DGIdb - ANPEP Gene Record

ANPEP 290 Druggable Genome

Alternate Names:

290
ALANYL AMINOPEPTIDASE, MEMBRANE
ANPEP
APN
CD13
GP150
LAP1
P150
PEPN
151530
500
ENSG00000166825
OTTHUMG00000149814
AMINOPEPTIDASE N (EC 3.4.11.2) (HAPN) (ALANYL AMINOPEPTIDASE) (MICROSOMAL AMINOPEPTIDASE) (AMINOPEPTIDASE M) (GP150) (MYELOID PLASMA MEMBRANE GLYCOPROTEIN CD13). [SOURCE:UNIPROT/SWISSPROT;ACC:P15144]
Myeloid plasma membrane glycoprotein CD13
Microsomal aminopeptidase
Aminopeptidase N
hAPN
AP-N
CD_antigen=CD13
Aminopeptidase M
AP-M
Alanyl aminopeptidase
1560
P15144
BE0001078
NP_001141
NM_001150
T67272

Gene Info:

Human Readable Name	DRUGGABLE GENOME
GuideToPharmacology Gene Category Name	M1: Aminopeptidase N
GuideToPharmacology Gene Category ID	737
Target Class	Enzymes
Target Subclass	EC:3.4.11.2
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

NEUTRAL ZINC METALLOPEPTIDASE
PROTEASE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
ENZYME

Publications:

Kramer et al., 2005, Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane., J. Biol. Chem.
Bawolak et al., 2006, The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors., Eur. J. Pharmacol.
Jordán et al., 1996, Influence of cephalosporins on intestinal enzymatic activity., Rev. Esp. Fisiol.
Xie et al., 1989, New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties., J. Med. Chem.
Danielsen et al., 1983, Biosynthesis of intestinal microvillar proteins. Role of the Golgi complex and microtubules., Biochem. J.
Ware et al., 1998, Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions., Chem. Res. Toxicol.
Stefanović et al., 1998, Kidney ectopeptidases in gentamicin and mercuric chloride-induced acute renal failure., Cell. Physiol. Biochem.
Konkoy et al., 1996, Subchronic haloperidol administration decreases aminopeptidase N activity and [Met5]enkephalin metabolism in rat striatum and cortex., Eur. J. Pharmacol.
Kushak et al., 1999, Regulation of intestinal peptidases by nutrients in human fetuses and children., Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
Mueller et al., 1990, Indicators of acute renal-transplant rejection in patients treated with cyclosporine., Clin. Chem.
van Hensbergen et al., 2004, Reduced growth, increased vascular area, and reduced response to cisplatin in CD13-overexpressing human ovarian cancer xenografts., Clin. Cancer Res.
Shim et al., 2003, Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin., Chem. Biol.

CEFADROXIL ANPEP

Interaction Score: 2.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8774083

Sources:
NCI
ICATIBANT ANPEP

Interaction Score: 2.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17026984

Sources:
DrugBank
TRIBUTYRIN ANPEP

Interaction Score: 2.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10629959

Sources:
NCI
EZETIMIBE ANPEP

Interaction Score: 2.18

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
15494415

Sources:
DrugBank
NALOXONE ANPEP

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2738884

Sources:
NCI
GENTAMICIN ANPEP

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9792955

Sources:
NCI
DICLOFENAC ANPEP

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9544613

Sources:
NCI
TOSEDOSTAT ANPEP

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Aminopeptidases inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
COLCHICINE ANPEP

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6651778

Sources:
NCI
CYCLOSPORINE ANPEP

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2337986

Sources:
NCI
CURCUMIN ANPEP

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12954328

Sources:
NCI
HALOPERIDOL ANPEP

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8851165

Sources:
NCI
CISPLATIN ANPEP

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14871998

Sources:
NCI

Ensembl: ENSG00000166825
- Version: 101_38
Alternate Names:

ANPEP Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000166825

Version: 26-July-2011

Alternate Names:

ANPEP Display Id

ENSG00000166825 Ensembl Gene Id

AMINOPEPTIDASE N (EC 3.4.11.2) (HAPN) (ALANYL AMINOPEPTIDASE) (MICROSOMAL AMINOPEPTIDASE) (AMINOPEPTIDASE M) (GP150) (MYELOID PLASMA MEMBRANE GLYCOPROTEIN CD13). [SOURCE:UNIPROT/SWISSPROT;ACC:P15144] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P15144
- Version: January-2014
Alternate Names:

ANPEP Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.11.2

Publications:
GuideToPharmacology: 290
- Version: 29-September-2020
Alternate Names:

500 HUGO Gene ID

500 HUGO Gene Symbol

alanyl aminopeptidase, membrane HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name M1: Aminopeptidase N

GuideToPharmacology Gene Category ID 737

Gene Categories:

ENZYME

Publications:

DrugBank: BE0001078

Version: 5.1.7

Alternate Names:

ANPEP DrugBank Gene Name

P15144 UniProt Accession

290 Entrez Gene Id

Gene Info:

Publications:

Kramer et al., 2005, Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane., J. Biol. Chem.

Bawolak et al., 2006, The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors., Eur. J. Pharmacol.

NCI: ANPEP

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Shim et al., 2003, Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin., Chem. Biol.

Braun et al., 2003, Differential regulation of aminopeptidase N (CD13) by transendothelial migration and cytokines on human eosinophils., Exp. Lung Res.

Jordán et al., 1996, Influence of cephalosporins on intestinal enzymatic activity., Rev. Esp. Fisiol.

HingoraniCasas: ENSG00000166825
- Version: 31-May-2017
Alternate Names:

ENSG00000166825 Gene Symbol

ANPEP Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: CD13
- Version: 12-May-2016
Alternate Names:

CD13 Gene Symbol

Gene Info:

Publications:
ChemblInteractions: APN
- Version: chembl_23
Alternate Names:

CD13 GENE_SYMBOL

PEPN GENE_SYMBOL

ANPEP GENE_SYMBOL

Gene Info:

Publications:
Pharos: ANPEP
- Version: 03-September-2020
Alternate Names:

Aminopeptidase N Gene Name

P15144 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: ANPEP
- Version: 05-September-2020
Alternate Names:

APN GO Gene Synonym

CD13 GO Gene Synonym

PEPN GO Gene Synonym

Gene Info:

Gene Categories:

NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
dGene: ANPEP
- Version: 27-Jun-2013
Alternate Names:

290 Gene ID

APN dGene Synonym

CD13 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Aminopeptidase N
- Version: 2020.06.01
Alternate Names:

ANPEP TTD Gene Abbreviation

T67272 TTD Target ID

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Aminopeptidases inhibitor

ANPEP	Display Id
ENSG00000166825	Ensembl Gene Id
AMINOPEPTIDASE N (EC 3.4.11.2) (HAPN) (ALANYL AMINOPEPTIDASE) (MICROSOMAL AMINOPEPTIDASE) (AMINOPEPTIDASE M) (GP150) (MYELOID PLASMA MEMBRANE GLYCOPROTEIN CD13). [SOURCE:UNIPROT/SWISSPROT;ACC:P15144]	Description

500	HUGO Gene ID
500	HUGO Gene Symbol
alanyl aminopeptidase, membrane	HUGO Gene Name

ANPEP	DrugBank Gene Name
P15144	UniProt Accession
290	Entrez Gene Id

ANPEP Gene Record

ANPEP 290 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8774083

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 17026984

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10629959

Sources: NCI

Interaction Types & Directionality: other/unknown

Interaction Info:

PMIDs: 15494415

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2738884

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9792955

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9544613

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Aminopeptidases inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6651778

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2337986

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12954328

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8851165

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14871998

Sources: NCI

Ensembl: ENSG00000166825

Alternate Names: ANPEP Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000166825

Alternate Names: ANPEP Display Id ENSG00000166825 Ensembl Gene Id AMINOPEPTIDASE N (EC 3.4.11.2) (HAPN) (ALANYL AMINOPEPTIDASE) (MICROSOMAL AMINOPEPTIDASE) (AMINOPEPTIDASE M) (GP150) (MYELOID PLASMA MEMBRANE GLYCOPROTEIN CD13). [SOURCE:UNIPROT/SWISSPROT;ACC:P15144] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P15144

Alternate Names: ANPEP Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.4.11.2

Publications:

GuideToPharmacology: 290

Alternate Names: 500 HUGO Gene ID 500 HUGO Gene Symbol alanyl aminopeptidase, membrane HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name M1: Aminopeptidase N GuideToPharmacology Gene Category ID 737

Gene Categories: ENZYME

Publications:

DrugBank: BE0001078

Alternate Names: ANPEP DrugBank Gene Name P15144 UniProt Accession 290 Entrez Gene Id

Gene Info:

NCI: ANPEP

Interaction Types & Directionality:

n/a

PMIDs:
8774083

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17026984

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10629959

Sources:
NCI

Interaction Types & Directionality:

other/unknown

PMIDs:
15494415

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
2738884

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9792955

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9544613

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Aminopeptidases inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
6651778

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2337986

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12954328

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8851165

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14871998

Sources:
NCI

Alternate Names:

ANPEP Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ANPEP Display Id

ENSG00000166825 Ensembl Gene Id

AMINOPEPTIDASE N (EC 3.4.11.2) (HAPN) (ALANYL AMINOPEPTIDASE) (MICROSOMAL AMINOPEPTIDASE) (AMINOPEPTIDASE M) (GP150) (MYELOID PLASMA MEMBRANE GLYCOPROTEIN CD13). [SOURCE:UNIPROT/SWISSPROT;ACC:P15144] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ANPEP Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.11.2

Alternate Names:

500 HUGO Gene ID

500 HUGO Gene Symbol

alanyl aminopeptidase, membrane HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name M1: Aminopeptidase N

GuideToPharmacology Gene Category ID 737

Gene Categories:

ENZYME

Alternate Names:

ANPEP DrugBank Gene Name

P15144 UniProt Accession

290 Entrez Gene Id

Alternate Names:

ENSG00000166825 Gene Symbol

ANPEP Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CD13 Gene Symbol

Alternate Names:

CD13 GENE_SYMBOL

PEPN GENE_SYMBOL

ANPEP GENE_SYMBOL

Alternate Names:

Aminopeptidase N Gene Name

P15144 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

APN GO Gene Synonym

CD13 GO Gene Synonym

PEPN GO Gene Synonym

Gene Categories:

NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

290 Gene ID

APN dGene Synonym

CD13 dGene Synonym

Gene Categories:

PROTEASE

Alternate Names:

ANPEP TTD Gene Abbreviation

T67272 TTD Target ID