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AKR1C3 Gene Record

  • Summary
  • Interactions
  • Claims
  • AKR1C3 8644 Druggable Genome

    Alternate Names:

    8644
    ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3
    AKR1C3
    DD3
    DDX
    HA1753
    HAKRB
    HAKRe
    HSD17B5
    PGFS
    hluPGFS
    603966
    386
    ENSG00000196139
    OTTHUMG00000017585
    P42330
    AK1C3_HUMAN
    PA24679
    ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (EC 1.1.1.-) (TRANS-1,2- DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE) (EC 1.3.1.20) (CHLORDECONE REDUCTASE HOMOLOG HAKRB) (HA1753) (DIHYDRODIOL DEHYDROGENASE, TYPE I) (DIHYDRODIOL DEHYDROGENASE 3) (DD3) (3-ALPHA-HYDROXYSTE
    Dihydrodiol dehydrogenase type I
    T60857

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001395
    Uniprot Status Swiss-Prot
    Interpro Name Aldo/keto reductase
    Interpro Short Name Aldo/ket_red
    Interpro Type Family
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Voon PJ et al., 2013, Correlation of aldo-ketoreductase (AKR) 1C3 genetic variant with doxorubicin pharmacodynamics in Asian breast cancer patients., Br J Clin Pharmacol
    Liedtke AJ et al., 2013, Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer., J Med Chem
    Lovering et al., 2004, Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin., Cancer Res.
    Penning et al., 2000, Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones., Biochem. J.
    Platt A et al., 2016, Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases., Pharmacogenet Genomics
    Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics
    Bains OS et al., 2010, Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin., J Pharmacol Exp Ther
    Adeniji AO et al., 2012, Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships., J Med Chem
    Endo S et al., 2012, Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis., J Nat Prod
  • CHEMBL1682200   AKR1C3

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22263837


    Sources:
    DTC

  • BACCHARIN   AKR1C3

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22506594


    Sources:
    DTC

  • CHEMBL1682202   AKR1C3

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22263837


    Sources:
    DTC

  • CHEMBL1682201   AKR1C3

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22263837


    Sources:
    DTC

  • EXEMESTANE   AKR1C3

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27111237


    Sources:
    PharmGKB

  • INDOMETHACIN   AKR1C3

    Interaction Score: 0.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    23432095 14996743


    Sources:
    DTC

  • TESTOSTERONE   AKR1C3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10998348


    Sources:
    NCI

  • DOXORUBICIN   AKR1C3

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23116553 21048526 20837989


    Sources:
    PharmGKB

  • DAUNORUBICIN   AKR1C3

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20837989


    Sources:
    PharmGKB

  • DOCETAXEL   AKR1C3

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23116553


    Sources:
    PharmGKB

  • Ensembl: ENSG00000196139

    • Version: 101_38

    Alternate Names:
    AKR1C3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000196139

    • Version: 26-July-2011

    Alternate Names:
    ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (EC 1.1.1.-) (TRANS-1,2- DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE) (EC 1.3.1.20) (CHLORDECONE REDUCTASE HOMOLOG HAKRB) (HA1753) (DIHYDRODIOL DEHYDROGENASE, TYPE I) (DIHYDRODIOL DEHYDROGENASE 3) (DD3) (3-ALPHA-HYDROXYSTE Description
    ENSG00000196139 Ensembl Gene Id
    AKR1C3 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P42330

    • Version: 11-September-2012

    Alternate Names:
    AKR1C3 Uniprot Gene Name
    8644 Entrez Gene Id
    ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 Uniprot Protein Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001395

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: AKR1C3

    • Version: 18-August-2020

    Alternate Names:
    PA24679 PharmGKB ID

    Gene Info:

    Publications:
    Voon PJ et al., 2013, Correlation of aldo-ketoreductase (AKR) 1C3 genetic variant with doxorubicin pharmacodynamics in Asian breast cancer patients., Br J Clin Pharmacol
    Platt A et al., 2016, Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases., Pharmacogenet Genomics
    Bains OS et al., 2010, Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin., J Pharmacol Exp Ther

  • NCI: AKR1C3

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Penning et al., 2000, Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones., Biochem. J.
    Desmond et al., 2003, The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs., Cancer Res.
    Lovering et al., 2004, Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin., Cancer Res.

  • DTC: AKR1C3

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Adeniji AO et al., 2012, Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships., J Med Chem
    Endo S et al., 2012, Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis., J Nat Prod
    Liedtke AJ et al., 2013, Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer., J Med Chem

  • HingoraniCasas: ENSG00000196139

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000196139 Gene Symbol
    AKR1C3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Dihydrodiol dehydrogenase type I

    • Version: 2020.06.01

    Alternate Names:
    AKR1C3 TTD Gene Abbreviation
    T60857 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: AKR1C3

    • Version: 01-February-2022

    Alternate Names:
    Aldo-keto reductase family 1 member C3 Gene Name
    P42330 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21