DGIdb - AKR1C1 Gene Record

AKR1C1 1645 Druggable Genome

Alternate Names:

1645
ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1
AKR1C1
2-ALPHA-HSD
20-ALPHA-HSD
C9
DD1
DD1/DD2
DDH
DDH1
H-37
HAKRC
HBAB
MBAB
600449
384
ENSG00000187134
OTTHUMG00000017580
Q04828
AK1C1_HUMAN
ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 (EC 1.1.1.-) (20-ALPHA- HYDROXYSTEROID DEHYDROGENASE) (EC 1.1.1.149) (20-ALPHA-HSD) (TRANS- 1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE) (EC 1.3.1.20) (HIGH- AFFINITY HEPATIC BILE ACID-BINDING PROTEIN) (HBAB) (CHLORDEC

Gene Info:

Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR001395
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Name	Aldo/keto reductase
Interpro Short Name	Aldo/ket_red
Interpro Type	Family
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Stefane B et al., 2009, New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3., Eur J Med Chem
Rabe et al., 1985, Regulation of human placental progesterone synthesis in vitro by naturally occurring steroids., J. Steroid Biochem.
El-Kabbani O et al., 2009, Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1)., J Med Chem
El-Kabbani O et al., 2011, Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis., Bioorg Med Chem Lett
Strickler et al., 1982, 20 alpha-Hydroxysteroid dehydrogenase and 17 beta-estradiol dehydrogenase localize in cytosol of human term placenta., Am. J. Physiol.
de la Llosa-Hermier et al., 1983, Inhibitory effect of ovine and human placental lactogens on progesterone catabolism in luteinized rat ovaries in vitro., Placenta
Jones et al., 1982, Regulation of ovarian progestin production by epidermal growth factor in cultured rat granulosa cells., J. Biol. Chem.
Fukuda et al., 1986, Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta., Endocrinol. Jpn.
Tsang et al., 1989, Influence of A23187 and dibutyryl cyclic AMP on progestagen production by rat granulosa cells in vitro., J. Reprod. Fertil.
Wu et al., 1976, Luteotropic regulation of dispersed rat luteal cells in early pregnancy., Endocrinology
Higaki et al., 2003, Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone., Chem. Biol. Interact.

CHEMBL449129 AKR1C1

Interaction Score: 24.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21414777

Sources:
DTC
CHEMBL447448 AKR1C1

Interaction Score: 24.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19397269

Sources:
DTC
CHEMBL562352 AKR1C1

Interaction Score: 24.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19237229

Sources:
DTC
ESTRONE AKR1C1

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3859707

Sources:
NCI
PROGESTERONE AKR1C1

Interaction Score: 1.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6950669 6584862 6288675 3859707 3463506 2547059 179793 12604236

Sources:
NCI

Ensembl: ENSG00000187134
- Version: 101_38
Alternate Names:

AKR1C1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000187134

Version: 26-July-2011

Alternate Names:

ENSG00000187134 Ensembl Gene Id

AKR1C1 Display Id

ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 (EC 1.1.1.-) (20-ALPHA- HYDROXYSTEROID DEHYDROGENASE) (EC 1.1.1.149) (20-ALPHA-HSD) (TRANS- 1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE) (EC 1.3.1.20) (HIGH- AFFINITY HEPATIC BILE ACID-BINDING PROTEIN) (HBAB) (CHLORDEC Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q04828
- Version: 11-September-2012
Alternate Names:

ENSG00000187134 Ensembl Gene Id

ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 Uniprot Protein Name

1645 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR001395

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: AKR1C1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Rabe et al., 1985, Regulation of human placental progesterone synthesis in vitro by naturally occurring steroids., J. Steroid Biochem.

Eckstein et al., 1979, Effect of human chorionic gonadotropin and prolactin on 20 alpha-hydroxysteroid dehydrogenase activity in granulosa cells of immature rat ovary., Endocrinology

de la Llosa-Hermier et al., 1983, Inhibitory effect of ovine and human placental lactogens on progesterone catabolism in luteinized rat ovaries in vitro., Placenta

DTC: AKR1C1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

El-Kabbani O et al., 2011, Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis., Bioorg Med Chem Lett

Stefane B et al., 2009, New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3., Eur J Med Chem

El-Kabbani O et al., 2009, Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1)., J Med Chem

HingoraniCasas: ENSG00000187134
- Version: 31-May-2017
Alternate Names:

ENSG00000187134 Gene Symbol

AKR1C1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: AKR1C1
- Version: 01-February-2022
Alternate Names:

Aldo-keto reductase family 1 member C1 Gene Name

Q04828 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

ENSG00000187134	Ensembl Gene Id
AKR1C1	Display Id
ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 (EC 1.1.1.-) (20-ALPHA- HYDROXYSTEROID DEHYDROGENASE) (EC 1.1.1.149) (20-ALPHA-HSD) (TRANS- 1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE) (EC 1.3.1.20) (HIGH- AFFINITY HEPATIC BILE ACID-BINDING PROTEIN) (HBAB) (CHLORDEC	Description

Aldo-keto reductase family 1 member C1	Gene Name
Q04828	UniProt ID

AKR1C1 Gene Record

AKR1C1 1645 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CHEMBL449129 AKR1C1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21414777

Sources: DTC

CHEMBL447448 AKR1C1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19397269

Sources: DTC

CHEMBL562352 AKR1C1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19237229

Sources: DTC

ESTRONE AKR1C1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3859707

Sources: NCI

PROGESTERONE AKR1C1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6950669 6584862 6288675 3859707 3463506 2547059 179793 12604236

Sources: NCI

Ensembl: ENSG00000187134

Alternate Names: AKR1C1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000187134

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: Q04828

Alternate Names: ENSG00000187134 Ensembl Gene Id ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 Uniprot Protein Name 1645 Entrez Gene Id

Gene Info: Uniprot Evidence 1: Evidence at protein level Interpro Acc IPR001395 Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

NCI: AKR1C1

Alternate Names:

Gene Info:

DTC: AKR1C1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000187134

Alternate Names: ENSG00000187134 Gene Symbol AKR1C1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: AKR1C1

Alternate Names: Aldo-keto reductase family 1 member C1 Gene Name Q04828 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
21414777

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19397269

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19237229

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
3859707

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6950669 6584862 6288675 3859707 3463506 2547059 179793 12604236

Sources:
NCI

Alternate Names:

AKR1C1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000187134 Ensembl Gene Id

ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 Uniprot Protein Name

1645 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR001395

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000187134 Gene Symbol

AKR1C1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Aldo-keto reductase family 1 member C1 Gene Name

Q04828 UniProt ID

Gene Categories:

ENZYME