DGIdb - ADORA2A Gene Record

ADORA2A 135 Druggable Genome

Alternate Names:

135
ADENOSINE A2A RECEPTOR
ADORA2A
A2aR
ADORA2
RDC8
102776
263
ENSG00000128271
OTTHUMG00000150761
AA2AR_HUMAN
P29274
Adenosine receptor A2a
ADENOSINE A2A RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P29274]
PA24584
T77365
hA2aR

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Type	Family
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Name	GPCR, rhodopsin-like, 7TM
Interpro Acc	IPR000276
Interpro Short Name	7TM_GPCR_Rhodpsn
Target Subclass	GPCR
Target Main Class	Receptors
Target Subclass	Rhodopsin
Transmembrane Helix Count	7
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Polosa R et al., 2009, Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease., Trends Pharmacol Sci
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Zhao et al., 2007, Caffeine attenuates the duration of coronary vasodilation and changes in hemodynamics induced by regadenoson (CVT-3146), a novel adenosine A2A receptor agonist., J. Cardiovasc. Pharmacol.
Riksen et al., 2007, The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo., Pharmacogenet. Genomics
Cornelis et al., 2007, Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption., Am. J. Clin. Nutr.
Domschke K et al., 2012, ADORA2A Gene variation, caffeine, and emotional processing: a multi-level interaction on startle reflex., Neuropsychopharmacology
Rogers PJ et al., 2010, Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption., Neuropsychopharmacology
Childs E et al., 2008, Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety., Neuropsychopharmacology
Rétey JV et al., 2007, A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep., Clin Pharmacol Ther
Alsene K et al., 2003, Association between A2a receptor gene polymorphisms and caffeine-induced anxiety., Neuropsychopharmacology
Hodgson et al., 2007, Coronary circulation responses to binodenoson, a selective adenosine A2A receptor agonist., Am. J. Cardiol.
Cerqueira, 2006, Advances in pharmacologic agents in imaging: new A2A receptor agonists., Curr Cardiol Rep
Pechlivanova et al., 2005, Effects of single and long-term theophylline treatment on the threshold of mechanical nociception: contribution of adenosine A1 and alpha2-adrenoceptors., Methods Find Exp Clin Pharmacol
Daly et al., 1987, Adenosine receptors: development of selective agonists and antagonists., Prog. Clin. Biol. Res.
Mukai M et al., 2018, Effects of Rifampin on the Pharmacokinetics of a Single Dose of Istradefylline in Healthy Subjects., J Clin Pharmacol
Dungo R et al., 2013, Istradefylline: first global approval., Drugs
Zoghbi et al., 2012, Selective adenosine agonists and myocardial perfusion imaging., J Nucl Cardiol
Tsujimoto S et al., 2016, Influence of ADORA2A gene polymorphism on leukoencephalopathy risk in MTX-treated pediatric patients affected by hematological malignancies., Pediatr Blood Cancer
Hider SL et al., 2008, Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX., Rheumatology (Oxford)
Ezeamuzie et al., 2007, The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages., Int. Immunopharmacol.
Kreckler et al., 2006, Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor., J. Pharmacol. Exp. Ther.
Kreckler et al., 2009, Adenosine suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production by murine macrophages through a protein kinase A- and exchange protein activated by cAMP-independent signaling pathway., J. Pharmacol. Exp. Ther.
Schenone et al., 2010, A1 receptors ligands: past, present and future trends., Curr Top Med Chem
Buenestado et al., 2010, The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages., Br. J. Pharmacol.
Funakoshi et al., 2007, A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction., Circulation
Haschemi et al., 2007, Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages., J. Immunol.
Trincavelli et al., 2010, Adenosine receptors: what we know and what we are learning., Curr Top Med Chem
Kreth et al., 2010, Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways., Shock
Carlsson J et al., 2010, Structure-based discovery of A2A adenosine receptor ligands., J Med Chem

APADENOSON ADORA2A

Interaction Score: 5.8

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2a receptor agonist

PMIDs:
16524538

Sources:
ChemblInteractions TTD
SONEDENOSON ADORA2A

Interaction Score: 3.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
UK432097 ADORA2A

Interaction Score: 3.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
ISTRADEFYLLINE ADORA2A

Interaction Score: 3.86

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor antagonist

Direct Interaction yes

PMIDs:
28881378 23700273

Sources:
ChemblInteractions TTD
BINODENOSON ADORA2A

Interaction Score: 3.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2a receptor agonist

PMIDs:
17531571 16524538

Sources:
ChemblInteractions TTD
EVODENOSON ADORA2A

Interaction Score: 3.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
GW-328267 ADORA2A

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19762093

Sources:
TTD
REGADENOSON ADORA2A

Interaction Score: 2.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor agonist

Direct Interaction yes

PMIDs:
22130964

Sources:
ChemblInteractions TEND TTD
ADENOSINE ADORA2A

Interaction Score: 2.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine receptor agonist

PMIDs:
17321471 16339914 19749080 20370661 20136829 17438146 17442976 20370662

Sources:
ChemblInteractions
AMP579 ADORA2A

Interaction Score: 1.93

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
VIPADENANT ADORA2A

Interaction Score: 1.93

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ST1535 ADORA2A

Interaction Score: 1.93

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOZADENANT ADORA2A

Interaction Score: 1.93

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2a receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
PBF-509 ADORA2A

Interaction Score: 1.93

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2a receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
CIFORADENANT ADORA2A

Interaction Score: 1.93

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
CGS-21680 ADORA2A

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20405927

Sources:
DTC
PBF-999 ADORA2A

Interaction Score: 0.97

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRELADENANT ADORA2A

Interaction Score: 0.97

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BVT.115959 ADORA2A

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2a receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
AB-928 ADORA2A

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CAFFEINE ADORA2A

Interaction Score: 0.93

Interaction Types & Directionality:

multitarget

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
11752352 17577101 17558310 17616786 22012471 20520601 18305461 17329997 12825092

Sources:
ChemblInteractions TEND PharmGKB TTD
CHEMBL136689 ADORA2A

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DEXEFAROXAN ADORA2A

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL27508 ADORA2A

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
OXTRIPHYLLINE ADORA2A

Interaction Score: 0.58

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
16357952 3588607

Sources:
ChemblInteractions
CAFFEINE, CITRATED ADORA2A

Interaction Score: 0.48

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TONAPOFYLLINE ADORA2A

Interaction Score: 0.48

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
THEOPHYLLINE ADORA2A

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
16357952 3588607

Sources:
ChemblInteractions TEND
AMINOPHYLLINE ADORA2A

Interaction Score: 0.19

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THEOPHYLLINE SODIUM GLYCINATE ADORA2A

Interaction Score: 0.19

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE ADORA2A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2 receptor antagonist

Direct Interaction yes

PMIDs:
19997047

Sources:
ChemblInteractions
METHOTREXATE ADORA2A

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27399166 18539621

Sources:
PharmGKB

Ensembl: ENSG00000128271
- Version: 101_38
Alternate Names:

ADORA2A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P29274
- Version: 01-August-2011
Alternate Names:

P29274 Uniprot Accession

ADORA2A Gene Symbol

AA2AR_HUMAN Uniprot Id

Gene Info:

Target Subclass GPCR

Target Main Class Receptors

Target Subclass Rhodopsin

Publications:
RussLampel: ENSG00000128271
- Version: 26-July-2011
Alternate Names:

ADORA2A Display Id

ENSG00000128271 Ensembl Gene Id

ADENOSINE A2A RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P29274] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P29274
- Version: 11-September-2012
Alternate Names:

ADORA2A Uniprot Gene Name

ENSG00000128271 Ensembl Gene Id

135 Entrez Gene Id

Gene Info:

Human Readable Name G PROTEIN COUPLED RECEPTOR

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

PharmGKB: ADORA2A

Version: 18-August-2020

Alternate Names:

PA24584 PharmGKB ID

Gene Info:

Publications:

Tsujimoto S et al., 2016, Influence of ADORA2A gene polymorphism on leukoencephalopathy risk in MTX-treated pediatric patients affected by hematological malignancies., Pediatr Blood Cancer

Hider SL et al., 2008, Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX., Rheumatology (Oxford)

Rogers PJ et al., 2010, Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption., Neuropsychopharmacology

TTD: Adenosine A2a receptor
- Version: 2020.06.01
Alternate Names:

ADORA2A TTD Gene Abbreviation

T77365 TTD Target ID

Gene Info:

Publications:

Polosa R et al., 2009, Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease., Trends Pharmacol Sci
DTC: ADORA2A
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Carlsson J et al., 2010, Structure-based discovery of A2A adenosine receptor ligands., J Med Chem
HingoraniCasas: ENSG00000128271
- Version: 31-May-2017
Alternate Names:

ENSG00000128271 Gene Symbol

ADORA2A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ADORA2
- Version: chembl_23
Alternate Names:

ADORA2 GENE_SYMBOL

ADORA2A GENE_SYMBOL

Adenosine receptor A2a UNIPROT

Gene Info:

Publications:
GO: ADORA2A
- Version: 01-February-2022
Alternate Names:

ADORA2 GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: ADORA2A
- Version: 27-Jun-2013
Alternate Names:

135 Gene ID

ADORA2 dGene Synonym

RDC8 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
Pharos: ADORA2A
- Version: 01-February-2022
Alternate Names:

Adenosine receptor A2a Gene Name

P29274 UniProt ID

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Direct Interaction	yes
Mechanism of Interaction	Adenosine A2a receptor agonist

Mechanism of Interaction	Adenosine A2a receptor antagonist
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Adenosine receptor agonist

Direct Interaction	yes
Mechanism of Interaction	Adenosine receptor antagonist

Mechanism of Interaction	Adenosine A2 receptor antagonist
Direct Interaction	yes

P29274	Uniprot Accession
ADORA2A	Gene Symbol
AA2AR_HUMAN	Uniprot Id

ADORA2A	Display Id
ENSG00000128271	Ensembl Gene Id
ADENOSINE A2A RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P29274]	Description

ADORA2A	Uniprot Gene Name
ENSG00000128271	Ensembl Gene Id
135	Entrez Gene Id

ADORA2	GENE_SYMBOL
ADORA2A	GENE_SYMBOL
Adenosine receptor A2a	UNIPROT

ADORA2A Gene Record

ADORA2A 135 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adenosine A2a receptor agonist

PMIDs: 16524538

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A2a receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A2a receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine A2a receptor antagonist Direct Interaction yes

PMIDs: 28881378 23700273

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adenosine A2a receptor agonist

PMIDs: 17531571 16524538

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A2a receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19762093

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A2a receptor agonist Direct Interaction yes

PMIDs: 22130964

Sources: ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adenosine receptor agonist

PMIDs: 17321471 16339914 19749080 20370661 20136829 17438146 17442976 20370662

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A2a receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine A2a receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine A2a receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adenosine A2a receptor antagonist

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adenosine A2a receptor antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20405927

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine A2a receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine A2a receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adenosine A2a receptor agonist

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2a receptor agonist

PMIDs:
16524538

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor antagonist

Direct Interaction yes

PMIDs:
28881378 23700273

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2a receptor agonist

PMIDs:
17531571 16524538

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
19762093

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor agonist

Direct Interaction yes

PMIDs:
22130964

Sources:
ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine receptor agonist

PMIDs:
17321471 16339914 19749080 20370661 20136829 17438146 17442976 20370662

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2a receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2a receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
20405927

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2a receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2a receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

multitarget

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
11752352 17577101 17558310 17616786 22012471 20520601 18305461 17329997 12825092

Sources:
ChemblInteractions TEND PharmGKB TTD