DGIdb - ALOX5 Gene Record

ALOX5 240 Druggable Genome

Alternate Names:

240
ARACHIDONATE 5-LIPOXYGENASE
ALOX5
5-LO
5-LOX
5LPG
LOG5
152390
435
ENSG00000012779
OTTHUMG00000018081
BE0000248
P09917
ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO). [SOURCE:UNIPROT/SWISSPROT;ACC:P09917]
5-lipoxygenase
1385
LOX5_HUMAN
PA46
T00140

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:1.13.11.34
Interpro Acc	IPR000907
Interpro Name	Lipoxygenase
Uniprot Status	Swiss-Prot
Interpro Short Name	LipOase
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Target Main Class	Enzymes
Target Subclass	1.13.11.34
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Lipoxygenases
GuideToPharmacology Gene Category ID	271

(9 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Allgayer et al., 1984, Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine., Eur. J. Clin. Pharmacol.
Nielsen et al., 1987, Inhibition of 5-lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic acid., Dig. Dis. Sci.
Sircar et al., 1983, Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis., Biochem. Pharmacol.
Wisastra R et al., 2013, Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection., Bioorg Med Chem
Qian et al., 2001, Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor., Pharmacol. Res.
Hardy et al., 1999, Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells., Biol. Reprod.
Guidot et al., 1994, Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity., Proc. Natl. Acad. Sci. U.S.A.
Zouboulis et al., 2010, Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis., Exp. Dermatol.
Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem
Vicente et al., 2001, Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages., Br. J. Pharmacol.
Wenzel et al., Zileuton: the first 5-lipoxygenase inhibitor for the treatment of asthma., Ann Pharmacother
Yamashita et al., 2000, Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells., Br. J. Pharmacol.
Coffey et al., 2001, Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton., J. Pharmacol. Exp. Ther.
Wenzel, Leukotriene receptor antagonists and related compounds., Can. Respir. J.
Berger et al., 2007, Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease., Int. J. Clin. Pract.
Zouboulis, 2009, Zileuton, a new efficient and safe systemic anti-acne drug., Dermatoendocrinol
Karg EM et al., 2009, Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase., J Med Chem
Schieferdecker S et al., 2015, Myxochelins target human 5-lipoxygenase., J Nat Prod
Taccone-Gallucci et al., 2006, N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity., Kidney Int.
Cernak et al., 1996, Leukotrienes in the pathogenesis of pulmonary blast injury., J Trauma
Gross et al., 1991, Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis., Radiat. Res.
Bach et al., 1986, Inhibition of the leukotriene synthetase of rat basophil leukemia cells by diethylcarbamazine, and synergism between diethylcarbamazine and piriprost, a 5-lipoxygenase inhibitor., Biochem. Pharmacol.
Davidson et al., 1992, Prolonged pulmonary hypertension caused by platelet-activating factor and leukotriene C4 in the rat lung., J. Appl. Physiol.
Zunić et al., Inhibition of leukotriene formation by diethylcarbamazine modifies the acid-base balance in the rabbits with blast injuries of the lungs., Vojnosanit Pregl
Ramires et al., 2004, Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast., Biochem. Biophys. Res. Commun.
Vidal et al., 2007, Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis., J. Pharmacol. Exp. Ther.
Armstrong MM et al., 2014, Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes., Bioorg Med Chem
Ribeiro D et al., 2014, Inhibition of LOX by flavonoids: a structure-activity relationship study., Eur J Med Chem
Chu et al., 2007, Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats., Acta Pharmacol. Sin.
Song et al., 2004, Minocycline protects PC12 cells from ischemic-like injury and inhibits 5-lipoxygenase activation., Neuroreport
Song et al., 2006, Minocycline protects PC12 cells against NMDA-induced injury via inhibiting 5-lipoxygenase activation., Brain Res.
Yu et al., 1992, Inhibition of canine tracheal smooth muscle by mediators from cultured bronchial epithelial cells., Am. J. Physiol.
Boctor et al., 1986, Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro., Prostaglandins Leukot Med
Manev et al., 1999, Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression., Ann. N. Y. Acad. Sci.
Rask-Madsen et al., 1992, 5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease., Agents Actions
Wiggins et al., 2009, Balsalazide: a novel 5-aminosalicylate prodrug for the treatment of active ulcerative colitis., Expert Opin Drug Metab Toxicol
Hawkes et al., 1994, The effect of methotrexate on ex vivo lipoxygenase metabolism in neutrophils from patients with rheumatoid arthritis., J. Rheumatol.
Audouin et al., 2001, N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase., Bioorg. Med. Chem. Lett.
Jeon et al., 2005, Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes., Biochem. Biophys. Res. Commun.
Azadzoi et al., 2004, Alteration of urothelial-mediated tone in the ischemic bladder: role of eicosanoids., Neurourol. Urodyn.
West et al., 2004, The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice., J. Neurochem.
Lambert et al., 2001, Pharmacokinetic analysis by high-performance liquid chromatography of intravenous nordihydroguaiaretic acid in the mouse., J. Chromatogr. B Biomed. Sci. Appl.
Singh B et al., 2012, The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition., J Ethnopharmacol
MacCarrone M et al., 1999, Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity., Eur J Biochem
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

DIETHYLCARBAMAZINE ALOX5

Interaction Score: 5.98

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8606397 1886988 3004501 1400062 11752352 10518442

Sources:
TTD DrugBank
ZILEUTON ALOX5

Interaction Score: 4.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Zyflo

Novel drug target Established target

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
11529688 10377029 8058773 19645854 24697244 11454666 8826571 10694244 11752352 11561080 10322101 17394438 20436887 19492852 25686392

Sources:
NCI TEND DTC PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
MASOPROCOL ALOX5

Interaction Score: 3.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11277534 11752352 15694390 15098224 15379894 11318430

Sources:
DrugBank
CHEMBL502496 ALOX5

Interaction Score: 2.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24231650

Sources:
DTC
ATRELEUTON ALOX5

Interaction Score: 2.99

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name VIA-2291

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
PF-4191834 ALOX5

Interaction Score: 2.99

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TTD GuideToPharmacology
LICOFELONE ALOX5

Interaction Score: 1.99

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name licofelone, ML3000

Novel drug target Established target

PMIDs:
17015640 11752352

Sources:
TdgClinicalTrial DrugBank
CHEMBL73148 ALOX5

Interaction Score: 1.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
BALSALAZIDE ALOX5

Interaction Score: 1.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name balsalazide disodium,Colazal, Giazo

Novel drug target Established target

PMIDs:
1359745 19743890

Sources:
TdgClinicalTrial DrugBank
5-OXO-ETE ALOX5

Interaction Score: 1.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24924423

Sources:
DTC
RILOPIROX ALOX5

Interaction Score: 1.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL416038 ALOX5

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24231650

Sources:
DTC
MECLOFENAMIC ACID ALOX5

Interaction Score: 0.9

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
1539679 3020588

Sources:
DrugBank
6BIO ALOX5

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24697244

Sources:
DTC
DARBUFELONE ALOX5

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TIPELUKAST ALOX5

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TENIDAP ALOX5

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TEPOXALIN ALOX5

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
HYPERFORIN ALOX5

Interaction Score: 0.6

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11752352

Sources:
DrugBank
SILYBIN A ALOX5

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TOCOPHEROL ACETATE ALOX5

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16531984

Sources:
DrugBank
MESALAMINE ALOX5

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MAX-002

Novel drug target Established target

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
6428914 2882965 6131674

Sources:
TdgClinicalTrial DrugBank ChemblInteractions
(+)-ALPHA-TOCOPHERYL SUCCINATE ALOX5

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16531984

Sources:
DrugBank
OLSALAZINE SODIUM ALOX5

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BALSALAZIDE DISODIUM ALOX5

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MINOCYCLINE ALOX5

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17506934 15371729 16574083

Sources:
DrugBank
MORNIFLUMATE ALOX5

Interaction Score: 0.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
SULFASALAZINE ALOX5

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
6428914 2882965 6131674

Sources:
DrugBank ChemblInteractions
MONTELUKAST ALOX5

Interaction Score: 0.25

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
15474500

Sources:
PharmGKB DrugBank
MECLOFENAMATE SODIUM ALOX5

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ACACETIN ALOX5

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24368208

Sources:
DTC
DIACEREIN ALOX5

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22449441

Sources:
DrugBank
VITAMIN E ALOX5

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16531984

Sources:
DrugBank
RHEIN ALOX5

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22449441

Sources:
DrugBank
MELATONIN ALOX5

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10668425

Sources:
NCI
RESVERATROL ALOX5

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10491155

Sources:
DrugBank
METHOTREXATE ALOX5

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8151588

Sources:
NCI
FOSTAMATINIB ALOX5

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000012779
- Version: 101_38
Alternate Names:

ALOX5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P09917
- Version: January-2014
Alternate Names:

ALOX5 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.13.11.34

Publications:
TEND: P09917
- Version: 01-August-2011
Alternate Names:

P09917 Uniprot Accession

240 Entrez Gene Id

ENSG00000012779 Ensembl Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 1.13.11.34

Publications:
RussLampel: ENSG00000012779
- Version: 26-July-2011
Alternate Names:

ALOX5 Display Id

ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO). [SOURCE:UNIPROT/SWISSPROT;ACC:P09917] Description

ENSG00000012779 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P09917
- Version: 11-September-2012
Alternate Names:

LOX5_HUMAN Uniprot Id

P09917 Uniprot Accession

ALOX5 Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR000907

Interpro Name Lipoxygenase

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 240
- Version: 29-September-2020
Alternate Names:

435 HUGO Gene ID

435 HUGO Gene Symbol

arachidonate 5-lipoxygenase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Lipoxygenases

GuideToPharmacology Gene Category ID 271

Gene Categories:

ENZYME

Publications:

DrugBank: BE0000248

Version: 5.1.7

Alternate Names:

ALOX5 DrugBank Gene Name

P09917 UniProt Accession

240 Entrez Gene Id

Gene Info:

Publications:

Audouin et al., 2001, N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase., Bioorg. Med. Chem. Lett.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Jeon et al., 2005, Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes., Biochem. Biophys. Res. Commun.

TTD: Arachidonate 5-lipoxygenase

Version: 2020.06.01

Alternate Names:

5-LOX TTD Gene Abbreviation

T00140 TTD Target ID

Gene Info:

Publications:

Stanke-Labesque F et al., 2003, Inhibition of leukotriene synthesis with MK-886 prevents a rise in blood pressure and reduces noradrenaline-evoked contraction in L-NAME-treated rats., Br J Pharmacol

NCI: ALOX5

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Manev et al., 1999, Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression., Ann. N. Y. Acad. Sci.

Jeon et al., 2005, Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes., Biochem. Biophys. Res. Commun.

Ghosh, 2004, Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase., Biochem. Biophys. Res. Commun.

DTC: ALOX5

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem

Karg EM et al., 2009, Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase., J Med Chem

Schieferdecker S et al., 2015, Myxochelins target human 5-lipoxygenase., J Nat Prod

ChemblInteractions: LOG5
- Version: chembl_23
Alternate Names:

LOG5 GENE_SYMBOL

ALOX5 GENE_SYMBOL

Arachidonate 5-lipoxygenase UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000012779
- Version: 31-May-2017
Alternate Names:

ENSG00000012779 Gene Symbol

ALOX5 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: ALOX5
- Version: 18-August-2020
Alternate Names:

PA46 PharmGKB ID

Gene Info:

Publications:

Trial Name	Zyflo
Novel drug target	Established target
Mechanism of Interaction	Arachidonate 5-lipoxygenase inhibitor

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Trial Name	licofelone, ML3000
Novel drug target	Established target

Trial Name	balsalazide disodium,Colazal, Giazo
Novel drug target	Established target

Trial Name	MAX-002
Novel drug target	Established target
Mechanism of Interaction	Arachidonate 5-lipoxygenase inhibitor

Mechanism of Interaction	Arachidonate 5-lipoxygenase inhibitor
Direct Interaction	yes

P09917	Uniprot Accession
240	Entrez Gene Id
ENSG00000012779	Ensembl Gene Id

ALOX5	Display Id
ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO). [SOURCE:UNIPROT/SWISSPROT;ACC:P09917]	Description
ENSG00000012779	Ensembl Gene Id

LOX5_HUMAN	Uniprot Id
P09917	Uniprot Accession
ALOX5	Uniprot Gene Name

435	HUGO Gene ID
435	HUGO Gene Symbol
arachidonate 5-lipoxygenase	HUGO Gene Name

ALOX5	DrugBank Gene Name
P09917	UniProt Accession
240	Entrez Gene Id

LOG5	GENE_SYMBOL
ALOX5	GENE_SYMBOL
Arachidonate 5-lipoxygenase	UNIPROT

ALOX5 Gene Record

ALOX5 240 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 8606397 1886988 3004501 1400062 11752352 10518442

Sources: TTD DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Zyflo Novel drug target Established target Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs: 11529688 10377029 8058773 19645854 24697244 11454666 8826571 10694244 11752352 11561080 10322101 17394438 20436887 19492852 25686392

Sources: NCI TEND DTC PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 11277534 11752352 15694390 15098224 15379894 11318430

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24231650

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name VIA-2291 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: TTD GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info: Trial Name licofelone, ML3000 Novel drug target Established target

PMIDs: 17015640 11752352

Sources: TdgClinicalTrial DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name balsalazide disodium,Colazal, Giazo Novel drug target Established target

PMIDs: 1359745 19743890

Sources: TdgClinicalTrial DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24924423

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24231650

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 1539679 3020588

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24697244

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
8606397 1886988 3004501 1400062 11752352 10518442

Sources:
TTD DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Zyflo

Novel drug target Established target

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
11529688 10377029 8058773 19645854 24697244 11454666 8826571 10694244 11752352 11561080 10322101 17394438 20436887 19492852 25686392

Sources:
NCI TEND DTC PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
11277534 11752352 15694390 15098224 15379894 11318430

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
24231650

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name VIA-2291

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TTD GuideToPharmacology

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name licofelone, ML3000

Novel drug target Established target

PMIDs:
17015640 11752352

Sources:
TdgClinicalTrial DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name balsalazide disodium,Colazal, Giazo

Novel drug target Established target

PMIDs:
1359745 19743890

Sources:
TdgClinicalTrial DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
24924423

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
24231650

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
1539679 3020588

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
24697244

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
11752352

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
16531984

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MAX-002

Novel drug target Established target

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

PMIDs:
6428914 2882965 6131674

Sources:
TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16531984

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Arachidonate 5-lipoxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)