DGIdb - ADRB2 Gene Record

ADRB2 154 Druggable Genome

Alternate Names:

154
ADRENOCEPTOR BETA 2
ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
109690
286
ENSG00000169252
OTTHUMG00000129933
Beta-2 adrenergic receptor
Beta-2 adrenoreceptor
Beta-2 adrenoceptor
BETA-2 ADRENERGIC RECEPTOR (BETA-2 ADRENOCEPTOR) (BETA-2 ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P07550]
PA39
P07550
ADRB2_HUMAN
Adrenergic receptor beta-2
T52522

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Target Subclass	GPCR
Transmembrane Helix Count	7
Target Subclass	Rhodopsin
Target Main Class	Receptors
Interpro Acc	IPR000276
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Type	Family
Uniprot Status	Swiss-Prot
Target Class	Receptors
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

KINASE
G PROTEIN COUPLED RECEPTOR
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Abrahamsson, 1986, The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat., Br. J. Pharmacol.
Brodde et al., 1986, Effect of propranolol, alprenolol, pindolol, and bopindolol on beta 2-adrenoceptor density in human lymphocytes., J. Cardiovasc. Pharmacol.
Brodde et al., 1985, Effects of beta-adrenoceptor antagonist administration on beta 2-adrenoceptor density in human lymphocytes. The role of the "intrinsic sympathomimetic activity"., Naunyn Schmiedebergs Arch. Pharmacol.
el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
Tarizzo et al., 1994, Pre- and postganglionic stimulation-induced noradrenaline overflow is markedly facilitated by a prejunctional beta 2-adrenoceptor-mediated control mechanism in the pithed rat., Naunyn Schmiedebergs Arch. Pharmacol.
Mersmann, 1998, Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action., J. Anim. Sci.
El-Armouche et al., 2009, Beta-adrenergic stimulation and myocardial function in the failing heart., Heart Fail Rev
Sanders, 1998, The role of norepinephrine and beta-2-adrenergic receptor stimulation in the modulation of Th1, Th2, and B lymphocyte function., Adv. Exp. Med. Biol.
Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
Joseph et al., 2004, Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers., Naunyn Schmiedebergs Arch. Pharmacol.
Yalcin et al., 2009, beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain., Ann. Neurol.
Doggrell, 1993, The effects of (+/-)-, (+)-, and (-)-atenolol, sotalol, and amosulalol on the rat left atria and portal vein., Chirality
Lowe et al., 2002, Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium., Br. J. Pharmacol.
Juberg et al., 1985, Beta 1- and beta 2-adrenoceptor binding and functional response in right and left atria of rat heart., Naunyn Schmiedebergs Arch. Pharmacol.
Prinz et al., 2001, beta-adrenergic receptor stimulation selectively inhibits IL-12p40 release in microglia., Brain Res.
Sekut et al., 1995, Anti-inflammatory activity of salmeterol: down-regulation of cytokine production., Clin. Exp. Immunol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Fujita et al., 1998, Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor., Neurosci. Lett.
Wheeldon et al., 1994, The effects of lower than conventional doses of oral nadolol on relative beta 1/beta 2-adrenoceptor blockade., Br J Clin Pharmacol
Liu et al., 1995, Contribution of beta 3-adrenoceptor activation to ephedrine-induced thermogenesis in humans., Int. J. Obes. Relat. Metab. Disord.
Wheeldon et al., 1992, Evaluation of in vivo partial beta 1/beta 2-agonist activity: a dose-ranging study with carteolol., Br J Clin Pharmacol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Ozakca et al., 2007, Role of beta-3-adrenoceptor in catecholamine-induced relaxations in gastric fundus from control and diabetic rats., Pharmacology
Varma et al., 1999, Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium., Br. J. Pharmacol.
Brogden et al., Salmeterol xinafoate: a review of its pharmacological properties and therapeutic potential in reversible obstructive airways disease., Allergol Immunopathol (Madr)
Finney et al., 2001, Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha)., Br. J. Pharmacol.
Rong et al., 1999, Probing the salmeterol binding site on the beta 2-adrenergic receptor using a novel photoaffinity ligand, [(125)I]iodoazidosalmeterol., Biochemistry
Green et al., 2001, The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s)., Eur. J. Pharmacol.
Meliton et al., 2003, Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils., J. Allergy Clin. Immunol.
Zuurhout MJ et al., 2013, Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: results of the PACMAN cohort., Pharmacogenomics
Lipworth BJ et al., 2013, Tailored second-line therapy in asthmatic children with the Arg(16) genotype., Clin Sci (Lond)
Wechsler ME et al., 2009, Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial., Lancet
Basu K et al., 2009, Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol., J Allergy Clin Immunol
Bleecker ER et al., 2007, Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies., Lancet
Israel E et al., 2004, Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial., Lancet
Cazzola M et al., 2002, Clinical pharmacokinetics of salmeterol., Clin Pharmacokinet
MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
Rouget et al., 2006, Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia., Biol. Reprod.
Isaza et al., 2005, Polymorphic variants of the beta2-adrenergic receptor (ADRB2) gene and ADRB2-related propanolol-induced dyslipidemia in the Colombian population., Methods Find Exp Clin Pharmacol
Horinouchi et al., 2007, Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol., Life Sci.
Illingworth et al., 2006, Classical polarization in hybrid QM/MM methods., J Phys Chem A
Rosendorff, 1993, Beta-blocking agents with vasodilator activity., J Hypertens Suppl
Doggrell, 1988, Relaxant and beta 2-adrenoceptor blocking activities of labetalol, dilevalol, amosulalol and KF-4317 on the rat isolated aorta., J. Pharm. Pharmacol.
Sassard et al., 1983, [Comparative effects of an alpha 1 and beta 1-2 blocker (labetalol) and a beta-1 blocker (atenolol) in the hypertensive patient]., J Pharmacol
Doggrell, 1992, The effects of labetalol and dilevalol on isolated cardiovascular preparations of the guinea-pig and rat., J. Pharm. Pharmacol.
van Zwieten, 1993, An overview of the pharmacodynamic properties and therapeutic potential of combined alpha- and beta-adrenoceptor antagonists., Drugs
Pujos et al., 2009, Comparison of the analysis of beta-blockers by different techniques., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Ferro et al., 1997, A prospective study of the effects of prolonged timolol therapy on alpha- and beta-adrenoceptor and angiotensin II receptor mediated responses in normal subjects., Br J Clin Pharmacol
Fuchsjager-Mayrl et al., 2005, Polymorphism of the beta-2 adrenoceptor and IOP lowering potency of topical timolol in healthy subjects., Mol. Vis.
Borger et al., 1998, Beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype., Am. J. Respir. Cell Mol. Biol.
Rotmensch et al., 1993, Comparisons of beta-adrenergic blocking properties of S- and R-timolol in humans., J Clin Pharmacol
Van der Graaf et al., 1995, Exposure and characterization of the action of noradrenaline at dopamine receptors mediating endothelium-independent relaxation of rat isolated small mesenteric arteries., Br. J. Pharmacol.
Chong et al., 2003, Desensitization of beta2-adrenoceptor-mediated responses by short-acting beta2-adrenoceptor agonists in human lung mast cells., Br. J. Pharmacol.
Hochhaus et al., 1992, Pharmacokinetic/pharmacodynamic characteristics of the beta-2-agonists terbutaline, salbutamol and fenoterol., Int J Clin Pharmacol Ther Toxicol
Cooperberg et al., 2008, Terbutaline and the prevention of nocturnal hypoglycemia in type 1 diabetes., Diabetes Care
Riether et al., 2011, Stimulation of β₂-adrenergic receptors inhibits calcineurin activity in CD4(+) T cells via PKA-AKAP interaction., Brain Behav. Immun.
Ramer-Quinn et al., 2000, Cytokine production by naive and primary effector CD4+ T cells exposed to norepinephrine., Brain Behav. Immun.
Schäfers et al., 1999, Disodium cromoglycate does not prevent terbutaline-induced desensitization of beta 2-adrenoceptor-mediated cardiovascular in vivo functions in human volunteers., J. Cardiovasc. Pharmacol.
Haahtela et al., 1991, Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma., N. Engl. J. Med.
Nakamura et al., 2001, Activation of beta(2)-adrenoceptor prevents shiga toxin 2-induced TNF-alpha gene transcription., J. Am. Soc. Nephrol.
Zetterlund et al., 2001, beta2-Adrenoceptor desensitization in human alveolar macrophages induced by inhaled terbutaline in vivo is not counteracted by budesonide., Clin. Sci.
Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg
Dishy V et al., 2001, The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization., N Engl J Med
Sato et al., 2004, Loss of beta-adrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger., J. Mol. Cell. Cardiol.
Angers et al., 2001, Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells., Life Sci.
Ding et al., 2000, Modulation of porcine adipocyte beta-adrenergic receptors by a beta-adrenergic agonist., J. Anim. Sci.
Skoumbourdis AP et al., 2009, Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors., Bioorg Med Chem Lett
Ahlquist, 1976, Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor., Am. Heart J.
Jones et al., 2003, Enhanced beta2-adrenergic receptor (beta2AR) signaling by adeno-associated viral (AAV)-mediated gene transfer., BMC Pharmacol.
Odley et al., 2004, Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling., Proc. Natl. Acad. Sci. U.S.A.
Uezono et al., 2004, Involvement of G protein betagamma-subunits in diverse signaling induced by G(i/o)-coupled receptors: study using the Xenopus oocyte expression system., Am. J. Physiol., Cell Physiol.
Teixeira et al., 2004, Atypical beta-adrenoceptor subtypes mediate relaxations of rabbit corpus cavernosum., J. Pharmacol. Exp. Ther.
Abraham et al., 2003, Pharmacological and biochemical characterization of the beta-adrenergic signal transduction pathway in different segments of the respiratory tract., Biochem. Pharmacol.
Bandaru S et al., 2017, Molecular dynamic simulations reveal suboptimal binding of salbutamol in T164I variant of β2 adrenergic receptor., PLoS One
Brichetto et al., 2003, Beclomethasone rapidly ablates allergen-induced beta 2-adrenoceptor pathway dysfunction in human isolated bronchi., Am. J. Physiol. Lung Cell Mol. Physiol.
Brouri et al., 2004, Blockade of beta 1- and desensitization of beta 2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis., Eur. J. Pharmacol.
Yamanishi et al., 2003, Role of beta-adrenoceptor subtypes in mediating relaxation of the pig bladder trigonal muscle in vitro., Neurourol. Urodyn.
Choudhry et al., 2005, Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma., Am. J. Respir. Crit. Care Med.
Bouyssou et al., 2010, Pharmacological characterization of olodaterol, a novel inhaled beta2-adrenoceptor agonist exerting a 24-hour-long duration of action in preclinical models., J. Pharmacol. Exp. Ther.
Handley et al., 2002, Biological actions of formoterol isomers., Pulm Pharmacol Ther
Faulds et al., 1991, Formoterol. A review of its pharmacological properties and therapeutic potential in reversible obstructive airways disease., Drugs
Scola et al., 2004, Desensitisation of mast cell beta2-adrenoceptor-mediated responses by salmeterol and formoterol., Br. J. Pharmacol.
Bartow et al., 1998, Formoterol. An update of its pharmacological properties and therapeutic efficacy in the management of asthma., Drugs
Cheer et al., 2002, Formoterol: a review of its use in chronic obstructive pulmonary disease., Am J Respir Med
Ryall et al., 2006, Systemic administration of beta2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses., Br. J. Pharmacol.
Löfdahl et al., 1989, Formoterol fumarate, a new beta 2-adrenoceptor agonist. Acute studies of selectivity and duration of effect after inhaled and oral administration., Allergy
Kompa et al., 1995, Beta-adrenoceptor regulation and functional responses in the guinea-pig following chronic administration of the long-acting beta 2-adrenoceptor agonist formoterol., Naunyn Schmiedebergs Arch. Pharmacol.
Steiropoulos et al., 2008, Formoterol in the management of chronic obstructive pulmonary disease., Int J Chron Obstruct Pulmon Dis
Op't Holt, 2007, Inhaled beta agonists., Respir Care
Hoffmann et al., 2004, Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells., Naunyn Schmiedebergs Arch. Pharmacol.
Rosberg et al., 1993, Bambuterol and terbutaline in human cerebrospinal fluid and plasma., Eur. J. Clin. Pharmacol.
Waldeck, 2002, Beta-adrenoceptor agonists and asthma--100 years of development., Eur. J. Pharmacol.
Svensson, 1988, Bambuterol, a bronchodilator prodrug with sustained action, enhances delivery of active drug to the lung., Agents Actions Suppl.
Coleman et al., 1996, Exosites: their current status, and their relevance to the duration of action of long-acting beta 2-adrenoceptor agonists., Trends Pharmacol. Sci.
Zhang et al., 2007, Enantiomeric separation of beta2-agonists on macrocyclic antibiotic chiral stationary phases in high performance liquid chromatography., Pharmazie
Chou et al., 2010, Effects of bambuterol and terbutaline on isolated rat's tracheal smooth muscle., Eur Arch Otorhinolaryngol
Park HW et al., 2009, Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response., Allergy
Arai et al., 2003, Beta-adrenergic receptor agonists and antagonists counteract LPS-induced neuronal death in retinal cultures by different mechanisms., Brain Res.
Drímal et al., 1987, External transport of beta-adrenergic binding sites in ischemic myocardium., Gen. Physiol. Biophys.
Bilcíková et al., 1987, The action of adrenoceptor agonists and antagonists on the guinea pig and dog trachea., Gen. Physiol. Biophys.
Noack, 1986, [Antiglaucomatous effectiveness of beta receptor blockers with special reference to metipranolol]., Klin Monbl Augenheilkd
Nuttall et al., 2003, A comparison of the beta1-selectivity of three beta1-selective beta-blockers., J Clin Pharm Ther
Iaccarino G et al., 2005, beta-Blockade and increased dyslipidemia in patients bearing Glu27 variant of beta2 adrenergic receptor gene., Pharmacogenomics J
Kim KM et al., 2012, Pharmacogenetics and healthcare outcomes in patients with chronic heart failure., Eur J Clin Pharmacol
Wheeldon et al., 1991, The effect of pindolol on creatine kinase is not due to beta 2-adrenoceptor partial agonist activity., Br J Clin Pharmacol
Rubenstein et al., 2006, Molecular dynamics of a biophysical model for beta2-adrenergic and G protein-coupled receptor activation., J. Mol. Graph. Model.
Dejgaard et al., 1991, Adrenergic receptors are a fallible index of adrenergic denervation hypersensitivity., Scand. J. Clin. Lab. Invest.
Doggrell, 1991, Effects of (+/-)- (+)- and (-)-metoprolol, (+/-)- (+)- and (-)-pindolol, (+/-)-mepindolol and (+/-)-bopindolol on the rat left atria and portal vein., Gen. Pharmacol.
Doggrell, 1990, Relaxant and beta 2-adrenoceptor blocking activities of (+/- )-, (+)- and (-)-pindolol on the rat isolated aorta., J. Pharm. Pharmacol.
Ryall et al., 2002, Beta 2-agonist fenoterol has greater effects on contractile function of rat skeletal muscles than clenbuterol., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Zhu et al., 2001, Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth factor-beta1 expression in rat hippocampus after transient forebrain ischemia., Neuroscience
Choo et al., 1992, Anabolic effects of clenbuterol on skeletal muscle are mediated by beta 2-adrenoceptor activation., Am. J. Physiol.
Sillence et al., 1991, Effects of clenbuterol, ICI118551 and sotalol on the growth of cardiac and skeletal muscle and on beta 2-adrenoceptor density in female rats., Naunyn Schmiedebergs Arch. Pharmacol.
Mazzanti et al., 2007, A pharmacodynamic study on clenbuterol-induced toxicity: beta1- and beta2-adrenoceptors involvement in guinea-pig tachycardia in an in vitro model., Food Chem. Toxicol.
Sehrt D et al., 2011, Carvedilol pharmacokinetics and pharmacodynamics in relation to CYP2D6 and ADRB pharmacogenetics., Pharmacogenomics
Metra M et al., 2010, Role of beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade with carvedilol in patients with chronic heart failure., Cardiovasc Drugs Ther
de Groote P et al., 2005, Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure., Pharmacogenet Genomics
Kaye et al., 2003, Beta-adrenoceptor genotype influences the response to carvedilol in patients with congestive heart failure., Pharmacogenetics
Maebara et al., 2002, Nightmares and panic disorder associated with carvedilol overdose., Ann Pharmacother
Irodova et al., 2002, [Carvedilol in treating primary pulmonary hypertension patients: effect on severity of cardiac failure, degree of pulmonary hypertension, concentration of catecholamines in blood plasma and dependence of cyclic AMP synthesis in lymphocytes on beta-adrenergic receptors]., Ter. Arkh.
Okajima et al., 2004, Activation of capsaicin-sensitive sensory neurons by carvedilol, a nonselective beta-blocker, in spontaneous hypertensive rats., J. Pharmacol. Exp. Ther.
Nichols et al., 1991, Studies on the mechanism of arterial vasodilation produced by the novel antihypertensive agent, carvedilol., Fundam Clin Pharmacol
Gelmont et al., 1988, Hypokalemia induced by inhaled bronchodilators., Chest
Singh et al., 1996, Beta 2-adrenergic function in cultured rat proximal tubule epithelial cells., Am. J. Physiol.
Hu et al., 2000, Influence of autonomic neurotransmitters on human uveal melanocytes in vitro., Exp. Eye Res.
Fitch, The use of anti-asthmatic drugs. Do they affect sports performance?, Sports Med
Kimura et al., 1999, Stimulation by transforming growth factor-alpha of DNA synthesis and proliferation of adult rat hepatocytes in primary cultures: modulation by alpha- and beta-adrenoceptor agonists., J. Pharmacol. Exp. Ther.
Cazzola et al., 2005, Ultra long-acting beta 2-agonists in development for asthma and chronic obstructive pulmonary disease., Expert Opin Investig Drugs
Bruck et al., 2004, Beta 2-adrenoceptor-mediated intrinsic sympathomimetic activity of carteolol: an in vivo study., Naunyn Schmiedebergs Arch. Pharmacol.
Marone et al., 1984, Inhibition of IgE-mediated histamine release from human basophils and mast cells by fenoterol., Int. Arch. Allergy Appl. Immunol.
Coqueret et al., 1996, Role of cyclic AMP in the modulation of IgE production by the beta 2-adrenoceptor agonist, fenoterol., Eur. Respir. J.
Boterman et al., 2006, Protein kinase C potentiates homologous desensitization of the beta2-adrenoceptor in bovine tracheal smooth muscle., Eur. J. Pharmacol.
Bouillon et al., 1996, Concentration-effect relationship of the positive chronotropic and hypokalaemic effects of fenoterol in healthy women of childbearing age., Eur. J. Clin. Pharmacol.
de Vries et al., 2001, Effect of fenoterol-induced constitutive beta(2)-adrenoceptor activity on contractile receptor function in airway smooth muscle., Eur. J. Pharmacol.
Hjorth et al., 1996, Raphe 5-HT1A autoreceptors, but not postsynaptic 5-HT1A receptors or beta-adrenoceptors, restrain the citalopram-induced increase in extracellular 5-hydroxytryptamine in vivo., Eur. J. Pharmacol.
Hjorth et al., 1993, In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol., J. Pharmacol. Exp. Ther.
Frishman et al., 1990, Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism., J Clin Pharmacol
Sánchez, 1993, Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats., Behav Pharmacol
Ijzerman et al., 1987, The membrane stabilizing activity of beta-adrenoceptor ligands. Quantitative evaluation of the interaction of phenoxypropanolamines with the [3H]batrachotoxinin A 20-alpha-benzoate binding site on voltage-sensitive sodium channels in rat brain., Biochem. Pharmacol.
Kulkarni et al., 1977, Beta-2 adrenoceptor blocking activity of penbutolol and propranolol at very low doses., Clin. Pharmacol. Ther.
Saiz-Rodríguez M et al., 2019, Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects., Basic Clin Pharmacol Toxicol
Zebrack et al., 2009, Beta-receptor selectivity of carvedilol and metoprolol succinate in patients with heart failure (SELECT trial): a randomized dose-ranging trial., Pharmacotherapy
Bjermer L et al., 2015, Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA)., Drug Des Devel Ther
Vansal et al., 1999, Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes., Biochem. Pharmacol.
Matsumoto et al., 1994, Beta 2- but not beta 1-adrenoceptors are involved in desipramine enhancement of aggressive behavior in long-term isolated mice., Pharmacol. Biochem. Behav.
Osadchii et al., 2007, Temporal changes in myocardial adrenergic regulation with the progression to pump dysfunction after chronic beta-adrenoreceptor activation in rats., Pflugers Arch.
Prenner et al., 2007, Reduction of high-affinity beta2-adrenergic receptor binding by hyperforin and hyperoside on rat C6 glioblastoma cells measured by fluorescence correlation spectroscopy., Biochemistry
Sapena et al., 1996, Desipramine treatment differently down-regulates beta-adrenoceptors of freshly isolated neurons and astrocytes., Eur. J. Pharmacol.
Abadie et al., 1996, Modulation of noradrenaline release from isolated human atrial appendages., J. Auton. Nerv. Syst.
Carie et al., 2007, A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway., Oncogene
Leier et al., 1982, Intravenous pirbuterol., Clin. Pharmacol. Ther.
Hamdad et al., 1996, Beta 2-adrenergic dilation of conductance coronary arteries involves flow-dependent NO formation in conscious dogs., Am. J. Physiol.
Lenard et al., 2003, Activation of beta2- and beta3-adrenergic receptors increases brain tryptophan., J. Pharmacol. Exp. Ther.
Huang G et al., 2004, Beta2 adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese., Clin Exp Hypertens
Lucin et al., 2007, Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation., Exp. Neurol.
Reiner S et al., 2010, Differential signaling of the endogenous agonists at the beta2-adrenergic receptor., J Biol Chem
Odekon L et al., 2015, The Effect of β2-Adrenoceptor Genotype on Phenylephrine Dose Administered During Spinal Anesthesia for Cesarean Delivery., Anesth Analg
Noguchi et al., 1991, Cardiac effects of beta-2 adrenoceptor stimulation with intracoronary procaterol in the absence and presence of regional myocardial ischemia in dogs., J. Pharmacol. Exp. Ther.
Brodde et al., 1990, Agonist-induced desensitization of beta-adrenoceptor function in humans. Subtype-selective reduction in beta 1- or beta 2-adrenoceptor-mediated physiological effects by xamoterol or procaterol., Circulation
Kobayashi et al., 2002, [beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers]., Nihon Kokyuki Gakkai Zasshi
Aizawa et al., 1991, Effects of procaterol, a beta-2-adrenoceptor stimulant, on neuroeffector transmission in human bronchial tissue., Respiration
Yamasaki et al., 2004, [Beta 2-adrenoceptor polymorphism and effects of inhaled beta 2-stimulant (procaterol) and an anti-cholinergic drug (oxitropium) on the airway resistance]., Nihon Kokyuki Gakkai Zasshi
Statler AK et al., 2020, Ephedrine,
Cazzola et al., 2010, Arformoterol tartrate in the treatment of COPD., Expert Rev Respir Med
2004, Arformoterol: (R,R)-eformoterol, (R,R)-formoterol, arformoterol tartrate, eformoterol-sepracor, formoterol-sepracor, R,R-eformoterol, R,R-formoterol., Drugs R D
Matera et al., 2007, ultra-long-acting beta2-adrenoceptor agonists: an emerging therapeutic option for asthma and COPD?, Drugs
Baumgartner et al., 2007, Nebulized arformoterol in patients with COPD: a 12-week, multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled trial., Clin Ther
Kharidia et al., 2008, A pharmacokinetic/pharmacodynamic study comparing arformoterol tartrate inhalation solution and racemic formoterol dry powder inhaler in subjects with chronic obstructive pulmonary disease., Pulm Pharmacol Ther
Quast et al., 1984, Binding of beta-adrenoceptor antagonists to rat and rabbit lung: special reference to levobunolol., Arzneimittelforschung
Brooks et al., Ocular beta-blockers in glaucoma management. Clinical pharmacological aspects., Drugs Aging
Harris et al., 1994, Correlates of acute exercise-induced ocular hypotension., Invest. Ophthalmol. Vis. Sci.
Sharif et al., 2001, Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes., J Ocul Pharmacol Ther
Gonzalez et al., 1987, Ocular levobunolol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy., Drugs
Lesar, 1987, Comparison of ophthalmic beta-blocking agents., Clin Pharm
Bianchetti et al., 1990, In vitro inhibition of intestinal motility by phenylethanolaminotetralines: evidence of atypical beta-adrenoceptors in rat colon., Br. J. Pharmacol.
Schwarz et al., 2003, Preterm labour: an overview of current and emerging therapeutics., Curr. Med. Chem.
Lye et al., 1992, Failure of ritodrine to prevent preterm labor in the sheep., Am. J. Obstet. Gynecol.
Tanaka et al., 2001, Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence., J. Med. Chem.
Lenselink et al., 1994, Cardiovascular teratogenicity of terbutaline and ritodrine in the chick embryo., Am. J. Obstet. Gynecol.
Weinshenker et al., 2001, Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine., J. Pharmacol. Exp. Ther.
Skrabal et al., 1989, Inverse regulation of alpha-2 and beta-2 adrenoceptors in salt-sensitive hypertension: an hypothesis., Life Sci.
Iaccarino G et al., 2006, Beta2-adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension., Clin Pharmacol Ther
Blake K et al., 2013, Methacholine PC20 in African Americans and whites with asthma with homozygous genotypes at ADRB2 codon 16., Pulm Pharmacol Ther
Gaulton et al., 2012, ChEMBL: a large-scale bioactivity database for drug discovery., Nucleic Acids Res.

TERBUTALINE ADRB2

Interaction Score: 6.28

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12569076 1358833 18782903 20674738 11120594 10226872 2062329 11752352 11675405 11256987

Sources:
TdgClinicalTrial TEND TTD
CLENBUTEROL ADRB2

Interaction Score: 5.31

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12388476 11720783 1322047 11752352 1685013 17449161 16680159

Sources:
DTC TdgClinicalTrial TEND TTD
FENOTEROL ADRB2

Interaction Score: 4.83

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6203844 8777955 16324695 8911881 11730729 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD
METAPROTERENOL ADRB2

Interaction Score: 4.35

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
3168573 8760245 10973730 11752352 2870555 10490901

Sources:
TdgClinicalTrial TEND PharmGKB
BAMBUTEROL ADRB2

Interaction Score: 3.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
8223836 12065188 3262993 8885698 18065099 11752352 20012638

Sources:
TTD
FORMOTEROL ADRB2

Interaction Score: 2.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name budesonide + formoterol,Symbicort

Novel drug target Established target

Trial Name CHF-1535, beclomethasone dipropionate + formoterol fumarate

PMIDs:
12090787 1718682 14662724 9506248 14720051 16432501 2544117 7675115 18686730 11752352 17594727 14730417

Sources:
TdgClinicalTrial TEND PharmGKB TTD
RITODRINE ADRB2

Interaction Score: 2.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1976401 12871140 1332478 11311067 8059831 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD
PIRBUTEROL ADRB2

Interaction Score: 2.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
11752352 17260025 7053311 8945911

Sources:
TTD
LEVOBUNOLOL ADRB2

Interaction Score: 2.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6147147 1351412 7928182 11572462 11752352 2892662 2891463

Sources:
TdgClinicalTrial TEND
PROCATEROL ADRB2

Interaction Score: 2.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1682484 1968366 12428391 11752352 1684063 15069780

Sources:
TdgClinicalTrial TEND TTD
SALMETEROL ADRB2

Interaction Score: 2.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Advair/Seretide/Adoair

Novel drug target Established target

Trial Name Serevent

PMIDs:
1359777 11250877 11752352 10471277 11516429 12897749 24279851 23126384 19932356 19800676 18156033 15500895 11825095

Sources:
TdgClinicalTrial TEND PharmGKB TTD
PENBUTOLOL ADRB2

Interaction Score: 1.93

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8982649 8098761 2189902 11224195 2446632 16716

Sources:
TdgClinicalTrial TEND
PINDOLOL ADRB2

Interaction Score: 1.93

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor partial agonist

Direct Interaction yes

Trial Name -

PMIDs:
2903243 1678274 16574446 1666931 11752352 1687398 1979630

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB
ARFORMOTEROL ADRB2

Interaction Score: 1.77

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
20406080 14725487 17352511 16022567 17472819 11752352 17594727 18501650

Sources:
TdgClinicalTrial TEND TTD
CARTEOLOL ADRB2

Interaction Score: 1.69

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1349493 11752352 15526107 2903243

Sources:
DTC TdgClinicalTrial TEND
OXPRENOLOL ADRB2

Interaction Score: 1.69

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11311890 7882570 17016423 17139284 9509999

Sources:
TdgClinicalTrial TEND
ALPRENOLOL ADRB2

Interaction Score: 1.69

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2871880 2439825 2859531 2903243

Sources:
DTC TdgClinicalTrial TEND
ALBUTEROL ADRB2

Interaction Score: 1.61

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

Trial Name albuterol,Ventolin

PMIDs:
16680159 2903243 29053759 24279851 23126384 19800676 18156033 15500895 12388338 14757145 12569076 12808710 15557128 11752352

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
TIMOLOL ADRB2

Interaction Score: 1.61

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name brimonidine tartrate/timolol maleate,Combigan

Novel drug target Established target

Trial Name latanoprost + timolol,Xalcom, Xalacom

PMIDs:
10592235 9088585 16205624 9730867 11752352 8103526 8719802

Sources:
TdgClinicalTrial ChemblInteractions TEND
BEDORADRINE SULFATE ADRB2

Interaction Score: 1.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MN-221

Novel drug target Established target

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
AZD3199 ADRB2

Interaction Score: 1.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

PMIDs:
25709399

Sources:
ChemblInteractions TTD
OLODATEROL ADRB2

Interaction Score: 1.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name BI-1744-CL

Novel drug target Established target

PMIDs:
20371707

Sources:
TdgClinicalTrial TTD
NADOLOL ADRB2

Interaction Score: 1.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
2903243 7981009 8574280 1349493 11752352 17622774 10433496

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND
METIPRANOLOL ADRB2

Interaction Score: 1.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
12967722 2895037 2885244 17016423 17139284 2876128

Sources:
TdgClinicalTrial TEND
ICI-118551 ADRB2

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2903243

Sources:
DTC
METHACHOLINE ADRB2

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23384627

Sources:
PharmGKB
VILANTEROL ADRB2

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name GW642444

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
CARMOTEROL ADRB2

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
MILVETEROL ADRB2

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name milveterol. TD-3327, GSK-159797

Novel drug target Established target

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
ABEDITEROL ADRB2

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name LAS-100977

Novel drug target Established target

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
BUPRANOLOL ADRB2

Interaction Score: 0.72

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2903243 12606631

Sources:
DTC
EPHEDRINE ADRB2

Interaction Score: 0.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
26771271 25730298 31613441

Sources:
PharmGKB
INDACATEROL MALEATE ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BUNITROLOL ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2903243

Sources:
DTC
GSK159802 ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
METAPROTERENOL SULFATE ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL531401 ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIRBUTEROL ACETATE ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BAMOSIRAN ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SYL040012

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
VILANTEROL TRIFENATATE ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALBUTEROL SULFATE ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BUNOLOL ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2903243

Sources:
DTC
BITOLTEROL MESYLATE ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEVALBUTEROL HYDROCHLORIDE ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PF-00610355 ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name PF-00610355

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
INDACATEROL ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Indacaterol

Novel drug target Established target

PMIDs:
16022567

Sources:
TdgClinicalTrial PharmGKB TTD
CHEMBL604311 ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TERBUTALINE SULFATE ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
DTC ChemblInteractions
CHEMBL579725 ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OLODATEROL HYDROCHLORIDE ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
PROTOKYLOL HYDROCHLORIDE ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
DICHLOROISOPROTERENOL ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2903243

Sources:
DTC
ARFORMOTEROL TARTRATE ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
ISOETHARINE HYDROCHLORIDE ADRB2

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
LABETALOL ADRB2

Interaction Score: 0.36

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
8104240 2907566 6355664 1361547 7684671 19879818 11752352

Sources:
TdgClinicalTrial TEND
DROXIDOPA ADRB2

Interaction Score: 0.36

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
7969507 9464897 19110970 9666280 18064417

Sources:
ChemblInteractions
CARVEDILOL ADRB2

Interaction Score: 0.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name carvedilol,Coreg

Novel drug target Established target

Direct Interaction yes

PMIDs:
21599570 20352314 15861037 12835612 12398570 12360591 14764656 1712335

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB
SOTALOL ADRB2

Interaction Score: 0.34

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
15060759 19259968 8095397 11815381 2865685 2903243

Sources:
DTC
ISOPROTERENOL ADRB2

Interaction Score: 0.33

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11586955 14734046 11358333 10784181 19464886 16680159 10722 14656380 15105445 11752352 15151902 14752060 12963495

Sources:
DTC TdgClinicalTrial NCI TEND PharmGKB TTD
TERTATOLOL ADRB2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2903243

Sources:
DTC
BUCINDOLOL ADRB2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bucindolol hydrochloride,Gencaro

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
MEPINDOLOL ADRB2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2903243

Sources:
DTC
BATEFENTEROL ADRB2

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
PROPRANOLOL ADRB2

Interaction Score: 0.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
16680159 2903243 11752352 16177222 16082424 17628611 16706406

Sources:
DTC TEND PharmGKB
RACEPINEPHRINE HYDROCHLORIDE ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL111201 ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL599896 ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ISOETHARINE ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
21948594

Sources:
TTD
ESMOLOL HYDROCHLORIDE ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METIPRANOLOL HYDROCHLORIDE ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TIMOLOL MALEATE ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEVOBUNOLOL HYDROCHLORIDE ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FENOTEROL HBR ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PENBUTOLOL SULFATE ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ISOETHARINE MESYLATE ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions
LEVOSALBUTAMOL ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
TTD
RITODRINE HYDROCHLORIDE ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
PROCATEROL HYDROCHLORIDE ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OXPRENOLOL HYDROCHLORIDE ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-2 adrenergic receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
NEBIVOLOL HYDROCHLORIDE ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LAS190792 ADRB2

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
DESIPRAMINE ADRB2

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7816863 17558518 17417877 8741184 8988485

Sources:
TdgClinicalTrial TEND
NOREPINEPHRINE ADRB2

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
2903243 9464897 7969507 11504801 19110970 18064417 9666280 17016423 17139284

Sources:
DTC
ISOPROTERENOL HYDROCHLORIDE ADRB2

Interaction Score: 0.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor beta agonist

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions
TIOTROPIUM ADRB2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19183167

Sources:
PharmGKB
REMIFENTANIL ADRB2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26771271

Sources:
PharmGKB
ROLIPRAM ADRB2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19464886

Sources:
DTC
METOPROLOL ADRB2

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
16027735 19637941

Sources:
PharmGKB
LY377604 ADRB2

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENYLEPHRINE HYDROCHLORIDE ADRB2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARTEOLOL HYDROCHLORIDE ADRB2

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor beta antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPRANOLOL HYDROCHLORIDE ADRB2

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CLENBUTEROL HYDROCHLORIDE ADRB2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EPINEPHRINE ADRB2

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name transdermal lidocaine/epinephrine patch,Lidosite

Novel drug target Established target

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
17417877 17622774 11752352 17597612 20837485

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB
BENAZEPRIL ADRB2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15554460

Sources:
PharmGKB
SALMETEROL XINAFOATE ADRB2

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions
DIPIVEFRIN HYDROCHLORIDE ADRB2

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions
SOTALOL HYDROCHLORIDE ADRB2

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOBUTAMINE HYDROCHLORIDE ADRB2

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
PSEUDOEPHEDRINE ADRB2

Interaction Score: 0.11

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
10449190 17016423 17139284

Sources:
TEND
PHENYLEPHRINE ADRB2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26771271 25730298

Sources:
PharmGKB
CARVEDILOL PHOSPHATE ADRB2

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor beta antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VOLANESORSEN SODIUM ADRB2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2557514

Sources:
NCI
CHEMBL531322 ADRB2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL590927 ADRB2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1257092 ADRB2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIENESTROL ADRB2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MEPHENTERMINE SULFATE ADRB2

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EPINEPHRINE BITARTRATE ADRB2

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions
FENTANYL ADRB2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30281924 26771271

Sources:
PharmGKB
HYDROXYAMPHETAMINE HYDROBROMIDE ADRB2

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL1256364 ADRB2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LABETALOL HYDROCHLORIDE ADRB2

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
SPIRONOLACTONE ADRB2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543981

Sources:
PharmGKB
ENALAPRIL ADRB2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17178264

Sources:
PharmGKB
PRILOCAINE HYDROCHLORIDE ADRB2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ATENOLOL ADRB2

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
12795776 16027735

Sources:
PharmGKB
NOREPINEPHRINE BITARTRATE ADRB2

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL116548 ADRB2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1465049 ADRB2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROPAFENONE HYDROCHLORIDE ADRB2

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOFOL ADRB2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26771271

Sources:
PharmGKB
3-O-METHYLQUERCETIN ADRB2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SEVOFLURANE ADRB2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26771271

Sources:
PharmGKB
DIGOXIN ADRB2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543981

Sources:
PharmGKB
CLOTRIMAZOLE ADRB2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM ADRB2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RISPERIDONE ADRB2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000169252
- Version: 101_38
Alternate Names:

ADRB2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000169252
- Version: 26-July-2011
Alternate Names:

ENSG00000169252 Ensembl Gene Id

ADRB2 Display Id

BETA-2 ADRENERGIC RECEPTOR (BETA-2 ADRENOCEPTOR) (BETA-2 ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P07550] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P07550
- Version: 01-August-2011
Alternate Names:

154 Entrez Gene Id

ADRB2 Gene Symbol

ENSG00000169252 Ensembl Gene Id

Gene Info:

Target Subclass GPCR

Transmembrane Helix Count 7

Target Subclass Rhodopsin

Publications:
TdgClinicalTrial: P07550
- Version: January-2014
Alternate Names:

ADRB2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: P07550
- Version: 11-September-2012
Alternate Names:

ADRB2_HUMAN Uniprot Id

P07550 Uniprot Accession

ADRB2 Uniprot Gene Name

Gene Info:

Interpro Acc IPR000276

Interpro Name GPCR, rhodopsin-like, 7TM

Human Readable Name G PROTEIN COUPLED RECEPTOR

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

PharmGKB: ADRB2

Version: 18-August-2020

Alternate Names:

PA39 PharmGKB ID

Gene Info:

Publications:

Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg

Saiz-Rodríguez M et al., 2019, Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects., Basic Clin Pharmacol Toxicol

Odekon L et al., 2015, The Effect of β2-Adrenoceptor Genotype on Phenylephrine Dose Administered During Spinal Anesthesia for Cesarean Delivery., Anesth Analg

TTD: Adrenergic receptor beta-2

Version: 2020.06.01

Alternate Names:

ADRB2 TTD Gene Abbreviation

T52522 TTD Target ID

Gene Info:

Publications:

Mantovani G et al., 2013, Drugs in development for treatment of patients with cancer-related anorexia and cachexia syndrome., Drug Des Devel Ther

Bjermer L et al., 2015, Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA)., Drug Des Devel Ther

NCI: ADRB2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Hart et al., 2005, Beta 2 adrenergic receptor polymorphisms in cystic fibrosis., Pediatr. Pulmonol.

Paetsch et al., 1993, 2-Phenylethylamine-induced changes in catecholamine receptor density: implications for antidepressant drug action., Neurochem. Res.

Angers et al., 2001, Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells., Life Sci.

DTC: ADRB2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

Skoumbourdis AP et al., 2009, Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors., Bioorg Med Chem Lett

MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

ChemblInteractions: ADRB2R
- Version: chembl_23
Alternate Names:

B2AR GENE_SYMBOL

ADRB2 GENE_SYMBOL

Beta-2 adrenergic receptor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000169252
- Version: 31-May-2017
Alternate Names:

ENSG00000169252 Gene Symbol

ADRB2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: ADRB2
- Version: 01-February-2022
Alternate Names:

ADRB2R GO Gene Synonym

B2AR GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
dGene: ADRB2
- Version: 27-Jun-2013
Alternate Names:

154 Gene ID

ADRB2R dGene Synonym

ADRBR dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
Pharos: ADRB2
- Version: 01-February-2022
Alternate Names:

Beta-2 adrenergic receptor Gene Name

P07550 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:

Trial Name	budesonide + formoterol,Symbicort
Novel drug target	Established target
Trial Name	CHF-1535, beclomethasone dipropionate + formoterol fumarate

Trial Name	Advair/Seretide/Adoair
Novel drug target	Established target
Trial Name	Serevent

Mechanism of Interaction	Beta-2 adrenergic receptor partial agonist
Direct Interaction	yes
Trial Name	-

Mechanism of Interaction	Beta-2 adrenergic receptor agonist
Direct Interaction	yes
Trial Name	albuterol,Ventolin

Trial Name	brimonidine tartrate/timolol maleate,Combigan
Novel drug target	Established target
Trial Name	latanoprost + timolol,Xalcom, Xalacom

Trial Name	MN-221
Novel drug target	Established target
Mechanism of Interaction	Beta-2 adrenergic receptor agonist

Trial Name	milveterol. TD-3327, GSK-159797
Novel drug target	Established target
Mechanism of Interaction	Beta-2 adrenergic receptor agonist

Trial Name	LAS-100977
Novel drug target	Established target
Direct Interaction	yes

Mechanism of Interaction	Adrenergic receptor agonist
Direct Interaction	yes

Trial Name	carvedilol,Coreg
Novel drug target	Established target
Direct Interaction	yes

Trial Name	bucindolol hydrochloride,Gencaro
Novel drug target	Established target

Mechanism of Interaction	Beta-2 adrenergic receptor antagonist
Direct Interaction	yes

Mechanism of Interaction	Adrenergic receptor beta agonist
Direct Interaction	yes

Mechanism of Interaction	Adrenergic receptor beta antagonist
Direct Interaction	yes

Trial Name	transdermal lidocaine/epinephrine patch,Lidosite
Novel drug target	Established target
Mechanism of Interaction	Adrenergic receptor agonist

Direct Interaction	yes
Mechanism of Interaction	Adrenergic receptor antagonist

ENSG00000169252	Ensembl Gene Id
ADRB2	Display Id
BETA-2 ADRENERGIC RECEPTOR (BETA-2 ADRENOCEPTOR) (BETA-2 ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P07550]	Description

154	Entrez Gene Id
ADRB2	Gene Symbol
ENSG00000169252	Ensembl Gene Id

ADRB2_HUMAN	Uniprot Id
P07550	Uniprot Accession
ADRB2	Uniprot Gene Name

B2AR	GENE_SYMBOL
ADRB2	GENE_SYMBOL
Beta-2 adrenergic receptor	UNIPROT

ADRB2 Gene Record

ADRB2 154 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12569076 1358833 18782903 20674738 11120594 10226872 2062329 11752352 11675405 11256987

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12388476 11720783 1322047 11752352 1685013 17449161 16680159

Sources: DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6203844 8777955 16324695 8911881 11730729 11752352

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 3168573 8760245 10973730 11752352 2870555 10490901

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 8223836 12065188 3262993 8885698 18065099 11752352 20012638

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name budesonide + formoterol,Symbicort Novel drug target Established target Trial Name CHF-1535, beclomethasone dipropionate + formoterol fumarate

PMIDs: 12090787 1718682 14662724 9506248 14720051 16432501 2544117 7675115 18686730 11752352 17594727 14730417

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1976401 12871140 1332478 11311067 8059831 11752352

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 11752352 17260025 7053311 8945911

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6147147 1351412 7928182 11572462 11752352 2892662 2891463

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1682484 1968366 12428391 11752352 1684063 15069780

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Advair/Seretide/Adoair Novel drug target Established target Trial Name Serevent

PMIDs: 1359777 11250877 11752352 10471277 11516429 12897749 24279851 23126384 19932356 19800676 18156033 15500895 11825095

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: partial agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8982649 8098761 2189902 11224195 2446632 16716

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Mechanism of Interaction Beta-2 adrenergic receptor partial agonist Direct Interaction yes Trial Name -

PMIDs: 2903243 1678274 16574446 1666931 11752352 1687398 1979630

Sources: DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 20406080 14725487 17352511 16022567 17472819 11752352 17594727 18501650

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1349493 11752352 15526107 2903243

Sources: DTC TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11311890 7882570 17016423 17139284 9509999

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2871880 2439825 2859531 2903243

Sources: DTC TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Beta-2 adrenergic receptor agonist Direct Interaction yes Trial Name albuterol,Ventolin

PMIDs: 16680159 2903243 29053759 24279851 23126384 19800676 18156033 15500895 12388338 14757145 12569076 12808710 15557128 11752352

Sources: DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name brimonidine tartrate/timolol maleate,Combigan Novel drug target Established target Trial Name latanoprost + timolol,Xalcom, Xalacom

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12569076 1358833 18782903 20674738 11120594 10226872 2062329 11752352 11675405 11256987

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12388476 11720783 1322047 11752352 1685013 17449161 16680159

Sources:
DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6203844 8777955 16324695 8911881 11730729 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
3168573 8760245 10973730 11752352 2870555 10490901

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

PMIDs:
8223836 12065188 3262993 8885698 18065099 11752352 20012638

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name budesonide + formoterol,Symbicort

Novel drug target Established target

Trial Name CHF-1535, beclomethasone dipropionate + formoterol fumarate

PMIDs:
12090787 1718682 14662724 9506248 14720051 16432501 2544117 7675115 18686730 11752352 17594727 14730417

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1976401 12871140 1332478 11311067 8059831 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

PMIDs:
11752352 17260025 7053311 8945911

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6147147 1351412 7928182 11572462 11752352 2892662 2891463

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1682484 1968366 12428391 11752352 1684063 15069780

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Advair/Seretide/Adoair

Novel drug target Established target

Trial Name Serevent

PMIDs:
1359777 11250877 11752352 10471277 11516429 12897749 24279851 23126384 19932356 19800676 18156033 15500895 11825095

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8982649 8098761 2189902 11224195 2446632 16716

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor partial agonist

Direct Interaction yes

Trial Name -

PMIDs:
2903243 1678274 16574446 1666931 11752352 1687398 1979630

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
20406080 14725487 17352511 16022567 17472819 11752352 17594727 18501650

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1349493 11752352 15526107 2903243

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11311890 7882570 17016423 17139284 9509999

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2871880 2439825 2859531 2903243

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

Trial Name albuterol,Ventolin

PMIDs:
16680159 2903243 29053759 24279851 23126384 19800676 18156033 15500895 12388338 14757145 12569076 12808710 15557128 11752352

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name brimonidine tartrate/timolol maleate,Combigan

Novel drug target Established target

Trial Name latanoprost + timolol,Xalcom, Xalacom

PMIDs:
10592235 9088585 16205624 9730867 11752352 8103526 8719802

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MN-221

Novel drug target Established target

Mechanism of Interaction Beta-2 adrenergic receptor agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes