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ADRA1A Gene Record

  • Summary
  • Interactions
  • Claims
  • ADRA1A 148 Druggable GenomeDrug Resistance

    Alternate Names:

    148
    ADRENOCEPTOR ALPHA 1A
    ADRA1A
    ADRA1C
    ADRA1L1
    ALPHA1AAR
    104221
    277
    ENSG00000120907
    OTTHUMG00000099459
    P35348
    ADA1A_HUMAN
    22
    NP_000671
    NM_000680
    &alpha;<sub>1A</sub>-adrenoceptor
    BE0004888
    Alpha-adrenergic receptor 1a
    Alpha-1D adrenoceptor
    Alpha-1D adrenoreceptor
    Alpha-1D adrenergic receptor
    Alpha-1A adrenergic receptor
    ADRA1D
    Alpha-1A adrenoceptor
    Alpha-1A adrenoreceptor
    Alpha-1C adrenergic receptor
    Alpha-adrenergic receptor 1c
    ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA 1A- ADRENORECEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1C). [SOURCE:UNIPROT/SWISSPROT;ACC:P35348]
    BE0000501
    BE0004863
    PA34
    Adrenergic receptor alpha-1A
    T92609

    Gene Info:

    GuideToPharmacology Gene Category Name Adrenoceptors
    GuideToPharmacology Gene Category ID 4
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Human Readable Name DRUGGABLE GENOME
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Target Main Class Receptors
    Transmembrane Helix Count 7
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    DRUG RESISTANCE
    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
    González-Espinosa et al., 2001, Molecular cloning and functional expression of the guinea pig alpha(1a)-adrenoceptor., Eur. J. Pharmacol.
    Furukawa et al., 1995, Alpha 1A-adrenoceptor-mediated contractile responses of the human vas deferens., Br. J. Pharmacol.
    Deplanne et al., 1996, Functional characterization of alpha-1-adrenoceptor subtypes in the prostatic urethra and trigone of male rabbit., J. Pharmacol. Exp. Ther.
    Shibata et al., 2001, [Excitatory effect of noradrenaline on rat airway parasympathetic ganglion neurons]., Fukuoka Igaku Zasshi
    Yang et al., 1996, (+/-)-tamsulosin, an alpha 1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart., Eur. J. Pharmacol.
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Keks et al., 1999, Risperidone (Risperdal): clinical experience with a new antipsychosis drug., Expert Opin Investig Drugs
    Nourian et al., 2008, Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function., Psychopharmacology (Berl.)
    Eltze, 1996, In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors., Eur. J. Pharmacol.
    Richelson et al., 2000, Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds., Life Sci.
    Corena-McLeod M, 2015, Comparative Pharmacology of Risperidone and Paliperidone., Drugs R D
    Sleight et al., 1993, Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors., Eur. J. Pharmacol.
    Fenton et al., 2005, Risperidone: a review of its use in the treatment of bipolar mania., CNS Drugs
    Buckner et al., 2002, ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes., Eur. J. Pharmacol.
    Moya-Huff et al., 1987, Adrenergic receptor subtype activation by (+)-, (-)- and (+/-)-norephedrine in the pithed rat., J. Pharm. Pharmacol.
    Wellman et al., Effects of the alpha 1a-adrenoceptor antagonist RS-17053 on phenylpropanolamine-induced anorexia in rats., Pharmacol. Biochem. Behav.
    Altenbach et al., 2004, Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist., J. Med. Chem.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Tomiyama et al., 2007, Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter., Eur. J. Pharmacol.
    Martínez-Salas et al., 2007, Alpha1A-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed., Auton Autacoid Pharmacol
    Huerta-Bahena et al., 1983, Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects., Mol. Pharmacol.
    Cahir et al., 2005, Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat., Eur Neuropsychopharmacol
    Michel et al., 1996, Drugs for treatment of benign prostatic hyperplasia: affinity comparison at cloned alpha 1-adrenoceptor subtypes and in human prostate., J Auton Pharmacol
    Chapple, 1998, Medical therapy and quality of life., Eur. Urol.
    Roehrborn et al., 2004, Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia., J. Urol.
    Lee et al., 1997, Clinical comparison of selective and non-selective alpha 1A-adrenoreceptor antagonists in benign prostatic hyperplasia: studies on tamsulosin in a fixed dose and terazosin in increasing doses., Br J Urol
    Na et al., 1998, Clinical comparison of selective and non-selective alpha 1A-adrenoceptor antagonists for bladder outlet obstruction associated with benign prostatic hyperplasia: studies on tamsulosin and terazosin in Chinese patients. The Chinese Tamsulosin Study Group., J Med
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Millan MJ et al., 2000, S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine., J Pharmacol Exp Ther
    Saeed et al., Alpha-adrenoceptor blockade by phentolamine causes beta-adrenergic vasodilation by increased catecholamine release due to presynaptic alpha-blockade., J. Cardiovasc. Pharmacol.
    Giussani et al., 1995, Alpha 1- and alpha 2-adrenoreceptor actions of phentolamine and prazosin on breathing movements in fetal sheep in utero., J. Physiol. (Lond.)
    Bylund, 1992, Subtypes of alpha 1- and alpha 2-adrenergic receptors., FASEB J.
    Freedman et al., 2005, Topical apraclonidine in the diagnosis of suspected Horner syndrome., J Neuroophthalmol
    Mirzai et al., 2006, Congenital Horner's syndrome and the usefulness of the apraclonidine test in its diagnosis., Indian J Ophthalmol
    Chen et al., 2006, Efficacy of apraclonidine 0.5% in the diagnosis of Horner syndrome in pediatric patients under low or high illumination., Am. J. Ophthalmol.
    Moodley et al., 2007, Apraclonidine in the diagnosis of Horner's syndrome., S. Afr. Med. J.
    Kawasaki et al., 2008, False negative apraclonidine test in two patients with Horner syndrome., Klin Monbl Augenheilkd
    Watts et al., 2007, Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants., J AAPOS
    Sueke et al., 2010, Using apraclonidine in diagnosing Horner syndrome in children., Am. J. Ophthalmol.
    Lepor et al., 2010, Silodosin for the treatment of benign prostatic hyperplasia: pharmacology and cardiovascular tolerability., Pharmacotherapy
    Taylor et al., 1995, Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug., J Clin Psychiatry
    Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
    Lindström et al., 2006, Sertindole: efficacy and safety in schizophrenia., Expert Opin Pharmacother
    Hietala et al., 2001, Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment., Psychopharmacology (Berl.)
    Millan et al., 2000, Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram., Eur. J. Neurosci.
    Nutt D, 1997, Mirtazapine: pharmacology in relation to adverse effects., Acta Psychiatr Scand Suppl
    Fernández et al., 2005, Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents., J. Med. Chem.
    Wikström et al., 2002, Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine., J. Med. Chem.
    de Boer et al., 1988, Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers., Neuropharmacology
    Du et al., 2010, Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists., Curr Comput Aided Drug Des
    Senard et al., 2001, Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management., Drugs Aging
    Burt et al., 1996, The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens., Br. J. Pharmacol.
    Bishop, 2007, Recent advances in the discovery of alpha1-adrenoceptor agonists., Curr Top Med Chem
    Lachnit et al., 1997, Pharmacological characterization of an alpha 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat., Br. J. Pharmacol.
    Morris et al., 2004, Cellular trafficking of human alpha1a-adrenergic receptors is continuous and primarily agonist-independent., Mol. Pharmacol.
    Zacharia et al., 2004, Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries., Br. J. Pharmacol.
    Suzuki et al., 2000, Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs., Eur. J. Pharmacol.
    Chang et al., 2003, Stimulatory effect of cinnamic acid analogues on alpha1A-adrenoceptors in-vitro., J. Pharm. Pharmacol.
    Andersohn et al., 2010, Priapism associated with antipsychotics: role of alpha1 adrenoceptor affinity., J Clin Psychopharmacol
    Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
    Bymaster et al., 1999, Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro., Schizophr. Res.
    Sanbe et al., 2007, Alpha1-adrenoceptors are required for normal male sexual function., Br. J. Pharmacol.
    Jensen et al., 2010, Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells., Naunyn Schmiedebergs Arch. Pharmacol.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.
    Ahlquist, 1976, Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor., Am. Heart J.
    Mohta et al., 2010, Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension., Anaesthesia
    Alvarez-Guerra et al., 1999, Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat., Fundam Clin Pharmacol
    Ogidigben et al., 2001, Naphazoline-induced suppression of aqueous humor pressure and flow: involvement of central and peripheral alpha(2)/I(1) receptors., Exp. Eye Res.
    Leonardi, 2005, Emerging drugs for ocular allergy., Expert Opin Emerg Drugs
    Kai, 1999, [Effects of topical alpha 1- and beta 2-adrenoceptor stimulants on nasal nitric oxide level]., Nippon Jibiinkoka Gakkai Kaiho
    Hrometz et al., 1999, Expression of multiple alpha1-adrenoceptors on vascular smooth muscle: correlation with the regulation of contraction., J. Pharmacol. Exp. Ther.
    Piletz et al., 1996, Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
    Bogacka, 1999, [Decongestants in treatment of nasal obstruction]., Otolaryngol Pol
    Southard BT et al., 2020, Promethazine,
    Tatsuta et al., 1998, Alpha1-adrenoceptor stimulation enhances experimental gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats., Int. J. Cancer
    Dale et al., 2007, Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter., Ann Pharmacother
    Heijman J et al., 2013, Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation., Clin Med Insights Cardiol
    Wellington et al., 2001, Cetirizine/pseudoephedrine., Drugs
    Johnson DA et al., 1993, The pharmacology of alpha-adrenergic decongestants., Pharmacotherapy
    Sassard et al., 1983, [Comparative effects of an alpha 1 and beta 1-2 blocker (labetalol) and a beta-1 blocker (atenolol) in the hypertensive patient]., J Pharmacol
    Rosendorff, 1993, Beta-blocking agents with vasodilator activity., J Hypertens Suppl
    Nakamura et al., 1999, Tamsulosin: assessment of affinityof (3)H-P razosin binding to two alpha-1- adrenoceptor subtypes in the canine aorta., Pharmacology
    Shiraishi et al., 1992, Alpha 1-adrenoceptor blocking activities of bevantolol hydrochloride(NC-1400) and labetalol in rat isolated thoracic aorta--do they distinguish between subtypes?, Gen. Pharmacol.
    van Zwieten, 1993, An overview of the pharmacodynamic properties and therapeutic potential of combined alpha- and beta-adrenoceptor antagonists., Drugs
    Bernstein et al., 1989, Partial attenuation of hemodynamic responses to rapid sequence induction and intubation with labetalol., J Clin Anesth
    Pedersen et al., 2007, The vasodilatory beta-blockers., Curr. Hypertens. Rep.
    Eltze, 1997, Affinity of the miotic drug, dapiprazole, at alpha 1-adrenoceptor subtypes A, B and D., J. Pharm. Pharmacol.
    Chapple et al., 1996, Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. A meta-analysis of two randomized, placebo-controlled, multicentre studies in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group., Eur. Urol.
    Schulman et al., 1996, Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. Analysis of a multinational, multicentre, open-label study assessing the long-term efficacy and safety in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group., Eur. Urol.
    Abrams et al., 1997, A dose-ranging study of the efficacy and safety of tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist, in patients with benign prostatic obstruction (symptomatic benign prostatic hyperplasia)., Br J Urol
    Michel et al., 2004, Efficacy and safety of tamsulosin in the treatment of urological diseases., Expert Opin Pharmacother
    Chen et al., 2009, Blockade of alpha 1A-adrenoceptor: a novel possible strategy for male contraception., Med. Hypotheses
    Richelson et al., 1984, Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro., J. Pharmacol. Exp. Ther.
    Buckley et al., 1998, Can the fatal toxicity of antidepressant drugs be predicted with pharmacological and toxicological data?, Drug Saf
    Fabre et al., [Mechanisms of action of antidepressants: new data from Escitalopram]., Encephale
    Sanchez C et al., 2014, A comparative review of escitalopram, paroxetine, and sertraline: Are they all alike?, Int Clin Psychopharmacol
    Bareggi et al., 2007, The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders., Expert Opin Drug Metab Toxicol
    Zupkó et al., 2003, Alpha-adrenergic blockade: a possible mechanism of tocolytic action of certain benzodiazepines in a postpartum rat model in vivo., Life Sci.
    Spencer RC et al., 2015, The cognition-enhancing effects of psychostimulants involve direct action in the prefrontal cortex., Biol Psychiatry
    Lee, 2003, Alfuzosin hydrochloride for the treatment of benign prostatic hyperplasia., Am J Health Syst Pharm
    Lowe, 2004, Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms., Clin Ther
    Kenny et al., 1996, Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies., Br. J. Pharmacol.
    Elhilali, 2006, Alfuzosin: an alpha1-receptor blocker for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia., Expert Opin Pharmacother
    Faure et al., 1994, Identification of alpha 1-adrenoceptor subtypes present in the human prostate., Life Sci.
    Martin et al., 1997, Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists., J. Pharmacol. Exp. Ther.
    Andersson et al., 1997, Prostatic alpha 1-adrenoceptors and uroselectivity., Prostate
    Bèïque et al., 1998, Are the new selective alpha-blockers better than non-selective alpha-blockers for benign prostatic hyperplasia?, Can Fam Physician
    Roehrborn, 2001, Alfuzosin: overview of pharmacokinetics, safety, and efficacy of a clinically uroselective alpha-blocker., Urology
    McVary, 2006, BPH: epidemiology and comorbidities., Am J Manag Care
    Greco et al., 2008, The role of combination medical therapy in benign prostatic hyperplasia., Int. J. Impot. Res.
    Schwinn DA et al., 2008, Alpha1-adrenoceptor subtypes and lower urinary tract symptoms., Int J Urol
    Martin, 1999, Preclinical pharmacology of alpha1-adrenoceptor antagonists., Eur. Urol.
    Ishizuka et al., 1997, Stimulation of bladder activity by volume, L-dopa and capsaicin in normal conscious rats--effects of spinal alpha 1-adrenoceptor blockade., Naunyn Schmiedebergs Arch. Pharmacol.
    Shannon et al., 2006, Effect of alpha1-adrenergic receptors in cardiac pathophysiology., Am. Heart J.
    Yono et al., 2004, Doxazosin-induced up-regulation of alpha 1A-adrenoceptor mRNA in the rat lower urinary tract., Can. J. Physiol. Pharmacol.
    Bae et al., 2005, The effects of alpha-adrenoceptor antagonists on the urethral perfusion pressure of the female rat., BJU Int.
    Nojimoto et al., The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors., Neuropharmacology
    O'Connell TD et al., 2013, Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance., Pharmacol Rev
    Jensen BC et al., 2009, {alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium., Circ Heart Fail
    Nakamura S et al., 1982, Changes in noradrenergic terminal excitability induced by amphetamine and their relation to impulse traffic., Neuroscience
    Shekim WO et al., 1994, Platelet alpha 2-adrenergic receptor binding and the effects of d-amphetamine in boys with attention deficit hyperactivity disorder., Neuropsychobiology
    Valdivia et al., 2004, Pharmacological analysis of the mechanisms involved in the tachycardic and vasopressor responses to the antimigraine agent, isometheptene, in pithed rats., Life Sci.
    Parker et al., 1988, Comparative effects of amphetamine, phenylethylamine and related drugs on dopamine efflux, dopamine uptake and mazindol binding., J. Pharmacol. Exp. Ther.
    Taniguchi et al., 1996, NS-49, an alpha 1A-adrenoceptor agonist, selectively increases intraurethral pressure in dogs., Eur. J. Pharmacol.
    Ashford JW, 2019, Treatment of Alzheimer's Disease: Trazodone, Sleep, Serotonin, Norepinephrine, and Future Directions., J Alzheimers Dis
    Spiller et al., 2008, Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline., Clin Toxicol (Phila)
    Sallés et al., 1996, Sustained increase in rat myocardial alpha 1A-adrenoceptors induced by 6-hydroxydopamine treatment involves a decelerated receptor turnover., Naunyn Schmiedebergs Arch. Pharmacol.
    Suzuki et al., 1990, Two pharmacologically distinct alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta: each subtype couples with a different Ca2+ signalling mechanism and plays a different physiological role., Mol. Pharmacol.
    Michel et al., 1994, Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle., Br. J. Pharmacol.
    Stam et al., 1999, Analysis of alpha 1L-adrenoceptor pharmacology in rat small mesenteric artery., Br. J. Pharmacol.
    Yu et al., 2003, Functional characterization of alpha-adrenoceptors mediating pupillary dilation in rats., Eur. J. Pharmacol.
    Statler AK et al., 2020, Ephedrine,
    Ma et al., 2007, Pharmacological effects of ephedrine alkaloids on human alpha(1)- and alpha(2)-adrenergic receptor subtypes., J. Pharmacol. Exp. Ther.
    Wellman et al., 2003, Noradrenergic modulation of ephedrine-induced hypophagia., Synapse
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Scatton et al., 2001, The preclinical pharmacologic profile of tiapride., Eur. Psychiatry
    Gibson A et al., 1979, The effects of bromocriptine on pre-synaptic and post-synaptic alpha-adrenoceptors in the mouse vas deferens., J Pharm Pharmacol
    Lam, 2000, Clinical pharmacology of dopamine agonists., Pharmacotherapy
    Cohen, Risperidone., Pharmacotherapy
    Megens et al., 1994, Survey on the pharmacodynamics of the new antipsychotic risperidone., Psychopharmacology (Berl.)
    Ferry DG et al., 1986, Interaction between antidepressants and alpha 1-adrenergic receptor antagonists on the binding to alpha 1-acid glycoprotein., J Pharm Sci
    Fujinaga et al., 1994, Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos., Dev. Biol.
    Zhang Y et al., 2009, Arg347Cys polymorphism of alpha1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients., J Hum Genet
    Kim DH et al., 2009, Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia., Neurotherapeutics
    Leung JY et al., 2012, Cardiovascular side-effects of antipsychotic drugs: the role of the autonomic nervous system., Pharmacol Ther
    Görnemann et al., 2008, Pharmacological properties of a wide array of ergolines at functional alpha(1)-adrenoceptor subtypes., Naunyn Schmiedebergs Arch. Pharmacol.
    Dupont et al., 1996, Epinastine (WAL 801CL) modulates the noncholinergic contraction in guinea-pig airways in vitro by a prejunctional 5-HT1-like receptor., Eur. Respir. J.
    POWE CE et al., 1962, Propiomazine hydrochloride in obstetrical analgesia. A controlled study of 520 patients., JAMA
    Stahl, 2008, Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines., CNS Spectr
    Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
    Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
    Bray, 2005, Drug Insight: appetite suppressants., Nat Clin Pract Gastroenterol Hepatol
    Rothman et al., 2006, Therapeutic potential of monoamine transporter substrates., Curr Top Med Chem
    Bray, 2000, A concise review on the therapeutics of obesity., Nutrition
    Teskin et al., 2006, Comparative effects of tolazoline and nitroprusside on human isolated radial artery., Ann. Thorac. Surg.
    Song et al., 1998, [Effects of some mexiletine derivatives on alpha 1-adrenoceptors]., Yao Xue Xue Bao
    Khalifa, 2003, Zuclopenthixol facilitates memory retrieval in rats: possible involvement of noradrenergic and serotonergic mechanisms., Pharmacol. Biochem. Behav.
    Satoh et al., 1994, Alpha 1-adrenoceptor subtypes mediating the regulation and modulation of Ca2+ sensitization in rabbit thoracic aorta., Eur. J. Pharmacol.
    Sattar et al., 1994, Evidence for an alpha 1-adrenoceptor subtype mediating adrenergic vasoconstriction in Wistar normotensive and stroke-prone spontaneously hypertensive rat kidney., J. Cardiovasc. Pharmacol.
    Piascik et al., 1991, Evidence for a complex interaction between the subtypes of the alpha 1-adrenoceptor., Eur. J. Pharmacol.
    Hoang et al., 1996, Characterization of alpha-adrenoceptor activity in the preterm piglet mesentery., J. Pediatr. Surg.
    Haenisch et al., 2010, Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline., Fundam Clin Pharmacol
    de Bartolomeis A et al., 2015, Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism., CNS Drugs
    Foglar R et al., 1995, Use of recombinant alpha 1-adrenoceptors to characterize subtype selectivity of drugs for the treatment of prostatic hypertrophy., Eur J Pharmacol
    Forray C et al., 1994, The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype., Mol Pharmacol
    Berger et al., 1996, Trimipramine: a challenge to current concepts on antidepressives., Eur Arch Psychiatry Clin Neurosci
    Millan et al., 2002, Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes., J. Pharmacol. Exp. Ther.
    Wei et al., 1990, [Comparison of the affinities of amoxapine and loxapine for various receptors in rat brain and the receptor down-regulation after chronic administration]., Yao Xue Xue Bao
    George et al., 2013, Newer antipsychotics and upcoming molecules for schizophrenia., Eur. J. Clin. Pharmacol.
    Zhu et al., 2010, Update of TTD: Therapeutic Target Database., Nucleic Acids Res.
    Gibson et al., 1988, Agonist profile of ergometrine (ergonovine) on a population of postsynaptic alpha-adrenoceptors., J. Pharm. Pharmacol.
    Ruffolo et al., 1982, Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist., J. Pharmacol. Exp. Ther.
    Horie et al., 1995, Selectivity of the imidazoline alpha-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned alpha 1-adrenoceptor subtypes., Br. J. Pharmacol.
    Reisine et al., 1980, Effects of combined administration of amphetamine and iprindole on brain adrenergic receptors., Brain Res.
    Leibowitz, 1970, Reciprocal hunger-regulating circuits involving alpha- and beta-adrenergic receptors located, respectively, in the ventromedial and lateral hypothalamus., Proc. Natl. Acad. Sci. U.S.A.
    Shayegan DK et al., 2004, Atypical antipsychotics: matching receptor profile to individual patient's clinical profile., CNS Spectr
    Li X et al., 2000, Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists., Bioorg Med Chem Lett
    Thayer et al., 1985, Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors., Biochem. Pharmacol.
    Kroeze et al., 2003, H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs., Neuropsychopharmacology
    Thomas DR et al., 1987, Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor., Psychopharmacology (Berl)
    Mylecharane EJ, 1991, 5-HT2 receptor antagonists and migraine therapy., J Neurol
    Huang YT et al., 2001, Hemodynamic effects of synephrine treatment in portal hypertensive rats., Jpn J Pharmacol
    Virsolvy A et al., 2015, Antagonism of Nav channels and α1-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine., Sci Rep
    Zhao G et al., 2011, Antiadrenergic and hemodynamic effects of ranolazine in conscious dogs., J Cardiovasc Pharmacol
    Rayner-Hartley E et al., 2016, Ranolazine: A Contemporary Review., J Am Heart Assoc
    Wand M et al., 1980, Thymoxamine hydrochloride: an alpha-adrenergic blocker., Surv Ophthalmol
    Kishi T et al., 2013, Efficacy and tolerability of perospirone in schizophrenia: a systematic review and meta-analysis of randomized controlled trials., CNS Drugs
    Abelaira HM et al., 2012, Lamotrigine treatment reverses depressive-like behavior and alters BDNF levels in the brains of maternally deprived adult rats., Pharmacol Biochem Behav
    Howland RH, 2015, Buspirone: Back to the Future., J Psychosoc Nurs Ment Health Serv
    Schotte et al., 1996, Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding., Psychopharmacology (Berl.)
    Shibata K et al., 1998, Effects of quinidine and verapamil on human cardiovascular alpha1-adrenoceptors., Circulation
    Shill HA et al., 2009, Update on ropinirole in the treatment of Parkinson's disease., Neuropsychiatr Dis Treat
    Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
    Takayanagi I et al., 1991, Differences in alpha 1-adrenoceptor mechanisms for phenylephrine and tizanidine in rabbit thoracic aorta and common iliac artery., Can J Physiol Pharmacol
    Takayanagi I et al., 1984, Actions of tizanidine on alpha 1-and alpha 2-adrenoceptors in the peripheral tissues., Gen Pharmacol
    Isah AO et al., 1991, Clinical pharmacology of prochlorperazine in healthy young males., Br J Clin Pharmacol
    Miyoshi K et al., 1996, Regional vascular effects of MPC-1304, a novel dihydropyridine derivative, in conscious normotensive and spontaneously hypertensive rats., J Pharmacol Exp Ther
    Jarema M et al., 2011, [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]., Psychiatr Pol
    Ruffolo RR Jr et al., 1981, Alpha and beta adrenergic effects of the stereoisomers of dobutamine., J Pharmacol Exp Ther
    Coppi G, 1992, [Dihydroergocristine. A review of pharmacology and toxicology]., Arzneimittelforschung
    Müller-Schweinitzer E, 1982, Actions of co-dergocrine mesylate and its components at vascular smooth muscle., Naunyn Schmiedebergs Arch Pharmacol
  • METHOXAMINE   ADRA1A

    Interaction Score: 1.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    7875228 7511752 1978244 1680715 8986981


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

  • PHENDIMETRAZINE   ADRA1A

    Interaction Score: 0.85

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16265126 17139284 17016423 17017961 11054601


    Sources:
    TEND TdgClinicalTrial DrugBank

  • DOXAZOSIN   ADRA1A

    Interaction Score: 0.8

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    19002123 18304211 8736427 10393471 14767264 9223558 9205965 17070143 15573147 11752352 16225542


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • SILODOSIN   ADRA1A

    Interaction Score: 0.74

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Alpha-1a adrenergic receptor antagonist
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    21114397


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • TAMSULOSIN   ADRA1A

    Interaction Score: 0.69

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name dutasteride + tamsulosin,Jalyn
    Novel drug target Established target
    Trial Name tamsulosin, YM-617,Harnal, Flomax

    PMIDs:
    8647141 8647140 9352698 9352700 10503165 11752352 14680444 19427736


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • ALFUZOSIN   ADRA1A

    Interaction Score: 0.68

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name alfuzosin,UroXatral
    Novel drug target Established target
    Specific Action of the Ligand Antagonist

    PMIDs:
    12892027 15639685 8799556 16553574 8196478 9223558 9122046 11752352 9870119 11750253 16613526


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • OXEDRINE   ADRA1A

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11286401


    Sources:
    DrugBank

  • DABUZALGRON   ADRA1A

    Interaction Score: 0.64

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • NICERGOLINE   ADRA1A

    Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    10027088


    Sources:
    TEND TdgClinicalTrial DrugBank

  • APRACLONIDINE   ADRA1A

    Interaction Score: 0.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    15937427 16921219 16935593 17824139 18454417 17572343 20399934


    Sources:
    DrugBank

  • NAPHAZOLINE   ADRA1A

    Interaction Score: 0.56

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    11180982 16083326 10459292 10381812 8930173 10481510


    Sources:
    DrugBank

  • MEPHENTERMINE   ADRA1A

    Interaction Score: 0.53

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    10722 21182601


    Sources:
    TEND TdgClinicalTrial DrugBank

  • ISOMETHEPTENE   ADRA1A

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    15094323 3129549


    Sources:
    DrugBank

  • DAPIPRAZOLE   ADRA1A

    Interaction Score: 0.48

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9401944 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • EPHEDRINE   ADRA1A

    Interaction Score: 0.45

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    31613441 17405867 12557268 10592235


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PHENYLPROPANOLAMINE   ADRA1A

    Interaction Score: 0.45

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    12163120 2881994 9164583 15163201 17016423


    Sources:
    TEND TdgClinicalTrial

  • INDORAMIN   ADRA1A

    Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    7536677 8183249


    Sources:
    DrugBank GuideToPharmacology

  • BENZPHETAMINE   ADRA1A

    Interaction Score: 0.38

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    25499957 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • BESIPIRDINE   ADRA1A

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DAPIPRAZOLE HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Alpha-1a adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOLAZOLINE   ADRA1A

    Interaction Score: 0.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16368348 17139284 11938943 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PRAZOSIN   ADRA1A

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Inverse agonist

    PMIDs:
    15258254 17658513 8925876 14980979 10771044 7855217 7691623 12841945


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • METARAMINOL   ADRA1A

    Interaction Score: 0.27

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17139284 17016423 9663612


    Sources:
    TEND TdgClinicalTrial DrugBank

  • LABETALOL   ADRA1A

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6355664 8104240 10529655 1358746 7684671 2696507 17686376


    Sources:
    TEND TdgClinicalTrial DrugBank

  • MIDODRINE   ADRA1A

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12163120 9007522 15163201


    Sources:
    TEND TdgClinicalTrial DrugBank

  • OXYMETAZOLINE   ADRA1A

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    11527538 8564226 8768700 11774707 8894610


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • TERAZOSIN   ADRA1A

    Interaction Score: 0.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Antagonist

    PMIDs:
    8736427 9732824 14767264 9352700 10503165 11752352


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • DROXIDOPA   ADRA1A

    Interaction Score: 0.22

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    20412040 11482743 8825367 17266602 9138687


    Sources:
    DrugBank ChemblInteractions

  • CHEMBL2365712   ADRA1A

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7063048


    Sources:
    DrugBank

  • MOXISYLYTE   ADRA1A

    Interaction Score: 0.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    6108620


    Sources:
    DrugBank

  • ALFUZOSIN HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-1 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • DEXTROAMPHETAMINE   ADRA1A

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inducer (activating)
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17139284 6292781 17016423 8022532


    Sources:
    DrugBank

  • ROPINIROLE   ADRA1A

    Interaction Score: 0.19

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    19557097 18691132


    Sources:
    DrugBank

  • ERGONOVINE   ADRA1A

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    19933260 2897449


    Sources:
    DrugBank

  • PHENOXYBENZAMINE   ADRA1A

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8935707 1978244 7911719 10401556 12818701


    Sources:
    TEND TdgClinicalTrial DrugBank

  • TIZANIDINE   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    1666331 6329897


    Sources:
    DrugBank

  • CIRAZOLINE   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    6123592 8564227


    Sources:
    DrugBank

  • PHENYLPROPANOLAMINE POLISTIREX   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Alpha-1a adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENYLPROPANOLAMINE HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Alpha-1a adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIPIVEFRIN   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17658513 17603545


    Sources:
    DrugBank

  • PROPIOMAZINE   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    19110200 17139284 17016423 14488364


    Sources:
    TEND TdgClinicalTrial DrugBank

  • TETRAHYDROZOLINE HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    18259967


    Sources:
    DrugBank ChemblInteractions

  • METHOXAMINE HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-1 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BEVANTOLOL   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    1358746


    Sources:
    DrugBank

  • METARAMINOL BITARTRATE   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-1 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MIDODRINE HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha-1 agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENYLEPHRINE   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    17658513 17584443


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

  • LISDEXAMFETAMINE   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • PHENYLEPHRINE BITARTRATE   ADRA1A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-1 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENTOLAMINE   ADRA1A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name aviptadil,Invicorp
    Novel drug target Established target
    Specific Action of the Ligand Antagonist

    PMIDs:
    6176798 7562640 1346768


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology

  • XYLOMETAZOLINE   ADRA1A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    20030735 8894610


    Sources:
    DrugBank

  • PALIPERIDONE   ADRA1A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15992090 18542932 8925876 11132243 7524043 7691623 7531353 15907153


    Sources:
    DrugBank

  • PARA-METHOXYAMPHETAMINE   ADRA1A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • FLUPENTIXOL   ADRA1A

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    10843225 17139284 17016423


    Sources:
    DrugBank

  • PROMAZINE   ADRA1A

    Interaction Score: 0.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    19110200 17139284 17016423 22565090


    Sources:
    TEND TdgClinicalTrial DrugBank

  • CHEMBL445001   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • DOBUTAMINE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    6270308


    Sources:
    DrugBank

  • LORPIPRAZOLE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    22232986


    Sources:
    DrugBank

  • ARANIDIPINE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    8667194


    Sources:
    DrugBank

  • NIGULDIPINE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8183249


    Sources:
    DrugBank

  • AROTINOLOL   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • RANOLAZINE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    26655634 21633249 26979079


    Sources:
    DrugBank

  • ETOPERIDONE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7855217


    Sources:
    DrugBank

  • NS-49   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • A-119637   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • A-123189   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • UPIDOSIN   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PHENYLEPHRINE HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-1 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TIAPRIDE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11520476


    Sources:
    DrugBank

  • THIOPROPERAZINE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15695070


    Sources:
    DrugBank

  • TAMSULOSIN HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NOREPINEPHRINE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8825367 17139284 17016423 17266602 9138687


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank

  • TERAZOSIN HYDROCHLORIDE HYDRATE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NEFAZODONE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7649970 7855217


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PERICIAZINE   ADRA1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • PSEUDOEPHEDRINE   ADRA1A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name fexofenadine + ps/
    Novel drug target Established target

    PMIDs:
    11772135 17139284 17016423 7507588


    Sources:
    TEND TdgClinicalTrial DrugBank

  • EPINEPHRINE   ADRA1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes
    Trial Name transdermal lidocaine/epinephrine patch,Lidosite

    PMIDs:
    20412040 17658513 17603545 20857090


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

  • DIHYDROERGOCRISTINE   ADRA1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    1492857


    Sources:
    DrugBank

  • PEROSPIRONE   ADRA1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    23812802


    Sources:
    DrugBank

  • EPINASTINE   ADRA1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    8836655


    Sources:
    DrugBank

  • TRAZODONE   ADRA1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    30776014 7855217


    Sources:
    TEND DrugBank

  • DROPERIDOL   ADRA1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    12505540


    Sources:
    DrugBank

  • DEBRISOQUIN   ADRA1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • MIRTAZAPINE   ADRA1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    10762339 9265949 15771415 12109911 3419539


    Sources:
    DrugBank

  • SERTINDOLE   ADRA1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name Serdolect

    PMIDs:
    16925508 11594443


    Sources:
    TEND TdgClinicalTrial DrugBank

  • ACEPROMAZINE   ADRA1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15695070


    Sources:
    DrugBank

  • CARVEDILOL   ADRA1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)
    potentiator

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-1 antagonist
    Direct Interaction yes
    Trial Name carvedilol, Coreg

    PMIDs:
    24368739 17139284 19919991 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • CHEMBL56331   ADRA1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • LEVOMEPROMAZINE   ADRA1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2870716 15701205


    Sources:
    TEND TdgClinicalTrial DrugBank

  • THIORIDAZINE   ADRA1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7691623 15695070


    Sources:
    TEND TdgClinicalTrial DrugBank

  • ERGOTAMINE   ADRA1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    18066532 17139284 17016423


    Sources:
    DrugBank

  • TRIFLUOPERAZINE   ADRA1A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8150214 17139284 17016423 6135146


    Sources:
    TEND TdgClinicalTrial DrugBank

  • ZUCLOPENTHIXOL   ADRA1A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    12957216


    Sources:
    DrugBank

  • BETHANIDINE   ADRA1A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • INDIGOTINDISULFONATE   ADRA1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • BUSPIRONE   ADRA1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    26535760


    Sources:
    DrugBank

  • AMPHETAMINE   ADRA1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    6245760 4399738


    Sources:
    TEND DrugBank

  • BMY-7378   ADRA1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CARVEDILOL PHOSPHATE   ADRA1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DOXAZOSIN MESYLATE   ADRA1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NAFTOPIDIL   ADRA1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • RAUWOLFIA SERPENTINA   ADRA1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROMETHAZINE   ADRA1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17139284 17016423 31335081


    Sources:
    DrugBank

  • ILOPERIDONE   ADRA1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name iloperidone,Fanapt, Fiapta, Zomaril
    Novel drug target Established target

    PMIDs:
    23545936


    Sources:
    TdgClinicalTrial DrugBank

  • DRONEDARONE   ADRA1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17389667 23997577


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PIPAMPERONE   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8935801


    Sources:
    DrugBank

  • ALSEROXYLON   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DOXEPIN   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    19179941 6086881 7855217


    Sources:
    DrugBank

  • NORTRIPTYLINE   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2870173 7855217 20363235


    Sources:
    DrugBank

  • SENREBOTASE   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AGN-214868
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • MEDETOMIDINE   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • FENOLDOPAM   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    7670737


    Sources:
    DrugBank

  • NAPHAZOLINE HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TEDATIOXETINE   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Alpha-1a adrenergic receptor antagonist
    Trial Name Lu AA24530

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ESCITALOPRAM   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    12876551 24424469 17916059


    Sources:
    DrugBank

  • CLONIDINE   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    11082457


    Sources:
    DrugBank

  • CABERGOLINE   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    12388666


    Sources:
    DrugBank GuideToPharmacology

  • PROPIVERINE   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • OXYMETAZOLINE HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PARDOPRUNOX   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name pardoprunox, SLV 308
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • TRIMIPRAMINE MALEATE   ADRA1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMOXAPINE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    6086881 9589848 1966571


    Sources:
    DrugBank

  • ASENAPINE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814


    Sources:
    TdgClinicalTrial DrugBank

  • RISPERIDONE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    15992090 18542932 8925876 11132243 25943458 7691623 15907153


    Sources:
    DrugBank GuideToPharmacology

  • PIZOTYLINE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2045831


    Sources:
    DrugBank

  • TOLAZOLINE HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIPIVEFRIN HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRAZOSIN HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MAPROTILINE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    6086881 9589848


    Sources:
    DrugBank

  • MEPHENTERMINE SULFATE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENTOLAMINE MESYLATE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZIPRASIDONE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17848919 20075651


    Sources:
    TEND DrugBank

  • LOFEXIDINE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • PERGOLIDE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    10641988


    Sources:
    DrugBank

  • CHEMBL88272   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PHENOXYBENZAMINE HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LABETALOL HYDROCHLORIDE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDROXYAMPHETAMINE HYDROBROMIDE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SPIROXATRINE   ADRA1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TRIMIPRAMINE   ADRA1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8863001


    Sources:
    DrugBank

  • BROMOCRIPTINE   ADRA1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    43367 10641988


    Sources:
    DrugBank

  • IMIPRAMINE   ADRA1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7855217 20363235


    Sources:
    DrugBank

  • QUETIAPINE   ADRA1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17848919 11132243 15475871


    Sources:
    DrugBank

  • CHEMBL609728   ADRA1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • DOTHIEPIN   ADRA1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • QUINIDINE   ADRA1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    9570190


    Sources:
    DrugBank

  • RACEPINEPHRINE   ADRA1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ERGOLOID MESYLATES   ADRA1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PIRIBEDIL   ADRA1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PROCHLORPERAZINE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    1768559


    Sources:
    DrugBank

  • CYPROHEPTADINE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TERGURIDE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DESIPRAMINE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7855217


    Sources:
    DrugBank

  • CHLORPROMAZINE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    6135146 15695070


    Sources:
    DrugBank

  • MIANSERIN   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    DrugBank GuideToPharmacology

  • AMIODARONE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name amiodarone HCl,Amio-Aqueous IV
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • AMITRIPTYLINE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    7855217 20363235


    Sources:
    DrugBank

  • ROXINDOLE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • NOREPINEPHRINE BITARTRATE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OLANZAPINE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ALKS 3831
    Trial Name OREX-003, olanzapine plus zonisamide SR
    Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

    PMIDs:
    17848919 25032030 10227113


    Sources:
    TdgClinicalTrial DrugBank

  • NICARDIPINE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2981533


    Sources:
    DrugBank

  • OCAPERIDONE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ARIPIPRAZOLE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17848919 26346901


    Sources:
    DrugBank

  • EPINEPHRINE BITARTRATE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PAROXETINE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    2962217


    Sources:
    DrugBank

  • LISURIDE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • SPIPERONE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • KETANSERIN   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • LAMOTRIGINE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22306746


    Sources:
    DrugBank

  • RITANSERIN   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • VERAPAMIL   ADRA1A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    9570190


    Sources:
    DrugBank

  • METHAMPHETAMINE   ADRA1A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • CLOZAPINE   ADRA1A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    17848919


    Sources:
    DrugBank GuideToPharmacology

  • NIFEDIPINE   ADRA1A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19444285


    Sources:
    PharmGKB

  • DOPAMINE   ADRA1A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LOXAPINE   ADRA1A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ISOPROTERENOL   ADRA1A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HALOPERIDOL   ADRA1A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12629531


    Sources:
    DrugBank

  • Ensembl: ENSG00000120907

    • Version: 101_38

    Alternate Names:
    ADRA1A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000120907

    • Version: 26-July-2011

    Alternate Names:
    ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA 1A- ADRENORECEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1C). [SOURCE:UNIPROT/SWISSPROT;ACC:P35348] Description
    ADRA1A Display Id
    ENSG00000120907 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P35348

    • Version: January-2014

    Alternate Names:
    ADRA1A Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • HopkinsGroom: P35348

    • Version: 11-September-2012

    Alternate Names:
    ADRA1A Uniprot Gene Name
    148 Entrez Gene Id
    ENSG00000120907 Ensembl Gene Id

    Gene Info:
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Human Readable Name G PROTEIN COUPLED RECEPTOR

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TEND: P35348

    • Version: 01-August-2011

    Alternate Names:
    ADRA1A Gene Symbol
    ADA1A_HUMAN Uniprot Id
    P35348 Uniprot Accession

    Gene Info:
    Transmembrane Helix Count 7
    Target Subclass GPCR
    Target Main Class Receptors

    Publications:

  • GuideToPharmacology: 148

    • Version: 29-September-2020

    Alternate Names:
    277 HUGO Gene ID
    277 HUGO Gene Symbol
    adrenoceptor alpha 1A HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Adrenoceptors
    GuideToPharmacology Gene Category ID 4

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • PharmGKB: ADRA1A

    • Version: 18-August-2020

    Alternate Names:
    PA34 PharmGKB ID

    Gene Info:

    Publications:
    Zhang Y et al., 2009, Arg347Cys polymorphism of alpha1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients., J Hum Genet

  • DrugBank: BE0004888

    • Version: 5.1.7

    Alternate Names:
    ADRA1A DrugBank Gene Name
    P35348 UniProt Accession
    148 Entrez Gene Id

    Gene Info:

    Publications:
    Reisine et al., 1980, Effects of combined administration of amphetamine and iprindole on brain adrenergic receptors., Brain Res.
    Leibowitz, 1970, Reciprocal hunger-regulating circuits involving alpha- and beta-adrenergic receptors located, respectively, in the ventromedial and lateral hypothalamus., Proc. Natl. Acad. Sci. U.S.A.
    Shill HA et al., 2009, Update on ropinirole in the treatment of Parkinson's disease., Neuropsychiatr Dis Treat

  • DrugBank: BE0004863

    • Version: 5.1.7

    Alternate Names:
    ADRA1A DrugBank Gene Name
    P35348 UniProt Accession
    148 Entrez Gene Id

    Gene Info:

    Publications:
    Virsolvy A et al., 2015, Antagonism of Nav channels and α1-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine., Sci Rep
    Zhao G et al., 2011, Antiadrenergic and hemodynamic effects of ranolazine in conscious dogs., J Cardiovasc Pharmacol
    Rayner-Hartley E et al., 2016, Ranolazine: A Contemporary Review., J Am Heart Assoc

  • DrugBank: BE0000501

    • Version: 5.1.7

    Alternate Names:
    ADRA1A DrugBank Gene Name
    P35348 UniProt Accession
    148 Entrez Gene Id

    Gene Info:

    Publications:
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Andersohn et al., 2010, Priapism associated with antipsychotics: role of alpha1 adrenoceptor affinity., J Clin Psychopharmacol
    Millan et al., 2002, Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes., J. Pharmacol. Exp. Ther.

  • HingoraniCasas: ENSG00000120907

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000120907 Gene Symbol
    ADRA1A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ADRA1C

    • Version: chembl_23

    Alternate Names:
    ADRA1C GENE_SYMBOL
    ADRA1A GENE_SYMBOL
    Alpha-1A adrenergic receptor UNIPROT

    Gene Info:

    Publications:

  • ChemblInteractions: ADRA1A

    • Version: chembl_23

    Alternate Names:
    ADRA1A GENE_SYMBOL
    ADRA1D GENE_SYMBOL
    Alpha-1D adrenergic receptor UNIPROT

    Gene Info:

    Publications:

  • GO: ADRA1A

    • Version: 05-September-2020

    Alternate Names:
    ADRA1C GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, DRUG RESISTANCE, G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: ADRA1A

    • Version: 27-Jun-2013

    Alternate Names:
    148 Gene ID
    ADRA1C dGene Synonym
    ADRA1L1 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Adrenergic receptor alpha-1A

    • Version: 2020.06.01

    Alternate Names:
    ADRA1A TTD Gene Abbreviation
    T92609 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21