DGIdb - ANXA1 Gene Record

ANXA1 301 Druggable GenomeDrug Resistance

Alternate Names:

301
ANNEXIN A1
ANXA1
ANX1
LPC1
151690
533
ENSG00000135046
OTTHUMG00000020016
P04083
ANXA1_HUMAN

Gene Info:

Target Main Class	Other
Target Subclass	Enzyme Inhibitor
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUG RESISTANCE
DRUGGABLE GENOME

Publications:

Serres et al., 1994, Expression of annexin I in freshly isolated human epidermal cells and in cultured keratinocytes., Arch. Dermatol. Res.
Serres et al., 1994, Annexin 1 regulation in human epidermal cells., Cell. Mol. Biol. (Noisy-le-grand)
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
White et al., 1991, Hydrocortisone inhibits rat basophilic leukemia cell mediator release induced by neutrophil-derived histamine releasing activity as well as by anti-IgE., J. Immunol.
Sato-Matsumura et al., 2000, Membrane expression of annexin I is enhanced by calcium and TPA in cultured human keratinocytes., Arch. Dermatol. Res.
Yang et al., 2004, Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis., Arthritis Rheum.
Davies et al., 2007, Expression and externalization of annexin 1 in the adrenal gland: structure and function of the adrenal gland in annexin 1-null mutant mice., Endocrinology
Wang et al., 2007, Involvement of annexin I in the dexamethasone-mediated upregulation of A549 cells phagocytosis of apoptotic eosinophils., Immunol. Lett.
Morand et al., 2006, Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1., Mediators Inflamm.
John et al., 2006, Time-specific effects of perinatal glucocorticoid treatment on anterior pituitary morphology, annexin 1 expression and adrenocorticotrophic hormone secretion in the adult female rat., J. Neuroendocrinol.
Edashige et al., 1992, Differentiation of HL-60 cells by phorbol ester is correlated with up-regulation of protein kinase C-alpha., Arch. Biochem. Biophys.

AMCINONIDE ANXA1

Interaction Score: 1.74

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
7981624 17016423 17139284

Sources:
TEND
HYDROCORTAMATE ANXA1

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
MOMETASONE ANXA1

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
DESONIDE ANXA1

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
ALCLOMETASONE ANXA1

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
DIFLORASONE ANXA1

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
CLOCORTOLONE ANXA1

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
PREDNICARBATE ANXA1

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
CLOBETASOL ANXA1

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
DESOXIMETASONE ANXA1

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
RIMEXOLONE ANXA1

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
HYDROCORTISONE ANXA1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
1712816 8060156 17016423 17139284 11142771

Sources:
NCI
METHYLPREDNISOLONE ANXA1

Interaction Score: 0.38

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
8060156

Sources:
TEND
BETAMETHASONE ANXA1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
DEXAMETHASONE ANXA1

Interaction Score: 0.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
15022342 17158208 17644190 16883066 17076770

Sources:
NCI TEND
BECLOMETHASONE ANXA1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
STAUROSPORINE ANXA1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1444457

Sources:
NCI
TRIAMCINOLONE ANXA1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
TRASTUZUMAB ANXA1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

Alteration ARID1A:.;ANXA1:over

Alteration ARID1A:amp;ANXA1:over

Drug family ERBB2 mAb inhibitor

PMIDs:
None found

Sources:
CGI
PREDNISOLONE ANXA1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
PREDNISONE ANXA1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND

Ensembl: ENSG00000135046
- Version: 101_38
Alternate Names:

ANXA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P04083
- Version: 01-August-2011
Alternate Names:

P04083 Uniprot Accession

ENSG00000135046 Ensembl Gene Id

ANXA1 Gene Symbol

Gene Info:

Target Main Class Other

Target Subclass Enzyme Inhibitor

Publications:

NCI: ANXA1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Yang et al., 2004, Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis., Arthritis Rheum.

Ambrose et al., 1990, Corticosteroids increase lipocortin I in alveolar epithelial cells., Am. J. Respir. Cell Mol. Biol.

Shi et al., 2003, [Study on the expression level of Annexin I, cPLA(2) and PCNA in cleft-palate mice induced by dexamethasone]., Zhonghua Kou Qiang Yi Xue Za Zhi

HingoraniCasas: ENSG00000135046
- Version: 31-May-2017
Alternate Names:

ENSG00000135046 Gene Symbol

ANXA1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: ANXA1
- Version: 01-May-2021
Alternate Names:

ANX1 GO Gene Synonym

LPC1 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, DRUG RESISTANCE

Publications:
CGI: ANXA1
- Version: 27-September-2017
Alternate Names:

Gene Info:

Publications:

Alteration	ARID1A:.;ANXA1:over
Alteration	ARID1A:amp;ANXA1:over
Drug family	ERBB2 mAb inhibitor

P04083	Uniprot Accession
ENSG00000135046	Ensembl Gene Id
ANXA1	Gene Symbol

ANXA1 Gene Record

ANXA1 301 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 7981624 17016423 17139284

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 1712816 8060156 17016423 17139284 11142771

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 8060156

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 15022342 17158208 17644190 16883066 17076770

Sources: NCI TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1444457

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info: Alteration ARID1A:.;ANXA1:over Alteration ARID1A:amp;ANXA1:over Drug family ERBB2 mAb inhibitor

Interaction Types & Directionality:

agonist (activating)

PMIDs:
7981624 17016423 17139284

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

agonist (activating)

PMIDs:
1712816 8060156 17016423 17139284 11142771

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

PMIDs:
8060156

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

agonist (activating)

PMIDs:
15022342 17158208 17644190 16883066 17076770

Sources:
NCI TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
1444457

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Alteration ARID1A:.;ANXA1:over

Alteration ARID1A:amp;ANXA1:over

Drug family ERBB2 mAb inhibitor

PMIDs:
None found

Sources:
CGI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Alternate Names:

ANXA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

P04083 Uniprot Accession

ENSG00000135046 Ensembl Gene Id

ANXA1 Gene Symbol

Gene Info:

Target Main Class Other

Target Subclass Enzyme Inhibitor

Alternate Names:

ENSG00000135046 Gene Symbol

ANXA1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ANX1 GO Gene Synonym

LPC1 GO Gene Synonym

Gene Categories:

CELL SURFACE, DRUG RESISTANCE