DGIdb - ANKK1 Gene Record

ANKK1 255239 Druggable Genome

Alternate Names:

255239
ANKYRIN REPEAT AND KINASE DOMAIN CONTAINING 1
ANKK1
DRD2
PKK2
608774
21027
ENSG00000170209
OTTHUMG00000167715
Q8NFD2
SGK288
ANKK1_HUMAN
ANKYRIN REPEAT AND KINASE DOMAIN CONTAINING 1 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_848605]
ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN 1
PA134872551

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR001245
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Interpro Type	Domain
Human Readable Name	KINASE
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME

Publications:

Tashiro M et al., 2014, Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients., Clin Chim Acta
Sukasem C et al., 2016, Impact of Pharmacogenetic Markers of CYP2D6 and DRD2 on Prolactin Response in Risperidone-Treated Thai Children and Adolescents With Autism Spectrum Disorders., J Clin Psychopharmacol
López-Rodríguez R et al., 2013, Pharmacodynamic genetic variants related to antipsychotic adverse reactions in healthy volunteers., Pharmacogenomics
Roke Y et al., 2013, The effect of the Taq1A variant in the dopamine D₂ receptor gene and common CYP2D6 alleles on prolactin levels in risperidone-treated boys., Pharmacogenet Genomics
Cabaleiro T et al., 2013, Polymorphisms influencing olanzapine metabolism and adverse effects in healthy subjects., Hum Psychopharmacol
Müller DJ et al., 2012, Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain., Pharmacogenomics J
Yasui-Furukori N et al., 2008, Association between dopamine-related polymorphisms and plasma concentrations of prolactin during risperidone treatment in schizophrenic patients., Prog Neuropsychopharmacol Biol Psychiatry
Bakker PR et al., 2008, Antipsychotic-induced tardive dyskinesia and polymorphic variations in COMT, DRD2, CYP1A2 and MnSOD genes: a meta-analysis of pharmacogenetic interactions., Mol Psychiatry
Alenius M et al., 2008, Gene polymorphism influencing treatment response in psychotic patients in a naturalistic setting., J Psychiatr Res
Zai CC et al., 2007, Meta-analysis of two dopamine D2 receptor gene polymorphisms with tardive dyskinesia in schizophrenia patients., Mol Psychiatry
Levran O et al., 2013, Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction., Pharmacogenomics
Shen YC et al., 2009, Effects of DRD2/ANKK1 gene variations and clinical factors on aripiprazole efficacy in schizophrenic patients., J Psychiatr Res
Ikeda M et al., 2008, Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia., Pharmacogenomics
Stapleton JA et al., 2011, Association between DRD2/ANKK1 Taq1A genotypes, depression and smoking cessation with nicotine replacement therapy., Pharmacogenet Genomics
Munafò MR et al., 2009, Lack of association of DRD2 rs1800497 (Taq1A) polymorphism with smoking cessation in a nicotine replacement therapy randomized trial., Nicotine Tob Res
Johnstone EC et al., 2004, Genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patch., Pharmacogenetics
Mihara K et al., 2000, Prolactin response to nemonapride, a selective antagonist for D2 like dopamine receptors, in schizophrenic patients in relation to Taq1A polymorphism of DRD2 gene., Psychopharmacology (Berl)
Tomaz PR et al., 2015, CYP2B6 rs2279343 polymorphism is associated with smoking cessation success in bupropion therapy., Eur J Clin Pharmacol
Choi HD et al., 2015, Lack of association between DRD2 Taq1A gene polymorphism and smoking cessation therapy: a meta-analysis., Int J Clin Pharmacol Ther
David SP et al., 2007, Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: analysis of pooled data from two clinical trials., Nicotine Tob Res
David SP et al., 2007, Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation., Nicotine Tob Res
Swan GE et al., 2005, Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion SR., Pharmacogenomics J
Lerman C et al., 2003, Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial., Health Psychol
Spellicy CJ et al., 2013, ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse., Pharmacogenet Genomics
Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics
Comings DE et al., 1994, The dopamine D2 receptor gene: a genetic risk factor in substance abuse., Drug Alcohol Depend
Ragia G et al., 2016, Association study of DRD2 A2/A1, DRD3 Ser9Gly, DβH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A polymorphisms with alcohol dependence., Drug Metab Pers Ther
Bolos AM et al., 1990, Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism., JAMA
Blum K et al., 1990, Allelic association of human dopamine D2 receptor gene in alcoholism., JAMA
Blum K et al., 1991, Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism., Alcohol
Smith L et al., 2008, Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: a HuGE gene-disease association review., Am J Epidemiol
Blomqvist O et al., 2000, Family-based study of DRD2 alleles in alcohol and drug dependence., Am J Med Genet
Town T et al., 1999, Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency., Am J Med Genet

NEMONAPRIDE ANKK1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10823405

Sources:
PharmGKB
BUPROPION ANKK1

Interaction Score: 2.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26153084 25881752 18058343 17654295 15492764 14570538

Sources:
PharmGKB
ARIPIPRAZOLE ANKK1

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18926547 18855532

Sources:
PharmGKB
RISPERIDONE ANKK1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26872113 23859574 23851570 20714340 18926547 18855532 18579277 18180754 18086475 17767146

Sources:
PharmGKB
CLOZAPINE ANKK1

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26872113 23859574 23851570 20714340 18579277 18180754 18086475 17767146

Sources:
PharmGKB
OLANZAPINE ANKK1

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26872113 23859574 23851570 23559402 20714340 18579277 18180754 18086475 17767146

Sources:
PharmGKB
ALCOHOL ANKK1

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8033754 27447243 1979357 1969501 1839129 17989061 11054774 10490697

Sources:
PharmGKB
PROCHLORPERAZINE ANKK1

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24360851

Sources:
PharmGKB
NICOTINE ANKK1

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21540761 19273465 15077009

Sources:
PharmGKB
METHADONE ANKK1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23651024

Sources:
PharmGKB
DISULFIRAM ANKK1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23635803

Sources:
PharmGKB
HALOPERIDOL ANKK1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27023437

Sources:
PharmGKB

Ensembl: ENSG00000170209
- Version: 101_38
Alternate Names:

ANKK1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000170209
- Version: 26-July-2011
Alternate Names:

ANKK1 Display Id

ENSG00000170209 Ensembl Gene Id

ANKYRIN REPEAT AND KINASE DOMAIN CONTAINING 1 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_848605] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: Q8NFD2
- Version: 11-September-2012
Alternate Names:

ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN 1 Uniprot Protein Name

Q8NFD2 Uniprot Accession

ANKK1 Uniprot Gene Name

Gene Info:

Interpro Acc IPR001245

Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain

Interpro Type Domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

PharmGKB: ANKK1

Version: 18-August-2020

Alternate Names:

PA134872551 PharmGKB ID

Gene Info:

Publications:

Tashiro M et al., 2014, Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients., Clin Chim Acta

Müller DJ et al., 2012, Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain., Pharmacogenomics J

López-Rodríguez R et al., 2013, Pharmacodynamic genetic variants related to antipsychotic adverse reactions in healthy volunteers., Pharmacogenomics

HingoraniCasas: ENSG00000170209
- Version: 31-May-2017
Alternate Names:

ENSG00000170209 Gene Symbol

ANKK1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: ANKK1
- Version: 01-February-2022
Alternate Names:

PKK2 GO Gene Synonym

SGK288 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: ANKK1
- Version: 27-Jun-2013
Alternate Names:

255239 Gene ID

PKK2 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
Pharos: ANKK1
- Version: 01-February-2022
Alternate Names:

Ankyrin repeat and protein kinase domain-containing protein 1 Gene Name

Q8NFD2 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:

ANKK1	Display Id
ENSG00000170209	Ensembl Gene Id
ANKYRIN REPEAT AND KINASE DOMAIN CONTAINING 1 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_848605]	Description

ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN 1	Uniprot Protein Name
Q8NFD2	Uniprot Accession
ANKK1	Uniprot Gene Name

Ankyrin repeat and protein kinase domain-containing protein 1	Gene Name
Q8NFD2	UniProt ID

ANKK1 Gene Record

ANKK1 255239 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10823405

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26153084 25881752 18058343 17654295 15492764 14570538

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18926547 18855532

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26872113 23859574 23851570 20714340 18926547 18855532 18579277 18180754 18086475 17767146

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26872113 23859574 23851570 20714340 18579277 18180754 18086475 17767146

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26872113 23859574 23851570 23559402 20714340 18579277 18180754 18086475 17767146

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8033754 27447243 1979357 1969501 1839129 17989061 11054774 10490697

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24360851

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21540761 19273465 15077009

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23651024

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23635803

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27023437

Sources: PharmGKB

Ensembl: ENSG00000170209

Alternate Names: ANKK1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000170209

Alternate Names: ANKK1 Display Id ENSG00000170209 Ensembl Gene Id ANKYRIN REPEAT AND KINASE DOMAIN CONTAINING 1 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_848605] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: Q8NFD2

Alternate Names: ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN 1 Uniprot Protein Name Q8NFD2 Uniprot Accession ANKK1 Uniprot Gene Name

Gene Info: Interpro Acc IPR001245 Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain Interpro Type Domain

Gene Categories: KINASE, DRUGGABLE GENOME

Publications:

PharmGKB: ANKK1

Alternate Names: PA134872551 PharmGKB ID

Gene Info:

HingoraniCasas: ENSG00000170209

Alternate Names: ENSG00000170209 Gene Symbol ANKK1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: ANKK1

Alternate Names: PKK2 GO Gene Synonym SGK288 GO Gene Synonym

Gene Info:

Gene Categories: SERINE THREONINE KINASE

Interaction Types & Directionality:

n/a

PMIDs:
10823405

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26153084 25881752 18058343 17654295 15492764 14570538

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18926547 18855532

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26872113 23859574 23851570 20714340 18926547 18855532 18579277 18180754 18086475 17767146

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26872113 23859574 23851570 20714340 18579277 18180754 18086475 17767146

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26872113 23859574 23851570 23559402 20714340 18579277 18180754 18086475 17767146

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8033754 27447243 1979357 1969501 1839129 17989061 11054774 10490697

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24360851

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21540761 19273465 15077009

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23651024

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23635803

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27023437

Sources:
PharmGKB

Alternate Names:

ANKK1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ANKK1 Display Id

ENSG00000170209 Ensembl Gene Id

ANKYRIN REPEAT AND KINASE DOMAIN CONTAINING 1 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_848605] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN 1 Uniprot Protein Name

Q8NFD2 Uniprot Accession

ANKK1 Uniprot Gene Name

Gene Info:

Interpro Acc IPR001245

Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain

Interpro Type Domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Alternate Names:

PA134872551 PharmGKB ID

Alternate Names:

ENSG00000170209 Gene Symbol

ANKK1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PKK2 GO Gene Synonym

SGK288 GO Gene Synonym

Gene Categories:

SERINE THREONINE KINASE

Alternate Names:

255239 Gene ID

PKK2 dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Alternate Names:

Ankyrin repeat and protein kinase domain-containing protein 1 Gene Name

Q8NFD2 UniProt ID

Gene Categories:

KINASE