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ADORA2A Gene Record

  • Summary
  • Interactions
  • Claims
  • ADORA2A 135 Druggable Genome

    Alternate Names:

    135
    ADENOSINE A2A RECEPTOR
    ADORA2A
    A2aR
    ADORA2
    RDC8
    102776
    263
    ENSG00000128271
    OTTHUMG00000150761
    AA2AR_HUMAN
    P29274
    Adenosine receptor A2a
    ADENOSINE A2A RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P29274]
    PA24584
    T77365
    hA2aR

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Target Subclass GPCR
    Target Main Class Receptors
    Target Subclass Rhodopsin
    Transmembrane Helix Count 7
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Polosa R et al., 2009, Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease., Trends Pharmacol Sci
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Zhao et al., 2007, Caffeine attenuates the duration of coronary vasodilation and changes in hemodynamics induced by regadenoson (CVT-3146), a novel adenosine A2A receptor agonist., J. Cardiovasc. Pharmacol.
    Riksen et al., 2007, The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo., Pharmacogenet. Genomics
    Cornelis et al., 2007, Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption., Am. J. Clin. Nutr.
    Domschke K et al., 2012, ADORA2A Gene variation, caffeine, and emotional processing: a multi-level interaction on startle reflex., Neuropsychopharmacology
    Rogers PJ et al., 2010, Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption., Neuropsychopharmacology
    Childs E et al., 2008, Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety., Neuropsychopharmacology
    Rétey JV et al., 2007, A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep., Clin Pharmacol Ther
    Alsene K et al., 2003, Association between A2a receptor gene polymorphisms and caffeine-induced anxiety., Neuropsychopharmacology
    Hodgson et al., 2007, Coronary circulation responses to binodenoson, a selective adenosine A2A receptor agonist., Am. J. Cardiol.
    Cerqueira, 2006, Advances in pharmacologic agents in imaging: new A2A receptor agonists., Curr Cardiol Rep
    Pechlivanova et al., 2005, Effects of single and long-term theophylline treatment on the threshold of mechanical nociception: contribution of adenosine A1 and alpha2-adrenoceptors., Methods Find Exp Clin Pharmacol
    Daly et al., 1987, Adenosine receptors: development of selective agonists and antagonists., Prog. Clin. Biol. Res.
    Mukai M et al., 2018, Effects of Rifampin on the Pharmacokinetics of a Single Dose of Istradefylline in Healthy Subjects., J Clin Pharmacol
    Dungo R et al., 2013, Istradefylline: first global approval., Drugs
    Zoghbi et al., 2012, Selective adenosine agonists and myocardial perfusion imaging., J Nucl Cardiol
    Tsujimoto S et al., 2016, Influence of ADORA2A gene polymorphism on leukoencephalopathy risk in MTX-treated pediatric patients affected by hematological malignancies., Pediatr Blood Cancer
    Hider SL et al., 2008, Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX., Rheumatology (Oxford)
    Ezeamuzie et al., 2007, The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages., Int. Immunopharmacol.
    Kreckler et al., 2006, Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor., J. Pharmacol. Exp. Ther.
    Kreckler et al., 2009, Adenosine suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production by murine macrophages through a protein kinase A- and exchange protein activated by cAMP-independent signaling pathway., J. Pharmacol. Exp. Ther.
    Schenone et al., 2010, A1 receptors ligands: past, present and future trends., Curr Top Med Chem
    Buenestado et al., 2010, The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages., Br. J. Pharmacol.
    Funakoshi et al., 2007, A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction., Circulation
    Haschemi et al., 2007, Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages., J. Immunol.
    Trincavelli et al., 2010, Adenosine receptors: what we know and what we are learning., Curr Top Med Chem
    Kreth et al., 2010, Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways., Shock
    Carlsson J et al., 2010, Structure-based discovery of A2A adenosine receptor ligands., J Med Chem
  • APADENOSON   ADORA2A

    Interaction Score: 5.8

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A2a receptor agonist

    PMIDs:
    16524538


    Sources:
    ChemblInteractions TTD

  • SONEDENOSON   ADORA2A

    Interaction Score: 3.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A2a receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • UK432097   ADORA2A

    Interaction Score: 3.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A2a receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ISTRADEFYLLINE   ADORA2A

    Interaction Score: 3.86

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A2a receptor antagonist
    Direct Interaction yes

    PMIDs:
    28881378 23700273


    Sources:
    ChemblInteractions TTD

  • BINODENOSON   ADORA2A

    Interaction Score: 3.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A2a receptor agonist

    PMIDs:
    17531571 16524538


    Sources:
    ChemblInteractions TTD

  • EVODENOSON   ADORA2A

    Interaction Score: 3.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A2a receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • GW-328267   ADORA2A

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19762093


    Sources:
    TTD

  • REGADENOSON   ADORA2A

    Interaction Score: 2.58

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A2a receptor agonist
    Direct Interaction yes

    PMIDs:
    22130964


    Sources:
    ChemblInteractions TEND TTD

  • ADENOSINE   ADORA2A

    Interaction Score: 2.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine receptor agonist

    PMIDs:
    17321471 16339914 19749080 20370661 20136829 17438146 17442976 20370662


    Sources:
    ChemblInteractions

  • AMP579   ADORA2A

    Interaction Score: 1.93

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A2a receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • VIPADENANT   ADORA2A

    Interaction Score: 1.93

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A2a receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ST1535   ADORA2A

    Interaction Score: 1.93

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A2a receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOZADENANT   ADORA2A

    Interaction Score: 1.93

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A2a receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • PBF-509   ADORA2A

    Interaction Score: 1.93

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A2a receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CIFORADENANT   ADORA2A

    Interaction Score: 1.93

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CGS-21680   ADORA2A

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20405927


    Sources:
    DTC

  • PBF-999   ADORA2A

    Interaction Score: 0.97

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A2a receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRELADENANT   ADORA2A

    Interaction Score: 0.97

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A2a receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BVT.115959   ADORA2A

    Interaction Score: 0.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A2a receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AB-928   ADORA2A

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CAFFEINE   ADORA2A

    Interaction Score: 0.93

    Interaction Types & Directionality:
    multitarget
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine receptor antagonist

    PMIDs:
    11752352 17577101 17558310 17616786 22012471 20520601 18305461 17329997 12825092


    Sources:
    ChemblInteractions TEND PharmGKB TTD

  • CHEMBL136689   ADORA2A

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DEXEFAROXAN   ADORA2A

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL27508   ADORA2A

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OXTRIPHYLLINE   ADORA2A

    Interaction Score: 0.58

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine receptor antagonist

    PMIDs:
    16357952 3588607


    Sources:
    ChemblInteractions

  • CAFFEINE, CITRATED   ADORA2A

    Interaction Score: 0.48

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TONAPOFYLLINE   ADORA2A

    Interaction Score: 0.48

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • THEOPHYLLINE   ADORA2A

    Interaction Score: 0.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    16357952 3588607


    Sources:
    ChemblInteractions TEND

  • AMINOPHYLLINE   ADORA2A

    Interaction Score: 0.19

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THEOPHYLLINE SODIUM GLYCINATE   ADORA2A

    Interaction Score: 0.19

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOXIFYLLINE   ADORA2A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A2 receptor antagonist
    Direct Interaction yes

    PMIDs:
    19997047


    Sources:
    ChemblInteractions

  • METHOTREXATE   ADORA2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27399166 18539621


    Sources:
    PharmGKB

  • Ensembl: ENSG00000128271

    • Version: 101_38

    Alternate Names:
    ADORA2A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P29274

    • Version: 01-August-2011

    Alternate Names:
    P29274 Uniprot Accession
    ADORA2A Gene Symbol
    AA2AR_HUMAN Uniprot Id

    Gene Info:
    Target Subclass GPCR
    Target Main Class Receptors
    Target Subclass Rhodopsin

    Publications:

  • RussLampel: ENSG00000128271

    • Version: 26-July-2011

    Alternate Names:
    ADORA2A Display Id
    ENSG00000128271 Ensembl Gene Id
    ADENOSINE A2A RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P29274] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P29274

    • Version: 11-September-2012

    Alternate Names:
    ADORA2A Uniprot Gene Name
    ENSG00000128271 Ensembl Gene Id
    135 Entrez Gene Id

    Gene Info:
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • PharmGKB: ADORA2A

    • Version: 18-August-2020

    Alternate Names:
    PA24584 PharmGKB ID

    Gene Info:

    Publications:
    Tsujimoto S et al., 2016, Influence of ADORA2A gene polymorphism on leukoencephalopathy risk in MTX-treated pediatric patients affected by hematological malignancies., Pediatr Blood Cancer
    Hider SL et al., 2008, Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX., Rheumatology (Oxford)
    Rogers PJ et al., 2010, Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption., Neuropsychopharmacology

  • TTD: Adenosine A2a receptor

    • Version: 2020.06.01

    Alternate Names:
    ADORA2A TTD Gene Abbreviation
    T77365 TTD Target ID

    Gene Info:

    Publications:
    Polosa R et al., 2009, Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease., Trends Pharmacol Sci

  • DTC: ADORA2A

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Carlsson J et al., 2010, Structure-based discovery of A2A adenosine receptor ligands., J Med Chem

  • HingoraniCasas: ENSG00000128271

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000128271 Gene Symbol
    ADORA2A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ADORA2

    • Version: chembl_23

    Alternate Names:
    ADORA2 GENE_SYMBOL
    ADORA2A GENE_SYMBOL
    Adenosine receptor A2a UNIPROT

    Gene Info:

    Publications:

  • GO: ADORA2A

    • Version: 01-February-2022

    Alternate Names:
    ADORA2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: ADORA2A

    • Version: 27-Jun-2013

    Alternate Names:
    135 Gene ID
    ADORA2 dGene Synonym
    RDC8 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • Pharos: ADORA2A

    • Version: 01-February-2022

    Alternate Names:
    Adenosine receptor A2a Gene Name
    P29274 UniProt ID

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21