names:

    316
    ALDEHYDE OXIDASE 1
    AOX1
    AO
    AOH1
    602841
    553
    ENSG00000138356
    OTTHUMG00000154536
    Q06278
    ALDEHYDE OXIDASE
    PA24842
    BE0003539
    T94444

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    DRUG METABOLISM

    Publications:

    Smith MA et al., 2009, Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease., Aliment Pharmacol Ther
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    Porter et al., 1994, 5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase., Biochem. Pharmacol.
    Obach RS et al., 2004, Human liver aldehyde oxidase: inhibition by 239 drugs., J Clin Pharmacol
  • ISOVANILLIN   AOX1

    Interaction Score: 8.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ENILURACIL   AOX1

    Interaction Score: 4.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8161345


    Sources:
    DrugBank

  • FEBUXOSTAT   AOX1

    Interaction Score: 1.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • CYCLOBENZAPRINE   AOX1

    Interaction Score: 1.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    14681337


    Sources:
    DrugBank

  • AZATHIOPRINE   AOX1

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19500084


    Sources:
    PharmGKB

  • ALLOPURINOL   AOX1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • MENADIONE   AOX1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000138356

    • Version: 101_38

    Alternate Names:
    AOX1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: AOX1

    • Version: 18-August-2020

    Alternate Names:
    PA24842 PharmGKB ID

    Gene Info:

    Publications:
    Smith MA et al., 2009, Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease., Aliment Pharmacol Ther
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int

  • DrugBank: BE0003539

    • Version: 5.1.7

    Alternate Names:
    AOX1 DrugBank Gene Name
    Q06278 UniProt Accession
    316 Entrez Gene Id

    Gene Info:

    Publications:
    Porter et al., 1994, 5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase., Biochem. Pharmacol.
    Obach RS et al., 2004, Human liver aldehyde oxidase: inhibition by 239 drugs., J Clin Pharmacol

  • HingoraniCasas: ENSG00000138356

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000138356 Gene Symbol
    AOX1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: AOX1

    • Version: 05-September-2020

    Alternate Names:
    AO GO Gene Synonym

    Gene Info:

    Gene Categories:
    DRUG METABOLISM

    Publications:

  • TTD: Aldehyde oxidase

    • Version: 2020.06.01

    Alternate Names:
    AOX1 TTD Gene Abbreviation
    T94444 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21