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ADRA2B Gene Record

  • Summary
  • Interactions
  • Claims
  • ADRA2B 151 Druggable Genome

    Alternate Names:

    151
    ADRENOCEPTOR ALPHA 2B
    ADRA2B
    ADRA2L1
    ADRA2RL1
    ADRARL1
    ALPHA2BAR
    FAME2
    alpha-2BAR
    104260
    282
    ENSG00000274286
    OTTHUMG00000188276
    ENSG00000181210
    ALPHA-2B ADRENERGIC RECEPTOR (ALPHA-2B ADRENOCEPTOR) (ALPHA-2B ADRENORECEPTOR) (SUBTYPE C2). [SOURCE:UNIPROT/SWISSPROT;ACC:P18089]
    BE0000572
    P18089
    ADA2B_HUMAN
    ENSG00000222040
    ALPHA-2B ADRENERGIC RECEPTOR
    Alpha-2B adrenoceptor
    Alpha-2B adrenoreceptor
    Alpha-2 adrenergic receptor subtype C2
    26
    &alpha;<sub>2B</sub>-adrenoceptor
    NP_000673
    NM_000682
    PA36
    Adrenergic receptor alpha-2B
    T41580

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Subclass GPCR
    Target Main Class Receptors
    Uniprot Status Swiss-Prot
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Acc IPR000276
    Uniprot Evidence 2: Evidence at transcript level
    Interpro Type Family
    Interpro Name GPCR, rhodopsin-like, 7TM
    GuideToPharmacology Gene Category Name Adrenoceptors
    GuideToPharmacology Gene Category ID 4
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Uhlén et al., 1991, Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound., Eur. J. Pharmacol.
    Gaulton et al., 2012, ChEMBL: a large-scale bioactivity database for drug discovery., Nucleic Acids Res.
    Millan MJ et al., 2000, S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine., J Pharmacol Exp Ther
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Rudling et al., 2000, A comparison of agonist-specific coupling of cloned human alpha(2)-adrenoceptor subtypes., Br. J. Pharmacol.
    Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
    Gobbi et al., 1990, The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype., Naunyn Schmiedebergs Arch. Pharmacol.
    Nash, 1990, Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism., Clin Cardiol
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Vizi et al., 2001, Evidence for presynaptic cannabinoid CB(1) receptor-mediated inhibition of noradrenaline release in the guinea pig lung., Eur. J. Pharmacol.
    Piletz et al., 1996, Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
    Trendelenburg et al., 2003, All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons., Naunyn Schmiedebergs Arch. Pharmacol.
    Bohmann et al., 1993, Methoxamine inhibits noradrenaline release through activation of alpha 1- and alpha 2-adrenoceptors in rat isolated kidney: involvement of purines and prostaglandins., Naunyn Schmiedebergs Arch. Pharmacol.
    Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
    Ariëns EJ et al., 1983, Physiological and pharmacological aspects of adrenergic receptor classification., Biochem Pharmacol
    Bylund DB, 1985, Heterogeneity of alpha-2 adrenergic receptors., Pharmacol Biochem Behav
    Adams HR, 1983, Pharmacologic problems in circulation research: alpha adrenergic blocking drugs., Circ Shock
    Yasuda G et al., 1991, Characterization of prazosin-sensitive alpha 2 B-adrenoceptors expressed by cultured rat IMCD cells., Am J Physiol
    Bylund et al., 1988, Alpha-2A and alpha-2B adrenergic receptor subtypes: antagonist binding in tissues and cell lines containing only one subtype., J. Pharmacol. Exp. Ther.
    Richelson et al., 2000, Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds., Life Sci.
    Corena-McLeod M, 2015, Comparative Pharmacology of Risperidone and Paliperidone., Drugs R D
    Fenton et al., 2005, Risperidone: a review of its use in the treatment of bipolar mania., CNS Drugs
    Newman-Tancredi et al., 2002, Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor., J. Pharmacol. Exp. Ther.
    Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
    Sharif et al., 2009, Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes., Exp. Eye Res.
    Lam, 2000, Clinical pharmacology of dopamine agonists., Pharmacotherapy
    de Leeuw van Weenen et al., 2010, The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells., Biochem. Pharmacol.
    Freitag et al., 1996, Adrenoceptor- and cholinoceptor-mediated mechanisms in the regulation of 5-hydroxytryptamine release from isolated tracheae of newborn rabbits., Br. J. Pharmacol.
    Alonso et al., 2007, Yohimbine prevents morphine-induced changes of glial fibrillary acidic protein in brainstem and alpha2-adrenoceptor gene expression in hippocampus., Neurosci. Lett.
    Cleary et al., 2002, Investigation of neurotransmission in vas deferens from alpha(2A/D)-adrenoceptor knockout mice., Br. J. Pharmacol.
    Takada et al., 2002, Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype., Anesthesiology
    Gyires et al., 2000, Functional evidence that gastroprotection can be induced by activation of central alpha(2B)-adrenoceptor subtypes in the rat., Eur. J. Pharmacol.
    Millan et al., 2000, Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states., Synapse
    de Bartolomeis A et al., 2015, Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism., CNS Drugs
    Haenisch et al., 2010, Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline., Fundam Clin Pharmacol
    Frang et al., 2001, Phenoxybenzamine binding reveals the helical orientation of the third transmembrane domain of adrenergic receptors., J. Biol. Chem.
    Koshimizu et al., 2004, Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors., Cardiovasc. Res.
    Creagh et al., 2010, Alpha-2B adrenergic receptor mediated hemodynamic profile of etomidate., P R Health Sci J
    Paris et al., 2003, Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate., Anesthesiology
    Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
    Tsukamoto et al., 1984, Interaction of neuroleptics and antidepressants with rat brain alpha 2-receptors: a possible relationship between alpha 2-receptor antagonism and antidepressant action., Biol. Psychiatry
    Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
    Kobayashi et al., 2003, The sympathomimetic actions of l-ephedrine and d-pseudoephedrine: direct receptor activation or norepinephrine release?, Anesth. Analg.
    Rothman et al., 2003, In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates., J. Pharmacol. Exp. Ther.
    Sulzer et al., 2005, Mechanisms of neurotransmitter release by amphetamines: a review., Prog. Neurobiol.
    Liu et al., 1991, Adrenergic mechanism in circadian elevation of intraocular pressure in rabbits., Invest. Ophthalmol. Vis. Sci.
    Davis, 2010, Recent advances in the treatment of pain., F1000 Med Rep
    Giovannoni et al., 2009, Alpha2-agonists as analgesic agents., Med Res Rev
    Jeng et al., 1998, Methamphetamine modulates GABA-induced electrophysiological depression by alternating noradrenergic actions in cerebellar Purkinje neurons., Psychopharmacology (Berl.)
    Suttajit S et al., 2014, Quetiapine for acute bipolar depression: a systematic review and meta-analysis., Drug Des Devel Ther
    Jensen et al., 2008, N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity., Neuropsychopharmacology
    Trendelenburg et al., 1997, Presynaptic alpha 2A/D-autoreceptors in the brain cortex of Cercopithecus aethiops., Naunyn Schmiedebergs Arch. Pharmacol.
    Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.
    Berger et al., 1996, Trimipramine: a challenge to current concepts on antidepressives., Eur Arch Psychiatry Clin Neurosci
    Scheller et al., 2009, The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease., Naunyn Schmiedebergs Arch. Pharmacol.
    Dale et al., 2007, Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter., Ann Pharmacother
    Heijman J et al., 2013, Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation., Clin Med Insights Cardiol
    Mylecharane EJ, 1991, 5-HT2 receptor antagonists and migraine therapy., J Neurol
    Kroeze et al., 2003, H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs., Neuropsychopharmacology
    Nawarskas JJ et al., 2017, Celiprolol: A Unique Selective Adrenoceptor Modulator., Cardiol Rev
  • GUANABENZ   ADRA2B

    Interaction Score: 0.46

    Interaction Types & Directionality:
    agonist (activating)
    binder

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    1666366


    Sources:
    DrugBank GuideToPharmacology

  • BRIMONIDINE   ADRA2B

    Interaction Score: 0.41

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    14610637 8097565


    Sources:
    TEND PharmGKB DrugBank GuideToPharmacology

  • YOHIMBINE   ADRA2B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    8872361 17123717 12110610 12170055 10822066 10611634


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

  • PRAZOSIN   ADRA2B

    Interaction Score: 0.33

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    1666366 2989948 6133635 1719824 2835476


    Sources:
    DrugBank GuideToPharmacology

  • DROXIDOPA   ADRA2B

    Interaction Score: 0.31

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    21173850 18064417 18680204


    Sources:
    DrugBank ChemblInteractions

  • APRACLONIDINE   ADRA2B

    Interaction Score: 0.31

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    1676991


    Sources:
    DrugBank

  • CLONIDINE   ADRA2B

    Interaction Score: 0.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    11082457


    Sources:
    PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • TOLAZOLINE   ADRA2B

    Interaction Score: 0.26

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of agonist-stimulated [<sup>35</sup>S]GTP&gamma;S binding
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    9089664


    Sources:
    DrugBank GuideToPharmacology

  • GUANFACINE   ADRA2B

    Interaction Score: 0.26

    Interaction Types & Directionality:
    agonist (activating)
    binder

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    1666366


    Sources:
    DrugBank GuideToPharmacology

  • FENOLDOPAM   ADRA2B

    Interaction Score: 0.26

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7670737 17139284 17016423


    Sources:
    TEND DrugBank

  • NOREPINEPHRINE   ADRA2B

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11053214 18064417 1979424 1980236 17139284 17016423 11728431


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank

  • CHEMBL362051   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BRIMONIDINE TARTRATE   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TIZANIDINE HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • APRACLONIDINE HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • XYLAZINE   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • METHYLDOPATE HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FADOLMIDINE HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DEXMEDETOMIDINE HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FIPAMEZOLE   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name fipamezole, JP-1730

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • LOFEXIDINE   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction Calculated from [<sup>3</sup>H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human &alpha;<sub>2B</sub>-AR.
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial GuideToPharmacology

  • TIZANIDINE   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name NVD-422, tizanidine oral spray
    Novel drug target Established target
    Trial Name tizanidine hydrochloride,Zanaflex

    PMIDs:
    8930173


    Sources:
    TdgClinicalTrial

  • CLONIDINE HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OXYMETAZOLINE   ADRA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)
    binder

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    1666366 21948594


    Sources:
    DrugBank GuideToPharmacology

  • EPINEPHRINE   ADRA2B

    Interaction Score: 0.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name transdermal lidocaine/epinephrine patch,Lidosite
    Novel drug target Established target
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    6134529 11053214 18064417 1979424 1980236 11728431


    Sources:
    PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

  • EPHEDRA   ADRA2B

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    14570629 12954796 15955613


    Sources:
    DrugBank

  • CABERGOLINE   ADRA2B

    Interaction Score: 0.19

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    12388667 18691132 18992242 10641988


    Sources:
    DrugBank GuideToPharmacology

  • ETOMIDATE   ADRA2B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    20496522 14508322


    Sources:
    TEND TdgClinicalTrial DrugBank

  • CELIPROLOL   ADRA2B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    28742547


    Sources:
    DrugBank

  • ROTIGOTINE   ADRA2B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    18704368


    Sources:
    DrugBank

  • XYLOMETAZOLINE   ADRA2B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    20030735


    Sources:
    DrugBank

  • DEBRISOQUIN   ADRA2B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • GUANFACINE HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.15

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MOXONIDINE   ADRA2B

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GUANABENZ ACETATE   ADRA2B

    Interaction Score: 0.15

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BETHANIDINE   ADRA2B

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • PHENOXYBENZAMINE   ADRA2B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    11395517


    Sources:
    DrugBank GuideToPharmacology

  • RAUWOLFIA SERPENTINA   ADRA2B

    Interaction Score: 0.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LEVOMEPROMAZINE   ADRA2B

    Interaction Score: 0.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2870716 6149771 15701205


    Sources:
    DrugBank

  • LISURIDE   ADRA2B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    other/unknown
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • ESMIRTAZAPINE MALEATE   ADRA2B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEDETOMIDINE   ADRA2B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PERGOLIDE   ADRA2B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    18691132 10641988


    Sources:
    GuideToPharmacology

  • ALSEROXYLON   ADRA2B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NAPHAZOLINE HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TETRAHYDROZOLINE HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SENREBOTASE   ADRA2B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AGN-214868
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • BROMOCRIPTINE   ADRA2B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    18691132 10641988 20138024


    Sources:
    DrugBank GuideToPharmacology

  • METHAMPHETAMINE   ADRA2B

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name low dose intravenous methamphetamine
    Novel drug target Established target

    PMIDs:
    9551769 15955613


    Sources:
    TdgClinicalTrial DrugBank

  • RAUWOLSCINE   ADRA2B

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • OXYMETAZOLINE HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ASENAPINE   ADRA2B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Asenapine

    PMIDs:
    18308814


    Sources:
    TdgClinicalTrial DrugBank

  • PIZOTYLINE   ADRA2B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2045831


    Sources:
    DrugBank

  • DIPIVEFRIN HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOLAZOLINE HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DEXMEDETOMIDINE   ADRA2B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • MEPHENTERMINE SULFATE   ADRA2B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENTOLAMINE MESYLATE   ADRA2B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • APOMORPHINE   ADRA2B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • PHENOXYBENZAMINE HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LABETALOL HYDROCHLORIDE   ADRA2B

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDROXYAMPHETAMINE HYDROBROMIDE   ADRA2B

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUETIAPINE   ADRA2B

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17848919 11132243 25028535 18059438


    Sources:
    DrugBank

  • DRONEDARONE   ADRA2B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17389667 23997577


    Sources:
    DrugBank

  • SPIROXATRINE   ADRA2B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TRIMIPRAMINE   ADRA2B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    8863001


    Sources:
    DrugBank

  • PALIPERIDONE   ADRA2B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11132243


    Sources:
    DrugBank

  • MIRTAZAPINE   ADRA2B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • CHEMBL609728   ADRA2B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • RACEPINEPHRINE   ADRA2B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • LEVONORDEFRIN   ADRA2B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ERGOLOID MESYLATES   ADRA2B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TERGURIDE   ADRA2B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PHENTOLAMINE   ADRA2B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • NOREPINEPHRINE BITARTRATE   ADRA2B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ROXINDOLE   ADRA2B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • OCAPERIDONE   ADRA2B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ARIPIPRAZOLE   ADRA2B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    ligand
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17848919 26346901


    Sources:
    DrugBank

  • CARVEDILOL   ADRA2B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15306222


    Sources:
    DrugBank

  • EPINEPHRINE BITARTRATE   ADRA2B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZOTEPINE   ADRA2B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • RISPERIDONE   ADRA2B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11132243 25943458 15907153


    Sources:
    DrugBank

  • ZIPRASIDONE   ADRA2B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17848919


    Sources:
    DrugBank

  • MIANSERIN   ADRA2B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • DOPAMINE   ADRA2B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LOXAPINE   ADRA2B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ISOPROTERENOL   ADRA2B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • OLANZAPINE   ADRA2B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ALKS 3831
    Trial Name OREX-003, olanzapine plus zonisamide SR
    Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

    PMIDs:
    17848919


    Sources:
    TdgClinicalTrial

  • HALOPERIDOL   ADRA2B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12629531


    Sources:
    DrugBank

  • CLOZAPINE   ADRA2B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17848919


    Sources:
    DrugBank

  • CHLORPROMAZINE   ADRA2B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • METHYLDOPA   ADRA2B

    Interaction Score: 0.0

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000274286

    • Version: 101_38

    Alternate Names:
    ADRA2B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P18089

    • Version: 11-September-2012

    Alternate Names:
    ADA2B_HUMAN Uniprot Id
    ALPHA-2B ADRENERGIC RECEPTOR Uniprot Protein Name
    ADRA2B Uniprot Gene Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Human Readable Name G PROTEIN COUPLED RECEPTOR

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P18089

    • Version: January-2014

    Alternate Names:
    ADRA2B Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • RussLampel: ENSG00000181210

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000181210 Ensembl Gene Id
    ALPHA-2B ADRENERGIC RECEPTOR (ALPHA-2B ADRENOCEPTOR) (ALPHA-2B ADRENORECEPTOR) (SUBTYPE C2). [SOURCE:UNIPROT/SWISSPROT;ACC:P18089] Description
    ADRA2B Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P18089

    • Version: 01-August-2011

    Alternate Names:
    ADA2B_HUMAN Uniprot Id
    ENSG00000222040 Ensembl Gene Id
    ADRA2B Gene Symbol

    Gene Info:
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Subclass GPCR

    Publications:

  • GuideToPharmacology: 151

    • Version: 29-September-2020

    Alternate Names:
    282 HUGO Gene ID
    282 HUGO Gene Symbol
    adrenoceptor alpha 2B HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Adrenoceptors
    GuideToPharmacology Gene Category ID 4

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • DrugBank: BE0000572

    • Version: 5.1.7

    Alternate Names:
    ADRA2B DrugBank Gene Name
    P18089 UniProt Accession
    151 Entrez Gene Id

    Gene Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Rudling et al., 2000, A comparison of agonist-specific coupling of cloned human alpha(2)-adrenoceptor subtypes., Br. J. Pharmacol.
    Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol

  • HingoraniCasas: ENSG00000222040

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000222040 Gene Symbol
    ADRA2B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ADRA2L1

    • Version: chembl_23

    Alternate Names:
    ADRA2RL1 GENE_SYMBOL
    ADRA2B GENE_SYMBOL
    Alpha-2B adrenergic receptor UNIPROT

    Gene Info:

    Publications:

  • PharmGKB: ADRA2B

    • Version: 18-August-2020

    Alternate Names:
    PA36 PharmGKB ID

    Gene Info:

    Publications:

  • GO: ADRA2B

    • Version: 05-September-2020

    Alternate Names:
    ADRA2L1 GO Gene Synonym
    ADRA2RL1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: ADRA2B

    • Version: 27-Jun-2013

    Alternate Names:
    151 Gene ID
    ADRA2L1 dGene Synonym
    ADRA2RL1 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Adrenergic receptor alpha-2B

    • Version: 2020.06.01

    Alternate Names:
    ADRA2B TTD Gene Abbreviation
    T41580 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21