• Interaction Score: 3.45

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A2b receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 1.72

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 1.57

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor agonist
    Direct Interaction yes
    Specific Action of the Ligand Agonist

  • Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name BVT.115959
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name SYN-115
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.86

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A2b receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.86

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Novel drug target Established target

    PMIDs:
    None found


  • Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.86

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.86

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Trial Name preladenant, SCH-420814

    PMIDs:
    None found


  • Interaction Score: 0.86

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name istradefylline, KW-6002
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


  • Interaction Score: 0.72

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ADC4022, low-dose inhaled theophylline
    Novel drug target Established target
    Mechanism of Interaction Adenosine receptor antagonist

  • Interaction Score: 0.69

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A2b receptor antagonist
    Specific Action of the Ligand Antagonist

  • Interaction Score: 0.69

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Trial Name regadenoson,Lexiscan

    PMIDs:
    None found


  • Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.43

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


  • Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.34

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.34

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


  • Interaction Score: 0.34

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes
    Specific Action of the Ligand Antagonist

  • Interaction Score: 0.22

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A2 receptor antagonist
    Novel drug target Established target

    • Version: 101_38

    Alternate Names:
    ADORA2B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    ADORA2B Gene Symbol
    AA2BR_HUMAN Uniprot Id
    P29275 Uniprot Accession

    Gene Info:
    Target Subclass Rhodopsin
    Target Subclass GPCR
    Target Main Class Receptors

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ADENOSINE A2B RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P29275] Description
    ENSG00000170425 Ensembl Gene Id
    ADORA2B Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000170425 Ensembl Gene Id
    ADENOSINE RECEPTOR A2B Uniprot Protein Name
    136 Entrez Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Short Name 7TM_GPCR_Rhodpsn

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    ADORA2B Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

    • Version: January-2014

    Alternate Names:
    ADORA2A Gene Symbol
    ADORA2B Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    264 HUGO Gene ID
    264 HUGO Gene Symbol
    adenosine A2b receptor HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Adenosine receptors
    GuideToPharmacology Gene Category ID 3

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000170425 Gene Symbol
    ADORA2B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    ADORA2B GENE_SYMBOL
    Adenosine receptor A2b UNIPROT

    Gene Info:

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    136 Gene ID
    ADORA2 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    ADORA2B TTD Gene Abbreviation
    T86679 TTD Target ID

    Gene Info:

    Publications: