AKT2 Gene Record

  • AKT2 208 Druggable GenomeClinically Actionable

    Alternate Names:

    208
    AKT SERINE/THREONINE KINASE 2
    AKT2
    HIHGHH
    PKBB
    PKBBETA
    PRKBB
    RAC-BETA
    164731
    392
    ENSG00000105221
    OTTHUMG00000137375
    AKT2_HUMAN
    P31751
    RAC-BETA SERINE/THREONINE-PROTEIN KINASE
    254
    RAC-PK-beta
    Protein kinase Akt-2
    PKB beta
    Protein kinase B beta
    RAC-BETA SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAC-PK-BETA) (PROTEIN KINASE AKT-2) (PROTEIN KINASE B, BETA) (PKB BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P31751]

    Gene Info:

    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name KINASE
    Interpro Acc IPR002290
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Target Class Enzymes
    Target Subclass EC:2.7.11.1
    Gene Biotype PROTEIN_CODING
    (15 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    TUMOR SUPPRESSOR
    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

  • IPATASERTIB   AKT2

    Interaction Score: 1.61

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes
    Trial Name GDC-0068

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions MyCancerGenomeClinicalTrial

  • BAY-1125976   AKT2

    Interaction Score: 1.41

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • XL-418   AKT2

    Interaction Score: 1.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name XL418
    Novel drug target Novel Target
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • TRICIRIBINE   AKT2

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name triciribine-phosphate, TCN-P, VQD-002
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ClearityFoundationClinicalTrial

  • AZD-5363   AKT2

    Interaction Score: 0.94

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRICIRIBINE PHOSPHATE   AKT2

    Interaction Score: 0.94

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ARCHEXIN   AKT2

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name RX-0201,Archexin
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • MK-2201   AKT2

    Interaction Score: 0.94

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MIRANSERTIB   AKT2

    Interaction Score: 0.94

    Interaction Types & Directionality:
    allosteric modulator
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AFURESERTIB   AKT2

    Interaction Score: 0.7

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MK-2206   AKT2

    Interaction Score: 0.66

    Interaction Types & Directionality:
    allosteric modulator
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name MK-2206
    Novel drug target Novel Target
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions MyCancerGenomeClinicalTrial

  • PERIFOSINE   AKT2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name perifosine, KRX-0401
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • LY-2780301   AKT2

    Interaction Score: 0.56

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • UPROSERTIB   AKT2

    Interaction Score: 0.47

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CAPIVASERTIB   AKT2

    Interaction Score: 0.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationClinicalTrial

  • TRASTUZUMAB   AKT2

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22842582


    Sources:
    CIViC

  • GSK-690693   AKT2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OMIPALISIB   AKT2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenomeClinicalTrial

  • LAUROGUADINE   AKT2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EVEROLIMUS   AKT2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenomeClinicalTrial

  • GSK-269962A   AKT2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SOTRASTAURIN   AKT2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000105221

    • Version: 101_38

    Alternate Names:
    AKT2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000105221

    • Version: 26-July-2011

    Alternate Names:
    AKT2 Display Id
    RAC-BETA SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAC-PK-BETA) (PROTEIN KINASE AKT-2) (PROTEIN KINASE B, BETA) (PKB BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P31751] Description
    ENSG00000105221 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P31751

    • Version: January-2014

    Alternate Names:
    AKT2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.1

    Publications:

  • HopkinsGroom: P31751

    • Version: 11-September-2012

    Alternate Names:
    208 Entrez Gene Id
    P31751 Uniprot Accession
    ENSG00000105221 Ensembl Gene Id

    Gene Info:
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • CIViC: AKT2

    • Version: 14-September-2020

    Alternate Names:
    208 Entrez Gene ID
    254 CIViC Gene ID

    Gene Info:

    Publications:
    Grell et al., 2012, Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab., Int. J. Oncol.

  • HingoraniCasas: ENSG00000105221

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000105221 Gene Symbol
    AKT2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: AKT2

    • Version: chembl_23

    Alternate Names:
    AKT2 GENE_SYMBOL
    RAC-beta serine/threonine-protein kinase UNIPROT
    Protein kinase Akt-2 UNIPROT

    Gene Info:

    Publications:

  • HumanProteinAtlas: AKT2

    • Version: 19.3

    Alternate Names:
    ENSG00000105221 Ensembl Gene ID
    AKT serine/threonine kinase 2 Human Protein Atlas Gene Description
    P31751 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Tempus: AKT2

    • Version: 11-November-2018

    Alternate Names:
    AKT2 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: AKT2

    • Version: 27-Jun-2013

    Alternate Names:
    208 Gene ID
    HIHGHH dGene Synonym
    PKBB dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • Pharos: AKT2

    • Version: 01-February-2022

    Alternate Names:
    RAC-beta serine/threonine-protein kinase Gene Name
    P31751 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER, KINASE, TRANSCRIPTION FACTOR

    Publications:

  • MskImpact: AKT2

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • MyCancerGenomeClinicalTrial: AKT2

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

  • ClearityFoundationClinicalTrial: AKT2

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

  • DTC: AKT2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

  • FoundationOneGenes: AKT2

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: AKT2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • GO: AKT2

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR, SERINE THREONINE KINASE

    Publications:

  • Oncomine: AKT2

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: