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AKT2 208 Druggable GenomeClinically Actionable
Alternate Names:
208 AKT SERINE/THREONINE KINASE 2 AKT2 HIHGHH PKBB PKBBETA PRKBB RAC-BETA 164731 392 ENSG00000105221 OTTHUMG00000137375 AKT2_HUMAN P31751 RAC-BETA SERINE/THREONINE-PROTEIN KINASE BE0001172 254 RAC-PK-beta Protein kinase Akt-2 PKB beta Protein kinase B beta 1480 NP_001617 NM_001243027 RAC-BETA SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAC-PK-BETA) (PROTEIN KINASE AKT-2) (PROTEIN KINASE B, BETA) (PKB BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P31751] Gene Info:
Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain Interpro Type Domain Uniprot Evidence 1: Evidence at protein level Uniprot Status Swiss-Prot Human Readable Name DRUGGABLE GENOME Human Readable Name KINASE Interpro Acc IPR002290 Interpro Short Name Ser/Thr_dual-sp_kinase_dom GuideToPharmacology Gene Category ID 285 Target Class Enzymes Target Subclass EC:2.7.11.1 Gene Biotype PROTEIN_CODING GuideToPharmacology Gene Category Name Akt (Protein kinase B, PKB) family Gene Categories: Category Details
TRANSPORTER KINASE SERINE THREONINE KINASE DRUGGABLE GENOME CLINICALLY ACTIONABLE ENZYME TRANSCRIPTION FACTOR
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Interaction Score: 1.51
Interaction Types & Directionality:
allosteric modulator inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True -
Interaction Score: 1.42
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition PMIDs:
None found
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Interaction Score: 1.14
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Interaction Score: 1.14
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Interaction Score: 1.14
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Serine/threonine-protein kinase AKT2 inhibitor Direct Interaction yes -
Interaction Score: 1.14
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition -
Interaction Score: 0.91
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name triciribine-phosphate, TCN-P, VQD-002 Novel drug target Novel Target -
Interaction Types & Directionality:
inhibitor (inhibitory) allosteric modulator Interaction Info:
Specific Action of the Ligand Negative Endogenous Drug? False Direct Interaction? True PMIDs:
None found
-
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor Direct Interaction yes -
Interaction Score: 0.76
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor Direct Interaction yes -
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name RX-0201,Archexin Novel drug target Novel Target -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name XL418 Novel drug target Novel Target Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor -
Interaction Score: 0.76
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition -
Interaction Score: 0.5
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True -
Interaction Score: 0.45
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.32
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name perifosine, KRX-0401 Novel drug target Novel Target -
Interaction Score: 0.21
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition -
Interaction Score: 0.19
-
Interaction Score: 0.12
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
-
Interaction Score: 0.08
-
Interaction Score: 0.06
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
-
Interaction Score: 0.05
-
Interaction Score: 0.04
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- Version: 101_38
Alternate Names:
AKT2 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 26-July-2011
Alternate Names:
AKT2 Display Id RAC-BETA SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAC-PK-BETA) (PROTEIN KINASE AKT-2) (PROTEIN KINASE B, BETA) (PKB BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P31751] Description ENSG00000105221 Ensembl Gene Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: January-2014
Alternate Names:
AKT2 Gene Symbol Gene Info:
Target Class Enzymes Target Subclass EC:2.7.11.1 Publications:
-
- Version: 11-September-2012
Alternate Names:
208 Entrez Gene Id P31751 Uniprot Accession ENSG00000105221 Ensembl Gene Id Gene Info:
Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain Interpro Type Domain Uniprot Evidence 1: Evidence at protein level Gene Categories:
KINASE, DRUGGABLE GENOME Publications:
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- Version: 29-September-2020
Alternate Names:
392 HUGO Gene ID 392 HUGO Gene Symbol AKT serine/threonine kinase 2 HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name Akt (Protein kinase B, PKB) family GuideToPharmacology Gene Category ID 285 Gene Categories:
ENZYME Publications:
-
Alternate Names:
208 Entrez Gene ID 254 CIViC Gene ID Gene Info:
-
Alternate Names:
AKT2 DrugBank Gene Name P31751 UniProt Accession 208 Entrez Gene Id Gene Info:
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- Version: 31-May-2017
Alternate Names:
ENSG00000105221 Gene Symbol AKT2 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: chembl_23
Alternate Names:
AKT2 GENE_SYMBOL RAC-beta serine/threonine-protein kinase UNIPROT Protein kinase Akt-2 UNIPROT Gene Info:
Publications:
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- Version: 19.3
Alternate Names:
ENSG00000105221 Ensembl Gene ID AKT serine/threonine kinase 2 Human Protein Atlas Gene Description P31751 UniProt ID Gene Info:
Gene Categories:
ENZYME Publications:
-
Alternate Names:
RAC-beta serine/threonine-protein kinase Gene Name P31751 UniProt ID Gene Info:
Gene Categories:
KINASE, TRANSCRIPTION FACTOR, TRANSPORTER Publications:
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Alternate Names:
AKT2 Gene Symbol Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
-
Alternate Names:
208 Gene ID HIHGHH dGene Synonym PKBB dGene Synonym Gene Info:
Gene Categories:
SERINE THREONINE KINASE, KINASE Publications:
-
Alternate Names:
Gene Info:
Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
-
- Version: 30-February-2014
Alternate Names:
Gene Info:
Publications:
-
- Version: 15-June-2013
Alternate Names:
Gene Info:
Publications:
-
Alternate Names:
Gene Info:
Publications:
-
- Version: 03-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
-
- Version: 04-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
SERINE THREONINE KINASE Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications: