153 |
ADRENOCEPTOR BETA 1 |
ADRB1 |
ADRB1R |
B1AR |
BETA1AR |
RHR |
109630 |
285 |
ENSG00000043591 |
OTTHUMG00000019079 |
P08588 |
ADRB1_HUMAN |
BETA-1 ADRENERGIC RECEPTOR |
Beta-1 adrenoceptor |
Beta-1 adrenoreceptor |
BETA-1 ADRENERGIC RECEPTOR (BETA-1 ADRENOCEPTOR) (BETA-1 ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P08588] |
PA38 |
Adrenergic receptor beta-1 |
T44068 |
FNSS2 |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
Uniprot Status | Swiss-Prot |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Family |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Interpro Acc | IPR000276 |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Transmembrane Helix Count | 7 |
Target Main Class | Receptors |
Gene Biotype | PROTEIN_CODING |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
n/a |
Trial Name | bucindolol hydrochloride,Gencaro |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
Trial Name | brimonidine tartrate/timolol maleate,Combigan |
partial agonist (activating) |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Beta-1 adrenergic receptor partial agonist |
antagonist (inhibitory) |
Trial Name | metoprolol succinate,Toprol-XL |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
Trial Name | - |
antagonist (inhibitory) |
Trial Name | carvedilol,Coreg |
Novel drug target | Established target |
Mechanism of Interaction | Adrenergic receptor beta antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
Trial Name | - |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Adrenergic receptor agonist |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Adrenergic receptor beta antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Novel drug target | Established target |
Trial Name | transdermal lidocaine/epinephrine patch,Lidosite |
Mechanism of Interaction | Adrenergic receptor agonist |
n/a |
Trial Name | budiodarone, ATI-2042 |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Beta-1 adrenergic receptor agonist |
Direct Interaction | yes |
agonist (activating) |
negative modulator (inhibitory) |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Trial Name | amiodarone HCl,Amio-Aqueous IV |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Adrenergic receptor beta antagonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor beta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Adrenergic receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Adrenergic receptor agonist |
agonist (activating) |
Mechanism of Interaction | Beta-1 adrenergic receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Beta-1 adrenergic receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Adrenergic receptor agonist |
ADRB1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ADRB1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
ADRB1 | Uniprot Gene Name |
BETA-1 ADRENERGIC RECEPTOR | Uniprot Protein Name |
P08588 | Uniprot Accession |
Uniprot Status | Swiss-Prot |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Human Readable Name | DRUGGABLE GENOME |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
ENSG00000043591 | Ensembl Gene Id |
ADRB1 | Display Id |
BETA-1 ADRENERGIC RECEPTOR (BETA-1 ADRENOCEPTOR) (BETA-1 ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P08588] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ADRB1 | Gene Symbol |
P08588 | Uniprot Accession |
ADRB1_HUMAN | Uniprot Id |
Transmembrane Helix Count | 7 |
Target Main Class | Receptors |
Target Subclass | Rhodopsin |
PA38 | PharmGKB ID |
ADRB1 | TTD Gene Abbreviation |
T44068 | TTD Target ID |
ENSG00000043591 | Gene Symbol |
ADRB1 | Ensembl Id |
DRUGGABLE GENOME |
B1AR | GENE_SYMBOL |
ADRB1 | GENE_SYMBOL |
Beta-1 adrenergic receptor | UNIPROT |
ADRB1R | GO Gene Synonym |
B1AR | GO Gene Synonym |
G PROTEIN COUPLED RECEPTOR |
153 | Gene ID |
ADRB1R | dGene Synonym |
B1AR | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |