DGIdb - ADRA1A Gene Record

ADRA1A 148 Druggable GenomeDrug Resistance

Alternate Names:

148
ADRENOCEPTOR ALPHA 1A
ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
104221
277
ENSG00000120907
OTTHUMG00000099459
P35348
ADA1A_HUMAN
22
NP_000671
NM_000680
α<sub>1A</sub>-adrenoceptor
Alpha-adrenergic receptor 1a
Alpha-1D adrenoceptor
Alpha-1D adrenoreceptor
Alpha-1D adrenergic receptor
Alpha-1A adrenergic receptor
ADRA1D
Alpha-1A adrenoceptor
Alpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
Alpha-adrenergic receptor 1c
ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA 1A- ADRENORECEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1C). [SOURCE:UNIPROT/SWISSPROT;ACC:P35348]
PA34
Adrenergic receptor alpha-1A
T92609

Gene Info:

GuideToPharmacology Gene Category Name	Adrenoceptors
GuideToPharmacology Gene Category ID	4
Interpro Acc	IPR000276
Interpro Short Name	7TM_GPCR_Rhodpsn
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Uniprot Evidence	1: Evidence at protein level
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Status	Swiss-Prot
Interpro Type	Family
Human Readable Name	DRUGGABLE GENOME
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Target Main Class	Receptors
Transmembrane Helix Count	7
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUG RESISTANCE
G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
González-Espinosa et al., 2001, Molecular cloning and functional expression of the guinea pig alpha(1a)-adrenoceptor., Eur. J. Pharmacol.
Yang et al., 1996, (+/-)-tamsulosin, an alpha 1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart., Eur. J. Pharmacol.
Shibata et al., 2001, [Excitatory effect of noradrenaline on rat airway parasympathetic ganglion neurons]., Fukuoka Igaku Zasshi
Furukawa et al., 1995, Alpha 1A-adrenoceptor-mediated contractile responses of the human vas deferens., Br. J. Pharmacol.
Deplanne et al., 1996, Functional characterization of alpha-1-adrenoceptor subtypes in the prostatic urethra and trigone of male rabbit., J. Pharmacol. Exp. Ther.
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Nourian et al., 2008, Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function., Psychopharmacology (Berl.)
Eltze, 1996, In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors., Eur. J. Pharmacol.
Keks et al., 1999, Risperidone (Risperdal): clinical experience with a new antipsychosis drug., Expert Opin Investig Drugs
Fenton et al., 2005, Risperidone: a review of its use in the treatment of bipolar mania., CNS Drugs
Richelson et al., 2000, Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds., Life Sci.
Sleight et al., 1993, Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors., Eur. J. Pharmacol.
Corena-McLeod M, 2015, Comparative Pharmacology of Risperidone and Paliperidone., Drugs R D
Moya-Huff et al., 1987, Adrenergic receptor subtype activation by (+)-, (-)- and (+/-)-norephedrine in the pithed rat., J. Pharm. Pharmacol.
Buckner et al., 2002, ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes., Eur. J. Pharmacol.
Altenbach et al., 2004, Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist., J. Med. Chem.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Wellman et al., Effects of the alpha 1a-adrenoceptor antagonist RS-17053 on phenylpropanolamine-induced anorexia in rats., Pharmacol. Biochem. Behav.
Martínez-Salas et al., 2007, Alpha1A-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed., Auton Autacoid Pharmacol
Tomiyama et al., 2007, Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter., Eur. J. Pharmacol.
Michel et al., 1996, Drugs for treatment of benign prostatic hyperplasia: affinity comparison at cloned alpha 1-adrenoceptor subtypes and in human prostate., J Auton Pharmacol
Lee et al., 1997, Clinical comparison of selective and non-selective alpha 1A-adrenoreceptor antagonists in benign prostatic hyperplasia: studies on tamsulosin in a fixed dose and terazosin in increasing doses., Br J Urol
Na et al., 1998, Clinical comparison of selective and non-selective alpha 1A-adrenoceptor antagonists for bladder outlet obstruction associated with benign prostatic hyperplasia: studies on tamsulosin and terazosin in Chinese patients. The Chinese Tamsulosin Study Group., J Med
Roehrborn et al., 2004, Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia., J. Urol.
Chapple, 1998, Medical therapy and quality of life., Eur. Urol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Saeed et al., Alpha-adrenoceptor blockade by phentolamine causes beta-adrenergic vasodilation by increased catecholamine release due to presynaptic alpha-blockade., J. Cardiovasc. Pharmacol.
Giussani et al., 1995, Alpha 1- and alpha 2-adrenoreceptor actions of phentolamine and prazosin on breathing movements in fetal sheep in utero., J. Physiol. (Lond.)
Bylund, 1992, Subtypes of alpha 1- and alpha 2-adrenergic receptors., FASEB J.
Lepor et al., 2010, Silodosin for the treatment of benign prostatic hyperplasia: pharmacology and cardiovascular tolerability., Pharmacotherapy
Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Taylor et al., 1995, Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug., J Clin Psychiatry
Hietala et al., 2001, Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment., Psychopharmacology (Berl.)
Lindström et al., 2006, Sertindole: efficacy and safety in schizophrenia., Expert Opin Pharmacother
Senard et al., 2001, Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management., Drugs Aging
Lachnit et al., 1997, Pharmacological characterization of an alpha 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat., Br. J. Pharmacol.
Du et al., 2010, Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists., Curr Comput Aided Drug Des
Burt et al., 1996, The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens., Br. J. Pharmacol.
Bishop, 2007, Recent advances in the discovery of alpha1-adrenoceptor agonists., Curr Top Med Chem
Morris et al., 2004, Cellular trafficking of human alpha1a-adrenergic receptors is continuous and primarily agonist-independent., Mol. Pharmacol.
Suzuki et al., 2000, Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs., Eur. J. Pharmacol.
Chang et al., 2003, Stimulatory effect of cinnamic acid analogues on alpha1A-adrenoceptors in-vitro., J. Pharm. Pharmacol.
Zacharia et al., 2004, Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries., Br. J. Pharmacol.
Andersohn et al., 2010, Priapism associated with antipsychotics: role of alpha1 adrenoceptor affinity., J Clin Psychopharmacol
Bymaster et al., 1999, Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro., Schizophr. Res.
Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
Jensen et al., 2010, Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells., Naunyn Schmiedebergs Arch. Pharmacol.
Sanbe et al., 2007, Alpha1-adrenoceptors are required for normal male sexual function., Br. J. Pharmacol.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Ahlquist, 1976, Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor., Am. Heart J.
Mohta et al., 2010, Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension., Anaesthesia
Alvarez-Guerra et al., 1999, Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat., Fundam Clin Pharmacol
Tatsuta et al., 1998, Alpha1-adrenoceptor stimulation enhances experimental gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats., Int. J. Cancer
Dale et al., 2007, Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter., Ann Pharmacother
Heijman J et al., 2013, Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation., Clin Med Insights Cardiol
Wellington et al., 2001, Cetirizine/pseudoephedrine., Drugs
Johnson DA et al., 1993, The pharmacology of alpha-adrenergic decongestants., Pharmacotherapy
Nakamura et al., 1999, Tamsulosin: assessment of affinityof (3)H-P razosin binding to two alpha-1- adrenoceptor subtypes in the canine aorta., Pharmacology
Rosendorff, 1993, Beta-blocking agents with vasodilator activity., J Hypertens Suppl
Bernstein et al., 1989, Partial attenuation of hemodynamic responses to rapid sequence induction and intubation with labetalol., J Clin Anesth
Shiraishi et al., 1992, Alpha 1-adrenoceptor blocking activities of bevantolol hydrochloride(NC-1400) and labetalol in rat isolated thoracic aorta--do they distinguish between subtypes?, Gen. Pharmacol.
Sassard et al., 1983, [Comparative effects of an alpha 1 and beta 1-2 blocker (labetalol) and a beta-1 blocker (atenolol) in the hypertensive patient]., J Pharmacol
van Zwieten, 1993, An overview of the pharmacodynamic properties and therapeutic potential of combined alpha- and beta-adrenoceptor antagonists., Drugs
Pedersen et al., 2007, The vasodilatory beta-blockers., Curr. Hypertens. Rep.
Eltze, 1997, Affinity of the miotic drug, dapiprazole, at alpha 1-adrenoceptor subtypes A, B and D., J. Pharm. Pharmacol.
Abrams et al., 1997, A dose-ranging study of the efficacy and safety of tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist, in patients with benign prostatic obstruction (symptomatic benign prostatic hyperplasia)., Br J Urol
Michel et al., 2004, Efficacy and safety of tamsulosin in the treatment of urological diseases., Expert Opin Pharmacother
Chen et al., 2009, Blockade of alpha 1A-adrenoceptor: a novel possible strategy for male contraception., Med. Hypotheses
Schulman et al., 1996, Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. Analysis of a multinational, multicentre, open-label study assessing the long-term efficacy and safety in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group., Eur. Urol.
Chapple et al., 1996, Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. A meta-analysis of two randomized, placebo-controlled, multicentre studies in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group., Eur. Urol.
Spencer RC et al., 2015, The cognition-enhancing effects of psychostimulants involve direct action in the prefrontal cortex., Biol Psychiatry
Bèïque et al., 1998, Are the new selective alpha-blockers better than non-selective alpha-blockers for benign prostatic hyperplasia?, Can Fam Physician
Elhilali, 2006, Alfuzosin: an alpha1-receptor blocker for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia., Expert Opin Pharmacother
Faure et al., 1994, Identification of alpha 1-adrenoceptor subtypes present in the human prostate., Life Sci.
Roehrborn, 2001, Alfuzosin: overview of pharmacokinetics, safety, and efficacy of a clinically uroselective alpha-blocker., Urology
McVary, 2006, BPH: epidemiology and comorbidities., Am J Manag Care
Martin et al., 1997, Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists., J. Pharmacol. Exp. Ther.
Andersson et al., 1997, Prostatic alpha 1-adrenoceptors and uroselectivity., Prostate
Kenny et al., 1996, Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies., Br. J. Pharmacol.
Lee, 2003, Alfuzosin hydrochloride for the treatment of benign prostatic hyperplasia., Am J Health Syst Pharm
Lowe, 2004, Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms., Clin Ther
Greco et al., 2008, The role of combination medical therapy in benign prostatic hyperplasia., Int. J. Impot. Res.
Shannon et al., 2006, Effect of alpha1-adrenergic receptors in cardiac pathophysiology., Am. Heart J.
Martin, 1999, Preclinical pharmacology of alpha1-adrenoceptor antagonists., Eur. Urol.
Yono et al., 2004, Doxazosin-induced up-regulation of alpha 1A-adrenoceptor mRNA in the rat lower urinary tract., Can. J. Physiol. Pharmacol.
Bae et al., 2005, The effects of alpha-adrenoceptor antagonists on the urethral perfusion pressure of the female rat., BJU Int.
Ishizuka et al., 1997, Stimulation of bladder activity by volume, L-dopa and capsaicin in normal conscious rats--effects of spinal alpha 1-adrenoceptor blockade., Naunyn Schmiedebergs Arch. Pharmacol.
Schwinn DA et al., 2008, Alpha1-adrenoceptor subtypes and lower urinary tract symptoms., Int J Urol
Cahir et al., 2005, Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat., Eur Neuropsychopharmacol
O'Connell TD et al., 2013, Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance., Pharmacol Rev
Jensen BC et al., 2009, {alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium., Circ Heart Fail
Taniguchi et al., 1996, NS-49, an alpha 1A-adrenoceptor agonist, selectively increases intraurethral pressure in dogs., Eur. J. Pharmacol.
Ashford JW, 2019, Treatment of Alzheimer's Disease: Trazodone, Sleep, Serotonin, Norepinephrine, and Future Directions., J Alzheimers Dis
Spiller et al., 2008, Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline., Clin Toxicol (Phila)
Suzuki et al., 1990, Two pharmacologically distinct alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta: each subtype couples with a different Ca2+ signalling mechanism and plays a different physiological role., Mol. Pharmacol.
Sallés et al., 1996, Sustained increase in rat myocardial alpha 1A-adrenoceptors induced by 6-hydroxydopamine treatment involves a decelerated receptor turnover., Naunyn Schmiedebergs Arch. Pharmacol.
Michel et al., 1994, Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle., Br. J. Pharmacol.
Stam et al., 1999, Analysis of alpha 1L-adrenoceptor pharmacology in rat small mesenteric artery., Br. J. Pharmacol.
Yu et al., 2003, Functional characterization of alpha-adrenoceptors mediating pupillary dilation in rats., Eur. J. Pharmacol.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Ma et al., 2007, Pharmacological effects of ephedrine alkaloids on human alpha(1)- and alpha(2)-adrenergic receptor subtypes., J. Pharmacol. Exp. Ther.
Wellman et al., 2003, Noradrenergic modulation of ephedrine-induced hypophagia., Synapse
Statler AK et al., 2020, Ephedrine,
Huerta-Bahena et al., 1983, Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects., Mol. Pharmacol.
Fujinaga et al., 1994, Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos., Dev. Biol.
Zhang Y et al., 2009, Arg347Cys polymorphism of alpha1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients., J Hum Genet
Kim DH et al., 2009, Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia., Neurotherapeutics
Leung JY et al., 2012, Cardiovascular side-effects of antipsychotic drugs: the role of the autonomic nervous system., Pharmacol Ther
POWE CE et al., 1962, Propiomazine hydrochloride in obstetrical analgesia. A controlled study of 520 patients., JAMA
Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
Rothman et al., 2006, Therapeutic potential of monoamine transporter substrates., Curr Top Med Chem
Bray, 2005, Drug Insight: appetite suppressants., Nat Clin Pract Gastroenterol Hepatol
Bray, 2000, A concise review on the therapeutics of obesity., Nutrition
Teskin et al., 2006, Comparative effects of tolazoline and nitroprusside on human isolated radial artery., Ann. Thorac. Surg.
Song et al., 1998, [Effects of some mexiletine derivatives on alpha 1-adrenoceptors]., Yao Xue Xue Bao
Satoh et al., 1994, Alpha 1-adrenoceptor subtypes mediating the regulation and modulation of Ca2+ sensitization in rabbit thoracic aorta., Eur. J. Pharmacol.
Hoang et al., 1996, Characterization of alpha-adrenoceptor activity in the preterm piglet mesentery., J. Pediatr. Surg.
Sattar et al., 1994, Evidence for an alpha 1-adrenoceptor subtype mediating adrenergic vasoconstriction in Wistar normotensive and stroke-prone spontaneously hypertensive rat kidney., J. Cardiovasc. Pharmacol.
Piascik et al., 1991, Evidence for a complex interaction between the subtypes of the alpha 1-adrenoceptor., Eur. J. Pharmacol.
Forray C et al., 1994, The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype., Mol Pharmacol
Foglar R et al., 1995, Use of recombinant alpha 1-adrenoceptors to characterize subtype selectivity of drugs for the treatment of prostatic hypertrophy., Eur J Pharmacol
Millan et al., 2002, Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes., J. Pharmacol. Exp. Ther.
George et al., 2013, Newer antipsychotics and upcoming molecules for schizophrenia., Eur. J. Clin. Pharmacol.
Reisine et al., 1980, Effects of combined administration of amphetamine and iprindole on brain adrenergic receptors., Brain Res.
Leibowitz, 1970, Reciprocal hunger-regulating circuits involving alpha- and beta-adrenergic receptors located, respectively, in the ventromedial and lateral hypothalamus., Proc. Natl. Acad. Sci. U.S.A.

PHENDIMETRAZINE ADRA1A

Interaction Score: 2.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17017961 17016423 17139284 16265126 11054601

Sources:
TdgClinicalTrial TEND
PHENYLPROPANOLAMINE ADRA1A

Interaction Score: 2.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2881994 12163120 15163201 17016423 9164583

Sources:
TdgClinicalTrial TEND
METHOXAMINE ADRA1A

Interaction Score: 1.77

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
1978244 7875228 8986981 7511752 1680715

Sources:
TdgClinicalTrial TEND GuideToPharmacology PharmGKB
DOXAZOSIN ADRA1A

Interaction Score: 1.65

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
8736427 19002123 17070143 10393471 14767264 11752352 15573147 16225542 9205965 9223558 18304211

Sources:
TdgClinicalTrial TEND GuideToPharmacology
ALFUZOSIN ADRA1A

Interaction Score: 1.38

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name alfuzosin,UroXatral

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
9870119 16553574 8196478 11750253 16613526 9223558 9122046 11752352 8799556 12892027 15639685

Sources:
TdgClinicalTrial TEND GuideToPharmacology
DABUZALGRON ADRA1A

Interaction Score: 1.18

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
EPHEDRINE ADRA1A

Interaction Score: 1.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10592235 17405867 12557268 31613441

Sources:
TdgClinicalTrial TEND
TAMSULOSIN ADRA1A

Interaction Score: 1.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name dutasteride + tamsulosin,Jalyn

Novel drug target Established target

Trial Name tamsulosin, YM-617,Harnal, Flomax

PMIDs:
9352698 9352700 14680444 10503165 19427736 11752352 8647140 8647141

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
MEPHENTERMINE ADRA1A

Interaction Score: 1.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10722 21182601

Sources:
TdgClinicalTrial TEND
SILODOSIN ADRA1A

Interaction Score: 1.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Alpha-1a adrenergic receptor antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
21114397

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
BENZPHETAMINE ADRA1A

Interaction Score: 0.98

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 25499957

Sources:
TdgClinicalTrial TEND
NICERGOLINE ADRA1A

Interaction Score: 0.89

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10027088

Sources:
TdgClinicalTrial TEND
DAPIPRAZOLE ADRA1A

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 9401944

Sources:
TdgClinicalTrial TEND
TOLAZOLINE ADRA1A

Interaction Score: 0.71

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16368348 17016423 17139284 11938943

Sources:
TdgClinicalTrial TEND
BESIPIRDINE ADRA1A

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
INDORAMIN ADRA1A

Interaction Score: 0.59

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
8183249 7536677

Sources:
GuideToPharmacology
DAPIPRAZOLE HYDROCHLORIDE ADRA1A

Interaction Score: 0.59

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Alpha-1a adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRAZOSIN ADRA1A

Interaction Score: 0.54

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inverse agonist

PMIDs:
7855217 15258254 10771044 17658513 12841945 14980979 8925876 7691623

Sources:
TdgClinicalTrial TEND GuideToPharmacology
TERAZOSIN ADRA1A

Interaction Score: 0.53

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
8736427 9352700 10503165 14767264 9732824 11752352

Sources:
TdgClinicalTrial TEND GuideToPharmacology
PHENOXYBENZAMINE ADRA1A

Interaction Score: 0.52

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1978244 8935707 7911719 10401556 12818701

Sources:
TdgClinicalTrial TEND
DROXIDOPA ADRA1A

Interaction Score: 0.44

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
11482743 9138687 20412040 8825367 17266602

Sources:
ChemblInteractions
MIDODRINE ADRA1A

Interaction Score: 0.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9007522 12163120 15163201

Sources:
TdgClinicalTrial TEND
METARAMINOL ADRA1A

Interaction Score: 0.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9663612 17016423 17139284

Sources:
TdgClinicalTrial TEND
LABETALOL ADRA1A

Interaction Score: 0.41

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10529655 8104240 2696507 1358746 6355664 7684671 17686376

Sources:
TdgClinicalTrial TEND
ALFUZOSIN HYDROCHLORIDE ADRA1A

Interaction Score: 0.39

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
OXYMETAZOLINE ADRA1A

Interaction Score: 0.39

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11527538 8894610 11774707 8564226 8768700

Sources:
TdgClinicalTrial TEND GuideToPharmacology
PHENYLPROPANOLAMINE POLISTIREX ADRA1A

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Alpha-1a adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENYLPROPANOLAMINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Alpha-1a adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METHOXAMINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DRONEDARONE ADRA1A

Interaction Score: 0.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17389667 23997577

Sources:
TdgClinicalTrial TEND
METARAMINOL BITARTRATE ADRA1A

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MIDODRINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

PMIDs:
None found

Sources:
ChemblInteractions
LISDEXAMFETAMINE ADRA1A

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
PHENYLEPHRINE BITARTRATE ADRA1A

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPIOMAZINE ADRA1A

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 19110200 14488364

Sources:
TdgClinicalTrial TEND
PHENYLEPHRINE ADRA1A

Interaction Score: 0.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
17584443 17658513

Sources:
TdgClinicalTrial TEND GuideToPharmacology PharmGKB
PERICIAZINE ADRA1A

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
PHENTOLAMINE ADRA1A

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name aviptadil,Invicorp

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
6176798 7562640 1346768

Sources:
TdgClinicalTrial GuideToPharmacology
CARVEDILOL ADRA1A

Interaction Score: 0.22

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

potentiator

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

Trial Name carvedilol, Coreg

PMIDs:
17016423 17139284 24368739 19919991

Sources:
TdgClinicalTrial ChemblInteractions TEND
NEFAZODONE ADRA1A

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7855217 7649970

Sources:
TdgClinicalTrial TEND
PSEUDOEPHEDRINE ADRA1A

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
11772135 17016423 17139284 7507588

Sources:
TdgClinicalTrial TEND
NOREPINEPHRINE ADRA1A

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17266602 9138687 8825367 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB
NS-49 ADRA1A

Interaction Score: 0.2

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
A-119637 ADRA1A

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
A-123189 ADRA1A

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
UPIDOSIN ADRA1A

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
PROMAZINE ADRA1A

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 19110200 22565090

Sources:
TdgClinicalTrial TEND
PHENYLEPHRINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.2

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRAHYDROZOLINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.2

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
18259967

Sources:
ChemblInteractions
TAMSULOSIN HYDROCHLORIDE ADRA1A

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DEBRISOQUIN ADRA1A

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
TERAZOSIN HYDROCHLORIDE HYDRATE ADRA1A

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
LEVOMEPROMAZINE ADRA1A

Interaction Score: 0.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15701205 2870716

Sources:
TdgClinicalTrial TEND
EPINEPHRINE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

Trial Name transdermal lidocaine/epinephrine patch,Lidosite

PMIDs:
20857090 17603545 17658513 20412040

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB
BETHANIDINE ADRA1A

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
CHEMBL56331 ADRA1A

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
TRIFLUOPERAZINE ADRA1A

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6135146 17016423 17139284 8150214

Sources:
TdgClinicalTrial TEND
TRAZODONE ADRA1A

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217 30776014

Sources:
TEND
SERTINDOLE ADRA1A

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Serdolect

PMIDs:
11594443 16925508

Sources:
TdgClinicalTrial TEND
AMPHETAMINE ADRA1A

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
6245760 4399738

Sources:
TEND
BMY-7378 ADRA1A

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CARVEDILOL PHOSPHATE ADRA1A

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOXAZOSIN MESYLATE ADRA1A

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THIORIDAZINE ADRA1A

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7691623 15695070

Sources:
TdgClinicalTrial TEND
NAFTOPIDIL ADRA1A

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
RAUWOLFIA SERPENTINA ADRA1A

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALSEROXYLON ADRA1A

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SENREBOTASE ADRA1A

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AGN-214868

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
MEDETOMIDINE ADRA1A

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NAPHAZOLINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha agonist

PMIDs:
None found

Sources:
ChemblInteractions
TEDATIOXETINE ADRA1A

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Alpha-1a adrenergic receptor antagonist

Trial Name Lu AA24530

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
OXYMETAZOLINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PARDOPRUNOX ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pardoprunox, SLV 308

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
TRIMIPRAMINE MALEATE ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
ZIPRASIDONE ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
20075651 17848919

Sources:
TEND
ILOPERIDONE ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23545936

Sources:
TdgClinicalTrial
CABERGOLINE ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
12388666

Sources:
GuideToPharmacology
TOLAZOLINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha antagonist

PMIDs:
None found

Sources:
ChemblInteractions
DIPIVEFRIN HYDROCHLORIDE ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRAZOSIN HYDROCHLORIDE ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
MEPHENTERMINE SULFATE ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENTOLAMINE MESYLATE ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RISPERIDONE ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18542932 8925876 15992090 15907153 11132243 7691623 25943458

Sources:
GuideToPharmacology
CYPROHEPTADINE ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL88272 ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PHENOXYBENZAMINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LABETALOL HYDROCHLORIDE ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROXYAMPHETAMINE HYDROBROMIDE ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
SPIROXATRINE ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ASENAPINE ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814

Sources:
TdgClinicalTrial
AMIODARONE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name amiodarone HCl,Amio-Aqueous IV

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
ERGOLOID MESYLATES ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PIRIBEDIL ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
TERGURIDE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ROXINDOLE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
NOREPINEPHRINE BITARTRATE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LISURIDE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
MIANSERIN ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
EPINEPHRINE BITARTRATE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
OLANZAPINE ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ALKS 3831

Trial Name OREX-003, olanzapine plus zonisamide SR

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
17848919 10227113 25032030

Sources:
TdgClinicalTrial
SPIPERONE ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
KETANSERIN ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
RITANSERIN ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
DOPAMINE ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METHAMPHETAMINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
NIFEDIPINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19444285

Sources:
PharmGKB
ISOPROTERENOL ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CLOZAPINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
17848919

Sources:
GuideToPharmacology

Ensembl: ENSG00000120907
- Version: 101_38
Alternate Names:

ADRA1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000120907

Version: 26-July-2011

Alternate Names:

ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA 1A- ADRENORECEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1C). [SOURCE:UNIPROT/SWISSPROT;ACC:P35348] Description

ADRA1A Display Id

ENSG00000120907 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P35348
- Version: January-2014
Alternate Names:

ADRA1A Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: P35348
- Version: 11-September-2012
Alternate Names:

ADRA1A Uniprot Gene Name

148 Entrez Gene Id

ENSG00000120907 Ensembl Gene Id

Gene Info:

Interpro Acc IPR000276

Interpro Short Name 7TM_GPCR_Rhodpsn

Human Readable Name G PROTEIN COUPLED RECEPTOR

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TEND: P35348
- Version: 01-August-2011
Alternate Names:

ADRA1A Gene Symbol

ADA1A_HUMAN Uniprot Id

P35348 Uniprot Accession

Gene Info:

Transmembrane Helix Count 7

Target Subclass GPCR

Target Main Class Receptors

Publications:
GuideToPharmacology: 148
- Version: 29-September-2020
Alternate Names:

277 HUGO Gene ID

277 HUGO Gene Symbol

adrenoceptor alpha 1A HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Adrenoceptors

GuideToPharmacology Gene Category ID 4

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
PharmGKB: ADRA1A
- Version: 18-August-2020
Alternate Names:

PA34 PharmGKB ID

Gene Info:

Publications:

Zhang Y et al., 2009, Arg347Cys polymorphism of alpha1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients., J Hum Genet
HingoraniCasas: ENSG00000120907
- Version: 31-May-2017
Alternate Names:

ENSG00000120907 Gene Symbol

ADRA1A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ADRA1C
- Version: chembl_23
Alternate Names:

ADRA1C GENE_SYMBOL

ADRA1A GENE_SYMBOL

Alpha-1A adrenergic receptor UNIPROT

Gene Info:

Publications:
ChemblInteractions: ADRA1A
- Version: chembl_23
Alternate Names:

ADRA1A GENE_SYMBOL

ADRA1D GENE_SYMBOL

Alpha-1D adrenergic receptor UNIPROT

Gene Info:

Publications:
dGene: ADRA1A
- Version: 27-Jun-2013
Alternate Names:

148 Gene ID

ADRA1C dGene Synonym

ADRA1L1 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Adrenergic receptor alpha-1A
- Version: 2020.06.01
Alternate Names:

ADRA1A TTD Gene Abbreviation

T92609 TTD Target ID

Gene Info:

Publications:
GO: ADRA1A
- Version: 01-May-2021
Alternate Names:

ADRA1C GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, DRUG RESISTANCE, G PROTEIN COUPLED RECEPTOR

Publications:

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Direct Interaction?	True

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

Trial Name	alfuzosin,UroXatral
Novel drug target	Established target
Specific Action of the Ligand	Antagonist

Specific Action of the Ligand	Agonist
Endogenous Drug?	False
Direct Interaction	yes

Trial Name	dutasteride + tamsulosin,Jalyn
Novel drug target	Established target
Trial Name	tamsulosin, YM-617,Harnal, Flomax

Mechanism of Interaction	Alpha-1a adrenergic receptor antagonist
Direct Interaction	yes
Novel drug target	Established target

Direct Interaction	yes
Mechanism of Interaction	Adrenergic receptor agonist

Mechanism of Interaction	Adrenergic receptor alpha-1 agonist
Direct Interaction	yes

Mechanism of Interaction	Alpha-1a adrenergic receptor agonist
Direct Interaction	yes

Trial Name	aviptadil,Invicorp
Novel drug target	Established target
Specific Action of the Ligand	Antagonist

partial agonist (activating)
agonist (activating)

Mechanism of Interaction	Adrenergic receptor alpha-1 antagonist
Direct Interaction	yes
Trial Name	carvedilol, Coreg

Trial Name	fexofenadine + ps/
Novel drug target	Established target

Specific Action of the Ligand	Partial agonist
Endogenous Drug?	False

Mechanism of Interaction	Adrenergic receptor alpha agonist
Direct Interaction	yes

Mechanism of Interaction	Adrenergic receptor alpha antagonist
Direct Interaction	yes

Trial Name	pardoprunox, SLV 308
Novel drug target	Established target

Trial Name	iloperidone,Fanapt, Fiapta, Zomaril
Novel drug target	Established target

Mechanism of Interaction	Adrenergic receptor antagonist
Direct Interaction	yes

Trial Name	amiodarone HCl,Amio-Aqueous IV
Novel drug target	Established target

Trial Name	ALKS 3831
Trial Name	OREX-003, olanzapine plus zonisamide SR
Trial Name	Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

ADRA1A Gene Record

ADRA1A 148 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17017961 17016423 17139284 16265126 11054601

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 2881994 12163120 15163201 17016423 9164583

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 1978244 7875228 8986981 7511752 1680715

Sources: TdgClinicalTrial TEND GuideToPharmacology PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 8736427 19002123 17070143 10393471 14767264 11752352 15573147 16225542 9205965 9223558 18304211

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name alfuzosin,UroXatral Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 9870119 16553574 8196478 11750253 16613526 9223558 9122046 11752352 8799556 12892027 15639685

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10592235 17405867 12557268 31613441

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name dutasteride + tamsulosin,Jalyn Novel drug target Established target Trial Name tamsulosin, YM-617,Harnal, Flomax

PMIDs: 9352698 9352700 14680444 10503165 19427736 11752352 8647140 8647141

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 10722 21182601

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Alpha-1a adrenergic receptor antagonist Direct Interaction yes Novel drug target Established target

PMIDs: 21114397

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 25499957

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 10027088

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 9401944

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16368348 17016423 17139284 11938943

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 8183249 7536677

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Alpha-1a adrenergic receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Inverse agonist

PMIDs: 7855217 15258254 10771044 17658513 12841945 14980979 8925876 7691623

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Antagonist

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17017961 17016423 17139284 16265126 11054601

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
2881994 12163120 15163201 17016423 9164583

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
1978244 7875228 8986981 7511752 1680715

Sources:
TdgClinicalTrial TEND GuideToPharmacology PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
8736427 19002123 17070143 10393471 14767264 11752352 15573147 16225542 9205965 9223558 18304211

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name alfuzosin,UroXatral

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
9870119 16553574 8196478 11750253 16613526 9223558 9122046 11752352 8799556 12892027 15639685

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10592235 17405867 12557268 31613441

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name dutasteride + tamsulosin,Jalyn

Novel drug target Established target

Trial Name tamsulosin, YM-617,Harnal, Flomax

PMIDs:
9352698 9352700 14680444 10503165 19427736 11752352 8647140 8647141

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10722 21182601

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Alpha-1a adrenergic receptor antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
21114397

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 25499957

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10027088

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 9401944

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16368348 17016423 17139284 11938943

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
8183249 7536677

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Alpha-1a adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inverse agonist

PMIDs:
7855217 15258254 10771044 17658513 12841945 14980979 8925876 7691623

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
8736427 9352700 10503165 14767264 9732824 11752352

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1978244 8935707 7911719 10401556 12818701

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA 1A- ADRENORECEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1C). [SOURCE:UNIPROT/SWISSPROT;ACC:P35348]	Description
ADRA1A	Display Id
ENSG00000120907	Ensembl Gene Id

ADRA1A	Uniprot Gene Name
148	Entrez Gene Id
ENSG00000120907	Ensembl Gene Id

ADRA1A	Gene Symbol
ADA1A_HUMAN	Uniprot Id
P35348	Uniprot Accession

277	HUGO Gene ID
277	HUGO Gene Symbol
adrenoceptor alpha 1A	HUGO Gene Name

ADRA1C	GENE_SYMBOL
ADRA1A	GENE_SYMBOL
Alpha-1A adrenergic receptor	UNIPROT