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AGTR1 Gene Record

  • Summary
  • Interactions
  • Claims
  • AGTR1 185 Druggable Genome

    Alternate Names:

    185
    ANGIOTENSIN II RECEPTOR TYPE 1
    AGTR1
    AG2S
    AGTR1B
    AT1
    AT1AR
    AT1B
    AT1BR
    AT1R
    AT2R1
    HAT1R
    106165
    336
    ENSG00000144891
    OTTHUMG00000159503
    P30556
    AGTR1_HUMAN
    AGTR1A
    AT2R1B
    Type-1 angiotensin II receptor
    Angiotensin II type-1 receptor
    34
    AT<sub>1</sub> receptor
    TYPE-1 ANGIOTENSIN II RECEPTOR (AT1) (AT1AR). [SOURCE:UNIPROT/SWISSPROT;ACC:P30556]
    NP_000676
    NM_000685
    PA43
    BE0000062
    Angiotensin II receptor type-1
    T74456
    AT2R1A

    Gene Info:

    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Subclass GPCR
    Target Main Class Receptors
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category Name Angiotensin receptors
    GuideToPharmacology Gene Category ID 6
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    (11 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Unger, 2001, Pharmacology of AT1-receptor blockers., Blood Press Suppl
    Elokdah et al., 2002, Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects., Bioorg. Med. Chem. Lett.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Maillard et al., 2000, Tasosartan, enoltasosartan, and angiotensin II receptor blockade: the confounding role of protein binding., J. Pharmacol. Exp. Ther.
    Rocha et al., 2003, Angiotensin AT1 receptor antagonist losartan and the defence reaction in the anaesthetised rat. Effect on the carotid chemoreflex., Exp. Physiol.
    Dickstein et al., 1998, Losartan: a selective angiotensin II type 1 (AT1) receptor antagonist for the treatment of heart failure., Expert Opin Investig Drugs
    Anand-Srivastava et al., 2003, Angiotensin-II-induced enhanced expression of Gi proteins is attenuated by losartan in A10 vascular smooth muscle cells: role of AT1 receptors., Can. J. Physiol. Pharmacol.
    Ismail MA et al., 2006, Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT1 receptor antagonists., J Med Chem
    Sookoian S et al., 2005, A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension., Am J Gastroenterol
    Miller JA et al., 1999, Angiotensin II type 1 receptor gene polymorphism predicts response to losartan and angiotensin II., Kidney Int
    Arsenault J et al., 2010, A single-nucleotide polymorphism of alanine to threonine at position 163 of the human angiotensin II type 1 receptor impairs Losartan affinity., Pharmacogenet Genomics
    Sardo et al., Effects of AT1 receptor antagonist losartan on sICAM-1 and TNF-alpha levels in uncomplicated hypertensive patients., Angiology
    Guan et al., 2004, [The effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats]., Sichuan Da Xue Xue Bao Yi Xue Ban
    Usune et al., 1996, Effects of SC-52458, a new nonpeptide angiotensin II receptor antagonist, on increase in cytoplasmic Ca2+ concentrations and contraction induced by angiotensin II and K(+)-depolarization in guinea-pig taenia coli., Gen. Pharmacol.
    Hagmann et al., 1997, SC-52458, an orally active angiotensin II-receptor antagonist: inhibition of blood pressure response to angiotensin II challenges and pharmacokinetics in normal volunteers., J. Cardiovasc. Pharmacol.
    Tokunaga et al., 2001, Possible involvement of calcium-calmodulin pathways in the positive chronotropic response to angiotensin II on the canine cardiac sympathetic ganglia., Jpn. J. Pharmacol.
    Wassmann et al., 2001, Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase., Mol. Pharmacol.
    Wu, From bedside to bench drug-induced tubulointerstitial disease cyclosporine nephropathy study from models of cultured renal epithelial cells., Chang Gung Med J
    van den Meiracker et al., 1995, Hemodynamic and biochemical effects of the AT1 receptor antagonist irbesartan in hypertension., Hypertension
    Morsing et al., 1999, Mechanistic differences of various AT1-receptor blockers in isolated vessels of different origin., Hypertension
    Adams et al., 2000, Irbesartan: review of pharmacology and comparative properties., Can J Clin Pharmacol
    Croom et al., 2004, Irbesartan: a review of its use in hypertension and in the management of diabetic nephropathy., Drugs
    Martin et al., 2004, Lesion progression in apoE-deficient mice: implication of chemokines and effect of the AT1 angiotensin II receptor antagonist irbesartan., J. Cardiovasc. Pharmacol.
    Croom et al., 2008, Irbesartan: a review of its use in hypertension and diabetic nephropathy., Drugs
    Carraway et al., 1999, Comparison of irbesartan with captopril effects on cardiac hypertrophy and gene expression in heart failure-prone male SHHF/Mcc-fa(cp) rats., J. Cardiovasc. Pharmacol.
    Hope et al., 1999, Comparison of the effects of AT1 receptor blockade and angiotensin converting enzyme inhibition on atherosclerosis., Am. J. Hypertens.
    Dol et al., 2001, Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice., J. Cardiovasc. Pharmacol.
    Waeber et al., 2003, AT1-receptor antagonism in hypertension: what has been learned with irbesartan?, Expert Rev Cardiovasc Ther
    Voigt et al., 2007, Hypophagic effect of the angiotensin AT1 receptor antagonist irbesartan in rats., Eur. J. Pharmacol.
    Mazzolai et al., 1999, Angiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists., Hypertension
    Timmermans, 1999, Pharmacological properties of angiotensin II receptor antagonists., Can J Cardiol
    Uemura et al., 2006, Renin-angiotensin system is an important factor in hormone refractory prostate cancer., Prostate
    Nap et al., 2003, Pre- and postsynaptic inhibitory potencies of the angiotensin AT1 receptor antagonists eprosartan and candesartan., Eur. J. Pharmacol.
    Suzuki et al., 2003, Effects of the AT1-receptor antagonist eprosartan on the progression of left ventricular dysfunction in dogs with heart failure., Br. J. Pharmacol.
    Ruilope et al., 2003, Eprosartan for the treatment of hypertension., Expert Opin Pharmacother
    Puig et al., 2002, Clinical profile of eprosartan., Cardiovasc Drugs Ther
    de la Sierra et al., 2007, Introduction: The pharmacological profile of eprosartan--implications for cerebrovascular and cardiovascular risk reduction., Curr Med Res Opin
    Heusser et al., 2003, AT1 antagonism by eprosartan lowers heart rate variability and baroreflex gain., Auton Neurosci
    Hedner, 2002, The clinical profile of the angiotensin II receptor blocker eprosartan., J Hypertens Suppl
    Murdoch et al., 2001, ADEPT: Addition of the AT1 receptor antagonist eprosartan to ACE inhibitor therapy in chronic heart failure trial: hemodynamic and neurohormonal effects., Am. Heart J.
    Gremmler et al., 2000, Improvement of cardiac output in patients with severe heart failure by use of ACE-inhibitors combined with the AT1-antagonist eprosartan., Eur. J. Heart Fail.
    Ilson et al., 1998, The effects of eprosartan, an angiotensin II AT1 receptor antagonist, on uric acid excretion in patients with mild to moderate essential hypertension., J Clin Pharmacol
    Criscione et al., 1993, Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype., Br. J. Pharmacol.
    Shargorodsky et al., 2002, Prolonged treatment with the AT1 receptor blocker, valsartan, increases small and large artery compliance in uncomplicated essential hypertension., Am. J. Hypertens.
    de Gasparo et al., 1995, Binding of valsartan to mammalian angiotensin AT1 receptors., Regul. Pept.
    Azizi et al., 2004, Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption., J. Am. Soc. Nephrol.
    Siragy et al., 2002, Differences in AT2 -receptor stimulation between AT1 -receptor blockers valsartan and losartan quantified by renal interstitial fluid cGMP., J. Hypertens.
    Kreutz et al., 2006, Pharmacokinetics of olmesartan medoxomil plus hydrochlorothiazide combination in healthy subjects., Clin Drug Investig
    Koike et al., 2001, In vitro and in vivo pharmacology of olmesartan medoxomil, an angiotensin II type AT1 receptor antagonist., J Hypertens Suppl
    Mire et al., 2005, A review of the structural and functional features of olmesartan medoxomil, an angiotensin receptor blocker., J. Cardiovasc. Pharmacol.
    Ochiai et al., 2006, Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling., J. Cardiovasc. Pharmacol.
    Warner et al., 2002, Olmesartan medoxomil., Drugs
    Rogers et al., 2007, Effect of sex hormones on renal estrogen and angiotensin type 1 receptors in female and male rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Volkan-Salanci B et al., 2009, Impact of renin-angiotensin system polymorphisms on renal haemodynamic responsiveness to acute angiotensin-converting enzyme inhibition in type 2 diabetes mellitus., J Renin Angiotensin Aldosterone Syst
    Malmqvist et al., 2000, Angiotensin II type 1 (AT1) receptor blockade in hypertensive women: benefits of candesartan cilexetil versus enalapril or hydrochlorothiazide., Am. J. Hypertens.
    Meredith, 2007, Candesartan cilexetil--a review of effects on cardiovascular complications in hypertension and chronic heart failure., Curr Med Res Opin
    Wada et al., 1996, Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats., Hypertens. Res.
    Engelhorn et al., 2006, Reduction of cerebral infarct size by the AT1-receptor blocker candesartan, the HMG-CoA reductase inhibitor rosuvastatin and their combination. An experimental study in rats., Neurosci. Lett.
    Baguet et al., 2009, Candesartan cilexetil in the treatment of chronic heart failure., Vasc Health Risk Manag
    Mendis et al., 2009, Candesartan: widening indications for this angiotensin II receptor blocker?, Expert Opin Pharmacother
    de Denus S et al., 2008, Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan., Ann Pharmacother
    Caballero-George et al., 2003, In vitro effect of sanguinarine alkaloid on binding of [3H]candesartan to the human angiotensin AT1 receptor., Eur. J. Pharmacol.
    McInnes et al., 2000, Comparison of the AT1-receptor blocker, candesartan cilexetil, and the ACE inhibitor, lisinopril, in fixed combination with low dose hydrochlorothiazide in hypertensive patients., J Hum Hypertens
    Vauquelin et al., 2006, Long-lasting angiotensin type 1 receptor binding and protection by candesartan: comparison with other biphenyl-tetrazole sartans., J Hypertens Suppl
    Cervenka et al., 1999, Renal responses of the nonclipped kidney of two-kidney/one-clip Goldblatt hypertensive rats to type 1 angiotensin II receptor blockade with candesartan., J. Am. Soc. Nephrol.
    Liakos et al., 1997, ANG II AT1 and AT2 receptors both inhibit bFGF-induced proliferation of bovine adrenocortical cells., Am. J. Physiol.
    McClellan et al., 1998, Telmisartan., Drugs
    Gohlke et al., 2001, AT1 receptor antagonist telmisartan administered peripherally inhibits central responses to angiotensin II in conscious rats., J. Pharmacol. Exp. Ther.
    Yamagishi et al., 2005, Telmisartan is a promising cardiometabolic sartan due to its unique PPAR-gamma-inducing property., Med. Hypotheses
    Tagami et al., 2009, A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones., Endocrinology
    Sharpe et al., 2001, Telmisartan: a review of its use in hypertension., Drugs
    Imayama et al., 2006, Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma., Cardiovasc. Res.
    Fujimoto et al., 2004, An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3-L1 adipocytes., FEBS Lett.
    Karlberg et al., 1999, Efficacy and safety of telmisartan, a selective AT1 receptor antagonist, compared with enalapril in elderly patients with primary hypertension. TEES Study Group., J. Hypertens.
    Balt et al., 2001, Effect of the AT1-receptor antagonists losartan, irbesartan, and telmisartan on angiotensin II-induced facilitation of sympathetic neurotransmission in the rat mesenteric artery., J. Cardiovasc. Pharmacol.
    Galzerano et al., 2010, New standards in hypertension and cardiovascular risk management: focus on telmisartan., Vasc Health Risk Manag
    Strohmenger et al., 1997, Effects of the AT1-selective angiotensin II antagonist, telmisartan, on hemodynamics and ventricular function after cardiopulmonary resuscitation in pigs., Resuscitation
    Yamagishi et al., 2007, Potential utility of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-modulating activity for the treatment of cardiometabolic disorders., Curr. Mol. Med.
    Kurtz, 2008, Beyond the classic angiotensin-receptor-blocker profile., Nat Clin Pract Cardiovasc Med
    Tamura et al., 1999, Renin-angiotensin system and fibronectin gene expression in Dahl Iwai salt-sensitive and salt-resistant rats., J. Hypertens.
    Bäumer et al., 2001, Reduction of oxidative stress and AT1 receptor expression by the selective oestrogen receptor modulator idoxifene., Br. J. Pharmacol.
    Brugts JJ et al., 2010, Tailored therapy of ACE inhibitors in stable coronary artery disease: pharmacogenetic profiling of treatment benefit., Pharmacogenomics
    Benetos A et al., 1996, Influence of the angiotensin II type 1 receptor gene polymorphism on the effects of perindopril and nitrendipine on arterial stiffness in hypertensive individuals., Hypertension
    Leduc et al., 1995, Involvement of a tyrosine kinase pathway in the growth-promoting effects of angiotensin II on aortic smooth muscle cells., Mol. Pharmacol.
    Cheng et al., 1998, Young SHR express increased type 1 angiotensin II receptors in renal proximal tubule., Am. J. Physiol.
    Kim JH et al., 2012, Fimasartan, a novel angiotensin II receptor antagonist., Arch Pharm Res
  • EPROSARTAN   AGTR1

    Interaction Score: 17.82

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    12782193 12540520 12517247 12766389 18093407 11752352 12927226 12184062 11320369 10856732 9602957


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • FORASARTAN   AGTR1

    Interaction Score: 8.91

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8981065 9156352 11569611 11752352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • VALSARTAN   AGTR1

    Interaction Score: 6.68

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    8242249 12460705 8577935 15579516 12023686 11752352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • SAPRISARTAN   AGTR1

    Interaction Score: 6.68

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10579749 11752352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • OLMESARTAN   AGTR1

    Interaction Score: 6.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Direct Interaction? True
    Specific Action of the Ligand Antagonist

    PMIDs:
    17163232 11451212 16220064 11752352 16775509 12076183


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • TASOSARTAN   AGTR1

    Interaction Score: 5.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Antagonist

    PMIDs:
    11683476 12113820 11752352 11046101


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • AZILSARTAN   AGTR1

    Interaction Score: 4.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name azilsartan medoxomil, TAK-491
    Novel drug target Established target
    Mechanism of Interaction Type-1 angiotensin II receptor antagonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD GuideToPharmacology ChemblInteractions

  • TELMISARTAN   AGTR1

    Interaction Score: 2.78

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name telmisartan,Micardis, Micardis HCT
    Novel drug target Established target
    Specific Action of the Ligand Antagonist

    PMIDs:
    9878991 11408526 15617852 19147680 11558835 16938288 15498586 10067800 11444497 20448797 9259062 11752352 17691961 18580862


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • FIMASARTAN   AGTR1

    Interaction Score: 2.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    22864732


    Sources:
    DrugBank

  • CANDESARTAN   AGTR1

    Interaction Score: 2.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    10826401 17588300 10968199 16901636 19436650 19563275 11752352 18594050 12504781 10805052 16601569 9892163


    Sources:
    TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • LOSARTAN   AGTR1

    Interaction Score: 2.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    12719755 15991937 12710529 16509571 15743363 10594793 20436376 15026875 11752352 15573751


    Sources:
    TEND DTC PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • IRBESARTAN   AGTR1

    Interaction Score: 1.76

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    7843749 10373224 10822210 15101793 14716205 18627212 11752352 10069682 10075381 11486244 15030294 17408613 10082498


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • LOSARTAN POTASSIUM   AGTR1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Type-1 angiotensin II receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CL-329167   AGTR1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • AZILSARTAN MEDOXOMIL   AGTR1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SARALASIN ACETATE   AGTR1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Type-1 angiotensin II receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • EPROSARTAN MESYLATE   AGTR1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Type-1 angiotensin II receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL347610   AGTR1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SPARSENTAN   AGTR1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology ChemblInteractions

  • CHEMBL400912   AGTR1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZILSARTAN KAMEDOXOMIL   AGTR1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Type-1 angiotensin II receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PERINDOPRIL   AGTR1

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20712529 8952600


    Sources:
    PharmGKB

  • SARALASIN   AGTR1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OLMESARTAN MEDOXOMIL   AGTR1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Type-1 angiotensin II receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IDOXIFENE   AGTR1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11588112


    Sources:
    NCI

  • PRATOSARTAN   AGTR1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Type-1 angiotensin II receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • CHEMBL1972216   AGTR1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1445650   AGTR1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL421088   AGTR1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYT006-ANGQB   AGTR1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • CHEMBL2094484   AGTR1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL261693   AGTR1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1390716   AGTR1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CANDESARTAN CILEXETIL   AGTR1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Type-1 angiotensin II receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VOLANESORSEN SODIUM   AGTR1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10100098


    Sources:
    NCI

  • CHEMBL1492017   AGTR1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NITRENDIPINE   AGTR1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8952600


    Sources:
    PharmGKB

  • CHEMBL591834   AGTR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ANDROSTANOLONE   AGTR1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16990489 16482568


    Sources:
    NCI

  • CAPTOPRIL   AGTR1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19286758


    Sources:
    PharmGKB

  • CHEMBL125044   AGTR1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL586135   AGTR1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL528694   AGTR1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HELENALIN   AGTR1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LEVODOPA   AGTR1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9458818


    Sources:
    NCI

  • INDOMETHACIN   AGTR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9357777


    Sources:
    NCI

  • ATORVASTATIN   AGTR1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11179461


    Sources:
    NCI PharmGKB

  • GENISTEIN   AGTR1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7476882


    Sources:
    NCI

  • CYCLOSPORINE   AGTR1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17477024


    Sources:
    NCI

  • DISULFIRAM   AGTR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DEXAMETHASONE   AGTR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16482568


    Sources:
    NCI

  • Ensembl: ENSG00000144891

    • Version: 101_38

    Alternate Names:
    AGTR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P30556

    • Version: 01-August-2011

    Alternate Names:
    P30556 Uniprot Accession
    185 Entrez Gene Id
    AGTR1_HUMAN Uniprot Id

    Gene Info:
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Subclass GPCR

    Publications:

  • HopkinsGroom: P30556

    • Version: 11-September-2012

    Alternate Names:
    TYPE-1 ANGIOTENSIN II RECEPTOR Uniprot Protein Name
    185 Entrez Gene Id
    AGTR1 Uniprot Gene Name

    Gene Info:
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Human Readable Name G PROTEIN COUPLED RECEPTOR

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000144891

    • Version: 26-July-2011

    Alternate Names:
    AGTR1 Display Id
    ENSG00000144891 Ensembl Gene Id
    TYPE-1 ANGIOTENSIN II RECEPTOR (AT1) (AT1AR). [SOURCE:UNIPROT/SWISSPROT;ACC:P30556] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P30556

    • Version: January-2014

    Alternate Names:
    AGTR1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • GuideToPharmacology: 185

    • Version: 29-September-2020

    Alternate Names:
    336 HUGO Gene ID
    336 HUGO Gene Symbol
    angiotensin II receptor type 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Angiotensin receptors
    GuideToPharmacology Gene Category ID 6

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • PharmGKB: AGTR1

    • Version: 18-August-2020

    Alternate Names:
    PA43 PharmGKB ID

    Gene Info:

    Publications:
    de Denus S et al., 2008, Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan., Ann Pharmacother
    Bozkurt O et al., 2009, Variation in Renin-Angiotensin system and salt-sensitivity genes and the risk of diabetes mellitus associated with the use of thiazide diuretics., Am J Hypertens
    Lee JK et al., 2013, Genetic variation-optimized treatment benefit of angiotensin-converting enzyme inhibitors in patients with stable coronary artery disease: a 12-year follow-up study., Pharmacogenet Genomics

  • DrugBank: BE0000062

    • Version: 5.1.7

    Alternate Names:
    AGTR1 DrugBank Gene Name
    P30556 UniProt Accession
    185 Entrez Gene Id

    Gene Info:

    Publications:
    Criscione et al., 1993, Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype., Br. J. Pharmacol.
    Shargorodsky et al., 2002, Prolonged treatment with the AT1 receptor blocker, valsartan, increases small and large artery compliance in uncomplicated essential hypertension., Am. J. Hypertens.
    de Gasparo et al., 1995, Binding of valsartan to mammalian angiotensin AT1 receptors., Regul. Pept.

  • NCI: AGTR1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Wu, From bedside to bench drug-induced tubulointerstitial disease cyclosporine nephropathy study from models of cultured renal epithelial cells., Chang Gung Med J
    Uemura et al., 2006, Renin-angiotensin system is an important factor in hormone refractory prostate cancer., Prostate
    Wassmann et al., 2001, Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase., Mol. Pharmacol.

  • DTC: AGTR1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Ismail MA et al., 2006, Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT1 receptor antagonists., J Med Chem

  • HingoraniCasas: ENSG00000144891

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000144891 Gene Symbol
    AGTR1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: AGTR1A

    • Version: chembl_23

    Alternate Names:
    AGTR1B GENE_SYMBOL
    AT2R1 GENE_SYMBOL
    AT2R1B GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: AGTR1

    • Version: 05-September-2020

    Alternate Names:
    AGTR1A GO Gene Synonym
    AGTR1B GO Gene Synonym
    AT2R1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: AGTR1

    • Version: 27-Jun-2013

    Alternate Names:
    185 Gene ID
    AG2S dGene Synonym
    AGTR1A dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Angiotensin II receptor type-1

    • Version: 2020.06.01

    Alternate Names:
    AGTR1 TTD Gene Abbreviation
    T74456 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21