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ALDH2 Gene Record

  • Summary
  • Interactions
  • Claims
  • ALDH2 217 Druggable GenomeClinically Actionable

    Alternate Names:

    217
    ALDEHYDE DEHYDROGENASE 2 FAMILY (MITOCHONDRIAL)
    ALDH2
    ALDH-E2
    ALDHI
    ALDM
    100650
    404
    ENSG00000111275
    OTTHUMG00000169603
    P05091
    ALDH2_HUMAN
    ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
    ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 1.2.1.3) (ALDH CLASS 2) (ALDHI) (ALDH-E2). [SOURCE:UNIPROT/SWISSPROT;ACC:P05091]
    2595
    ALDH class 2
    BE0000133
    aldehyde dehydrogenase 2 family member
    PA24696
    Mitochondrial aldehyde dehydrogenase
    T44282
    NP_001122302
    NM_001128830

    Gene Info:

    Target Subclass 1.2.1.3
    Target Main Class Enzymes
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Aldehyde_DH_dom
    Interpro Name Aldehyde dehydrogenase domain
    Interpro Acc IPR015590
    Target Class Enzymes
    Target Subclass EC:1.2.1.3
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name 1.-.-.- Oxidoreductases
    GuideToPharmacology Gene Category ID 840
    (10 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

    Mackenzie et al., 2005, Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans., Arterioscler. Thromb. Vasc. Biol.
    Ho et al., 2007, Refractive hypotension in a patient with disulfiram-ethanol reaction., Am. J. Med. Sci.
    Kopczyński Z et al., 1984, Studies on the effects of low-molecular uraemic toxins on the activity of 3-phospho-D-glycerol aldehyde dehydrogenase (E.C.1.2.1.12) in human erythrocytes., Acta Physiol Pol
    Kikonyogo A et al., 1997, Cimetidine and other H2-receptor antagonists as inhibitors of human E3 aldehyde dehydrogenase., Mol Pharmacol
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Lee YJ et al., 2019, The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea., Alcohol
    Wang TY et al., 2012, The aldehyde dehydrogenase 2 gene is associated with heroin dependence., Drug Alcohol Depend
    Matsumoto et al., 1996, Mitochondrial ALDH polymorphism affects ethanol-derived acetate disposition in Wistar rats., Alcohol. Clin. Exp. Res.
    Kim SA et al., 2004, Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients., Alcohol
    Nishizawa D et al., 2006, Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population., Neuropsychobiology
    Quintanilla et al., 2006, The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake., Addict Biol
    Quintanilla et al., 2007, Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective., Am. J. Physiol. Endocrinol. Metab.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
  • CROTONALDEHYDE   ALDH2

    Interaction Score: 18.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • GUANIDINE   ALDH2

    Interaction Score: 7.89

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    6100768 9271349 17139284 17016423


    Sources:
    DrugBank

  • DAIDZIN   ALDH2

    Interaction Score: 6.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • PRUNETIN   ALDH2

    Interaction Score: 6.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Details of Interaction <i>In vitro</i> inhibition of recombinant human mitochondrial alcohol dehydrogenase
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ACETALDEHYDE   ALDH2

    Interaction Score: 2.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31002879


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   ALDH2

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21723677


    Sources:
    PharmGKB

  • DISULFIRAM   ALDH2

    Interaction Score: 0.97

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Aldehyde dehydrogenase inhibitor
    Trial Name -

    PMIDs:
    16051882 17220694


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • ALCOHOL   ALDH2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8986223 31002879 15902904 16679777


    Sources:
    NCI PharmGKB

  • CHEMBL1161866   ALDH2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16961761 17488809


    Sources:
    DrugBank

  • Ensembl: ENSG00000111275

    • Version: 101_38

    Alternate Names:
    ALDH2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P05091

    • Version: 01-August-2011

    Alternate Names:
    217 Entrez Gene Id
    P05091 Uniprot Accession
    ALDH2_HUMAN Uniprot Id

    Gene Info:
    Target Subclass 1.2.1.3
    Target Main Class Enzymes

    Publications:

  • TdgClinicalTrial: P05091

    • Version: January-2014

    Alternate Names:
    ALDH2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.2.1.3

    Publications:

  • RussLampel: ENSG00000111275

    • Version: 26-July-2011

    Alternate Names:
    ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 1.2.1.3) (ALDH CLASS 2) (ALDHI) (ALDH-E2). [SOURCE:UNIPROT/SWISSPROT;ACC:P05091] Description
    ALDH2 Display Id
    ENSG00000111275 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P05091

    • Version: 11-September-2012

    Alternate Names:
    ALDH2 Uniprot Gene Name
    ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL Uniprot Protein Name
    P05091 Uniprot Accession

    Gene Info:
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 217

    • Version: 29-September-2020

    Alternate Names:
    404 HUGO Gene ID
    404 HUGO Gene Symbol
    aldehyde dehydrogenase 2 family member HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 1.-.-.- Oxidoreductases
    GuideToPharmacology Gene Category ID 840

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: ALDH2

    • Version: 18-August-2020

    Alternate Names:
    PA24696 PharmGKB ID

    Gene Info:

    Publications:
    Lee YJ et al., 2019, The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea., Alcohol
    Kim SA et al., 2004, Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients., Alcohol
    Nishizawa D et al., 2006, Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population., Neuropsychobiology

  • DrugBank: BE0000133

    • Version: 5.1.7

    Alternate Names:
    ALDH2 DrugBank Gene Name
    P05091 UniProt Accession
    217 Entrez Gene Id

    Gene Info:

    Publications:
    Kopczyński Z et al., 1984, Studies on the effects of low-molecular uraemic toxins on the activity of 3-phospho-D-glycerol aldehyde dehydrogenase (E.C.1.2.1.12) in human erythrocytes., Acta Physiol Pol
    Kikonyogo A et al., 1997, Cimetidine and other H2-receptor antagonists as inhibitors of human E3 aldehyde dehydrogenase., Mol Pharmacol
    Mackenzie et al., 2005, Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans., Arterioscler. Thromb. Vasc. Biol.

  • NCI: ALDH2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Matsumoto et al., 1996, Mitochondrial ALDH polymorphism affects ethanol-derived acetate disposition in Wistar rats., Alcohol. Clin. Exp. Res.

  • ChemblInteractions: ALDM

    • Version: chembl_23

    Alternate Names:
    ALDM GENE_SYMBOL
    ALDH2 GENE_SYMBOL
    Aldehyde dehydrogenase, mitochondrial UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000111275

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000111275 Gene Symbol
    ALDH2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: ALDH2

    • Version: 03-September-2020

    Alternate Names:
    Aldehyde dehydrogenase, mitochondrial Gene Name
    P05091 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Mitochondrial aldehyde dehydrogenase

    • Version: 2020.06.01

    Alternate Names:
    ALDH2 TTD Gene Abbreviation
    T44282 TTD Target ID

    Gene Info:

    Publications:

  • CarisMolecularIntelligence: ALDH2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21