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ADORA3 Gene Record

  • Summary
  • Interactions
  • Claims
  • ADORA3 140 Druggable Genome

    Alternate Names:

    140
    ADENOSINE A3 RECEPTOR
    ADORA3
    A3AR
    600445
    268
    ENSG00000282608
    OTTHUMG00000011957
    Adenosine receptor A3
    P33765
    ENSG00000121933
    ADENOSINE A3 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P33765]
    AA3R_HUMAN
    T36059
    AD026
    bA552M11.5

    Gene Info:

    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Type Family
    Interpro Acc IPR000276
    Uniprot Status Swiss-Prot
    Uniprot Evidence 2: Evidence at transcript level
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Name GPCR, rhodopsin-like, 7TM
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Franchetti et al., 2009, N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice., J. Med. Chem.
    Ribeiro et al., 2010, Caffeine and adenosine., J. Alzheimers Dis.
    Ezeamuzie et al., 2007, The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages., Int. Immunopharmacol.
    Kreckler et al., 2006, Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor., J. Pharmacol. Exp. Ther.
    Schenone et al., 2010, A1 receptors ligands: past, present and future trends., Curr Top Med Chem
    Buenestado et al., 2010, The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages., Br. J. Pharmacol.
    Funakoshi et al., 2007, A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction., Circulation
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Haschemi et al., 2007, Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages., J. Immunol.
    Trincavelli et al., 2010, Adenosine receptors: what we know and what we are learning., Curr Top Med Chem
    Choi WJ et al., 2009, Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists., Bioorg Med Chem
    Kim Y et al., 2009, Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor., J Med Chem
    Stella et al., 1998, The role of A3 adenosine receptors in central regulation of arterial blood pressure., Br. J. Pharmacol.
    Gaspar A et al., 2012, In search for new chemical entities as adenosine receptor ligands: development of agents based on benzo-γ-pyrone skeleton., Eur J Med Chem
    Gao ZG et al., 2006, Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists., J Med Chem
  • NAMODENOSON   ADORA3

    Interaction Score: 8.14

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A3 receptor agonist
    Direct Interaction yes
    Trial Name CF-102

    PMIDs:
    19879151 19284749


    Sources:
    DTC TdgClinicalTrial ChemblInteractions

  • CHEMBL382194   ADORA3

    Interaction Score: 6.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16640329


    Sources:
    DTC

  • IB-MECA   ADORA3

    Interaction Score: 4.34

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A3 receptor agonist
    Direct Interaction yes

    PMIDs:
    19879151


    Sources:
    DTC ChemblInteractions TTD

  • ADENOSINE   ADORA3

    Interaction Score: 3.66

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor agonist
    Direct Interaction yes

    PMIDs:
    17321471 16339914 20370661 20136829 17438146 11752352 17442976 20370662


    Sources:
    ChemblInteractions

  • CHROMOCARB   ADORA3

    Interaction Score: 3.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22703703


    Sources:
    DTC

  • PICLIDENOSON   ADORA3

    Interaction Score: 3.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name CF-101
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • QAF805   ADORA3

    Interaction Score: 1.63

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A3 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CIPARGAMIN   ADORA3

    Interaction Score: 1.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • N6-CYCLOPENTYLADENOSINE   ADORA3

    Interaction Score: 1.63

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    19317449


    Sources:
    DTC

  • NECA   ADORA3

    Interaction Score: 1.3

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    19284749


    Sources:
    DTC

  • CHEMBL136689   ADORA3

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TONAPOFYLLINE   ADORA3

    Interaction Score: 0.81

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CAFFEINE, CITRATED   ADORA3

    Interaction Score: 0.81

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMINOPHYLLINE   ADORA3

    Interaction Score: 0.65

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    9806324


    Sources:
    ChemblInteractions

  • OXTRIPHYLLINE   ADORA3

    Interaction Score: 0.33

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THEOPHYLLINE SODIUM GLYCINATE   ADORA3

    Interaction Score: 0.33

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CAFFEINE   ADORA3

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    20164566


    Sources:
    ChemblInteractions

  • VANOXERINE   ADORA3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • THEOPHYLLINE   ADORA3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000282608

    • Version: 101_38

    Alternate Names:
    ADORA3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P33765

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000121933 Ensembl Gene Id
    AA3R_HUMAN Uniprot Id
    P33765 Uniprot Accession

    Gene Info:
    Interpro Type Family
    Interpro Acc IPR000276
    Uniprot Status Swiss-Prot

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P33765

    • Version: January-2014

    Alternate Names:
    ADORA3 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • RussLampel: ENSG00000121933

    • Version: 26-July-2011

    Alternate Names:
    ADORA3 Display Id
    ADENOSINE A3 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P33765] Description
    ENSG00000121933 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • DTC: ADORA3

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Choi WJ et al., 2009, Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists., Bioorg Med Chem
    Kim Y et al., 2009, Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor., J Med Chem
    Gao ZG et al., 2006, Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists., J Med Chem

  • ChemblInteractions: ADORA3

    • Version: chembl_23

    Alternate Names:
    ADORA3 GENE_SYMBOL
    Adenosine receptor A3 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000121933

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000121933 Gene Symbol
    ADORA3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: ADORA3

    • Version: 27-Jun-2013

    Alternate Names:
    140 Gene ID
    A3AR dGene Synonym
    AD026 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Adenosine A3 receptor

    • Version: 2020.06.01

    Alternate Names:
    ADORA3 TTD Gene Abbreviation
    T36059 TTD Target ID

    Gene Info:

    Publications:

  • GO: ADORA3

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21