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AKR1C1 Gene Record

  • Summary
  • Interactions
  • Claims
  • AKR1C1 1645 Druggable Genome

    Alternate Names:

    1645
    ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1
    AKR1C1
    2-ALPHA-HSD
    20-ALPHA-HSD
    C9
    DD1
    DD1/DD2
    DDH
    DDH1
    H-37
    HAKRC
    HBAB
    MBAB
    600449
    384
    ENSG00000187134
    OTTHUMG00000017580
    Q04828
    AK1C1_HUMAN
    ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 (EC 1.1.1.-) (20-ALPHA- HYDROXYSTEROID DEHYDROGENASE) (EC 1.1.1.149) (20-ALPHA-HSD) (TRANS- 1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE) (EC 1.3.1.20) (HIGH- AFFINITY HEPATIC BILE ACID-BINDING PROTEIN) (HBAB) (CHLORDEC

    Gene Info:

    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001395
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Name Aldo/keto reductase
    Interpro Short Name Aldo/ket_red
    Interpro Type Family
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Stefane B et al., 2009, New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3., Eur J Med Chem
    Rabe et al., 1985, Regulation of human placental progesterone synthesis in vitro by naturally occurring steroids., J. Steroid Biochem.
    El-Kabbani O et al., 2009, Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1)., J Med Chem
    El-Kabbani O et al., 2011, Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis., Bioorg Med Chem Lett
    Strickler et al., 1982, 20 alpha-Hydroxysteroid dehydrogenase and 17 beta-estradiol dehydrogenase localize in cytosol of human term placenta., Am. J. Physiol.
    de la Llosa-Hermier et al., 1983, Inhibitory effect of ovine and human placental lactogens on progesterone catabolism in luteinized rat ovaries in vitro., Placenta
    Jones et al., 1982, Regulation of ovarian progestin production by epidermal growth factor in cultured rat granulosa cells., J. Biol. Chem.
    Fukuda et al., 1986, Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta., Endocrinol. Jpn.
    Tsang et al., 1989, Influence of A23187 and dibutyryl cyclic AMP on progestagen production by rat granulosa cells in vitro., J. Reprod. Fertil.
    Wu et al., 1976, Luteotropic regulation of dispersed rat luteal cells in early pregnancy., Endocrinology
    Higaki et al., 2003, Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone., Chem. Biol. Interact.
  • CHEMBL449129   AKR1C1

    Interaction Score: 24.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21414777


    Sources:
    DTC

  • CHEMBL447448   AKR1C1

    Interaction Score: 24.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19397269


    Sources:
    DTC

  • CHEMBL562352   AKR1C1

    Interaction Score: 24.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19237229


    Sources:
    DTC

  • ESTRONE   AKR1C1

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3859707


    Sources:
    NCI

  • PROGESTERONE   AKR1C1

    Interaction Score: 1.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6950669 6584862 6288675 3859707 3463506 2547059 179793 12604236


    Sources:
    NCI

  • Ensembl: ENSG00000187134

    • Version: 101_38

    Alternate Names:
    AKR1C1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000187134

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000187134 Ensembl Gene Id
    AKR1C1 Display Id
    ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 (EC 1.1.1.-) (20-ALPHA- HYDROXYSTEROID DEHYDROGENASE) (EC 1.1.1.149) (20-ALPHA-HSD) (TRANS- 1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE) (EC 1.3.1.20) (HIGH- AFFINITY HEPATIC BILE ACID-BINDING PROTEIN) (HBAB) (CHLORDEC Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q04828

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000187134 Ensembl Gene Id
    ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1 Uniprot Protein Name
    1645 Entrez Gene Id

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001395
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: AKR1C1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Rabe et al., 1985, Regulation of human placental progesterone synthesis in vitro by naturally occurring steroids., J. Steroid Biochem.
    Eckstein et al., 1979, Effect of human chorionic gonadotropin and prolactin on 20 alpha-hydroxysteroid dehydrogenase activity in granulosa cells of immature rat ovary., Endocrinology
    de la Llosa-Hermier et al., 1983, Inhibitory effect of ovine and human placental lactogens on progesterone catabolism in luteinized rat ovaries in vitro., Placenta

  • DTC: AKR1C1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    El-Kabbani O et al., 2011, Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis., Bioorg Med Chem Lett
    Stefane B et al., 2009, New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3., Eur J Med Chem
    El-Kabbani O et al., 2009, Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1)., J Med Chem

  • HingoraniCasas: ENSG00000187134

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000187134 Gene Symbol
    AKR1C1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: AKR1C1

    • Version: 01-February-2022

    Alternate Names:
    Aldo-keto reductase family 1 member C1 Gene Name
    Q04828 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21