DGIdb - ALOX5 Gene Record

ALOX5 240 Druggable Genome

Alternate Names:

240
ARACHIDONATE 5-LIPOXYGENASE
ALOX5
5-LO
5-LOX
5LPG
LOG5
152390
435
ENSG00000012779
OTTHUMG00000018081
P09917
ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO). [SOURCE:UNIPROT/SWISSPROT;ACC:P09917]
5-lipoxygenase
LOX5_HUMAN
PA46
T00140

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:1.13.11.34
Interpro Acc	IPR000907
Interpro Name	Lipoxygenase
Uniprot Status	Swiss-Prot
Interpro Short Name	LipOase
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Target Main Class	Enzymes
Target Subclass	1.13.11.34
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Allgayer et al., 1984, Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine., Eur. J. Clin. Pharmacol.
Nielsen et al., 1987, Inhibition of 5-lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic acid., Dig. Dis. Sci.
Sircar et al., 1983, Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis., Biochem. Pharmacol.
Wisastra R et al., 2013, Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection., Bioorg Med Chem
Yamashita et al., 2000, Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells., Br. J. Pharmacol.
Wenzel, Leukotriene receptor antagonists and related compounds., Can. Respir. J.
Qian et al., 2001, Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor., Pharmacol. Res.
Coffey et al., 2001, Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton., J. Pharmacol. Exp. Ther.
Hardy et al., 1999, Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells., Biol. Reprod.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Wenzel et al., Zileuton: the first 5-lipoxygenase inhibitor for the treatment of asthma., Ann Pharmacother
Guidot et al., 1994, Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity., Proc. Natl. Acad. Sci. U.S.A.
Berger et al., 2007, Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease., Int. J. Clin. Pract.
Zouboulis et al., 2010, Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis., Exp. Dermatol.
Zouboulis, 2009, Zileuton, a new efficient and safe systemic anti-acne drug., Dermatoendocrinol
Vicente et al., 2001, Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages., Br. J. Pharmacol.
Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem
Karg EM et al., 2009, Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase., J Med Chem
Schieferdecker S et al., 2015, Myxochelins target human 5-lipoxygenase., J Nat Prod
Zunić et al., Inhibition of leukotriene formation by diethylcarbamazine modifies the acid-base balance in the rabbits with blast injuries of the lungs., Vojnosanit Pregl
Gross et al., 1991, Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis., Radiat. Res.
Bach et al., 1986, Inhibition of the leukotriene synthetase of rat basophil leukemia cells by diethylcarbamazine, and synergism between diethylcarbamazine and piriprost, a 5-lipoxygenase inhibitor., Biochem. Pharmacol.
Davidson et al., 1992, Prolonged pulmonary hypertension caused by platelet-activating factor and leukotriene C4 in the rat lung., J. Appl. Physiol.
Cernak et al., 1996, Leukotrienes in the pathogenesis of pulmonary blast injury., J Trauma
Ramires et al., 2004, Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast., Biochem. Biophys. Res. Commun.
Vidal et al., 2007, Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis., J. Pharmacol. Exp. Ther.
Armstrong MM et al., 2014, Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes., Bioorg Med Chem
Ribeiro D et al., 2014, Inhibition of LOX by flavonoids: a structure-activity relationship study., Eur J Med Chem
Manev et al., 1999, Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression., Ann. N. Y. Acad. Sci.
Rask-Madsen et al., 1992, 5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease., Agents Actions
Wiggins et al., 2009, Balsalazide: a novel 5-aminosalicylate prodrug for the treatment of active ulcerative colitis., Expert Opin Drug Metab Toxicol
Hawkes et al., 1994, The effect of methotrexate on ex vivo lipoxygenase metabolism in neutrophils from patients with rheumatoid arthritis., J. Rheumatol.

DIETHYLCARBAMAZINE ALOX5

Interaction Score: 17.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10518442 1886988 3004501 11752352 1400062 8606397

Sources:
TTD
ZILEUTON ALOX5

Interaction Score: 6.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Zyflo

Novel drug target Established target

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
10694244 10322101 11529688 11561080 10377029 11752352 8826571 8058773 17394438 19645854 20436887 11454666 24697244 19492852 25686392

Sources:
DTC TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB TTD
CHEMBL502496 ALOX5

Interaction Score: 4.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24231650

Sources:
DTC
ATRELEUTON ALOX5

Interaction Score: 4.95

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name VIA-2291

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
LICOFELONE ALOX5

Interaction Score: 3.71

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name licofelone, ML3000

Novel drug target Established target

PMIDs:
17015640 11752352

Sources:
TdgClinicalTrial
5-OXO-ETE ALOX5

Interaction Score: 2.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24924423

Sources:
DTC
RILOPIROX ALOX5

Interaction Score: 2.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PF-4191834 ALOX5

Interaction Score: 2.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
TENIDAP ALOX5

Interaction Score: 2.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BALSALAZIDE ALOX5

Interaction Score: 1.85

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name balsalazide disodium,Colazal, Giazo

Novel drug target Established target

PMIDs:
1359745 19743890

Sources:
TdgClinicalTrial
6BIO ALOX5

Interaction Score: 1.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24697244

Sources:
DTC
CHEMBL416038 ALOX5

Interaction Score: 1.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24231650

Sources:
DTC
DARBUFELONE ALOX5

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TIPELUKAST ALOX5

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TEPOXALIN ALOX5

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SILYBIN A ALOX5

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
OLSALAZINE SODIUM ALOX5

Interaction Score: 0.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BALSALAZIDE DISODIUM ALOX5

Interaction Score: 0.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MESALAMINE ALOX5

Interaction Score: 0.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MAX-002

Novel drug target Established target

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
6428914 2882965 6131674

Sources:
TdgClinicalTrial ChemblInteractions
SULFASALAZINE ALOX5

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
6428914 2882965 6131674

Sources:
ChemblInteractions
MECLOFENAMATE SODIUM ALOX5

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ACACETIN ALOX5

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24368208

Sources:
DTC
MONTELUKAST ALOX5

Interaction Score: 0.27

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
15474500

Sources:
PharmGKB
MELATONIN ALOX5

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10668425

Sources:
NCI
METHOTREXATE ALOX5

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8151588

Sources:
NCI

Ensembl: ENSG00000012779
- Version: 101_38
Alternate Names:

ALOX5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P09917
- Version: January-2014
Alternate Names:

ALOX5 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.13.11.34

Publications:
TEND: P09917
- Version: 01-August-2011
Alternate Names:

P09917 Uniprot Accession

240 Entrez Gene Id

ENSG00000012779 Ensembl Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 1.13.11.34

Publications:
RussLampel: ENSG00000012779
- Version: 26-July-2011
Alternate Names:

ALOX5 Display Id

ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO). [SOURCE:UNIPROT/SWISSPROT;ACC:P09917] Description

ENSG00000012779 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P09917
- Version: 11-September-2012
Alternate Names:

LOX5_HUMAN Uniprot Id

P09917 Uniprot Accession

ALOX5 Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR000907

Interpro Name Lipoxygenase

Gene Categories:

DRUGGABLE GENOME

Publications:

TTD: Arachidonate 5-lipoxygenase

Version: 2020.06.01

Alternate Names:

5-LOX TTD Gene Abbreviation

T00140 TTD Target ID

Gene Info:

Publications:

Stanke-Labesque F et al., 2003, Inhibition of leukotriene synthesis with MK-886 prevents a rise in blood pressure and reduces noradrenaline-evoked contraction in L-NAME-treated rats., Br J Pharmacol

NCI: ALOX5

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Manev et al., 1999, Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression., Ann. N. Y. Acad. Sci.

Jeon et al., 2005, Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes., Biochem. Biophys. Res. Commun.

Ghosh, 2004, Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase., Biochem. Biophys. Res. Commun.

DTC: ALOX5

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem

Karg EM et al., 2009, Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase., J Med Chem

Schieferdecker S et al., 2015, Myxochelins target human 5-lipoxygenase., J Nat Prod

ChemblInteractions: LOG5
- Version: chembl_23
Alternate Names:

LOG5 GENE_SYMBOL

ALOX5 GENE_SYMBOL

Arachidonate 5-lipoxygenase UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000012779
- Version: 31-May-2017
Alternate Names:

ENSG00000012779 Gene Symbol

ALOX5 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: ALOX5
- Version: 18-August-2020
Alternate Names:

PA46 PharmGKB ID

Gene Info:

Publications:

Trial Name	Zyflo
Novel drug target	Established target
Mechanism of Interaction	Arachidonate 5-lipoxygenase inhibitor

Trial Name	licofelone, ML3000
Novel drug target	Established target

Trial Name	balsalazide disodium,Colazal, Giazo
Novel drug target	Established target

Mechanism of Interaction	Arachidonate 5-lipoxygenase inhibitor
Direct Interaction	yes

Trial Name	MAX-002
Novel drug target	Established target
Mechanism of Interaction	Arachidonate 5-lipoxygenase inhibitor

P09917	Uniprot Accession
240	Entrez Gene Id
ENSG00000012779	Ensembl Gene Id

ALOX5	Display Id
ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO). [SOURCE:UNIPROT/SWISSPROT;ACC:P09917]	Description
ENSG00000012779	Ensembl Gene Id

LOX5_HUMAN	Uniprot Id
P09917	Uniprot Accession
ALOX5	Uniprot Gene Name

LOG5	GENE_SYMBOL
ALOX5	GENE_SYMBOL
Arachidonate 5-lipoxygenase	UNIPROT

ALOX5 Gene Record

ALOX5 240 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 10518442 1886988 3004501 11752352 1400062 8606397

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Zyflo Novel drug target Established target Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs: 10694244 10322101 11529688 11561080 10377029 11752352 8826571 8058773 17394438 19645854 20436887 11454666 24697244 19492852 25686392

Sources: DTC TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24231650

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name VIA-2291 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name licofelone, ML3000 Novel drug target Established target

PMIDs: 17015640 11752352

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24924423

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name balsalazide disodium,Colazal, Giazo Novel drug target Established target

PMIDs: 1359745 19743890

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24697244

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24231650

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MAX-002 Novel drug target Established target Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
10518442 1886988 3004501 11752352 1400062 8606397

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Zyflo

Novel drug target Established target

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
10694244 10322101 11529688 11561080 10377029 11752352 8826571 8058773 17394438 19645854 20436887 11454666 24697244 19492852 25686392

Sources:
DTC TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
24231650

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name VIA-2291

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name licofelone, ML3000

Novel drug target Established target

PMIDs:
17015640 11752352

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
24924423

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name balsalazide disodium,Colazal, Giazo

Novel drug target Established target

PMIDs:
1359745 19743890

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
24697244

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24231650

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MAX-002

Novel drug target Established target

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
6428914 2882965 6131674

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
6428914 2882965 6131674

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
24368208

Sources:
DTC

Interaction Types & Directionality:

other/unknown

PMIDs:
15474500

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
10668425