DGIdb - ADRA2A Gene Record

ADRA2A 150 Druggable Genome

Alternate Names:

150
ADRENOCEPTOR ALPHA 2A
ADRA2A
ADRA2
ADRA2R
ADRAR
ALPHA2AAR
ZNF32
104210
281
ENSG00000150594
OTTHUMG00000019050
P08913
ADA2A_HUMAN
PA35
ALPHA-2A ADRENERGIC RECEPTOR
Alpha-2AAR
Alpha-2A adrenoceptor
Alpha-2A adrenoreceptor
Alpha-2 adrenergic receptor subtype C10
ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-2A ADRENORECEPTOR) (ALPHA-2AAR SUBTYPE C10). [SOURCE:UNIPROT/SWISSPROT;ACC:P08913]
Adrenergic receptor Alpha-2
T31424
Adrenergic receptor alpha-2A
T11448

Gene Info:

Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Transmembrane Helix Count	7
Target Main Class	Receptors
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Type	Family
Interpro Acc	IPR000276
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Status	Swiss-Prot
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Erb et al., 2000, Alpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking., Neuropsychopharmacology
Strang et al., 1999, Lofexidine for opiate detoxification: review of recent randomised and open controlled trials., Am J Addict
Jin et al., 1992, Effects of lofexidine, an alpha 2-adrenoreceptor agonist, on ocular blood flow and ion transport of rabbit iris-ciliary body., J Ocul Pharmacol
Scheibner et al., 2002, Alpha 2-adrenoceptors in the enteric nervous system: a study in alpha 2A-adrenoceptor-deficient mice., Br. J. Pharmacol.
Dawson et al., 2004, Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action., Anesthesiology
Ozdogan et al., 2004, The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice., Eur. J. Pharmacol.
Fairbanks et al., 2002, alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy., J. Pharmacol. Exp. Ther.
Davies et al., 2004, Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala., Neuropsychopharmacology
Menon et al., 2007, Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans., J. Am. Coll. Cardiol.
Yağar S et al., 2011, The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery., Mol Biol Rep
Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
Lavand'homme et al., 2002, Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury., Anesthesiology
Wang et al., 2002, Effect of antisense knock-down of alpha(2a)- and alpha(2c)-adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat., Pain
Ozdoğan et al., 2004, Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice., Eur. J. Pharmacol.
Millan MJ et al., 2000, S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine., J Pharmacol Exp Ther
Bockman et al., 1993, Binding and functional characterization of alpha-2 adrenergic receptor subtypes on pig vascular endothelium., J. Pharmacol. Exp. Ther.
Bockman et al., 1996, Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats., J. Pharmacol. Exp. Ther.
Galeotti et al., 2004, Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype., Behav. Brain Res.
van Zwieten, 1997, Centrally acting antihypertensives: a renaissance of interest. Mechanisms and haemodynamics., J Hypertens Suppl
Piletz et al., 1993, Nonadrenergic imidazoline binding sites on human platelets., J. Pharmacol. Exp. Ther.
Ivgy-May et al., 2015, Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial., Sleep Med.
Dekeyne et al., 2006, Discriminative stimulus properties of the selective and highly potent alpha2-adrenoceptor agonist, S18616, in rats: mediation by the alpha2A subtype, and blockade by the atypical antidepressants, mirtazapine and mianserin., Neuropharmacology
Liljedahl U et al., 2004, Single nucleotide polymorphisms predict the change in left ventricular mass in response to antihypertensive treatment., J Hypertens
Sueke et al., 2010, Using apraclonidine in diagnosing Horner syndrome in children., Am. J. Ophthalmol.
Mirzai et al., 2006, Congenital Horner's syndrome and the usefulness of the apraclonidine test in its diagnosis., Indian J Ophthalmol
Moodley et al., 2007, Apraclonidine in the diagnosis of Horner's syndrome., S. Afr. Med. J.
Chen et al., 2006, Efficacy of apraclonidine 0.5% in the diagnosis of Horner syndrome in pediatric patients under low or high illumination., Am. J. Ophthalmol.
Wikberg-Matsson et al., 2001, Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries., Invest. Ophthalmol. Vis. Sci.
Costa et al., 2003, The effects of antiglaucoma and systemic medications on ocular blood flow., Prog Retin Eye Res
Scheinfeld, 2005, The use of apraclonidine eyedrops to treat ptosis after the administration of botulinum toxin to the upper face., Dermatol. Online J.
Watts et al., 2007, Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants., J AAPOS
2003, New topical drugs for open-angle glaucoma., Drug Ther Bull
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Piletz et al., 1996, Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
Fairbanks CA et al., 2009, Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis., Pharmacol Ther
Giovannitti JA Jr et al., 2015, Alpha-2 adrenergic receptor agonists: a review of current clinical applications., Anesth Prog
Leiphart JW et al., 2004, Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain., J Neurosurg
Spencer RC et al., 2015, The cognition-enhancing effects of psychostimulants involve direct action in the prefrontal cortex., Biol Psychiatry
Trendelenburg et al., 2003, Crosstalk between presynaptic angiotensin receptors, bradykinin receptors and alpha 2-autoreceptors in sympathetic neurons: a study in alpha 2-adrenoceptor-deficient mice., Br. J. Pharmacol.
Bylund, 1992, Subtypes of alpha 1- and alpha 2-adrenergic receptors., FASEB J.
Polak et al., 2005, Dynamic strength training improves insulin sensitivity and functional balance between adrenergic alpha 2A and beta pathways in subcutaneous adipose tissue of obese subjects., Diabetologia
Giussani et al., 1995, Alpha 1- and alpha 2-adrenoreceptor actions of phentolamine and prazosin on breathing movements in fetal sheep in utero., J. Physiol. (Lond.)
Blandizzi et al., 2003, Altered prejunctional modulation of intestinal cholinergic and noradrenergic pathways by alpha2-adrenoceptors in the presence of experimental colitis., Br. J. Pharmacol.
Vonend et al., 2007, Alpha(2A)-adrenoceptors regulate sympathetic transmitter release in mice kidneys., Br. J. Pharmacol.
Molderings et al., 2000, Species-specific pharmacological properties of human alpha(2A)-adrenoceptors., Hypertension
Saeed et al., Alpha-adrenoceptor blockade by phentolamine causes beta-adrenergic vasodilation by increased catecholamine release due to presynaptic alpha-blockade., J. Cardiovasc. Pharmacol.
Leprêtre et al., 1994, Alpha 2-adrenoceptors activate dihydropyridine-sensitive calcium channels via Gi-proteins and protein kinase C in rat portal vein myocytes., Pflugers Arch.
MacKinnon et al., 1992, [3H]-RS-15385-197, a selective and high affinity radioligand for alpha 2-adrenoceptors: implications for receptor classification., Br. J. Pharmacol.
Mitrani et al., 2007, Role of the autonomic nervous system in the development of hyperinsulinemia by high-carbohydrate formula feeding to neonatal rats., Am. J. Physiol. Endocrinol. Metab.
Kawasaki, 1997, [Centrally acting sympathetic inhibitors for therapy of patients with hypertension]., Nippon Rinsho
van Zwieten, New central mediators as targets of centrally acting antihypertensive drugs., Clin. Exp. Hypertens.
Head, 1999, Central imidazoline- and alpha 2-receptors involved in the cardiovascular actions of centrally acting antihypertensive agents., Ann. N. Y. Acad. Sci.
van Zwieten, 1992, Development and trends in the drug treatment of essential hypertension., J Hypertens Suppl
Sica, 2007, Centrally acting antihypertensive agents: an update., J Clin Hypertens (Greenwich)
Velliquette et al., 2003, Contrasting metabolic effects of antihypertensive agents., J. Pharmacol. Exp. Ther.
Jeng et al., 1998, Methamphetamine modulates GABA-induced electrophysiological depression by alternating noradrenergic actions in cerebellar Purkinje neurons., Psychopharmacology (Berl.)
Nishio et al., 2002, Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice., Neurosci. Lett.
Sulzer et al., 2005, Mechanisms of neurotransmitter release by amphetamines: a review., Prog. Neurobiol.
Zádori et al., 2007, Pre- and postsynaptic mechanisms in the clonidine- and oxymetazoline-induced inhibition of gastric motility in the rat., Neurochem. Int.
Laurila et al., 2007, The second extracellular loop of alpha2A-adrenoceptors contributes to the binding of yohimbine analogues., Br. J. Pharmacol.
Ozdoğan et al., 2006, The analgesic efficacy of partial opioid agonists is increased in mice with targeted inactivation of the alpha2A-adrenoceptor gene., Eur. J. Pharmacol.
Kalkman et al., 2003, alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs., Eur. J. Pharmacol.
Paul et al., 1999, Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors., J. Biol. Chem.
Millan et al., 2000, Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states., Synapse
Johnson DA et al., 1993, The pharmacology of alpha-adrenergic decongestants., Pharmacotherapy
Nash, 1990, Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism., Clin Cardiol
Hieble et al., 1998, Molecular basis for the stereoselective interactions of catecholamines with alpha-adrenoceptors., Proc. West. Pharmacol. Soc.
Giovannoni et al., 2009, Alpha2-agonists as analgesic agents., Med Res Rev
Nyrönen et al., 2001, Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine., Mol. Pharmacol.
MacLennan et al., 2000, Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using extracellular acidification rate changes., Br. J. Pharmacol.
Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
Rauly et al., 2000, alpha(2A)-adrenoceptor: G(alphai1) protein-mediated pertussis toxin-resistant attenuation of G(s) coupling to the cyclic AMP pathway., Biochem. Pharmacol.
Meana et al., 1992, Decreased density of presynaptic alpha 2-adrenoceptors in postmortem brains of patients with Alzheimer's disease., J. Neurochem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Davis, 2010, Recent advances in the treatment of pain., F1000 Med Rep
Anttila et al., 2001, A review of the pharmacological and clinical profile of mirtazapine., CNS Drug Rev
Rogoz et al., 2002, Effect of repeated treatment with mirtazapine on the central alpha1-adrenergic receptors., J. Physiol. Pharmacol.
Besson et al., 2000, Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain., Eur Neuropsychopharmacol
Rogóz et al., Effect of repeated treatment with mirtazapine on the central dopaminergic D2/D3 receptors., Pol J Pharmacol
Schreiber et al., Venlafaxine and mirtazapine: different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects--a possible opioid involvement in severe depression?, J. Mol. Neurosci.
García-Sevilla et al., 2004, Regulation of platelet alpha 2A-adrenoceptors, Gi proteins and receptor kinases in major depression: effects of mirtazapine treatment., Neuropsychopharmacology
Haddjeri N et al., 1997, Effects of long-term treatment with the alpha 2-adrenoceptor antagonist mirtazapine on 5-HT neurotransmission., Naunyn Schmiedebergs Arch Pharmacol
Lee HY et al., 2009, Association of the adrenergic alpha 2a receptor--1291C/G polymorphism with weight change and treatment response to mirtazapine in patients with major depressive disorder., Brain Res
de Boer, 1995, The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission., Int Clin Psychopharmacol
de Andrade et al., 2009, Involvement of central alpha1-adrenoceptors on renal responses to central moxonidine and alpha-methylnoradrenaline., Eur. J. Pharmacol.
Avery et al., 2000, The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task., Neuropsychopharmacology
Sagvolden, 2006, The alpha-2A adrenoceptor agonist guanfacine improves sustained attention and reduces overactivity and impulsiveness in an animal model of Attention-Deficit/Hyperactivity Disorder (ADHD)., Behav Brain Funct
Birnbaum et al., 2000, Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats., Pharmacol. Biochem. Behav.
Stahl, 2010, Mechanism of action of alpha 2A-adrenergic agonists in attention-deficit/hyperactivity disorder with or without oppositional symptoms., J Clin Psychiatry
Yuan et al., 2005, G-protein-coupled alpha2A-adrenoreceptor agonists differentially alter citrus leaf and fruit abscission by affecting expression of ACC synthase and ACC oxidase., J. Exp. Bot.
Millan, 1992, Evidence that an alpha 2A-adrenoceptor subtype mediates antinociception in mice., Eur. J. Pharmacol.
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Marek et al., 1992, A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action., Psychopharmacology (Berl.)
Price LH et al., 1986, Effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients., Psychopharmacology (Berl)
Arthur S et al., 2011, Update on the role of alpha-agonists in glaucoma management., Exp Eye Res
Flavahan, 2005, Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha2-adrenoceptors., J. Pharmacol. Exp. Ther.
Ariëns EJ et al., 1983, Physiological and pharmacological aspects of adrenergic receptor classification., Biochem Pharmacol
Noshiro et al., 1989, Functional relationship between platelet alpha 2-adrenoceptors and sympathetic nerve activity in man., Clin Exp Hypertens A
Noshiro et al., 1990, Functional relationships between platelet alpha 2-adrenoceptors and sympathetic nerve activity in clinical hypertensive states., J. Hypertens.
Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.
Stone LS et al., 2003, Moxonidine, a mixed alpha(2)-adrenergic and imidazoline receptor agonist, identifies a novel adrenergic target for spinal analgesia., Ann N Y Acad Sci
Buccafusco JJ et al., 1995, Role of medullary I1-imidazoline and alpha 2-adrenergic receptors in the antihypertensive responses evoked by central administration of clonidine analogs in conscious spontaneously hypertensive rats., J Pharmacol Exp Ther
Zhu QM et al., 1999, Cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild-type and D79N alpha2A-adrenoceptor transgenic mice., Br J Pharmacol
Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)

APRACLONIDINE ADRA2A

Interaction Score: 12.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
20399934 16921219 17824139 16935593 11481271 14575724 15748550 17572343 12630335 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
GUANABENZ ADRA2A

Interaction Score: 3.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7903385 8819507 15265636 9050980 8263811

Sources:
TdgClinicalTrial TEND TTD
PHENYLPROPANOLAMINE ADRA2A

Interaction Score: 2.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15608085 17016423 17139284

Sources:
TdgClinicalTrial TEND
DIPIVEFRIN ADRA2A

Interaction Score: 2.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 21524649

Sources:
TdgClinicalTrial TEND
CHEMBL1257057 ADRA2A

Interaction Score: 1.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16407989

Sources:
DTC
CHEMBL10332 ADRA2A

Interaction Score: 1.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16407989

Sources:
DTC
MOXONIDINE ADRA2A

Interaction Score: 1.74

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
16407989 15028616 7791087 10217548

Sources:
DTC TTD
RAUWOLSCINE ADRA2A

Interaction Score: 1.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
16407989

Sources:
DTC
YOHIMBINE ADRA2A

Interaction Score: 1.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17664022 17558432 16325800 12591093 10506165 10611634 16407989

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD
DEXMEDETOMIDINE ADRA2A

Interaction Score: 1.6

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11834617 15087625 15306201 11752127 14583739 17692748 21104443

Sources:
TdgClinicalTrial TEND PharmGKB TTD
TIZANIDINE ADRA2A

Interaction Score: 1.52

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name NVD-422, tizanidine oral spray

Novel drug target Established target

Trial Name tizanidine hydrochloride,Zanaflex

PMIDs:
8930173 19393691 25849473 15481719

Sources:
TdgClinicalTrial TEND TTD
BENZPHETAMINE ADRA2A

Interaction Score: 1.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 25499957

Sources:
TdgClinicalTrial TEND
GUANFACINE ADRA2A

Interaction Score: 1.39

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name guanfacine, SPD 503,Intuniv

Novel drug target Established target

PMIDs:
10942848 17173664 11164065 20331927 15928018 1356794

Sources:
TdgClinicalTrial TEND
OXYMETAZOLINE ADRA2A

Interaction Score: 1.39

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Trial Name OMS-103HP

Novel drug target Established target

PMIDs:
16407989 7892112 1327384 17164433

Sources:
DTC TdgClinicalTrial TEND TTD
LOFEXIDINE ADRA2A

Interaction Score: 1.31

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name lofexidine,BritLofex

Novel drug target Established target

PMIDs:
10882840 10598217 1357064

Sources:
TdgClinicalTrial TEND TTD
CLONIDINE ADRA2A

Interaction Score: 1.26

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs:
16407989 12357167 12098614 15306201 11752127 14757140 11082457

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
PHENTOLAMINE ADRA2A

Interaction Score: 1.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name aviptadil,Invicorp

Novel drug target Established target

Trial Name -

PMIDs:
16407989 12721093 1346768 16273345 7562640 12770936 17115069 10988273 6176798

Sources:
DTC TdgClinicalTrial TEND
BRIMONIDINE ADRA2A

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name brimonidine tartrate,Alphagan

Novel drug target Established target

Trial Name brimonidine tartrate/timolol maleate,Combigan

PMIDs:
16407989 10799649 1373179 11481271 11752352

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD
FIPAMEZOLE ADRA2A

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name fipamezole , JP-1730

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
ESMIRTAZAPINE ADRA2A

Interaction Score: 0.58

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name esmirtazapine, ORG-4420

PMIDs:
26047892

Sources:
TdgClinicalTrial
MIRTAZAPINE ADRA2A

Interaction Score: 0.55

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

Direct Interaction yes

Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

PMIDs:
11607047 11939713 10793320 12523492 11931344 14628003 9007838 19401164 8930006

Sources:
TdgClinicalTrial ChemblInteractions TEND
NOREPINEPHRINE ADRA2A

Interaction Score: 0.49

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16407989 1980236 9836297 18680204 11306720 10742288 18064417 17016423 17139284

Sources:
DTC TdgClinicalTrial TEND PharmGKB
FENOLDOPAM ADRA2A

Interaction Score: 0.44

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17016423 17139284 7670737

Sources:
TEND
BETHANIDINE ADRA2A

Interaction Score: 0.44

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2545383 1962798

Sources:
TdgClinicalTrial TEND
FADOLMIDINE ADRA2A

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NICERGOLINE ADRA2A

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DROXIDOPA ADRA2A

Interaction Score: 0.44

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
18680204 21173850 11306720

Sources:
ChemblInteractions
TRAZODONE ADRA2A

Interaction Score: 0.4

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217 17016423 17139284 1365657 3016788

Sources:
TEND
METHYLDOPA ADRA2A

Interaction Score: 0.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

PMIDs:
9284427 8743022 10415926 1363322 17485976 14557373 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
TIZANIDINE HYDROCHLORIDE ADRA2A

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CLONIDINE HYDROCHLORIDE ADRA2A

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EPINEPHRINE ADRA2A

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name transdermal lidocaine/epinephrine patch,Lidosite

Novel drug target Established target

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
1980236 9836297 18680204 11306720 10742288 18064417 6134529

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB
DEXMEDETOMIDINE HYDROCHLORIDE ADRA2A

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

PMIDs:
None found

Sources:
ChemblInteractions
FADOLMIDINE HYDROCHLORIDE ADRA2A

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
APRACLONIDINE HYDROCHLORIDE ADRA2A

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METHYLDOPATE HYDROCHLORIDE ADRA2A

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DEBRISOQUIN ADRA2A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
BRIMONIDINE TARTRATE ADRA2A

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

PMIDs:
None found

Sources:
ChemblInteractions
MIANSERIN ADRA2A

Interaction Score: 0.26

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16814817

Sources:
TdgClinicalTrial TEND
PSEUDOEPHEDRINE ADRA2A

Interaction Score: 0.26

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
17016423 17139284 7507588

Sources:
TdgClinicalTrial TEND
GUANFACINE HYDROCHLORIDE ADRA2A

Interaction Score: 0.22

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GUANABENZ ACETATE ADRA2A

Interaction Score: 0.22

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPERIDINE ADRA2A

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
RAUWOLFIA SERPENTINA ADRA2A

Interaction Score: 0.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MILNACIPRAN ADRA2A

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LEVONORDEFRIN ADRA2A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
19326476

Sources:
ChemblInteractions
ALSEROXYLON ADRA2A

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEDETOMIDINE ADRA2A

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NAPHAZOLINE HYDROCHLORIDE ADRA2A

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESMIRTAZAPINE MALEATE ADRA2A

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
TETRAHYDROZOLINE HYDROCHLORIDE ADRA2A

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SENREBOTASE ADRA2A

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AGN-214868

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
DOPAMINE ADRA2A

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16407989

Sources:
DTC PharmGKB
METHAMPHETAMINE ADRA2A

Interaction Score: 0.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name low dose intravenous methamphetamine

Novel drug target Established target

PMIDs:
9551769 12453616 15955613

Sources:
TdgClinicalTrial
PARDOPRUNOX ADRA2A

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pardoprunox, SLV 308

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
OXYMETAZOLINE HYDROCHLORIDE ADRA2A

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPHENTERMINE SULFATE ADRA2A

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPIVEFRIN HYDROCHLORIDE ADRA2A

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOLAZOLINE HYDROCHLORIDE ADRA2A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENTOLAMINE MESYLATE ADRA2A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha antagonist

PMIDs:
None found

Sources:
ChemblInteractions
ASENAPINE ADRA2A

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814

Sources:
TdgClinicalTrial
HYDROXYAMPHETAMINE HYDROBROMIDE ADRA2A

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LABETALOL HYDROCHLORIDE ADRA2A

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENOXYBENZAMINE HYDROCHLORIDE ADRA2A

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha antagonist

PMIDs:
None found

Sources:
ChemblInteractions
NOREPINEPHRINE BITARTRATE ADRA2A

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ERGOLOID MESYLATES ADRA2A

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha antagonist

PMIDs:
None found

Sources:
ChemblInteractions
AMPHETAMINE ADRA2A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
EPINEPHRINE BITARTRATE ADRA2A

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ATENOLOL ADRA2A

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15614026

Sources:
PharmGKB
ISOPROTERENOL ADRA2A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
OLANZAPINE ADRA2A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv

Novel drug target Established target

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
17848919

Sources:
TdgClinicalTrial

Ensembl: ENSG00000150594
- Version: 101_38
Alternate Names:

ADRA2A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000150594

Version: 26-July-2011

Alternate Names:

ENSG00000150594 Ensembl Gene Id

ADRA2A Display Id

ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-2A ADRENORECEPTOR) (ALPHA-2AAR SUBTYPE C10). [SOURCE:UNIPROT/SWISSPROT;ACC:P08913] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P08913
- Version: January-2014
Alternate Names:

ADRA2A Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
TEND: P08913
- Version: 01-August-2011
Alternate Names:

150 Entrez Gene Id

ADRA2A Gene Symbol

P08913 Uniprot Accession

Gene Info:

Target Subclass Rhodopsin

Transmembrane Helix Count 7

Target Main Class Receptors

Publications:
HopkinsGroom: P08913
- Version: 11-September-2012
Alternate Names:

ADRA2A Uniprot Gene Name

P08913 Uniprot Accession

150 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Human Readable Name G PROTEIN COUPLED RECEPTOR

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

PharmGKB: ADRA2A

Version: 18-August-2020

Alternate Names:

PA35 PharmGKB ID

Gene Info:

Publications:

Yin L et al., 2015, TPH, SLC6A2, SLC6A3, DRD2 and DRD4 Polymorphisms and Neuroendocrine Factors Predict SSRIs Treatment Outcome in the Chinese Population with Major Depression., Pharmacopsychiatry

Liljedahl U et al., 2004, Single nucleotide polymorphisms predict the change in left ventricular mass in response to antihypertensive treatment., J Hypertens

Yağar S et al., 2011, The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery., Mol Biol Rep

TTD: Adrenergic receptor Alpha-2
- Version: 2020.06.01
Alternate Names:

ADRA2 TTD Gene Abbreviation

T31424 TTD Target ID

Gene Info:

Publications:

Khalil A et al., 2008, Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders., PLoS One
DTC: ADRA2A
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
HingoraniCasas: ENSG00000150594
- Version: 31-May-2017
Alternate Names:

ENSG00000150594 Gene Symbol

ADRA2A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ADRA2R
- Version: chembl_23
Alternate Names:

ADRAR GENE_SYMBOL

ADRA2A GENE_SYMBOL

Alpha-2A adrenergic receptor UNIPROT

Gene Info:

Publications:
GO: ADRA2A
- Version: 01-February-2022
Alternate Names:

ADRA2R GO Gene Synonym

ADRAR GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: ADRA2A
- Version: 27-Jun-2013
Alternate Names:

150 Gene ID

ADRA2 dGene Synonym

ADRA2R dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Adrenergic receptor alpha-2A
- Version: 2020.06.01
Alternate Names:

ADRA2A TTD Gene Abbreviation

T11448 TTD Target ID

Gene Info:

Publications:

Trial Name	NVD-422, tizanidine oral spray
Novel drug target	Established target
Trial Name	tizanidine hydrochloride,Zanaflex

Trial Name	guanfacine, SPD 503,Intuniv
Novel drug target	Established target

Trial Name	lofexidine,BritLofex
Novel drug target	Established target

Mechanism of Interaction	Adrenergic receptor alpha-2 agonist
Direct Interaction	yes
Trial Name	ARC-4558, 0.1% clonidine hycrochloride gel

Trial Name	aviptadil,Invicorp
Novel drug target	Established target
Trial Name	-

Trial Name	brimonidine tartrate,Alphagan
Novel drug target	Established target
Trial Name	brimonidine tartrate/timolol maleate,Combigan

Trial Name	fipamezole , JP-1730
Novel drug target	Established target

Mechanism of Interaction	Adrenergic receptor alpha-2 antagonist
Direct Interaction	yes
Trial Name	mirtazapine,Remeron, Remeron SolTab, Reflex

Direct Interaction	yes
Mechanism of Interaction	Adrenergic receptor agonist

Trial Name	transdermal lidocaine/epinephrine patch,Lidosite
Novel drug target	Established target
Mechanism of Interaction	Adrenergic receptor agonist

Trial Name	fexofenadine + ps/
Novel drug target	Established target

Mechanism of Interaction	Adrenergic receptor alpha antagonist
Direct Interaction	yes

Mechanism of Interaction	Adrenergic receptor alpha agonist
Direct Interaction	yes

Trial Name	low dose intravenous methamphetamine
Novel drug target	Established target

Trial Name	pardoprunox, SLV 308
Novel drug target	Established target

Mechanism of Interaction	Adrenergic receptor antagonist
Direct Interaction	yes

Trial Name	olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv
Novel drug target	Established target
Trial Name	Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

ENSG00000150594	Ensembl Gene Id
ADRA2A	Display Id
ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-2A ADRENORECEPTOR) (ALPHA-2AAR SUBTYPE C10). [SOURCE:UNIPROT/SWISSPROT;ACC:P08913]	Description

ADRA2A	Uniprot Gene Name
P08913	Uniprot Accession
150	Entrez Gene Id

ADRAR	GENE_SYMBOL
ADRA2A	GENE_SYMBOL
Alpha-2A adrenergic receptor	UNIPROT

ADRA2A Gene Record

ADRA2A 150 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 20399934 16921219 17824139 16935593 11481271 14575724 15748550 17572343 12630335 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 7903385 8819507 15265636 9050980 8263811

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15608085 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 21524649

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16407989

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16407989

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 16407989 15028616 7791087 10217548

Sources: DTC TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 16407989

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17664022 17558432 16325800 12591093 10506165 10611634 16407989

Sources: DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11834617 15087625 15306201 11752127 14583739 17692748 21104443

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name NVD-422, tizanidine oral spray Novel drug target Established target Trial Name tizanidine hydrochloride,Zanaflex

PMIDs: 8930173 19393691 25849473 15481719

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 25499957

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name guanfacine, SPD 503,Intuniv Novel drug target Established target

PMIDs: 10942848 17173664 11164065 20331927 15928018 1356794

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Trial Name OMS-103HP Novel drug target Established target

PMIDs: 16407989 7892112 1327384 17164433

Sources: DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name lofexidine,BritLofex Novel drug target Established target

PMIDs: 10882840 10598217 1357064

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs: 16407989 12357167 12098614 15306201 11752127 14757140 11082457

Sources: DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name aviptadil,Invicorp Novel drug target Established target Trial Name -

PMIDs: 16407989 12721093 1346768 16273345 7562640 12770936 17115069 10988273 6176798

Sources: DTC TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name brimonidine tartrate,Alphagan Novel drug target Established target Trial Name brimonidine tartrate/timolol maleate,Combigan

PMIDs: 16407989 10799649 1373179 11481271 11752352

Sources: DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name fipamezole , JP-1730 Novel drug target Established target

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
20399934 16921219 17824139 16935593 11481271 14575724 15748550 17572343 12630335 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7903385 8819507 15265636 9050980 8263811

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15608085 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 21524649

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
16407989

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16407989

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

PMIDs:
16407989 15028616 7791087 10217548

Sources:
DTC TTD

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
16407989

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17664022 17558432 16325800 12591093 10506165 10611634 16407989

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11834617 15087625 15306201 11752127 14583739 17692748 21104443

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name NVD-422, tizanidine oral spray

Novel drug target Established target

Trial Name tizanidine hydrochloride,Zanaflex

PMIDs:
8930173 19393691 25849473 15481719

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 25499957

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name guanfacine, SPD 503,Intuniv

Novel drug target Established target

PMIDs:
10942848 17173664 11164065 20331927 15928018 1356794

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Trial Name OMS-103HP

Novel drug target Established target

PMIDs:
16407989 7892112 1327384 17164433

Sources:
DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name lofexidine,BritLofex

Novel drug target Established target

PMIDs:
10882840 10598217 1357064

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

PMIDs:
16407989 12357167 12098614 15306201 11752127 14757140 11082457

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name aviptadil,Invicorp

Novel drug target Established target

Trial Name -

PMIDs:
16407989 12721093 1346768 16273345 7562640 12770936 17115069 10988273 6176798

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name brimonidine tartrate,Alphagan

Novel drug target Established target

Trial Name brimonidine tartrate/timolol maleate,Combigan

PMIDs:
16407989 10799649 1373179 11481271 11752352

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name fipamezole , JP-1730

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name esmirtazapine, ORG-4420

PMIDs:
26047892

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

Direct Interaction yes

Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

PMIDs:
11607047 11939713 10793320 12523492 11931344 14628003 9007838 19401164 8930006

Sources:
TdgClinicalTrial ChemblInteractions TEND