DGIdb - AHR Gene Record

AHR 196 Druggable Genome

Alternate Names:

196
ARYL HYDROCARBON RECEPTOR
AHR
bHLHe76
600253
348
ENSG00000106546
ENSG00000283321
OTTHUMG00000149967
OTTHUMG00000191686
P35869
PA24641
AC019117.3
T23666
RP85

Gene Info:

Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR COMPLEX
NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Koyano S et al., 2005, Functional analysis of six human aryl hydrocarbon receptor variants in a Japanese population., Drug Metab Dispos
Dzeletovic N et al., 1997, Regulation of dioxin receptor function by omeprazole., J Biol Chem
Mezrich JD et al., 2012, SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation., PLoS One
Murata M et al., 2004, An electrochemical device for the assay of the interaction between a dioxin receptor and its various ligands., Bioorg Med Chem Lett
Zhang S et al., 2003, Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context., Environ Health Perspect
Söderberg MM et al., 2013, Influence of CYP1A1/CYP1A2 and AHR polymorphisms on systemic olanzapine exposure., Pharmacogenet Genomics
Liu J et al., 2015, A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2., J Med Chem
Gasiewicz TA et al., 1991, Alpha-naphthoflavone acts as an antagonist of 2,3,7, 8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor., Mol Pharmacol
Klinge CM et al., 2000, The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1., Arch Biochem Biophys
de Medina P et al., 2005, Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators., J Med Chem
Monk et al., 2001, Transient expression of CYP1A1 in rat epithelial cells cultured in suspension., Arch. Biochem. Biophys.

2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN AHR

Interaction Score: 2.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14684315

Sources:
DTC
BETA-NAPHTHOFLAVONE AHR

Interaction Score: 1.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14684315 26222195 1658599 10620335

Sources:
DTC
METHYLCELLULOSE AHR

Interaction Score: 1.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11516172

Sources:
NCI
CHEMBL541230 AHR

Interaction Score: 1.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUINALPHOS AHR

Interaction Score: 1.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZO[DEF]CHRYSENE AHR

Interaction Score: 1.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14684315

Sources:
DTC
CHEMBL597452 AHR

Interaction Score: 1.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL57394 AHR

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHABENZTHIAZURON AHR

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RIMSULFURON AHR

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PYRAFLUFEN-ETHYL AHR

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL295337 AHR

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL26138 AHR

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LINURON AHR

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIFLUBENZURON AHR

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DESMEDIPHAM AHR

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SALICYLANILIDE AHR

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHRYSENE AHR

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALDICARB AHR

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1873684 AHR

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYPRODINIL AHR

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
YANGONIN AHR

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZOFURAN AHR

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPHENYLUREA AHR

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICHLON AHR

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL70582 AHR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIMETHYL YELLOW AHR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
3-METHYLCHOLANTHRENE AHR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DESMETHOXYYANGONIN AHR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL538965 AHR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL77675 AHR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLAVONE AHR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROMIPLOSTIM AHR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22970246

Sources:
TTD
1-NAPHTHYLISOTHIOCYANATE AHR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NAPHTHOQUINONE AHR

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUESTIOMYCIN B AHR

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIBENZ[A,H]ANTHRACENE AHR

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
THIABENDAZOLE AHR

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL84685 AHR

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARBARIL AHR

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZO[B]FLUORANTHENE AHR

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL375270 AHR

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COLFORSIN AHR

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LEVOTHYROXINE AHR

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MICHLER'S KETONE AHR

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZO(K)FLUORANTHENE AHR

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIPERINE AHR

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL329673 AHR

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OMEPRAZOLE AHR

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
15860653 9139728

Sources:
PharmGKB
NITAZOXANIDE AHR

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EMODIN AHR

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
14644660

Sources:
DTC
PENTACHLOROPHENOL AHR

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHRYSIN AHR

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENAZOPYRIDINE HYDROCHLORIDE AHR

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLIOQUINOL AHR

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL AHR

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15634023

Sources:
DTC
NICLOSAMIDE AHR

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OLANZAPINE AHR

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23492908

Sources:
PharmGKB
GENISTEIN AHR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000283321
- Version: 101_38
Alternate Names:

AC019117.3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
Ensembl: ENSG00000106546
- Version: 101_38
Alternate Names:

AHR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: AHR

Version: 18-August-2020

Alternate Names:

PA24641 PharmGKB ID

Gene Info:

Publications:

Söderberg MM et al., 2013, Influence of CYP1A1/CYP1A2 and AHR polymorphisms on systemic olanzapine exposure., Pharmacogenet Genomics

Kawajiri K et al., 2007, Cytochrome P450 gene regulation and physiological functions mediated by the aryl hydrocarbon receptor., Arch Biochem Biophys

Koyano S et al., 2005, Functional analysis of six human aryl hydrocarbon receptor variants in a Japanese population., Drug Metab Dispos

TTD: Aryl hydrocarbon receptor
- Version: 2020.06.01
Alternate Names:

AHR TTD Gene Abbreviation

T23666 TTD Target ID

Gene Info:

Publications:

Mezrich JD et al., 2012, SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation., PLoS One
NCI: AHR
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Monk et al., 2001, Transient expression of CYP1A1 in rat epithelial cells cultured in suspension., Arch. Biochem. Biophys.

DTC: AHR

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Murata M et al., 2004, An electrochemical device for the assay of the interaction between a dioxin receptor and its various ligands., Bioorg Med Chem Lett

Liu J et al., 2015, A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2., J Med Chem

HingoraniCasas: ENSG00000106546
- Version: 31-May-2017
Alternate Names:

ENSG00000106546 Gene Symbol

AHR Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: AHR
- Version: 01-February-2022
Alternate Names:

BHLHE76 GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX, NUCLEAR HORMONE RECEPTOR

Publications:
Pharos: AHR
- Version: 01-February-2022
Alternate Names:

Aryl hydrocarbon receptor Gene Name

P35869 UniProt ID

Gene Info:

Gene Categories:

ENZYME, TRANSCRIPTION FACTOR

Publications:

AHR Gene Record

AHR 196 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14684315

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14684315 26222195 1658599 10620335

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11516172

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14684315

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
14684315

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
14684315 26222195 1658599 10620335

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
11516172

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
14684315

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found