DGIdb - ADRA1A Gene Record

ADRA1A 148 Druggable GenomeDrug Resistance

Alternate Names:

148
ADRENOCEPTOR ALPHA 1A
ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
104221
277
ENSG00000120907
OTTHUMG00000099459
P35348
ADA1A_HUMAN
22
NP_000671
NM_000680
α<sub>1A</sub>-adrenoceptor
BE0004888
Alpha-adrenergic receptor 1a
Alpha-1D adrenoceptor
Alpha-1D adrenoreceptor
Alpha-1D adrenergic receptor
Alpha-1A adrenergic receptor
ADRA1D
Alpha-1A adrenoceptor
Alpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
Alpha-adrenergic receptor 1c
ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA 1A- ADRENORECEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1C). [SOURCE:UNIPROT/SWISSPROT;ACC:P35348]
BE0000501
BE0004863
PA34
Adrenergic receptor alpha-1A
T92609

Gene Info:

GuideToPharmacology Gene Category Name	Adrenoceptors
GuideToPharmacology Gene Category ID	4
Interpro Acc	IPR000276
Interpro Short Name	7TM_GPCR_Rhodpsn
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Uniprot Evidence	1: Evidence at protein level
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Status	Swiss-Prot
Interpro Type	Family
Human Readable Name	DRUGGABLE GENOME
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Target Main Class	Receptors
Transmembrane Helix Count	7
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUG RESISTANCE
G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
González-Espinosa et al., 2001, Molecular cloning and functional expression of the guinea pig alpha(1a)-adrenoceptor., Eur. J. Pharmacol.
Furukawa et al., 1995, Alpha 1A-adrenoceptor-mediated contractile responses of the human vas deferens., Br. J. Pharmacol.
Deplanne et al., 1996, Functional characterization of alpha-1-adrenoceptor subtypes in the prostatic urethra and trigone of male rabbit., J. Pharmacol. Exp. Ther.
Shibata et al., 2001, [Excitatory effect of noradrenaline on rat airway parasympathetic ganglion neurons]., Fukuoka Igaku Zasshi
Yang et al., 1996, (+/-)-tamsulosin, an alpha 1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart., Eur. J. Pharmacol.
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Keks et al., 1999, Risperidone (Risperdal): clinical experience with a new antipsychosis drug., Expert Opin Investig Drugs
Nourian et al., 2008, Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function., Psychopharmacology (Berl.)
Eltze, 1996, In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors., Eur. J. Pharmacol.
Richelson et al., 2000, Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds., Life Sci.
Corena-McLeod M, 2015, Comparative Pharmacology of Risperidone and Paliperidone., Drugs R D
Sleight et al., 1993, Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors., Eur. J. Pharmacol.
Fenton et al., 2005, Risperidone: a review of its use in the treatment of bipolar mania., CNS Drugs
Buckner et al., 2002, ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes., Eur. J. Pharmacol.
Moya-Huff et al., 1987, Adrenergic receptor subtype activation by (+)-, (-)- and (+/-)-norephedrine in the pithed rat., J. Pharm. Pharmacol.
Wellman et al., Effects of the alpha 1a-adrenoceptor antagonist RS-17053 on phenylpropanolamine-induced anorexia in rats., Pharmacol. Biochem. Behav.
Altenbach et al., 2004, Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist., J. Med. Chem.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Tomiyama et al., 2007, Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter., Eur. J. Pharmacol.
Martínez-Salas et al., 2007, Alpha1A-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed., Auton Autacoid Pharmacol
Huerta-Bahena et al., 1983, Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects., Mol. Pharmacol.
Cahir et al., 2005, Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat., Eur Neuropsychopharmacol
Michel et al., 1996, Drugs for treatment of benign prostatic hyperplasia: affinity comparison at cloned alpha 1-adrenoceptor subtypes and in human prostate., J Auton Pharmacol
Chapple, 1998, Medical therapy and quality of life., Eur. Urol.
Roehrborn et al., 2004, Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia., J. Urol.
Lee et al., 1997, Clinical comparison of selective and non-selective alpha 1A-adrenoreceptor antagonists in benign prostatic hyperplasia: studies on tamsulosin in a fixed dose and terazosin in increasing doses., Br J Urol
Na et al., 1998, Clinical comparison of selective and non-selective alpha 1A-adrenoceptor antagonists for bladder outlet obstruction associated with benign prostatic hyperplasia: studies on tamsulosin and terazosin in Chinese patients. The Chinese Tamsulosin Study Group., J Med
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Millan MJ et al., 2000, S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine., J Pharmacol Exp Ther
Saeed et al., Alpha-adrenoceptor blockade by phentolamine causes beta-adrenergic vasodilation by increased catecholamine release due to presynaptic alpha-blockade., J. Cardiovasc. Pharmacol.
Giussani et al., 1995, Alpha 1- and alpha 2-adrenoreceptor actions of phentolamine and prazosin on breathing movements in fetal sheep in utero., J. Physiol. (Lond.)
Bylund, 1992, Subtypes of alpha 1- and alpha 2-adrenergic receptors., FASEB J.
Freedman et al., 2005, Topical apraclonidine in the diagnosis of suspected Horner syndrome., J Neuroophthalmol
Mirzai et al., 2006, Congenital Horner's syndrome and the usefulness of the apraclonidine test in its diagnosis., Indian J Ophthalmol
Chen et al., 2006, Efficacy of apraclonidine 0.5% in the diagnosis of Horner syndrome in pediatric patients under low or high illumination., Am. J. Ophthalmol.
Moodley et al., 2007, Apraclonidine in the diagnosis of Horner's syndrome., S. Afr. Med. J.
Kawasaki et al., 2008, False negative apraclonidine test in two patients with Horner syndrome., Klin Monbl Augenheilkd
Watts et al., 2007, Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants., J AAPOS
Sueke et al., 2010, Using apraclonidine in diagnosing Horner syndrome in children., Am. J. Ophthalmol.
Lepor et al., 2010, Silodosin for the treatment of benign prostatic hyperplasia: pharmacology and cardiovascular tolerability., Pharmacotherapy
Taylor et al., 1995, Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug., J Clin Psychiatry
Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Lindström et al., 2006, Sertindole: efficacy and safety in schizophrenia., Expert Opin Pharmacother
Hietala et al., 2001, Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment., Psychopharmacology (Berl.)
Millan et al., 2000, Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram., Eur. J. Neurosci.
Nutt D, 1997, Mirtazapine: pharmacology in relation to adverse effects., Acta Psychiatr Scand Suppl
Fernández et al., 2005, Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents., J. Med. Chem.
Wikström et al., 2002, Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine., J. Med. Chem.
de Boer et al., 1988, Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers., Neuropharmacology
Du et al., 2010, Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists., Curr Comput Aided Drug Des
Senard et al., 2001, Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management., Drugs Aging
Burt et al., 1996, The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens., Br. J. Pharmacol.
Bishop, 2007, Recent advances in the discovery of alpha1-adrenoceptor agonists., Curr Top Med Chem
Lachnit et al., 1997, Pharmacological characterization of an alpha 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat., Br. J. Pharmacol.
Morris et al., 2004, Cellular trafficking of human alpha1a-adrenergic receptors is continuous and primarily agonist-independent., Mol. Pharmacol.
Zacharia et al., 2004, Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries., Br. J. Pharmacol.
Suzuki et al., 2000, Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs., Eur. J. Pharmacol.
Chang et al., 2003, Stimulatory effect of cinnamic acid analogues on alpha1A-adrenoceptors in-vitro., J. Pharm. Pharmacol.
Andersohn et al., 2010, Priapism associated with antipsychotics: role of alpha1 adrenoceptor affinity., J Clin Psychopharmacol
Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
Bymaster et al., 1999, Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro., Schizophr. Res.
Sanbe et al., 2007, Alpha1-adrenoceptors are required for normal male sexual function., Br. J. Pharmacol.
Jensen et al., 2010, Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells., Naunyn Schmiedebergs Arch. Pharmacol.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.
Ahlquist, 1976, Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor., Am. Heart J.
Mohta et al., 2010, Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension., Anaesthesia
Alvarez-Guerra et al., 1999, Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat., Fundam Clin Pharmacol
Ogidigben et al., 2001, Naphazoline-induced suppression of aqueous humor pressure and flow: involvement of central and peripheral alpha(2)/I(1) receptors., Exp. Eye Res.
Leonardi, 2005, Emerging drugs for ocular allergy., Expert Opin Emerg Drugs
Kai, 1999, [Effects of topical alpha 1- and beta 2-adrenoceptor stimulants on nasal nitric oxide level]., Nippon Jibiinkoka Gakkai Kaiho
Hrometz et al., 1999, Expression of multiple alpha1-adrenoceptors on vascular smooth muscle: correlation with the regulation of contraction., J. Pharmacol. Exp. Ther.
Piletz et al., 1996, Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
Bogacka, 1999, [Decongestants in treatment of nasal obstruction]., Otolaryngol Pol
Southard BT et al., 2020, Promethazine,
Tatsuta et al., 1998, Alpha1-adrenoceptor stimulation enhances experimental gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats., Int. J. Cancer
Dale et al., 2007, Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter., Ann Pharmacother
Heijman J et al., 2013, Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation., Clin Med Insights Cardiol
Wellington et al., 2001, Cetirizine/pseudoephedrine., Drugs
Johnson DA et al., 1993, The pharmacology of alpha-adrenergic decongestants., Pharmacotherapy
Sassard et al., 1983, [Comparative effects of an alpha 1 and beta 1-2 blocker (labetalol) and a beta-1 blocker (atenolol) in the hypertensive patient]., J Pharmacol
Rosendorff, 1993, Beta-blocking agents with vasodilator activity., J Hypertens Suppl
Nakamura et al., 1999, Tamsulosin: assessment of affinityof (3)H-P razosin binding to two alpha-1- adrenoceptor subtypes in the canine aorta., Pharmacology
Shiraishi et al., 1992, Alpha 1-adrenoceptor blocking activities of bevantolol hydrochloride(NC-1400) and labetalol in rat isolated thoracic aorta--do they distinguish between subtypes?, Gen. Pharmacol.
van Zwieten, 1993, An overview of the pharmacodynamic properties and therapeutic potential of combined alpha- and beta-adrenoceptor antagonists., Drugs
Bernstein et al., 1989, Partial attenuation of hemodynamic responses to rapid sequence induction and intubation with labetalol., J Clin Anesth
Pedersen et al., 2007, The vasodilatory beta-blockers., Curr. Hypertens. Rep.
Eltze, 1997, Affinity of the miotic drug, dapiprazole, at alpha 1-adrenoceptor subtypes A, B and D., J. Pharm. Pharmacol.
Chapple et al., 1996, Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. A meta-analysis of two randomized, placebo-controlled, multicentre studies in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group., Eur. Urol.
Schulman et al., 1996, Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. Analysis of a multinational, multicentre, open-label study assessing the long-term efficacy and safety in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group., Eur. Urol.
Abrams et al., 1997, A dose-ranging study of the efficacy and safety of tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist, in patients with benign prostatic obstruction (symptomatic benign prostatic hyperplasia)., Br J Urol
Michel et al., 2004, Efficacy and safety of tamsulosin in the treatment of urological diseases., Expert Opin Pharmacother
Chen et al., 2009, Blockade of alpha 1A-adrenoceptor: a novel possible strategy for male contraception., Med. Hypotheses
Richelson et al., 1984, Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro., J. Pharmacol. Exp. Ther.
Buckley et al., 1998, Can the fatal toxicity of antidepressant drugs be predicted with pharmacological and toxicological data?, Drug Saf
Fabre et al., [Mechanisms of action of antidepressants: new data from Escitalopram]., Encephale
Sanchez C et al., 2014, A comparative review of escitalopram, paroxetine, and sertraline: Are they all alike?, Int Clin Psychopharmacol
Bareggi et al., 2007, The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders., Expert Opin Drug Metab Toxicol
Zupkó et al., 2003, Alpha-adrenergic blockade: a possible mechanism of tocolytic action of certain benzodiazepines in a postpartum rat model in vivo., Life Sci.
Spencer RC et al., 2015, The cognition-enhancing effects of psychostimulants involve direct action in the prefrontal cortex., Biol Psychiatry
Lee, 2003, Alfuzosin hydrochloride for the treatment of benign prostatic hyperplasia., Am J Health Syst Pharm
Lowe, 2004, Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms., Clin Ther
Kenny et al., 1996, Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies., Br. J. Pharmacol.
Elhilali, 2006, Alfuzosin: an alpha1-receptor blocker for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia., Expert Opin Pharmacother
Faure et al., 1994, Identification of alpha 1-adrenoceptor subtypes present in the human prostate., Life Sci.
Martin et al., 1997, Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists., J. Pharmacol. Exp. Ther.
Andersson et al., 1997, Prostatic alpha 1-adrenoceptors and uroselectivity., Prostate
Bèïque et al., 1998, Are the new selective alpha-blockers better than non-selective alpha-blockers for benign prostatic hyperplasia?, Can Fam Physician
Roehrborn, 2001, Alfuzosin: overview of pharmacokinetics, safety, and efficacy of a clinically uroselective alpha-blocker., Urology
McVary, 2006, BPH: epidemiology and comorbidities., Am J Manag Care
Greco et al., 2008, The role of combination medical therapy in benign prostatic hyperplasia., Int. J. Impot. Res.
Schwinn DA et al., 2008, Alpha1-adrenoceptor subtypes and lower urinary tract symptoms., Int J Urol
Martin, 1999, Preclinical pharmacology of alpha1-adrenoceptor antagonists., Eur. Urol.
Ishizuka et al., 1997, Stimulation of bladder activity by volume, L-dopa and capsaicin in normal conscious rats--effects of spinal alpha 1-adrenoceptor blockade., Naunyn Schmiedebergs Arch. Pharmacol.
Shannon et al., 2006, Effect of alpha1-adrenergic receptors in cardiac pathophysiology., Am. Heart J.
Yono et al., 2004, Doxazosin-induced up-regulation of alpha 1A-adrenoceptor mRNA in the rat lower urinary tract., Can. J. Physiol. Pharmacol.
Bae et al., 2005, The effects of alpha-adrenoceptor antagonists on the urethral perfusion pressure of the female rat., BJU Int.
Nojimoto et al., The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors., Neuropharmacology
O'Connell TD et al., 2013, Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance., Pharmacol Rev
Jensen BC et al., 2009, {alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium., Circ Heart Fail
Nakamura S et al., 1982, Changes in noradrenergic terminal excitability induced by amphetamine and their relation to impulse traffic., Neuroscience
Shekim WO et al., 1994, Platelet alpha 2-adrenergic receptor binding and the effects of d-amphetamine in boys with attention deficit hyperactivity disorder., Neuropsychobiology
Valdivia et al., 2004, Pharmacological analysis of the mechanisms involved in the tachycardic and vasopressor responses to the antimigraine agent, isometheptene, in pithed rats., Life Sci.
Parker et al., 1988, Comparative effects of amphetamine, phenylethylamine and related drugs on dopamine efflux, dopamine uptake and mazindol binding., J. Pharmacol. Exp. Ther.
Taniguchi et al., 1996, NS-49, an alpha 1A-adrenoceptor agonist, selectively increases intraurethral pressure in dogs., Eur. J. Pharmacol.
Ashford JW, 2019, Treatment of Alzheimer's Disease: Trazodone, Sleep, Serotonin, Norepinephrine, and Future Directions., J Alzheimers Dis
Spiller et al., 2008, Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline., Clin Toxicol (Phila)
Sallés et al., 1996, Sustained increase in rat myocardial alpha 1A-adrenoceptors induced by 6-hydroxydopamine treatment involves a decelerated receptor turnover., Naunyn Schmiedebergs Arch. Pharmacol.
Suzuki et al., 1990, Two pharmacologically distinct alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta: each subtype couples with a different Ca2+ signalling mechanism and plays a different physiological role., Mol. Pharmacol.
Michel et al., 1994, Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle., Br. J. Pharmacol.
Stam et al., 1999, Analysis of alpha 1L-adrenoceptor pharmacology in rat small mesenteric artery., Br. J. Pharmacol.
Yu et al., 2003, Functional characterization of alpha-adrenoceptors mediating pupillary dilation in rats., Eur. J. Pharmacol.
Statler AK et al., 2020, Ephedrine,
Ma et al., 2007, Pharmacological effects of ephedrine alkaloids on human alpha(1)- and alpha(2)-adrenergic receptor subtypes., J. Pharmacol. Exp. Ther.
Wellman et al., 2003, Noradrenergic modulation of ephedrine-induced hypophagia., Synapse
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Scatton et al., 2001, The preclinical pharmacologic profile of tiapride., Eur. Psychiatry
Gibson A et al., 1979, The effects of bromocriptine on pre-synaptic and post-synaptic alpha-adrenoceptors in the mouse vas deferens., J Pharm Pharmacol
Lam, 2000, Clinical pharmacology of dopamine agonists., Pharmacotherapy
Cohen, Risperidone., Pharmacotherapy
Megens et al., 1994, Survey on the pharmacodynamics of the new antipsychotic risperidone., Psychopharmacology (Berl.)
Ferry DG et al., 1986, Interaction between antidepressants and alpha 1-adrenergic receptor antagonists on the binding to alpha 1-acid glycoprotein., J Pharm Sci
Fujinaga et al., 1994, Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos., Dev. Biol.
Zhang Y et al., 2009, Arg347Cys polymorphism of alpha1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients., J Hum Genet
Kim DH et al., 2009, Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia., Neurotherapeutics
Leung JY et al., 2012, Cardiovascular side-effects of antipsychotic drugs: the role of the autonomic nervous system., Pharmacol Ther
Görnemann et al., 2008, Pharmacological properties of a wide array of ergolines at functional alpha(1)-adrenoceptor subtypes., Naunyn Schmiedebergs Arch. Pharmacol.
Dupont et al., 1996, Epinastine (WAL 801CL) modulates the noncholinergic contraction in guinea-pig airways in vitro by a prejunctional 5-HT1-like receptor., Eur. Respir. J.
POWE CE et al., 1962, Propiomazine hydrochloride in obstetrical analgesia. A controlled study of 520 patients., JAMA
Stahl, 2008, Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines., CNS Spectr
Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
Bray, 2005, Drug Insight: appetite suppressants., Nat Clin Pract Gastroenterol Hepatol
Rothman et al., 2006, Therapeutic potential of monoamine transporter substrates., Curr Top Med Chem
Bray, 2000, A concise review on the therapeutics of obesity., Nutrition
Teskin et al., 2006, Comparative effects of tolazoline and nitroprusside on human isolated radial artery., Ann. Thorac. Surg.
Song et al., 1998, [Effects of some mexiletine derivatives on alpha 1-adrenoceptors]., Yao Xue Xue Bao
Khalifa, 2003, Zuclopenthixol facilitates memory retrieval in rats: possible involvement of noradrenergic and serotonergic mechanisms., Pharmacol. Biochem. Behav.
Satoh et al., 1994, Alpha 1-adrenoceptor subtypes mediating the regulation and modulation of Ca2+ sensitization in rabbit thoracic aorta., Eur. J. Pharmacol.
Sattar et al., 1994, Evidence for an alpha 1-adrenoceptor subtype mediating adrenergic vasoconstriction in Wistar normotensive and stroke-prone spontaneously hypertensive rat kidney., J. Cardiovasc. Pharmacol.
Piascik et al., 1991, Evidence for a complex interaction between the subtypes of the alpha 1-adrenoceptor., Eur. J. Pharmacol.
Hoang et al., 1996, Characterization of alpha-adrenoceptor activity in the preterm piglet mesentery., J. Pediatr. Surg.
Haenisch et al., 2010, Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline., Fundam Clin Pharmacol
de Bartolomeis A et al., 2015, Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism., CNS Drugs
Foglar R et al., 1995, Use of recombinant alpha 1-adrenoceptors to characterize subtype selectivity of drugs for the treatment of prostatic hypertrophy., Eur J Pharmacol
Forray C et al., 1994, The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype., Mol Pharmacol
Berger et al., 1996, Trimipramine: a challenge to current concepts on antidepressives., Eur Arch Psychiatry Clin Neurosci
Millan et al., 2002, Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes., J. Pharmacol. Exp. Ther.
Wei et al., 1990, [Comparison of the affinities of amoxapine and loxapine for various receptors in rat brain and the receptor down-regulation after chronic administration]., Yao Xue Xue Bao
George et al., 2013, Newer antipsychotics and upcoming molecules for schizophrenia., Eur. J. Clin. Pharmacol.
Zhu et al., 2010, Update of TTD: Therapeutic Target Database., Nucleic Acids Res.
Gibson et al., 1988, Agonist profile of ergometrine (ergonovine) on a population of postsynaptic alpha-adrenoceptors., J. Pharm. Pharmacol.
Ruffolo et al., 1982, Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist., J. Pharmacol. Exp. Ther.
Horie et al., 1995, Selectivity of the imidazoline alpha-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned alpha 1-adrenoceptor subtypes., Br. J. Pharmacol.
Reisine et al., 1980, Effects of combined administration of amphetamine and iprindole on brain adrenergic receptors., Brain Res.
Leibowitz, 1970, Reciprocal hunger-regulating circuits involving alpha- and beta-adrenergic receptors located, respectively, in the ventromedial and lateral hypothalamus., Proc. Natl. Acad. Sci. U.S.A.
Shayegan DK et al., 2004, Atypical antipsychotics: matching receptor profile to individual patient's clinical profile., CNS Spectr
Li X et al., 2000, Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists., Bioorg Med Chem Lett
Thayer et al., 1985, Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors., Biochem. Pharmacol.
Kroeze et al., 2003, H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs., Neuropsychopharmacology
Thomas DR et al., 1987, Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor., Psychopharmacology (Berl)
Mylecharane EJ, 1991, 5-HT2 receptor antagonists and migraine therapy., J Neurol
Huang YT et al., 2001, Hemodynamic effects of synephrine treatment in portal hypertensive rats., Jpn J Pharmacol
Virsolvy A et al., 2015, Antagonism of Nav channels and α1-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine., Sci Rep
Zhao G et al., 2011, Antiadrenergic and hemodynamic effects of ranolazine in conscious dogs., J Cardiovasc Pharmacol
Rayner-Hartley E et al., 2016, Ranolazine: A Contemporary Review., J Am Heart Assoc
Wand M et al., 1980, Thymoxamine hydrochloride: an alpha-adrenergic blocker., Surv Ophthalmol
Kishi T et al., 2013, Efficacy and tolerability of perospirone in schizophrenia: a systematic review and meta-analysis of randomized controlled trials., CNS Drugs
Abelaira HM et al., 2012, Lamotrigine treatment reverses depressive-like behavior and alters BDNF levels in the brains of maternally deprived adult rats., Pharmacol Biochem Behav
Howland RH, 2015, Buspirone: Back to the Future., J Psychosoc Nurs Ment Health Serv
Schotte et al., 1996, Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding., Psychopharmacology (Berl.)
Shibata K et al., 1998, Effects of quinidine and verapamil on human cardiovascular alpha1-adrenoceptors., Circulation
Shill HA et al., 2009, Update on ropinirole in the treatment of Parkinson's disease., Neuropsychiatr Dis Treat
Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
Takayanagi I et al., 1991, Differences in alpha 1-adrenoceptor mechanisms for phenylephrine and tizanidine in rabbit thoracic aorta and common iliac artery., Can J Physiol Pharmacol
Takayanagi I et al., 1984, Actions of tizanidine on alpha 1-and alpha 2-adrenoceptors in the peripheral tissues., Gen Pharmacol
Isah AO et al., 1991, Clinical pharmacology of prochlorperazine in healthy young males., Br J Clin Pharmacol
Miyoshi K et al., 1996, Regional vascular effects of MPC-1304, a novel dihydropyridine derivative, in conscious normotensive and spontaneously hypertensive rats., J Pharmacol Exp Ther
Jarema M et al., 2011, [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]., Psychiatr Pol
Ruffolo RR Jr et al., 1981, Alpha and beta adrenergic effects of the stereoisomers of dobutamine., J Pharmacol Exp Ther
Coppi G, 1992, [Dihydroergocristine. A review of pharmacology and toxicology]., Arzneimittelforschung
Müller-Schweinitzer E, 1982, Actions of co-dergocrine mesylate and its components at vascular smooth muscle., Naunyn Schmiedebergs Arch Pharmacol

METHOXAMINE ADRA1A

Interaction Score: 1.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
7875228 7511752 1978244 1680715 8986981

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology
PHENDIMETRAZINE ADRA1A

Interaction Score: 0.85

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16265126 17139284 17016423 17017961 11054601

Sources:
TEND TdgClinicalTrial DrugBank
DOXAZOSIN ADRA1A

Interaction Score: 0.8

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
19002123 18304211 8736427 10393471 14767264 9223558 9205965 17070143 15573147 11752352 16225542

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
SILODOSIN ADRA1A

Interaction Score: 0.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Alpha-1a adrenergic receptor antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
21114397

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
TAMSULOSIN ADRA1A

Interaction Score: 0.69

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name dutasteride + tamsulosin,Jalyn

Novel drug target Established target

Trial Name tamsulosin, YM-617,Harnal, Flomax

PMIDs:
8647141 8647140 9352698 9352700 10503165 11752352 14680444 19427736

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology
ALFUZOSIN ADRA1A

Interaction Score: 0.68

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name alfuzosin,UroXatral

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
12892027 15639685 8799556 16553574 8196478 9223558 9122046 11752352 9870119 11750253 16613526

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
OXEDRINE ADRA1A

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11286401

Sources:
DrugBank
DABUZALGRON ADRA1A

Interaction Score: 0.64

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction yes

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
NICERGOLINE ADRA1A

Interaction Score: 0.64

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10027088

Sources:
TEND TdgClinicalTrial DrugBank
APRACLONIDINE ADRA1A

Interaction Score: 0.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
15937427 16921219 16935593 17824139 18454417 17572343 20399934

Sources:
DrugBank
NAPHAZOLINE ADRA1A

Interaction Score: 0.56

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
11180982 16083326 10459292 10381812 8930173 10481510

Sources:
DrugBank
MEPHENTERMINE ADRA1A

Interaction Score: 0.53

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10722 21182601

Sources:
TEND TdgClinicalTrial DrugBank
ISOMETHEPTENE ADRA1A

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
15094323 3129549

Sources:
DrugBank
DAPIPRAZOLE ADRA1A

Interaction Score: 0.48

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9401944 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank
EPHEDRINE ADRA1A

Interaction Score: 0.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
31613441 17405867 12557268 10592235

Sources:
TEND TdgClinicalTrial DrugBank
PHENYLPROPANOLAMINE ADRA1A

Interaction Score: 0.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
12163120 2881994 9164583 15163201 17016423

Sources:
TEND TdgClinicalTrial
INDORAMIN ADRA1A

Interaction Score: 0.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
7536677 8183249

Sources:
DrugBank GuideToPharmacology
BENZPHETAMINE ADRA1A

Interaction Score: 0.38

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
25499957 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank
BESIPIRDINE ADRA1A

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DAPIPRAZOLE HYDROCHLORIDE ADRA1A

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Alpha-1a adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOLAZOLINE ADRA1A

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16368348 17139284 11938943 17016423

Sources:
TEND TdgClinicalTrial DrugBank
PRAZOSIN ADRA1A

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inverse agonist

PMIDs:
15258254 17658513 8925876 14980979 10771044 7855217 7691623 12841945

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
METARAMINOL ADRA1A

Interaction Score: 0.27

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17139284 17016423 9663612

Sources:
TEND TdgClinicalTrial DrugBank
LABETALOL ADRA1A

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6355664 8104240 10529655 1358746 7684671 2696507 17686376

Sources:
TEND TdgClinicalTrial DrugBank
MIDODRINE ADRA1A

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12163120 9007522 15163201

Sources:
TEND TdgClinicalTrial DrugBank
OXYMETAZOLINE ADRA1A

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11527538 8564226 8768700 11774707 8894610

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
TERAZOSIN ADRA1A

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
8736427 9732824 14767264 9352700 10503165 11752352

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
DROXIDOPA ADRA1A

Interaction Score: 0.22

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
20412040 11482743 8825367 17266602 9138687

Sources:
DrugBank ChemblInteractions
CHEMBL2365712 ADRA1A

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

PMIDs:
7063048

Sources:
DrugBank
MOXISYLYTE ADRA1A

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
6108620

Sources:
DrugBank
ALFUZOSIN HYDROCHLORIDE ADRA1A

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
DEXTROAMPHETAMINE ADRA1A

Interaction Score: 0.2

Interaction Types & Directionality:

inducer (activating)

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17139284 6292781 17016423 8022532

Sources:
DrugBank
ROPINIROLE ADRA1A

Interaction Score: 0.19

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
19557097 18691132

Sources:
DrugBank
ERGONOVINE ADRA1A

Interaction Score: 0.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
19933260 2897449

Sources:
DrugBank
PHENOXYBENZAMINE ADRA1A

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8935707 1978244 7911719 10401556 12818701

Sources:
TEND TdgClinicalTrial DrugBank
TIZANIDINE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
1666331 6329897

Sources:
DrugBank
CIRAZOLINE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
6123592 8564227

Sources:
DrugBank
PHENYLPROPANOLAMINE POLISTIREX ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Alpha-1a adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENYLPROPANOLAMINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Alpha-1a adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPIVEFRIN ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
17658513 17603545

Sources:
DrugBank
PROPIOMAZINE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19110200 17139284 17016423 14488364

Sources:
TEND TdgClinicalTrial DrugBank
TETRAHYDROZOLINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
18259967

Sources:
DrugBank ChemblInteractions
METHOXAMINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BEVANTOLOL ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
1358746

Sources:
DrugBank
METARAMINOL BITARTRATE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MIDODRINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

PMIDs:
None found

Sources:
ChemblInteractions
PHENYLEPHRINE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
17658513 17584443

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology
LISDEXAMFETAMINE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
PHENYLEPHRINE BITARTRATE ADRA1A

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENTOLAMINE ADRA1A

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name aviptadil,Invicorp

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
6176798 7562640 1346768

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology
XYLOMETAZOLINE ADRA1A

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
20030735 8894610

Sources:
DrugBank
PALIPERIDONE ADRA1A

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
15992090 18542932 8925876 11132243 7524043 7691623 7531353 15907153

Sources:
DrugBank
PARA-METHOXYAMPHETAMINE ADRA1A

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
FLUPENTIXOL ADRA1A

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10843225 17139284 17016423

Sources:
DrugBank
PROMAZINE ADRA1A

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19110200 17139284 17016423 22565090

Sources:
TEND TdgClinicalTrial DrugBank
CHEMBL445001 ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
DOBUTAMINE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
6270308

Sources:
DrugBank
LORPIPRAZOLE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
22232986

Sources:
DrugBank
ARANIDIPINE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
8667194

Sources:
DrugBank
NIGULDIPINE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
8183249

Sources:
DrugBank
AROTINOLOL ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
RANOLAZINE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
26655634 21633249 26979079

Sources:
DrugBank
ETOPERIDONE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217

Sources:
DrugBank
NS-49 ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
A-119637 ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
A-123189 ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
UPIDOSIN ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
PHENYLEPHRINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TIAPRIDE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
11520476

Sources:
DrugBank
THIOPROPERAZINE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
15695070

Sources:
DrugBank
TAMSULOSIN HYDROCHLORIDE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NOREPINEPHRINE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8825367 17139284 17016423 17266602 9138687

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank
TERAZOSIN HYDROCHLORIDE HYDRATE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
NEFAZODONE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7649970 7855217

Sources:
TEND TdgClinicalTrial DrugBank
PERICIAZINE ADRA1A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
PSEUDOEPHEDRINE ADRA1A

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name fexofenadine + ps/

Novel drug target Established target

PMIDs:
11772135 17139284 17016423 7507588

Sources:
TEND TdgClinicalTrial DrugBank
EPINEPHRINE ADRA1A

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

Trial Name transdermal lidocaine/epinephrine patch,Lidosite

PMIDs:
20412040 17658513 17603545 20857090

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions
DIHYDROERGOCRISTINE ADRA1A

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

PMIDs:
1492857

Sources:
DrugBank
PEROSPIRONE ADRA1A

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
23812802

Sources:
DrugBank
EPINASTINE ADRA1A

Interaction Score: 0.09

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
8836655

Sources:
DrugBank
TRAZODONE ADRA1A

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
30776014 7855217

Sources:
TEND DrugBank
DROPERIDOL ADRA1A

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
12505540

Sources:
DrugBank
DEBRISOQUIN ADRA1A

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
MIRTAZAPINE ADRA1A

Interaction Score: 0.09

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

PMIDs:
10762339 9265949 15771415 12109911 3419539

Sources:
DrugBank
SERTINDOLE ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Serdolect

PMIDs:
16925508 11594443

Sources:
TEND TdgClinicalTrial DrugBank
ACEPROMAZINE ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
15695070

Sources:
DrugBank
CARVEDILOL ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

potentiator

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

Trial Name carvedilol, Coreg

PMIDs:
24368739 17139284 19919991 17016423

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions
CHEMBL56331 ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
LEVOMEPROMAZINE ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2870716 15701205

Sources:
TEND TdgClinicalTrial DrugBank
THIORIDAZINE ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7691623 15695070

Sources:
TEND TdgClinicalTrial DrugBank
ERGOTAMINE ADRA1A

Interaction Score: 0.08

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
18066532 17139284 17016423

Sources:
DrugBank
TRIFLUOPERAZINE ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8150214 17139284 17016423 6135146

Sources:
TEND TdgClinicalTrial DrugBank
ZUCLOPENTHIXOL ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
12957216

Sources:
DrugBank
BETHANIDINE ADRA1A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
INDIGOTINDISULFONATE ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
BUSPIRONE ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
26535760

Sources:
DrugBank
AMPHETAMINE ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
6245760 4399738

Sources:
TEND DrugBank
BMY-7378 ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CARVEDILOL PHOSPHATE ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOXAZOSIN MESYLATE ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NAFTOPIDIL ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
RAUWOLFIA SERPENTINA ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROMETHAZINE ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17139284 17016423 31335081

Sources:
DrugBank
ILOPERIDONE ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23545936

Sources:
TdgClinicalTrial DrugBank
DRONEDARONE ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17389667 23997577

Sources:
TEND TdgClinicalTrial DrugBank
PIPAMPERONE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
8935801

Sources:
DrugBank
ALSEROXYLON ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOXEPIN ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
19179941 6086881 7855217

Sources:
DrugBank
NORTRIPTYLINE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2870173 7855217 20363235

Sources:
DrugBank
SENREBOTASE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AGN-214868

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
MEDETOMIDINE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
FENOLDOPAM ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
7670737

Sources:
DrugBank
NAPHAZOLINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha agonist

PMIDs:
None found

Sources:
ChemblInteractions
TEDATIOXETINE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Alpha-1a adrenergic receptor antagonist

Trial Name Lu AA24530

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
ESCITALOPRAM ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

PMIDs:
12876551 24424469 17916059

Sources:
DrugBank
CLONIDINE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
11082457

Sources:
DrugBank
CABERGOLINE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
12388666

Sources:
DrugBank GuideToPharmacology
PROPIVERINE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
OXYMETAZOLINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PARDOPRUNOX ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pardoprunox, SLV 308

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
TRIMIPRAMINE MALEATE ADRA1A

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
AMOXAPINE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
6086881 9589848 1966571

Sources:
DrugBank
ASENAPINE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814

Sources:
TdgClinicalTrial DrugBank
RISPERIDONE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
15992090 18542932 8925876 11132243 25943458 7691623 15907153

Sources:
DrugBank GuideToPharmacology
PIZOTYLINE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2045831

Sources:
DrugBank
TOLAZOLINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha antagonist

PMIDs:
None found

Sources:
ChemblInteractions
DIPIVEFRIN HYDROCHLORIDE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRAZOSIN HYDROCHLORIDE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
MAPROTILINE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
6086881 9589848

Sources:
DrugBank
MEPHENTERMINE SULFATE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENTOLAMINE MESYLATE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ZIPRASIDONE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17848919 20075651

Sources:
TEND DrugBank
LOFEXIDINE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
PERGOLIDE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
10641988

Sources:
DrugBank
CHEMBL88272 ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PHENOXYBENZAMINE HYDROCHLORIDE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LABETALOL HYDROCHLORIDE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROXYAMPHETAMINE HYDROBROMIDE ADRA1A

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
SPIROXATRINE ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
TRIMIPRAMINE ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
8863001

Sources:
DrugBank
BROMOCRIPTINE ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

PMIDs:
43367 10641988

Sources:
DrugBank
IMIPRAMINE ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217 20363235

Sources:
DrugBank
QUETIAPINE ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17848919 11132243 15475871

Sources:
DrugBank
CHEMBL609728 ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
DOTHIEPIN ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
QUINIDINE ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
9570190

Sources:
DrugBank
RACEPINEPHRINE ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ERGOLOID MESYLATES ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PIRIBEDIL ADRA1A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PROCHLORPERAZINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
1768559

Sources:
DrugBank
CYPROHEPTADINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
TERGURIDE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
DESIPRAMINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217

Sources:
DrugBank
CHLORPROMAZINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

PMIDs:
6135146 15695070

Sources:
DrugBank
MIANSERIN ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
DrugBank GuideToPharmacology
AMIODARONE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name amiodarone HCl,Amio-Aqueous IV

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
AMITRIPTYLINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

PMIDs:
7855217 20363235

Sources:
DrugBank
ROXINDOLE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
NOREPINEPHRINE BITARTRATE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OLANZAPINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ALKS 3831

Trial Name OREX-003, olanzapine plus zonisamide SR

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
17848919 25032030 10227113

Sources:
TdgClinicalTrial DrugBank
NICARDIPINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2981533

Sources:
DrugBank
OCAPERIDONE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ARIPIPRAZOLE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17848919 26346901

Sources:
DrugBank
EPINEPHRINE BITARTRATE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
PAROXETINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
2962217

Sources:
DrugBank
LISURIDE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SPIPERONE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
KETANSERIN ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
LAMOTRIGINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22306746

Sources:
DrugBank
RITANSERIN ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
VERAPAMIL ADRA1A

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
9570190

Sources:
DrugBank
METHAMPHETAMINE ADRA1A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
CLOZAPINE ADRA1A

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
17848919

Sources:
DrugBank GuideToPharmacology
NIFEDIPINE ADRA1A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19444285

Sources:
PharmGKB
DOPAMINE ADRA1A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LOXAPINE ADRA1A

Interaction Score: 0.01

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ISOPROTERENOL ADRA1A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HALOPERIDOL ADRA1A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12629531

Sources:
DrugBank

Ensembl: ENSG00000120907
- Version: 101_38
Alternate Names:

ADRA1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000120907

Version: 26-July-2011

Alternate Names:

ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA 1A- ADRENORECEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1C). [SOURCE:UNIPROT/SWISSPROT;ACC:P35348] Description

ADRA1A Display Id

ENSG00000120907 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P35348
- Version: January-2014
Alternate Names:

ADRA1A Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: P35348
- Version: 11-September-2012
Alternate Names:

ADRA1A Uniprot Gene Name

148 Entrez Gene Id

ENSG00000120907 Ensembl Gene Id

Gene Info:

Interpro Acc IPR000276

Interpro Short Name 7TM_GPCR_Rhodpsn

Human Readable Name G PROTEIN COUPLED RECEPTOR

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TEND: P35348
- Version: 01-August-2011
Alternate Names:

ADRA1A Gene Symbol

ADA1A_HUMAN Uniprot Id

P35348 Uniprot Accession

Gene Info:

Transmembrane Helix Count 7

Target Subclass GPCR

Target Main Class Receptors

Publications:
GuideToPharmacology: 148
- Version: 29-September-2020
Alternate Names:

277 HUGO Gene ID

277 HUGO Gene Symbol

adrenoceptor alpha 1A HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Adrenoceptors

GuideToPharmacology Gene Category ID 4

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
PharmGKB: ADRA1A
- Version: 18-August-2020
Alternate Names:

PA34 PharmGKB ID

Gene Info:

Publications:

Zhang Y et al., 2009, Arg347Cys polymorphism of alpha1A-adrenoceptor gene is associated with blood pressure response to nifedipine GITS in Chinese hypertensive patients., J Hum Genet

DrugBank: BE0004888

Version: 5.1.7

Alternate Names:

ADRA1A DrugBank Gene Name

P35348 UniProt Accession

148 Entrez Gene Id

Gene Info:

Publications:

Reisine et al., 1980, Effects of combined administration of amphetamine and iprindole on brain adrenergic receptors., Brain Res.

Leibowitz, 1970, Reciprocal hunger-regulating circuits involving alpha- and beta-adrenergic receptors located, respectively, in the ventromedial and lateral hypothalamus., Proc. Natl. Acad. Sci. U.S.A.

Shill HA et al., 2009, Update on ropinirole in the treatment of Parkinson's disease., Neuropsychiatr Dis Treat

DrugBank: BE0004863

Version: 5.1.7

Alternate Names:

ADRA1A DrugBank Gene Name

P35348 UniProt Accession

148 Entrez Gene Id

Gene Info:

Publications:

Virsolvy A et al., 2015, Antagonism of Nav channels and α1-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine., Sci Rep

Zhao G et al., 2011, Antiadrenergic and hemodynamic effects of ranolazine in conscious dogs., J Cardiovasc Pharmacol

Rayner-Hartley E et al., 2016, Ranolazine: A Contemporary Review., J Am Heart Assoc

DrugBank: BE0000501

Version: 5.1.7

Alternate Names:

ADRA1A DrugBank Gene Name

P35348 UniProt Accession

148 Entrez Gene Id

Gene Info:

Publications:

Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry

Andersohn et al., 2010, Priapism associated with antipsychotics: role of alpha1 adrenoceptor affinity., J Clin Psychopharmacol

Millan et al., 2002, Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes., J. Pharmacol. Exp. Ther.

HingoraniCasas: ENSG00000120907
- Version: 31-May-2017
Alternate Names:

ENSG00000120907 Gene Symbol

ADRA1A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ADRA1C
- Version: chembl_23
Alternate Names:

ADRA1C GENE_SYMBOL

ADRA1A GENE_SYMBOL

Alpha-1A adrenergic receptor UNIPROT

Gene Info:

Publications:
ChemblInteractions: ADRA1A
- Version: chembl_23
Alternate Names:

ADRA1A GENE_SYMBOL

ADRA1D GENE_SYMBOL

Alpha-1D adrenergic receptor UNIPROT

Gene Info:

Publications:
GO: ADRA1A
- Version: 05-September-2020
Alternate Names:

ADRA1C GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, DRUG RESISTANCE, G PROTEIN COUPLED RECEPTOR

Publications:
dGene: ADRA1A
- Version: 27-Jun-2013
Alternate Names:

148 Gene ID

ADRA1C dGene Synonym

ADRA1L1 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Adrenergic receptor alpha-1A
- Version: 2020.06.01
Alternate Names:

ADRA1A TTD Gene Abbreviation

T92609 TTD Target ID

Gene Info:

Publications:

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Direct Interaction?	True

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

Mechanism of Interaction	Alpha-1a adrenergic receptor antagonist
Direct Interaction	yes
Novel drug target	Established target

Trial Name	dutasteride + tamsulosin,Jalyn
Novel drug target	Established target
Trial Name	tamsulosin, YM-617,Harnal, Flomax

Trial Name	alfuzosin,UroXatral
Novel drug target	Established target
Specific Action of the Ligand	Antagonist

Specific Action of the Ligand	Agonist
Endogenous Drug?	False
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Adrenergic receptor agonist

Mechanism of Interaction	Adrenergic receptor alpha-1 agonist
Direct Interaction	yes

Mechanism of Interaction	Alpha-1a adrenergic receptor agonist
Direct Interaction	yes

Mechanism of Interaction	Adrenergic receptor alpha agonist
Direct Interaction	yes

partial agonist (activating)
agonist (activating)

Trial Name	aviptadil,Invicorp
Novel drug target	Established target
Specific Action of the Ligand	Antagonist

Specific Action of the Ligand	Partial agonist
Endogenous Drug?	False

Mechanism of Interaction	Adrenergic receptor alpha-1 antagonist
Direct Interaction	yes

Trial Name	fexofenadine + ps/
Novel drug target	Established target

Mechanism of Interaction	Adrenergic receptor alpha antagonist
Direct Interaction	yes

Trial Name	iloperidone,Fanapt, Fiapta, Zomaril
Novel drug target	Established target

Trial Name	pardoprunox, SLV 308
Novel drug target	Established target

Mechanism of Interaction	Adrenergic receptor antagonist
Direct Interaction	yes

Trial Name	amiodarone HCl,Amio-Aqueous IV
Novel drug target	Established target

Trial Name	ALKS 3831
Trial Name	OREX-003, olanzapine plus zonisamide SR
Trial Name	Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

ADRA1A Gene Record

ADRA1A 148 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 7875228 7511752 1978244 1680715 8986981

Sources: TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16265126 17139284 17016423 17017961 11054601

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 19002123 18304211 8736427 10393471 14767264 9223558 9205965 17070143 15573147 11752352 16225542

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Alpha-1a adrenergic receptor antagonist Direct Interaction yes Novel drug target Established target

PMIDs: 21114397

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name dutasteride + tamsulosin,Jalyn Novel drug target Established target Trial Name tamsulosin, YM-617,Harnal, Flomax

PMIDs: 8647141 8647140 9352698 9352700 10503165 11752352 14680444 19427736

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name alfuzosin,UroXatral Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 12892027 15639685 8799556 16553574 8196478 9223558 9122046 11752352 9870119 11750253 16613526

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11286401

Sources: DrugBank

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction yes

PMIDs: None found

Sources: GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 10027088

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 15937427 16921219 16935593 17824139 18454417 17572343 20399934

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 11180982 16083326 10459292 10381812 8930173 10481510

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 10722 21182601

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 15094323 3129549

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9401944 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 31613441 17405867 12557268 10592235

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 12163120 2881994 9164583 15163201 17016423

Sources: TEND TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 7536677 8183249

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 25499957 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
7875228 7511752 1978244 1680715 8986981

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16265126 17139284 17016423 17017961 11054601

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
19002123 18304211 8736427 10393471 14767264 9223558 9205965 17070143 15573147 11752352 16225542

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Alpha-1a adrenergic receptor antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
21114397

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name dutasteride + tamsulosin,Jalyn

Novel drug target Established target

Trial Name tamsulosin, YM-617,Harnal, Flomax

PMIDs:
8647141 8647140 9352698 9352700 10503165 11752352 14680444 19427736

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name alfuzosin,UroXatral

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
12892027 15639685 8799556 16553574 8196478 9223558 9122046 11752352 9870119 11750253 16613526

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
11286401

Sources:
DrugBank

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction yes

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10027088

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
15937427 16921219 16935593 17824139 18454417 17572343 20399934

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
11180982 16083326 10459292 10381812 8930173 10481510

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10722 21182601

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
15094323 3129549

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9401944 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
31613441 17405867 12557268 10592235

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
12163120 2881994 9164583 15163201 17016423

Sources:
TEND TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
7536677 8183249

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
25499957 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Alpha-1a adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16368348 17139284 11938943 17016423

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA 1A- ADRENORECEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1C). [SOURCE:UNIPROT/SWISSPROT;ACC:P35348]	Description
ADRA1A	Display Id
ENSG00000120907	Ensembl Gene Id

ADRA1A	Uniprot Gene Name
148	Entrez Gene Id
ENSG00000120907	Ensembl Gene Id

ADRA1A	Gene Symbol
ADA1A_HUMAN	Uniprot Id
P35348	Uniprot Accession

277	HUGO Gene ID
277	HUGO Gene Symbol
adrenoceptor alpha 1A	HUGO Gene Name

ADRA1A	DrugBank Gene Name
P35348	UniProt Accession
148	Entrez Gene Id

ADRA1C	GENE_SYMBOL
ADRA1A	GENE_SYMBOL
Alpha-1A adrenergic receptor	UNIPROT