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ANPEP Gene Record

  • Summary
  • Interactions
  • Claims
  • ANPEP 290 Druggable Genome

    Alternate Names:

    290
    ALANYL AMINOPEPTIDASE, MEMBRANE
    ANPEP
    APN
    CD13
    GP150
    LAP1
    P150
    PEPN
    151530
    500
    ENSG00000166825
    OTTHUMG00000149814
    AMINOPEPTIDASE N (EC 3.4.11.2) (HAPN) (ALANYL AMINOPEPTIDASE) (MICROSOMAL AMINOPEPTIDASE) (AMINOPEPTIDASE M) (GP150) (MYELOID PLASMA MEMBRANE GLYCOPROTEIN CD13). [SOURCE:UNIPROT/SWISSPROT;ACC:P15144]
    Myeloid plasma membrane glycoprotein CD13
    Microsomal aminopeptidase
    Aminopeptidase N
    hAPN
    AP-N
    CD_antigen=CD13
    Aminopeptidase M
    AP-M
    Alanyl aminopeptidase
    P15144
    T67272

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:3.4.11.2
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    NEUTRAL ZINC METALLOPEPTIDASE
    PROTEASE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Jordán et al., 1996, Influence of cephalosporins on intestinal enzymatic activity., Rev. Esp. Fisiol.
    Xie et al., 1989, New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties., J. Med. Chem.
    Danielsen et al., 1983, Biosynthesis of intestinal microvillar proteins. Role of the Golgi complex and microtubules., Biochem. J.
    Ware et al., 1998, Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions., Chem. Res. Toxicol.
    Stefanović et al., 1998, Kidney ectopeptidases in gentamicin and mercuric chloride-induced acute renal failure., Cell. Physiol. Biochem.
    Konkoy et al., 1996, Subchronic haloperidol administration decreases aminopeptidase N activity and [Met5]enkephalin metabolism in rat striatum and cortex., Eur. J. Pharmacol.
    Kushak et al., 1999, Regulation of intestinal peptidases by nutrients in human fetuses and children., Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
    Mueller et al., 1990, Indicators of acute renal-transplant rejection in patients treated with cyclosporine., Clin. Chem.
    van Hensbergen et al., 2004, Reduced growth, increased vascular area, and reduced response to cisplatin in CD13-overexpressing human ovarian cancer xenografts., Clin. Cancer Res.
    Shim et al., 2003, Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin., Chem. Biol.
  • CEFADROXIL   ANPEP

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8774083


    Sources:
    NCI

  • TRIBUTYRIN   ANPEP

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10629959


    Sources:
    NCI

  • NALOXONE   ANPEP

    Interaction Score: 1.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2738884


    Sources:
    NCI

  • GENTAMICIN   ANPEP

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9792955


    Sources:
    NCI

  • DICLOFENAC   ANPEP

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9544613


    Sources:
    NCI

  • TOSEDOSTAT   ANPEP

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Aminopeptidases inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • COLCHICINE   ANPEP

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6651778


    Sources:
    NCI

  • CYCLOSPORINE   ANPEP

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2337986


    Sources:
    NCI

  • HALOPERIDOL   ANPEP

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8851165


    Sources:
    NCI

  • CURCUMIN   ANPEP

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12954328


    Sources:
    NCI

  • CISPLATIN   ANPEP

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14871998


    Sources:
    NCI

  • Ensembl: ENSG00000166825

    • Version: 101_38

    Alternate Names:
    ANPEP Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000166825

    • Version: 26-July-2011

    Alternate Names:
    ANPEP Display Id
    ENSG00000166825 Ensembl Gene Id
    AMINOPEPTIDASE N (EC 3.4.11.2) (HAPN) (ALANYL AMINOPEPTIDASE) (MICROSOMAL AMINOPEPTIDASE) (AMINOPEPTIDASE M) (GP150) (MYELOID PLASMA MEMBRANE GLYCOPROTEIN CD13). [SOURCE:UNIPROT/SWISSPROT;ACC:P15144] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P15144

    • Version: January-2014

    Alternate Names:
    ANPEP Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.11.2

    Publications:

  • NCI: ANPEP

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Shim et al., 2003, Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin., Chem. Biol.
    Braun et al., 2003, Differential regulation of aminopeptidase N (CD13) by transendothelial migration and cytokines on human eosinophils., Exp. Lung Res.
    Jordán et al., 1996, Influence of cephalosporins on intestinal enzymatic activity., Rev. Esp. Fisiol.

  • HingoraniCasas: ENSG00000166825

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000166825 Gene Symbol
    ANPEP Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: CD13

    • Version: 12-May-2016

    Alternate Names:
    CD13 Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: APN

    • Version: chembl_23

    Alternate Names:
    CD13 GENE_SYMBOL
    PEPN GENE_SYMBOL
    ANPEP GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: ANPEP

    • Version: 01-February-2022

    Alternate Names:
    APN GO Gene Synonym
    CD13 GO Gene Synonym
    PEPN GO Gene Synonym

    Gene Info:

    Gene Categories:
    NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • dGene: ANPEP

    • Version: 27-Jun-2013

    Alternate Names:
    290 Gene ID
    APN dGene Synonym
    CD13 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Aminopeptidase N

    • Version: 2020.06.01

    Alternate Names:
    ANPEP TTD Gene Abbreviation
    T67272 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: ANPEP

    • Version: 01-February-2022

    Alternate Names:
    Aminopeptidase N Gene Name
    P15144 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21