DGIdb - AKR1C3 Gene Record

AKR1C3 8644 Druggable Genome

Alternate Names:

8644
ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3
AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
603966
386
ENSG00000196139
OTTHUMG00000017585
P42330
AK1C3_HUMAN
PA24679
ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (EC 1.1.1.-) (TRANS-1,2- DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE) (EC 1.3.1.20) (CHLORDECONE REDUCTASE HOMOLOG HAKRB) (HA1753) (DIHYDRODIOL DEHYDROGENASE, TYPE I) (DIHYDRODIOL DEHYDROGENASE 3) (DD3) (3-ALPHA-HYDROXYSTE
Dihydrodiol dehydrogenase type I
T60857

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR001395
Uniprot Status	Swiss-Prot
Interpro Name	Aldo/keto reductase
Interpro Short Name	Aldo/ket_red
Interpro Type	Family
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Voon PJ et al., 2013, Correlation of aldo-ketoreductase (AKR) 1C3 genetic variant with doxorubicin pharmacodynamics in Asian breast cancer patients., Br J Clin Pharmacol
Liedtke AJ et al., 2013, Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer., J Med Chem
Lovering et al., 2004, Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin., Cancer Res.
Penning et al., 2000, Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones., Biochem. J.
Platt A et al., 2016, Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases., Pharmacogenet Genomics
Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics
Bains OS et al., 2010, Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin., J Pharmacol Exp Ther
Adeniji AO et al., 2012, Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships., J Med Chem
Endo S et al., 2012, Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis., J Nat Prod

CHEMBL1682200 AKR1C3

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22263837

Sources:
DTC
BACCHARIN AKR1C3

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22506594

Sources:
DTC
CHEMBL1682202 AKR1C3

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22263837

Sources:
DTC
CHEMBL1682201 AKR1C3

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22263837

Sources:
DTC
EXEMESTANE AKR1C3

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27111237

Sources:
PharmGKB
INDOMETHACIN AKR1C3

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
23432095 14996743

Sources:
DTC
TESTOSTERONE AKR1C3

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10998348

Sources:
NCI
DOXORUBICIN AKR1C3

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23116553 21048526 20837989

Sources:
PharmGKB
DAUNORUBICIN AKR1C3

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20837989

Sources:
PharmGKB
DOCETAXEL AKR1C3

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23116553

Sources:
PharmGKB

Ensembl: ENSG00000196139
- Version: 101_38
Alternate Names:

AKR1C3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000196139

Version: 26-July-2011

Alternate Names:

ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (EC 1.1.1.-) (TRANS-1,2- DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE) (EC 1.3.1.20) (CHLORDECONE REDUCTASE HOMOLOG HAKRB) (HA1753) (DIHYDRODIOL DEHYDROGENASE, TYPE I) (DIHYDRODIOL DEHYDROGENASE 3) (DD3) (3-ALPHA-HYDROXYSTE Description

ENSG00000196139 Ensembl Gene Id

AKR1C3 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P42330
- Version: 11-September-2012
Alternate Names:

AKR1C3 Uniprot Gene Name

8644 Entrez Gene Id

ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR001395

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: AKR1C3

Version: 18-August-2020

Alternate Names:

PA24679 PharmGKB ID

Gene Info:

Publications:

Voon PJ et al., 2013, Correlation of aldo-ketoreductase (AKR) 1C3 genetic variant with doxorubicin pharmacodynamics in Asian breast cancer patients., Br J Clin Pharmacol

Platt A et al., 2016, Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases., Pharmacogenet Genomics

Bains OS et al., 2010, Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin., J Pharmacol Exp Ther

NCI: AKR1C3

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Penning et al., 2000, Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones., Biochem. J.

Desmond et al., 2003, The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs., Cancer Res.

Lovering et al., 2004, Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin., Cancer Res.

DTC: AKR1C3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Adeniji AO et al., 2012, Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships., J Med Chem

Endo S et al., 2012, Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis., J Nat Prod

Liedtke AJ et al., 2013, Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer., J Med Chem

HingoraniCasas: ENSG00000196139
- Version: 31-May-2017
Alternate Names:

ENSG00000196139 Gene Symbol

AKR1C3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Dihydrodiol dehydrogenase type I
- Version: 2020.06.01
Alternate Names:

AKR1C3 TTD Gene Abbreviation

T60857 TTD Target ID

Gene Info:

Publications:
Pharos: AKR1C3
- Version: 01-February-2022
Alternate Names:

Aldo-keto reductase family 1 member C3 Gene Name

P42330 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (EC 1.1.1.-) (TRANS-1,2- DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE) (EC 1.3.1.20) (CHLORDECONE REDUCTASE HOMOLOG HAKRB) (HA1753) (DIHYDRODIOL DEHYDROGENASE, TYPE I) (DIHYDRODIOL DEHYDROGENASE 3) (DD3) (3-ALPHA-HYDROXYSTE	Description
ENSG00000196139	Ensembl Gene Id
AKR1C3	Display Id

AKR1C3	Uniprot Gene Name
8644	Entrez Gene Id
ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3	Uniprot Protein Name

Aldo-keto reductase family 1 member C3	Gene Name
P42330	UniProt ID

AKR1C3 Gene Record

AKR1C3 8644 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22263837

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22506594

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22263837

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22263837

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27111237

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 23432095 14996743

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10998348

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23116553 21048526 20837989

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20837989

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23116553

Sources: PharmGKB

Ensembl: ENSG00000196139

Alternate Names: AKR1C3 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000196139

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P42330

Alternate Names: AKR1C3 Uniprot Gene Name 8644 Entrez Gene Id ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 Uniprot Protein Name

Gene Info: Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level Interpro Acc IPR001395

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: AKR1C3

Alternate Names: PA24679 PharmGKB ID

Gene Info:

NCI: AKR1C3

Alternate Names:

Gene Info:

DTC: AKR1C3

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000196139

Alternate Names: ENSG00000196139 Gene Symbol AKR1C3 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Dihydrodiol dehydrogenase type I

Alternate Names: AKR1C3 TTD Gene Abbreviation T60857 TTD Target ID

Gene Info:

Publications:

Pharos: AKR1C3

Alternate Names: Aldo-keto reductase family 1 member C3 Gene Name P42330 UniProt ID

Gene Info:

Interaction Types & Directionality:

n/a

PMIDs:
22263837

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22506594

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22263837

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22263837

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
27111237

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
23432095 14996743

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10998348

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23116553 21048526 20837989

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20837989

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23116553

Sources:
PharmGKB

Alternate Names:

AKR1C3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

AKR1C3 Uniprot Gene Name

8644 Entrez Gene Id

ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR001395

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA24679 PharmGKB ID

Alternate Names:

ENSG00000196139 Gene Symbol

AKR1C3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

AKR1C3 TTD Gene Abbreviation

T60857 TTD Target ID

Alternate Names:

Aldo-keto reductase family 1 member C3 Gene Name

P42330 UniProt ID

Gene Categories:

ENZYME