DGIdb - ADORA3 Gene Record

ADORA3 140 Druggable Genome

Alternate Names:

140
ADENOSINE A3 RECEPTOR
ADORA3
A3AR
600445
268
ENSG00000282608
OTTHUMG00000011957
Adenosine receptor A3
P33765
ENSG00000121933
ADENOSINE A3 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P33765]
AA3R_HUMAN
T36059
AD026
bA552M11.5

Gene Info:

Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Type	Family
Interpro Acc	IPR000276
Uniprot Status	Swiss-Prot
Uniprot Evidence	2: Evidence at transcript level
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Name	GPCR, rhodopsin-like, 7TM
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Franchetti et al., 2009, N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice., J. Med. Chem.
Ribeiro et al., 2010, Caffeine and adenosine., J. Alzheimers Dis.
Ezeamuzie et al., 2007, The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages., Int. Immunopharmacol.
Kreckler et al., 2006, Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor., J. Pharmacol. Exp. Ther.
Schenone et al., 2010, A1 receptors ligands: past, present and future trends., Curr Top Med Chem
Buenestado et al., 2010, The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages., Br. J. Pharmacol.
Funakoshi et al., 2007, A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction., Circulation
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Haschemi et al., 2007, Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages., J. Immunol.
Trincavelli et al., 2010, Adenosine receptors: what we know and what we are learning., Curr Top Med Chem
Choi WJ et al., 2009, Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists., Bioorg Med Chem
Kim Y et al., 2009, Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor., J Med Chem
Stella et al., 1998, The role of A3 adenosine receptors in central regulation of arterial blood pressure., Br. J. Pharmacol.
Gaspar A et al., 2012, In search for new chemical entities as adenosine receptor ligands: development of agents based on benzo-γ-pyrone skeleton., Eur J Med Chem
Gao ZG et al., 2006, Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists., J Med Chem

NAMODENOSON ADORA3

Interaction Score: 8.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A3 receptor agonist

Direct Interaction yes

Trial Name CF-102

PMIDs:
19879151 19284749

Sources:
DTC TdgClinicalTrial ChemblInteractions
CHEMBL382194 ADORA3

Interaction Score: 6.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16640329

Sources:
DTC
IB-MECA ADORA3

Interaction Score: 4.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A3 receptor agonist

Direct Interaction yes

PMIDs:
19879151

Sources:
DTC ChemblInteractions TTD
ADENOSINE ADORA3

Interaction Score: 3.66

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine receptor agonist

Direct Interaction yes

PMIDs:
17321471 16339914 20370661 20136829 17438146 11752352 17442976 20370662

Sources:
ChemblInteractions
CHROMOCARB ADORA3

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22703703

Sources:
DTC
PICLIDENOSON ADORA3

Interaction Score: 3.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name CF-101

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
QAF805 ADORA3

Interaction Score: 1.63

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A3 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CIPARGAMIN ADORA3

Interaction Score: 1.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
N6-CYCLOPENTYLADENOSINE ADORA3

Interaction Score: 1.63

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
19317449

Sources:
DTC
NECA ADORA3

Interaction Score: 1.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
19284749

Sources:
DTC
CHEMBL136689 ADORA3

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TONAPOFYLLINE ADORA3

Interaction Score: 0.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
CAFFEINE, CITRATED ADORA3

Interaction Score: 0.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
AMINOPHYLLINE ADORA3

Interaction Score: 0.65

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
9806324

Sources:
ChemblInteractions
OXTRIPHYLLINE ADORA3

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THEOPHYLLINE SODIUM GLYCINATE ADORA3

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CAFFEINE ADORA3

Interaction Score: 0.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
20164566

Sources:
ChemblInteractions
VANOXERINE ADORA3

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
THEOPHYLLINE ADORA3

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000282608
- Version: 101_38
Alternate Names:

ADORA3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P33765
- Version: 11-September-2012
Alternate Names:

ENSG00000121933 Ensembl Gene Id

AA3R_HUMAN Uniprot Id

P33765 Uniprot Accession

Gene Info:

Interpro Type Family

Interpro Acc IPR000276

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P33765
- Version: January-2014
Alternate Names:

ADORA3 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
RussLampel: ENSG00000121933
- Version: 26-July-2011
Alternate Names:

ADORA3 Display Id

ADENOSINE A3 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P33765] Description

ENSG00000121933 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

DTC: ADORA3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Choi WJ et al., 2009, Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists., Bioorg Med Chem

Kim Y et al., 2009, Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor., J Med Chem

Gao ZG et al., 2006, Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists., J Med Chem

ChemblInteractions: ADORA3
- Version: chembl_23
Alternate Names:

ADORA3 GENE_SYMBOL

Adenosine receptor A3 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000121933
- Version: 31-May-2017
Alternate Names:

ENSG00000121933 Gene Symbol

ADORA3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: ADORA3
- Version: 27-Jun-2013
Alternate Names:

140 Gene ID

A3AR dGene Synonym

AD026 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Adenosine A3 receptor
- Version: 2020.06.01
Alternate Names:

ADORA3 TTD Gene Abbreviation

T36059 TTD Target ID

Gene Info:

Publications:
GO: ADORA3
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Mechanism of Interaction	Adenosine A3 receptor agonist
Direct Interaction	yes
Trial Name	CF-102

Mechanism of Interaction	Adenosine receptor agonist
Direct Interaction	yes

Mechanism of Interaction	Adenosine A3 receptor antagonist
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Adenosine receptor antagonist

ENSG00000121933	Ensembl Gene Id
AA3R_HUMAN	Uniprot Id
P33765	Uniprot Accession

ADORA3	Display Id
ADENOSINE A3 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P33765]	Description
ENSG00000121933	Ensembl Gene Id

ADORA3 Gene Record

ADORA3 140 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A3 receptor agonist Direct Interaction yes Trial Name CF-102

PMIDs: 19879151 19284749

Sources: DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16640329

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A3 receptor agonist Direct Interaction yes

PMIDs: 19879151

Sources: DTC ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine receptor agonist Direct Interaction yes

PMIDs: 17321471 16339914 20370661 20136829 17438146 11752352 17442976 20370662

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22703703

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name CF-101 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine A3 receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 19317449

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 19284749

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adenosine receptor antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: 9806324

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: 20164566

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A3 receptor agonist

Direct Interaction yes

Trial Name CF-102

PMIDs:
19879151 19284749

Sources:
DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16640329

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A3 receptor agonist

Direct Interaction yes

PMIDs:
19879151

Sources:
DTC ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine receptor agonist

Direct Interaction yes

PMIDs:
17321471 16339914 20370661 20136829 17438146 11752352 17442976 20370662

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22703703

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name CF-101

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A3 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

PMIDs:
19317449

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

PMIDs:
19284749

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
9806324

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
20164566

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

ADORA3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000121933 Ensembl Gene Id

AA3R_HUMAN Uniprot Id

P33765 Uniprot Accession

Gene Info:

Interpro Type Family

Interpro Acc IPR000276

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

ADORA3 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

ADORA3 Display Id

ADENOSINE A3 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P33765] Description

ENSG00000121933 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ADORA3 GENE_SYMBOL

Adenosine receptor A3 UNIPROT

Alternate Names:

ENSG00000121933 Gene Symbol

ADORA3 Ensembl Id