• Interaction Score: 31.9

    Interaction Types & Directionality:
    antibody (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name BTT-1023, VAP-1 monoclonal antibody
    Details of the Assay for Interaction Value varies slightly between a time-resolved immunofluorometric assay and real time direct binding assay using a BIACORE® surface plasmon resonance assay.

    PMIDs:
    None found


  • Interaction Score: 10.63

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Amine oxidase, copper containing inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 9.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name hydralazine HCl/isosorbide,BiDil
    Novel drug target Established target

  • Interaction Score: 5.72

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

  • Interaction Score: 5.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of recombinant hSSAO/VAP-1.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 1.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

    • Version: 101_38

    Alternate Names:
    AOC3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: January-2014

    Alternate Names:
    AOC3 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.4.3.21

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    550 HUGO Gene ID
    550 HUGO Gene Symbol
    amine oxidase copper containing 3 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 1.-.-.- Oxidoreductases
    GuideToPharmacology Gene Category ID 840

    Gene Categories:
    ENZYME

    Publications:

    • Version: chembl_23

    Alternate Names:
    VAP1 GENE_SYMBOL
    AOC3 GENE_SYMBOL
    Membrane primary amine oxidase UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000131471 Gene Symbol
    AOC3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    AOC3 TTD Gene Abbreviation
    T69619 TTD Target ID

    Gene Info:

    Publications:

  • GO: AOC3

    • Version: 01-May-2021

    Alternate Names:
    VAP1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications: