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ALOX5 Gene Record

  • Summary
  • Interactions
  • Claims
  • ALOX5 240 Druggable Genome

    Alternate Names:

    240
    ARACHIDONATE 5-LIPOXYGENASE
    ALOX5
    5-LO
    5-LOX
    5LPG
    LOG5
    152390
    435
    ENSG00000012779
    OTTHUMG00000018081
    BE0000248
    P09917
    ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO). [SOURCE:UNIPROT/SWISSPROT;ACC:P09917]
    5-lipoxygenase
    1385
    LOX5_HUMAN
    PA46
    T00140

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:1.13.11.34
    Interpro Acc IPR000907
    Interpro Name Lipoxygenase
    Uniprot Status Swiss-Prot
    Interpro Short Name LipOase
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Target Main Class Enzymes
    Target Subclass 1.13.11.34
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Lipoxygenases
    GuideToPharmacology Gene Category ID 271
    (9 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Allgayer et al., 1984, Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine., Eur. J. Clin. Pharmacol.
    Nielsen et al., 1987, Inhibition of 5-lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic acid., Dig. Dis. Sci.
    Sircar et al., 1983, Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis., Biochem. Pharmacol.
    Wisastra R et al., 2013, Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection., Bioorg Med Chem
    Qian et al., 2001, Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor., Pharmacol. Res.
    Hardy et al., 1999, Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells., Biol. Reprod.
    Guidot et al., 1994, Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity., Proc. Natl. Acad. Sci. U.S.A.
    Zouboulis et al., 2010, Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis., Exp. Dermatol.
    Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem
    Vicente et al., 2001, Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages., Br. J. Pharmacol.
    Wenzel et al., Zileuton: the first 5-lipoxygenase inhibitor for the treatment of asthma., Ann Pharmacother
    Yamashita et al., 2000, Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells., Br. J. Pharmacol.
    Coffey et al., 2001, Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton., J. Pharmacol. Exp. Ther.
    Wenzel, Leukotriene receptor antagonists and related compounds., Can. Respir. J.
    Berger et al., 2007, Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease., Int. J. Clin. Pract.
    Zouboulis, 2009, Zileuton, a new efficient and safe systemic anti-acne drug., Dermatoendocrinol
    Karg EM et al., 2009, Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase., J Med Chem
    Schieferdecker S et al., 2015, Myxochelins target human 5-lipoxygenase., J Nat Prod
    Taccone-Gallucci et al., 2006, N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity., Kidney Int.
    Cernak et al., 1996, Leukotrienes in the pathogenesis of pulmonary blast injury., J Trauma
    Gross et al., 1991, Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis., Radiat. Res.
    Bach et al., 1986, Inhibition of the leukotriene synthetase of rat basophil leukemia cells by diethylcarbamazine, and synergism between diethylcarbamazine and piriprost, a 5-lipoxygenase inhibitor., Biochem. Pharmacol.
    Davidson et al., 1992, Prolonged pulmonary hypertension caused by platelet-activating factor and leukotriene C4 in the rat lung., J. Appl. Physiol.
    Zunić et al., Inhibition of leukotriene formation by diethylcarbamazine modifies the acid-base balance in the rabbits with blast injuries of the lungs., Vojnosanit Pregl
    Ramires et al., 2004, Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast., Biochem. Biophys. Res. Commun.
    Vidal et al., 2007, Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis., J. Pharmacol. Exp. Ther.
    Armstrong MM et al., 2014, Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes., Bioorg Med Chem
    Ribeiro D et al., 2014, Inhibition of LOX by flavonoids: a structure-activity relationship study., Eur J Med Chem
    Chu et al., 2007, Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats., Acta Pharmacol. Sin.
    Song et al., 2004, Minocycline protects PC12 cells from ischemic-like injury and inhibits 5-lipoxygenase activation., Neuroreport
    Song et al., 2006, Minocycline protects PC12 cells against NMDA-induced injury via inhibiting 5-lipoxygenase activation., Brain Res.
    Yu et al., 1992, Inhibition of canine tracheal smooth muscle by mediators from cultured bronchial epithelial cells., Am. J. Physiol.
    Boctor et al., 1986, Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro., Prostaglandins Leukot Med
    Manev et al., 1999, Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression., Ann. N. Y. Acad. Sci.
    Rask-Madsen et al., 1992, 5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease., Agents Actions
    Wiggins et al., 2009, Balsalazide: a novel 5-aminosalicylate prodrug for the treatment of active ulcerative colitis., Expert Opin Drug Metab Toxicol
    Hawkes et al., 1994, The effect of methotrexate on ex vivo lipoxygenase metabolism in neutrophils from patients with rheumatoid arthritis., J. Rheumatol.
    Audouin et al., 2001, N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase., Bioorg. Med. Chem. Lett.
    Jeon et al., 2005, Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes., Biochem. Biophys. Res. Commun.
    Azadzoi et al., 2004, Alteration of urothelial-mediated tone in the ischemic bladder: role of eicosanoids., Neurourol. Urodyn.
    West et al., 2004, The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice., J. Neurochem.
    Lambert et al., 2001, Pharmacokinetic analysis by high-performance liquid chromatography of intravenous nordihydroguaiaretic acid in the mouse., J. Chromatogr. B Biomed. Sci. Appl.
    Singh B et al., 2012, The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition., J Ethnopharmacol
    MacCarrone M et al., 1999, Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity., Eur J Biochem
    Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
  • DIETHYLCARBAMAZINE   ALOX5

    Interaction Score: 5.98

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    8606397 1886988 3004501 1400062 11752352 10518442


    Sources:
    TTD DrugBank

  • ZILEUTON   ALOX5

    Interaction Score: 4.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Zyflo
    Novel drug target Established target
    Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

    PMIDs:
    11529688 10377029 8058773 19645854 24697244 11454666 8826571 10694244 11752352 11561080 10322101 17394438 20436887 19492852 25686392


    Sources:
    NCI TEND DTC PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • MASOPROCOL   ALOX5

    Interaction Score: 3.49

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11277534 11752352 15694390 15098224 15379894 11318430


    Sources:
    DrugBank

  • CHEMBL502496   ALOX5

    Interaction Score: 2.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24231650


    Sources:
    DTC

  • ATRELEUTON   ALOX5

    Interaction Score: 2.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name VIA-2291
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • PF-4191834   ALOX5

    Interaction Score: 2.99

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology

  • LICOFELONE   ALOX5

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name licofelone, ML3000
    Novel drug target Established target

    PMIDs:
    17015640 11752352


    Sources:
    TdgClinicalTrial DrugBank

  • CHEMBL73148   ALOX5

    Interaction Score: 1.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • BALSALAZIDE   ALOX5

    Interaction Score: 1.49

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name balsalazide disodium,Colazal, Giazo
    Novel drug target Established target

    PMIDs:
    1359745 19743890


    Sources:
    TdgClinicalTrial DrugBank

  • 5-OXO-ETE   ALOX5

    Interaction Score: 1.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24924423


    Sources:
    DTC

  • RILOPIROX   ALOX5

    Interaction Score: 1.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL416038   ALOX5

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24231650


    Sources:
    DTC

  • MECLOFENAMIC ACID   ALOX5

    Interaction Score: 0.9

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    1539679 3020588


    Sources:
    DrugBank

  • 6BIO   ALOX5

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24697244


    Sources:
    DTC

  • DARBUFELONE   ALOX5

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TIPELUKAST   ALOX5

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TENIDAP   ALOX5

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TEPOXALIN   ALOX5

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • HYPERFORIN   ALOX5

    Interaction Score: 0.6

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11752352


    Sources:
    DrugBank

  • SILYBIN A   ALOX5

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TOCOPHEROL ACETATE   ALOX5

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16531984


    Sources:
    DrugBank

  • MESALAMINE   ALOX5

    Interaction Score: 0.43

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name MAX-002
    Novel drug target Established target
    Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

    PMIDs:
    6428914 2882965 6131674


    Sources:
    TdgClinicalTrial DrugBank ChemblInteractions

  • (+)-ALPHA-TOCOPHERYL SUCCINATE   ALOX5

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16531984


    Sources:
    DrugBank

  • OLSALAZINE SODIUM   ALOX5

    Interaction Score: 0.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BALSALAZIDE DISODIUM   ALOX5

    Interaction Score: 0.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MINOCYCLINE   ALOX5

    Interaction Score: 0.35

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17506934 15371729 16574083


    Sources:
    DrugBank

  • MORNIFLUMATE   ALOX5

    Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • SULFASALAZINE   ALOX5

    Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

    PMIDs:
    6428914 2882965 6131674


    Sources:
    DrugBank ChemblInteractions

  • MONTELUKAST   ALOX5

    Interaction Score: 0.25

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    15474500


    Sources:
    PharmGKB DrugBank

  • MECLOFENAMATE SODIUM   ALOX5

    Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ACACETIN   ALOX5

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24368208


    Sources:
    DTC

  • DIACEREIN   ALOX5

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22449441


    Sources:
    DrugBank

  • VITAMIN E   ALOX5

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16531984


    Sources:
    DrugBank

  • RHEIN   ALOX5

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22449441


    Sources:
    DrugBank

  • MELATONIN   ALOX5

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10668425


    Sources:
    NCI

  • RESVERATROL   ALOX5

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10491155


    Sources:
    DrugBank

  • METHOTREXATE   ALOX5

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8151588


    Sources:
    NCI

  • FOSTAMATINIB   ALOX5

    Interaction Score: 0.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26516587


    Sources:
    DrugBank

  • Ensembl: ENSG00000012779

    • Version: 101_38

    Alternate Names:
    ALOX5 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P09917

    • Version: January-2014

    Alternate Names:
    ALOX5 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.13.11.34

    Publications:

  • TEND: P09917

    • Version: 01-August-2011

    Alternate Names:
    P09917 Uniprot Accession
    240 Entrez Gene Id
    ENSG00000012779 Ensembl Gene Id

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 1.13.11.34

    Publications:

  • RussLampel: ENSG00000012779

    • Version: 26-July-2011

    Alternate Names:
    ALOX5 Display Id
    ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO). [SOURCE:UNIPROT/SWISSPROT;ACC:P09917] Description
    ENSG00000012779 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P09917

    • Version: 11-September-2012

    Alternate Names:
    LOX5_HUMAN Uniprot Id
    P09917 Uniprot Accession
    ALOX5 Uniprot Gene Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000907
    Interpro Name Lipoxygenase

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 240

    • Version: 29-September-2020

    Alternate Names:
    435 HUGO Gene ID
    435 HUGO Gene Symbol
    arachidonate 5-lipoxygenase HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Lipoxygenases
    GuideToPharmacology Gene Category ID 271

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0000248

    • Version: 5.1.7

    Alternate Names:
    ALOX5 DrugBank Gene Name
    P09917 UniProt Accession
    240 Entrez Gene Id

    Gene Info:

    Publications:
    Audouin et al., 2001, N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase., Bioorg. Med. Chem. Lett.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Jeon et al., 2005, Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes., Biochem. Biophys. Res. Commun.

  • TTD: Arachidonate 5-lipoxygenase

    • Version: 2020.06.01

    Alternate Names:
    5-LOX TTD Gene Abbreviation
    T00140 TTD Target ID

    Gene Info:

    Publications:
    Stanke-Labesque F et al., 2003, Inhibition of leukotriene synthesis with MK-886 prevents a rise in blood pressure and reduces noradrenaline-evoked contraction in L-NAME-treated rats., Br J Pharmacol

  • NCI: ALOX5

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Manev et al., 1999, Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression., Ann. N. Y. Acad. Sci.
    Jeon et al., 2005, Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes., Biochem. Biophys. Res. Commun.
    Ghosh, 2004, Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase., Biochem. Biophys. Res. Commun.

  • DTC: ALOX5

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem
    Karg EM et al., 2009, Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase., J Med Chem
    Schieferdecker S et al., 2015, Myxochelins target human 5-lipoxygenase., J Nat Prod

  • ChemblInteractions: LOG5

    • Version: chembl_23

    Alternate Names:
    LOG5 GENE_SYMBOL
    ALOX5 GENE_SYMBOL
    Arachidonate 5-lipoxygenase UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000012779

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000012779 Gene Symbol
    ALOX5 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: ALOX5

    • Version: 18-August-2020

    Alternate Names:
    PA46 PharmGKB ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21