DGIdb - ADRB1 Gene Record

ADRB1 153 Druggable Genome

Alternate Names:

153
ADRENOCEPTOR BETA 1
ADRB1
ADRB1R
B1AR
BETA1AR
RHR
109630
285
ENSG00000043591
OTTHUMG00000019079
P08588
ADRB1_HUMAN
BETA-1 ADRENERGIC RECEPTOR
Beta-1 adrenoceptor
Beta-1 adrenoreceptor
BETA-1 ADRENERGIC RECEPTOR (BETA-1 ADRENOCEPTOR) (BETA-1 ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P08588]
PA38
Adrenergic receptor beta-1
T44068
FNSS2

Gene Info:

Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Uniprot Status	Swiss-Prot
Interpro Short Name	7TM_GPCR_Rhodpsn
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Acc	IPR000276
Interpro Name	GPCR, rhodopsin-like, 7TM
Transmembrane Helix Count	7
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Abrahamsson, 1989, Characterization of the beta 1-adrenoceptor stimulatory effects of the partial beta 1-agonists acebutolol, xamoterol, H142/08 and H201/70., Eur. J. Pharmacol.
Fraysse et al., 2005, Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia., Environ. Toxicol. Chem.
van den Meiracker et al., 1988, Acute and long-term effects of acebutolol on systemic and renal hemodynamics, body fluid volumes, catecholamines, active renin, aldosterone, and lymphocyte beta-adrenoceptor density., J. Cardiovasc. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
Rau T et al., 2012, Impact of the β1-adrenoceptor Arg389Gly polymorphism on heart-rate responses to bisoprolol and carvedilol in heart-failure patients., Clin Pharmacol Ther
Huntgeburth M et al., 2011, The Arg389Gly β1-adrenoceptor gene polymorphism influences the acute effects of β-adrenoceptor blockade on contractility in the human heart., Clin Res Cardiol
Baudhuin LM et al., 2010, Relation of ADRB1, CYP2D6, and UGT1A1 polymorphisms with dose of, and response to, carvedilol or metoprolol therapy in patients with chronic heart failure., Am J Cardiol
Metra M et al., 2010, Role of beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade with carvedilol in patients with chronic heart failure., Cardiovasc Drugs Ther
Filigheddu F et al., 2010, Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension., Pharmacogenomics
Chen L et al., 2007, Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol., Pharmacogenet Genomics
Lobmeyer MT et al., 2007, Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure., Pharmacogenet Genomics
Liu J et al., 2006, beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension., Clin Pharmacol Ther
de Groote P et al., 2005, Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure., Pharmacogenet Genomics
Mialet Perez J et al., 2003, Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure., Nat Med
Johnson et al., 2003, Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol., Clin. Pharmacol. Ther.
Sofowora GG et al., 2003, A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade., Clin Pharmacol Ther
Beitelshees AL et al., 2006, Influence of phenotype and pharmacokinetics on beta-blocker drug target pharmacogenetics., Pharmacogenomics J
Terra SG et al., 2005, Beta1-adrenergic receptor polymorphisms and left ventricular remodeling changes in response to beta-blocker therapy., Pharmacogenet Genomics
Terra SG et al., 2005, beta-Adrenergic receptor polymorphisms and responses during titration of metoprolol controlled release/extended release in heart failure., Clin Pharmacol Ther
Liu et al., 2003, Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol., Clin. Pharmacol. Ther.
White HL et al., 2003, An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study., Eur J Heart Fail
Schäfer et al., 2000, Hypertrophic effect of selective beta(1)-adrenoceptor stimulation on ventricular cardiomyocytes from adult rat., Am. J. Physiol., Cell Physiol.
Staudt et al., 2003, Beta1-adrenoceptor antibodies induce apoptosis in adult isolated cardiomyocytes., Eur. J. Pharmacol.
Staudt et al., 2001, beta(1)-Adrenoceptor antibodies induce positive inotropic response in isolated cardiomyocytes., Eur. J. Pharmacol.
Hoffmann et al., 2004, Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells., Naunyn Schmiedebergs Arch. Pharmacol.
Chidlow et al., 2000, Betaxolol, a beta(1)-adrenoceptor antagonist, reduces Na(+) influx into cortical synaptosomes by direct interaction with Na(+) channels: comparison with other beta-adrenoceptor antagonists., Br. J. Pharmacol.
Brooks et al., Ocular beta-blockers in glaucoma management. Clinical pharmacological aspects., Drugs Aging
Harris et al., 1994, Correlates of acute exercise-induced ocular hypotension., Invest. Ophthalmol. Vis. Sci.
Sharif et al., 2001, Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes., J Ocul Pharmacol Ther
Gonzalez et al., 1987, Ocular levobunolol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy., Drugs
Lesar, 1987, Comparison of ophthalmic beta-blocking agents., Clin Pharm
Hino et al., 1989, Attenuation of ischaemia-induced regional myocardial acidosis by bevantolol, a beta 1-adrenoceptor antagonist, in dogs., Pharmacol. Toxicol.
Dukes et al., 1985, Cardiovascular effects of bevantolol, a selective beta 1-adrenoceptor antagonist with a novel pharmacological profile., Br. J. Pharmacol.
Löfdahl et al., Selectivity of bevantolol hydrochloride, a beta 1-adrenoceptor antagonist, in asthmatic patients., Pharmacotherapy
Horinouchi et al., 2007, Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol., Life Sci.
Vaughan Williams, 1987, Bevantolol: a beta-1 adrenoceptor antagonist with unique additional actions., J Clin Pharmacol
Saarnivaara et al., 1984, Effects of practolol and metoprolol on QT interval, heart rate and arterial pressure during induction of anaesthesia., Acta Anaesthesiol Scand
Abrahamsson, 1986, The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat., Br. J. Pharmacol.
Keyriläinen et al., 1978, A comparative study of three beta 1-adrenoreceptor blocking drugs with different degree of intrinsic stimulating activity (metoprolol, practolol and H 87/07) in patients with angina pectoris., Ann. Clin. Res.
Buxton et al., 1985, Direct analysis of beta-adrenergic receptor subtypes on intact adult ventricular myocytes of the rat., Circ. Res.
Floreani et al., 2005, In vitro evidence that carteolol is a nonconventional partial agonist of guinea pig cardiac beta1-adrenoceptors: a comparison with xamoterol., J. Pharmacol. Exp. Ther.
Bruck et al., 2004, Beta 2-adrenoceptor-mediated intrinsic sympathomimetic activity of carteolol: an in vivo study., Naunyn Schmiedebergs Arch. Pharmacol.
Rouget et al., 2006, Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia., Biol. Reprod.
Lewis et al., 2004, Overexpression of beta 1-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for 'putative' beta 4-adrenoceptor pharmacology., Br. J. Pharmacol.
Rezmann-Vitti et al., 2004, Site-directed mutagenesis of the rat beta1-adrenoceptor. Involvement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol binding., Eur J Med Chem
Yazawa et al., 2007, Verrucotoxin, a stonefish venom, modulates calcium channel activity in guinea-pig ventricular myocytes., Br. J. Pharmacol.
Gielen et al., 2006, Nebivolol: a review of its clinical and pharmacological characteristics., Int J Clin Pharmacol Ther
de Boer et al., 2007, Nebivolol: third-generation beta-blockade., Expert Opin Pharmacother
Campbell et al., Effects of prolonged administration of oxprenolol on severity of ischaemic arrhythmias, enzyme leakage, infarct size, and intracellular cardiac muscle action potentials., J. Cardiovasc. Pharmacol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Lemmer, 1982, [Pharmacological basis for the therapy of cardiovascular disease with beta-adrenoceptor blocking drugs (author's transl)]., Herz
Ahlquist, 1976, Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor., Am. Heart J.
Jurgens et al., 2005, Beta1 adrenergic receptor-mediated enhancement of hippocampal CA3 network activity., J. Pharmacol. Exp. Ther.
Kobayashi et al., 2005, Beta-arrestin2 enhances beta2-adrenergic receptor-mediated nuclear translocation of ERK., Cell. Signal.
Sato et al., 2004, Loss of beta-adrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger., J. Mol. Cell. Cardiol.
McCrink KA et al., 2016, β<sub>1</sub>-adrenoceptor Arg389Gly polymorphism confers differential β-arrestin-binding tropism in cardiac myocytes., Pharmacogenomics
Kirshenbaum, 1989, Nonthrombolytic intervention in acute myocardial infarction., Am. J. Cardiol.
Howie et al., 1990, Esmolol reduces autonomic hypersensitivity and length of seizures induced by electroconvulsive therapy., Anesth. Analg.
Jahn et al., 1995, Beta 1-adrenoceptor subtype selective antagonism of esmolol and its major metabolite in vitro and in man. Investigations using tricresylphosphate as red blood cell carboxylesterase inhibitor., Arzneimittelforschung
Jacobs et al., 1988, Esmolol and left ventricular function in the awake dog., Anesthesiology
Volz-Zang et al., 1994, Esmolol, an ultrashort-acting, selective beta 1-adrenoceptor antagonist: pharmacodynamic and pharmacokinetic properties., Eur. J. Clin. Pharmacol.
Rosendorff, 1993, Beta-blocking agents with vasodilator activity., J Hypertens Suppl
Monopoli et al., 1984, Effects of the R, R-isomer of labetalol, SCH 19927, in isolated tissues and in spontaneously hypertensive rats during a repeated treatment., Arch Int Pharmacodyn Ther
Nakagawa et al., 1981, [Antihypertensive effects of labetalol in three types of hypertensive models of rats (author's transl)]., Nippon Yakurigaku Zasshi
Sassard et al., 1983, [Comparative effects of an alpha 1 and beta 1-2 blocker (labetalol) and a beta-1 blocker (atenolol) in the hypertensive patient]., J Pharmacol
van Zwieten, 1993, An overview of the pharmacodynamic properties and therapeutic potential of combined alpha- and beta-adrenoceptor antagonists., Drugs
Riva et al., 1991, The alpha- and beta-adrenoceptor blocking activities of labetalol and its RR-SR (50:50) stereoisomers., Br. J. Pharmacol.
Pujos et al., 2009, Comparison of the analysis of beta-blockers by different techniques., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Turner ST et al., 2003, Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide., Am J Hypertens
Maitland-van der Zee AH et al., 2005, Demographic, environmental, and genetic predictors of metabolic side effects of hydrochlorothiazide treatment in hypertensive subjects., Am J Hypertens
Maitland-van der Zee AH et al., 2005, A multilocus approach to the antihypertensive pharmacogenetics of hydrochlorothiazide., Pharmacogenet Genomics
Rudoy et al., 2007, Betaxolol, a selective beta(1)-adrenergic receptor antagonist, diminishes anxiety-like behavior during early withdrawal from chronic cocaine administration in rats., Prog. Neuropsychopharmacol. Biol. Psychiatry
Satoh et al., 1990, Effects of betaxolol on cardiohemodynamics and coronary circulation in anesthetized dogs: comparison with atenolol and propranolol., Jpn. J. Pharmacol.
McLean et al., 2002, Generation and analysis of constitutively active and physically destabilized mutants of the human beta(1)-adrenoceptor., Mol. Pharmacol.
Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics
Wang et al., 1996, (--)-Timolol is a more potent antagonist of the positive inotropic effects of (--)-adrenaline than of those of (--)-noradrenaline in human atrium., Br J Clin Pharmacol
Nieminen et al., 2005, Polymorphisms of genes CYP2D6, ADRB1 and GNAS1 in pharmacokinetics and systemic effects of ophthalmic timolol. A pilot study., Eur. J. Clin. Pharmacol.
Bhattacharyya et al., 2002, (-)-Isoproterenol modulation of maxi-K(+) channel in nonpigmented ciliary epithelial cells through a G-protein gated pathway., Curr. Eye Res.
Hirooka et al., 2000, Suppressive actions of betaxolol on ionic currents in retinal ganglion cells may explain its neuroprotective effects., Exp. Eye Res.
Varma et al., 1999, Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium., Br. J. Pharmacol.
Zimmerman et al., The beta-adrenergic blocking agents and the treatment of glaucoma., Surv Ophthalmol
Varma, 1999, Ligand-independent negative chronotropic responses of rat and mouse right atria to beta-adrenoceptor antagonists., Can. J. Physiol. Pharmacol.
Wheeldon et al., 1994, The effects of lower than conventional doses of oral nadolol on relative beta 1/beta 2-adrenoceptor blockade., Br J Clin Pharmacol
Wheeldon et al., 1994, Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man., Br J Clin Pharmacol
Koshiji et al., 1992, A comparison of guanfacine, bunazosin, atenolol and nadolol on blood pressure and plasma noradrenaline responses to cold pressor testing., Clin. Exp. Pharmacol. Physiol.
Watkins et al., 1996, Loss of [125I]-pindolol binding to beta-adrenoceptors on rat nodose ganglion after chronic isoprenaline treatment., J. Auton. Nerv. Syst.
Berendsen et al., 1990, Antagonism of 8-OH-DPAT-induced behaviour in rats., Eur. J. Pharmacol.
Brodde et al., 1988, Chronic beta-adrenoceptor antagonist treatment modulates human cardiac and vascular beta-adrenoceptor density in a subtype-selective fashion., J Hypertens Suppl
Joseph et al., 2003, Intrinsic sympathomimetic activity of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta1-adrenoceptor in human atrium and recombinant receptors., Naunyn Schmiedebergs Arch. Pharmacol.
Doggrell, 1991, Effects of (+/-)- (+)- and (-)-metoprolol, (+/-)- (+)- and (-)-pindolol, (+/-)-mepindolol and (+/-)-bopindolol on the rat left atria and portal vein., Gen. Pharmacol.
O'Shaughnessy KM et al., 2000, The gain-of-function G389R variant of the beta1-adrenoceptor does not influence blood pressure or heart rate response to beta-blockade in hypertensive subjects., Clin Sci (Lond)
Alberti et al., 1997, Mechanism and pressor relevance of the short-term cardiovascular and renin excitatory actions of the selective A2A-adenosine receptor agonists., J. Cardiovasc. Pharmacol.
Brown et al., 2002, Dietary Mg(2+) supplementation restores impaired vasoactive responses in isolated rat aorta induced by chronic ethanol consumption., Eur. J. Pharmacol.
Rydén M et al., 2001, The Arg 389 Gly beta1-adrenergic receptor gene polymorphism and human fat cell lipolysis., Int J Obes Relat Metab Disord
Bruck et al., 2005, The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity., J. Am. Coll. Cardiol.
La Rosée et al., 2004, The Arg389Gly beta1-adrenoceptor gene polymorphism determines contractile response to catecholamines., Pharmacogenetics
Junker et al., 2002, Stimulation of beta-adrenoceptors activates astrocytes and provides neuroprotection., Eur. J. Pharmacol.
Raddatz et al., 2006, Dobutamine improves liver function after hemorrhagic shock through induction of heme oxygenase-1., Am. J. Respir. Crit. Care Med.
Doggrell et al., 2002, Present and future pharmacotherapy for heart failure., Expert Opin Pharmacother
Disatnik MH et al., 1991, Regulation of beta-adrenoceptors by thyroid hormone and amiodarone in rat myocardiac cells in culture., Biochem Pharmacol
Drvota V et al., 1999, The effect of amiodarone on the beta-adrenergic receptor is due to a downregulation of receptor protein and not to a receptor-ligand interaction., Biochem Biophys Res Commun
Kim KM et al., 2012, Pharmacogenetics and healthcare outcomes in patients with chronic heart failure., Eur J Clin Pharmacol
Arai et al., 2003, Beta-adrenergic receptor agonists and antagonists counteract LPS-induced neuronal death in retinal cultures by different mechanisms., Brain Res.
Drímal et al., 1987, External transport of beta-adrenergic binding sites in ischemic myocardium., Gen. Physiol. Biophys.
Bilcíková et al., 1987, The action of adrenoceptor agonists and antagonists on the guinea pig and dog trachea., Gen. Physiol. Biophys.
El-Armouche et al., 2009, Beta-adrenergic stimulation and myocardial function in the failing heart., Heart Fail Rev
Mersmann, 1998, Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action., J. Anim. Sci.
Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
Nichols et al., 1989, The interaction of the enantiomers of carvedilol with alpha 1- and beta 1-adrenoceptors., Chirality
Nichols et al., 1989, In vitro pharmacologic profile of the novel beta-adrenoceptor antagonist and vasodilator, carvedilol., Pharmacology
de Mey et al., 1994, Dose-effect and pharmacokinetic-pharmacodynamic relationships of the beta 1-adrenergic receptor blocking properties of various doses of carvedilol in healthy humans., Clin. Pharmacol. Ther.
Nichols et al., 1991, Studies on the mechanism of arterial vasodilation produced by the novel antihypertensive agent, carvedilol., Fundam Clin Pharmacol
Mudunkotuwa et al., 1996, Desipramine administration in the olfactory bulbectomized rat: changes in brain beta-adrenoceptor and 5-HT2A binding sites and their relationship to behaviour., Br. J. Pharmacol.
Matsumoto et al., 1994, Beta 2- but not beta 1-adrenoceptors are involved in desipramine enhancement of aggressive behavior in long-term isolated mice., Pharmacol. Biochem. Behav.
Sapena et al., 1996, Desipramine treatment differently down-regulates beta-adrenoceptors of freshly isolated neurons and astrocytes., Eur. J. Pharmacol.
Samnick et al., 2004, Technetium-99m labeled 1-(4-fluorobenzyl)-4-(2-mercapto-2-methyl-4-azapentyl)-4-(2-mercapto-2-methylpropylamino)-piperidine and iodine-123 metaiodobenzylguanidine for studying cardiac adrenergic function: a comparison of the uptake characteristics in vascular smooth muscle cells and neonatal cardiac myocytes, and an investigation in rats., Nucl. Med. Biol.
Bürgi et al., 2003, Antidepressant-induced switch of beta 1-adrenoceptor trafficking as a mechanism for drug action., J. Biol. Chem.
Brouri et al., 2004, Blockade of beta 1- and desensitization of beta 2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis., Eur. J. Pharmacol.
Breed et al., 1992, Quality of life perception during antihypertensive treatment: a comparative study of bisoprolol and enalapril., J. Cardiovasc. Pharmacol.
Mauz et al., 1990, Beta-adrenoceptor-binding studies of the cardioselective beta blockers bisoprolol, H-I 42 BS, and HX-CH 44 BS to heart membranes and intact ventricular myocytes of adult rats: two beta 1-binding sites for bisoprolol., J. Cardiovasc. Pharmacol.
Lipworth et al., 1991, A dose-ranging study to evaluate the beta 1-adrenoceptor selectivity of bisoprolol., Eur. J. Clin. Pharmacol.
Doze et al., 2002, Synthesis and evaluation of radiolabeled antagonists for imaging of beta-adrenoceptors in the brain with PET., Neurochem. Int.
Venter et al., 1982, Ethnic differences in beta-1-adrenoceptor sensitivity., S. Afr. Med. J.
Sánchez, 1993, Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats., Behav Pharmacol
Frishman et al., 1990, Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism., J Clin Pharmacol
Rodrigues et al., 2006, Peripheral sympathetic component of the temporomandibular joint inflammatory pain in rats., J Pain
Terra et al., 2005, Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study., Int J Obes (Lond)
Muszkat, 2007, Interethnic differences in drug response: the contribution of genetic variability in beta adrenergic receptor and cytochrome P4502C9., Clin. Pharmacol. Ther.
Burniston et al., 2006, Relative myotoxic and haemodynamic effects of the beta-agonists fenoterol and clenbuterol measured in conscious unrestrained rats., Exp. Physiol.
Molenaar P et al., 2002, Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro., J Am Coll Cardiol
Ozakca et al., 2007, Role of beta-3-adrenoceptor in catecholamine-induced relaxations in gastric fundus from control and diabetic rats., Pharmacology
Leineweber et al., 2007, In patients chronically treated with metoprolol, the demand of inotropic catecholamine support after coronary artery bypass grafting is determined by the Arg389Gly-beta 1-adrenoceptor polymorphism., Naunyn Schmiedebergs Arch. Pharmacol.
Strosberg AD, 1993, Structure, function, and regulation of adrenergic receptors., Protein Sci
Khasar SG et al., 1999, Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors., J Neurophysiol
Abou-Mohamed et al., 1996, Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing., Cardiovasc Drugs Ther
Doggrell, 1993, The effects of (+/-)-, (+)-, and (-)-atenolol, sotalol, and amosulalol on the rat left atria and portal vein., Chirality
Juberg et al., 1985, Beta 1- and beta 2-adrenoceptor binding and functional response in right and left atria of rat heart., Naunyn Schmiedebergs Arch. Pharmacol.
Yalcin et al., 2009, beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain., Ann. Neurol.
Joseph et al., 2004, Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers., Naunyn Schmiedebergs Arch. Pharmacol.
Lowe et al., 2002, Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium., Br. J. Pharmacol.
De Ponti et al., 1995, Inhibitory effects of SR 58611A on canine colonic motility: evidence for a role of beta 3-adrenoceptors., Br. J. Pharmacol.
Surman et al., 1993, Alprenolol and bromoacetylalprenololmenthane are competitive slowly reversible antagonists at the beta 1-adrenoceptors of rat left atria., J. Cardiovasc. Pharmacol.
Im et al., 1988, Interactions of pure beta gamma-subunits of G-proteins with purified beta 1-adrenoceptor., FEBS Lett.
Brahmadevara et al., 2003, Evidence against beta 3-adrenoceptors or low affinity state of beta 1-adrenoceptors mediating relaxation in rat isolated aorta., Br. J. Pharmacol.
Zelaszczyk et al., 2009, Four close bupranolol analogues are antagonists at the low-affinity state of beta1-adrenoceptors., J. Physiol. Pharmacol.
Dale et al., 2007, Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter., Ann Pharmacother
Heijman J et al., 2013, Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation., Clin Med Insights Cardiol
Bacaner et al., 1982, Antiarrhythmic, antifibrillatory, and hemodynamic actions of bethanidine sulfate: an orally effective analog of bretylium for suppression of ventricular tachyarrhythmias., Am. J. Cardiol.
Hart et al., 1981, Withdrawal syndromes and the cessation of antihypertensive therapy., Arch. Intern. Med.
Yao et al., 2008, Effects of the antioxidative beta-blocker celiprolol on endothelial progenitor cells in hypertensive rats., Am. J. Hypertens.
Chen et al., 2007, Celiprolol, a selective beta1-blocker, reduces the infarct size through production of nitric oxide in a rabbit model of myocardial infarction., Circ. J.
Hayashi et al., 2007, beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes., Life Sci.

BETAXOLOL ADRB1

Interaction Score: 7.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2903243 2891463 17513029 11752352 2077180 12181453

Sources:
DTC TdgClinicalTrial TEND TTD
PRACTOLOL ADRB1

Interaction Score: 7.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2903243 11752352 6524278 2871880 30388 2857116

Sources:
DTC TdgClinicalTrial TEND TTD
ESMOLOL ADRB1

Interaction Score: 6.7

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2568748 1975995 7612051 2894187 7957532 11752352

Sources:
TdgClinicalTrial TEND TTD
BISOPROLOL ADRB1

Interaction Score: 4.84

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15861037 16325050 14757145 1280737 1691366 11752352 1676675 2903243

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD
BUCINDOLOL ADRB1

Interaction Score: 4.72

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bucindolol hydrochloride,Gencaro

Novel drug target Established target

PMIDs:
22617224 21311897 20643254 20352314 20235788 18075464 17496726 16815314 15864115 15861037 15735607 14534524 14502278 12921807 12844134 12709726

Sources:
TdgClinicalTrial PharmGKB TTD
ARBUTAMINE ADRB1

Interaction Score: 4.47

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 8723169

Sources:
TdgClinicalTrial TEND TTD
ALPRENOLOL ADRB1

Interaction Score: 3.72

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7606348 7678677 2828119 11752352 12522078 10433496 2903243

Sources:
DTC TdgClinicalTrial TEND
ACEBUTOLOL ADRB1

Interaction Score: 3.72

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2568935 16268148 2453744 11752352 2903243

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD
OXPRENOLOL ADRB1

Interaction Score: 3.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2871880 11752352 6202960 17016423 17139284 6124492

Sources:
TdgClinicalTrial TEND TTD
CARTEOLOL ADRB1

Interaction Score: 3.35

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16160085 10864881 15526107 11752352 2903243

Sources:
DTC TdgClinicalTrial TEND TTD
LEVOBUNOLOL ADRB1

Interaction Score: 3.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10864881 1351412 7928182 11572462 2892662 2891463

Sources:
TdgClinicalTrial TEND TTD
TIMOLOL ADRB1

Interaction Score: 3.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

Trial Name brimonidine tartrate/timolol maleate,Combigan

PMIDs:
8864321 16315032 12221524 11752352 10870519 10433496 2903243

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
PINDOLOL ADRB1

Interaction Score: 2.98

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Beta-1 adrenergic receptor partial agonist

PMIDs:
8884690 2148726 2907348 14608456 11752352 1687398 2903243

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
PENBUTOLOL ADRB1

Interaction Score: 2.61

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11738481 6755764 11224195 2189902

Sources:
TdgClinicalTrial TEND TTD
BEVANTOLOL ADRB1

Interaction Score: 2.61

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2568629 2858236 6148733 17628611 2888789

Sources:
TdgClinicalTrial TEND
METOPROLOL ADRB1

Interaction Score: 2.51

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name metoprolol succinate,Toprol-XL

Novel drug target Established target

Trial Name -

PMIDs:
22617224 21311897 20643254 20352314 20235788 18075464 17496726 16815314 15861037 14502278 12844134 12709726 16402084 15864115 15735607 14534524 12921807 2903243 10913016 11752352 12679135 11448474

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD
DOBUTAMINE ADRB1

Interaction Score: 2.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11753577 16325050 15564877 12098582 16627864 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD
NADOLOL ADRB1

Interaction Score: 2.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
10606440 7981009 7912539 1354084 11752352 10433496 2903243

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
BUFURALOL ADRB1

Interaction Score: 2.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2903243 37605

Sources:
DTC
NEBIVOLOL ADRB1

Interaction Score: 2.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name nebivolol ,Bystolic

PMIDs:
16961165 17661735 11752352

Sources:
TdgClinicalTrial TEND TTD
METIPRANOLOL ADRB1

Interaction Score: 1.99

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12967722 17016423 17139284 2895037 2885244

Sources:
TdgClinicalTrial TEND TTD
CELIPROLOL ADRB1

Interaction Score: 1.86

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2903243 18636069 17384462 17141277

Sources:
DTC
ISOETHARINE ADRB1

Interaction Score: 1.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17157779 15917856 17329986 17628611 16973691

Sources:
TdgClinicalTrial TEND
BUPRANOLOL ADRB1

Interaction Score: 1.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2903243 19439807

Sources:
DTC
CARVEDILOL ADRB1

Interaction Score: 1.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name carvedilol,Coreg

Novel drug target Established target

Mechanism of Interaction Adrenergic receptor beta antagonist

PMIDs:
27643874 22617224 21311897 20643254 20352314 20235788 18075464 17496726 16815314 15864115 15861037 15735607 14534524 14502278 12921807 12844134 12709726 2577144 2575762 7908256 1712335

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB
METOPROLOL SUCCINATE ADRB1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BISOPROLOL FUMARATE ADRB1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
BRETYLIUM ADRB1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ACEBUTOLOL HYDROCHLORIDE ADRB1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEVOBETAXOLOL HYDROCHLORIDE ADRB1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ANISODAMINE ADRB1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BUNOLOL ADRB1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2903243

Sources:
DTC
BUNITROLOL ADRB1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2903243

Sources:
DTC
DICHLOROISOPROTERENOL ADRB1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2903243

Sources:
DTC
LEVOBETAXOLOL ADRB1

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
SOTALOL ADRB1

Interaction Score: 0.67

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
8095397 2865685 19259968 11752352 15060759 11815381 2903243

Sources:
DTC TTD
ATENOLOL ADRB1

Interaction Score: 0.64

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
2903243 22617224 21311897 20643254 20352314 20235788 18075464 17496726 16815314 15864115 15861037 15735607 14534524 14502278 12921807 12844134 11787477 12709726 9300315 10913016 12065078 17628611 11752352

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
LABETALOL ADRB1

Interaction Score: 0.62

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
8104240 6151824 7286847 6355664 7684671 1687367 19879818 11752352

Sources:
TdgClinicalTrial TEND
PROPRANOLOL ADRB1

Interaction Score: 0.51

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name VT-122

Novel drug target Established target

PMIDs:
16177222 17628611 14757703 11752352 15236843 17572694 2903243

Sources:
DTC TdgClinicalTrial TEND TTD
MEPINDOLOL ADRB1

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2903243

Sources:
DTC
TERTATOLOL ADRB1

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2903243

Sources:
DTC
ESMOLOL HYDROCHLORIDE ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METIPRANOLOL HYDROCHLORIDE ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEVOBUNOLOL HYDROCHLORIDE ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TIMOLOL MALEATE ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPIVEFRIN ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BETHANIDINE ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
6812406 6114720 11752352

Sources:
TTD
DRONEDARONE ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17389667 23997577

Sources:
TdgClinicalTrial TEND
CHEMBL111201 ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
OXPRENOLOL HYDROCHLORIDE ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BETAXOLOL HYDROCHLORIDE ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DROXIDOPA ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
19110970 9464897 18064417

Sources:
ChemblInteractions
NEBIVOLOL HYDROCHLORIDE ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENBUTOLOL SULFATE ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SALMETEROL ADRB1

Interaction Score: 0.37

Interaction Types & Directionality:

inverse agonist (inhibitory)

Interaction Info:

PMIDs:
14730417

Sources:
DTC
DESIPRAMINE ADRB1

Interaction Score: 0.35

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8730743 7816863 8741184 15093822 12393876

Sources:
TdgClinicalTrial TEND
NOREPINEPHRINE ADRB1

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
2903243 19110970 9464897 18064417 11752352 12383575

Sources:
DTC PharmGKB TTD
ISOPROTERENOL ADRB1

Interaction Score: 0.27

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10722 11752352 15908512 16038799 14734046 27643874

Sources:
TdgClinicalTrial TEND PharmGKB TTD
CARTEOLOL HYDROCHLORIDE ADRB1

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor beta antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LY377604 ADRB1

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPRANOLOL HYDROCHLORIDE ADRB1

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EPINEPHRINE ADRB1

Interaction Score: 0.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name transdermal lidocaine/epinephrine patch,Lidosite

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
17622774 11752352 17541557 8401205 10085337

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
MURAGLITAZAR ADRB1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18794727

Sources:
PharmGKB
BUDIODARONE ADRB1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name budiodarone, ATI-2042

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SOTALOL HYDROCHLORIDE ADRB1

Interaction Score: 0.19

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOBUTAMINE HYDROCHLORIDE ADRB1

Interaction Score: 0.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INDACATEROL ADRB1

Interaction Score: 0.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMIODARONE ADRB1

Interaction Score: 0.18

Interaction Types & Directionality:

negative modulator (inhibitory)

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name amiodarone HCl,Amio-Aqueous IV

Novel drug target Established target

PMIDs:
12083991 1672592 10049740

Sources:
TdgClinicalTrial TEND
CARVEDILOL PHOSPHATE ADRB1

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor beta antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ISOPROTERENOL HYDROCHLORIDE ADRB1

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor beta agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPHENTERMINE SULFATE ADRB1

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPIVEFRIN HYDROCHLORIDE ADRB1

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LABETALOL HYDROCHLORIDE ADRB1

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROXYAMPHETAMINE HYDROBROMIDE ADRB1

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
HYDROCHLOROTHIAZIDE ADRB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14553962 16109321 15864129

Sources:
PharmGKB
SPIRONOLACTONE ADRB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543981

Sources:
PharmGKB
DOPAMINE HYDROCHLORIDE ADRB1

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NOREPINEPHRINE BITARTRATE ADRB1

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPAFENONE HYDROCHLORIDE ADRB1

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EPINEPHRINE BITARTRATE ADRB1

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
DIGOXIN ADRB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543981

Sources:
PharmGKB
ZIPRASIDONE ADRB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
DOPAMINE ADRB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000043591
- Version: 101_38
Alternate Names:

ADRB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P08588
- Version: January-2014
Alternate Names:

ADRB1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: P08588
- Version: 11-September-2012
Alternate Names:

ADRB1 Uniprot Gene Name

BETA-1 ADRENERGIC RECEPTOR Uniprot Protein Name

P08588 Uniprot Accession

Gene Info:

Uniprot Status Swiss-Prot

Interpro Short Name 7TM_GPCR_Rhodpsn

Human Readable Name DRUGGABLE GENOME

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000043591
- Version: 26-July-2011
Alternate Names:

ENSG00000043591 Ensembl Gene Id

ADRB1 Display Id

BETA-1 ADRENERGIC RECEPTOR (BETA-1 ADRENOCEPTOR) (BETA-1 ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P08588] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P08588
- Version: 01-August-2011
Alternate Names:

ADRB1 Gene Symbol

P08588 Uniprot Accession

ADRB1_HUMAN Uniprot Id

Gene Info:

Transmembrane Helix Count 7

Target Main Class Receptors

Target Subclass Rhodopsin

Publications:

PharmGKB: ADRB1

Version: 18-August-2020

Alternate Names:

PA38 PharmGKB ID

Gene Info:

Publications:

Terra SG et al., 2005, Beta1-adrenergic receptor polymorphisms and left ventricular remodeling changes in response to beta-blocker therapy., Pharmacogenet Genomics

Baudhuin LM et al., 2010, Relation of ADRB1, CYP2D6, and UGT1A1 polymorphisms with dose of, and response to, carvedilol or metoprolol therapy in patients with chronic heart failure., Am J Cardiol

de Groote P et al., 2005, Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure., Pharmacogenet Genomics

TTD: Adrenergic receptor beta-1
- Version: 2020.06.01
Alternate Names:

ADRB1 TTD Gene Abbreviation

T44068 TTD Target ID

Gene Info:

Publications:

Aggerbeck et al., 1979, N-Aralkyl substitution increases the affinity of adrenergic drugs for the alpha-adrenoceptor in rat liver., Br. J. Pharmacol.
DTC: ADRB1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
HingoraniCasas: ENSG00000043591
- Version: 31-May-2017
Alternate Names:

ENSG00000043591 Gene Symbol

ADRB1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ADRB1R
- Version: chembl_23
Alternate Names:

B1AR GENE_SYMBOL

ADRB1 GENE_SYMBOL

Beta-1 adrenergic receptor UNIPROT

Gene Info:

Publications:
GO: ADRB1
- Version: 01-February-2022
Alternate Names:

ADRB1R GO Gene Synonym

B1AR GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: ADRB1
- Version: 27-Jun-2013
Alternate Names:

153 Gene ID

ADRB1R dGene Synonym

B1AR dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Trial Name	bucindolol hydrochloride,Gencaro
Novel drug target	Established target

Mechanism of Interaction	Beta-1 adrenergic receptor antagonist
Direct Interaction	yes
Trial Name	brimonidine tartrate/timolol maleate,Combigan

Trial Name	metoprolol succinate,Toprol-XL
Novel drug target	Established target
Trial Name	-

Trial Name	carvedilol,Coreg
Novel drug target	Established target
Mechanism of Interaction	Adrenergic receptor beta antagonist

Direct Interaction	yes
Mechanism of Interaction	Adrenergic receptor agonist

Trial Name	budiodarone, ATI-2042
Novel drug target	Established target

Mechanism of Interaction	Beta-1 adrenergic receptor agonist
Direct Interaction	yes

Trial Name	amiodarone HCl,Amio-Aqueous IV
Novel drug target	Established target

Mechanism of Interaction	Adrenergic receptor beta agonist
Direct Interaction	yes

Mechanism of Interaction	Adrenergic receptor antagonist
Direct Interaction	yes

ADRB1	Uniprot Gene Name
BETA-1 ADRENERGIC RECEPTOR	Uniprot Protein Name
P08588	Uniprot Accession

ENSG00000043591	Ensembl Gene Id
ADRB1	Display Id
BETA-1 ADRENERGIC RECEPTOR (BETA-1 ADRENOCEPTOR) (BETA-1 ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P08588]	Description

ADRB1	Gene Symbol
P08588	Uniprot Accession
ADRB1_HUMAN	Uniprot Id

B1AR	GENE_SYMBOL
ADRB1	GENE_SYMBOL
Beta-1 adrenergic receptor	UNIPROT

ADRB1 Gene Record

ADRB1 153 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2903243 2891463 17513029 11752352 2077180 12181453

Sources: DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2903243 11752352 6524278 2871880 30388 2857116

Sources: DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 2568748 1975995 7612051 2894187 7957532 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15861037 16325050 14757145 1280737 1691366 11752352 1676675 2903243

Sources: DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name bucindolol hydrochloride,Gencaro Novel drug target Established target

PMIDs: 22617224 21311897 20643254 20352314 20235788 18075464 17496726 16815314 15864115 15861037 15735607 14534524 14502278 12921807 12844134 12709726

Sources: TdgClinicalTrial PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 8723169

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 7606348 7678677 2828119 11752352 12522078 10433496 2903243

Sources: DTC TdgClinicalTrial TEND

Interaction Types & Directionality: partial agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2568935 16268148 2453744 11752352 2903243

Sources: DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2871880 11752352 6202960 17016423 17139284 6124492

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16160085 10864881 15526107 11752352 2903243

Sources: DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10864881 1351412 7928182 11572462 2892662 2891463

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Beta-1 adrenergic receptor antagonist Direct Interaction yes Trial Name brimonidine tartrate/timolol maleate,Combigan

PMIDs: 8864321 16315032 12221524 11752352 10870519 10433496 2903243

Sources: DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Beta-1 adrenergic receptor partial agonist

PMIDs: 8884690 2148726 2907348 14608456 11752352 1687398 2903243

Sources: DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: partial agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11738481 6755764 11224195 2189902

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2568629 2858236 6148733 17628611 2888789

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name metoprolol succinate,Toprol-XL Novel drug target Established target Trial Name -

PMIDs: 22617224 21311897 20643254 20352314 20235788 18075464 17496726 16815314 15861037 14502278 12844134 12709726 16402084 15864115 15735607 14534524 12921807 2903243 10913016 11752352 12679135 11448474

Sources: DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11753577 16325050 15564877 12098582 16627864 11752352

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Beta-1 adrenergic receptor antagonist Direct Interaction yes Trial Name -

PMIDs: 10606440 7981009 7912539 1354084 11752352 10433496 2903243

Sources: DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2903243 2891463 17513029 11752352 2077180 12181453

Sources:
DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2903243 11752352 6524278 2871880 30388 2857116

Sources:
DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2568748 1975995 7612051 2894187 7957532 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15861037 16325050 14757145 1280737 1691366 11752352 1676675 2903243

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bucindolol hydrochloride,Gencaro

Novel drug target Established target

PMIDs:
22617224 21311897 20643254 20352314 20235788 18075464 17496726 16815314 15864115 15861037 15735607 14534524 14502278 12921807 12844134 12709726

Sources:
TdgClinicalTrial PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 8723169

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7606348 7678677 2828119 11752352 12522078 10433496 2903243

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2568935 16268148 2453744 11752352 2903243

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2871880 11752352 6202960 17016423 17139284 6124492

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16160085 10864881 15526107 11752352 2903243

Sources:
DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10864881 1351412 7928182 11572462 2892662 2891463

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

Trial Name brimonidine tartrate/timolol maleate,Combigan

PMIDs:
8864321 16315032 12221524 11752352 10870519 10433496 2903243

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Beta-1 adrenergic receptor partial agonist

PMIDs:
8884690 2148726 2907348 14608456 11752352 1687398 2903243

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11738481 6755764 11224195 2189902

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2568629 2858236 6148733 17628611 2888789

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name metoprolol succinate,Toprol-XL

Novel drug target Established target

Trial Name -

PMIDs:
22617224 21311897 20643254 20352314 20235788 18075464 17496726 16815314 15861037 14502278 12844134 12709726 16402084 15864115 15735607 14534524 12921807 2903243 10913016 11752352 12679135 11448474

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11753577 16325050 15564877 12098582 16627864 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-1 adrenergic receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
10606440 7981009 7912539 1354084 11752352 10433496 2903243

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
2903243 37605

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name nebivolol ,Bystolic

PMIDs:
16961165 17661735 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)