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ANXA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • ANXA1 301 Druggable Genome

    Alternate Names:

    301
    ANNEXIN A1
    ANXA1
    ANX1
    LPC1
    151690
    533
    ENSG00000135046
    OTTHUMG00000020016
    P04083
    ANXA1_HUMAN

    Gene Info:

    Target Main Class Other
    Target Subclass Enzyme Inhibitor
    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    DRUGGABLE GENOME

    Publications:

    Serres et al., 1994, Expression of annexin I in freshly isolated human epidermal cells and in cultured keratinocytes., Arch. Dermatol. Res.
    Serres et al., 1994, Annexin 1 regulation in human epidermal cells., Cell. Mol. Biol. (Noisy-le-grand)
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    White et al., 1991, Hydrocortisone inhibits rat basophilic leukemia cell mediator release induced by neutrophil-derived histamine releasing activity as well as by anti-IgE., J. Immunol.
    Sato-Matsumura et al., 2000, Membrane expression of annexin I is enhanced by calcium and TPA in cultured human keratinocytes., Arch. Dermatol. Res.
    Yang et al., 2004, Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis., Arthritis Rheum.
    Davies et al., 2007, Expression and externalization of annexin 1 in the adrenal gland: structure and function of the adrenal gland in annexin 1-null mutant mice., Endocrinology
    Wang et al., 2007, Involvement of annexin I in the dexamethasone-mediated upregulation of A549 cells phagocytosis of apoptotic eosinophils., Immunol. Lett.
    Morand et al., 2006, Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1., Mediators Inflamm.
    John et al., 2006, Time-specific effects of perinatal glucocorticoid treatment on anterior pituitary morphology, annexin 1 expression and adrenocorticotrophic hormone secretion in the adult female rat., J. Neuroendocrinol.
    Edashige et al., 1992, Differentiation of HL-60 cells by phorbol ester is correlated with up-regulation of protein kinase C-alpha., Arch. Biochem. Biophys.
  • AMCINONIDE   ANXA1

    Interaction Score: 1.77

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    7981624 17016423 17139284


    Sources:
    TEND

  • HYDROCORTAMATE   ANXA1

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • MOMETASONE   ANXA1

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • DESONIDE   ANXA1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • ALCLOMETASONE   ANXA1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • DIFLORASONE   ANXA1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • CLOCORTOLONE   ANXA1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • PREDNICARBATE   ANXA1

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • CLOBETASOL   ANXA1

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • DESOXIMETASONE   ANXA1

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • RIMEXOLONE   ANXA1

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • HYDROCORTISONE   ANXA1

    Interaction Score: 0.5

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    1712816 8060156 17016423 17139284 11142771


    Sources:
    NCI

  • METHYLPREDNISOLONE   ANXA1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    8060156


    Sources:
    TEND

  • BETAMETHASONE   ANXA1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • DEXAMETHASONE   ANXA1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    15022342 17158208 17644190 16883066 17076770


    Sources:
    NCI TEND

  • BECLOMETHASONE   ANXA1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • STAUROSPORINE   ANXA1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1444457


    Sources:
    NCI

  • TRIAMCINOLONE   ANXA1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • PREDNISOLONE   ANXA1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • PREDNISONE   ANXA1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • Ensembl: ENSG00000135046

    • Version: 101_38

    Alternate Names:
    ANXA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P04083

    • Version: 01-August-2011

    Alternate Names:
    P04083 Uniprot Accession
    ENSG00000135046 Ensembl Gene Id
    ANXA1 Gene Symbol

    Gene Info:
    Target Main Class Other
    Target Subclass Enzyme Inhibitor

    Publications:

  • NCI: ANXA1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Yang et al., 2004, Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis., Arthritis Rheum.
    Ambrose et al., 1990, Corticosteroids increase lipocortin I in alveolar epithelial cells., Am. J. Respir. Cell Mol. Biol.
    Shi et al., 2003, [Study on the expression level of Annexin I, cPLA(2) and PCNA in cleft-palate mice induced by dexamethasone]., Zhonghua Kou Qiang Yi Xue Za Zhi

  • HingoraniCasas: ENSG00000135046

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000135046 Gene Symbol
    ANXA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: ANXA1

    • Version: 01-February-2022

    Alternate Names:
    ANX1 GO Gene Synonym
    LPC1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21