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ADORA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • ADORA1 134 Druggable Genome

    Alternate Names:

    134
    ADENOSINE A1 RECEPTOR
    ADORA1
    RDC7
    102775
    262
    ENSG00000163485
    OTTHUMG00000042125
    P30542
    AA1R_HUMAN
    ADENOSINE RECEPTOR A1
    ADENOSINE A1 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P30542]
    18
    NP_000665
    NM_000674
    A<sub>1</sub> receptor
    BE0000013
    PA24583
    T92072

    Gene Info:

    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000276
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Type Family
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot
    GuideToPharmacology Gene Category Name Adenosine receptors
    GuideToPharmacology Gene Category ID 3
    Target Main Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Transmembrane Helix Count 7
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Gaytan et al., 2006, Effect of postnatal exposure to caffeine on the pattern of adenosine A1 receptor distribution in respiration-related nuclei of the rat brainstem., Auton Neurosci
    Rieg et al., 2007, Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite., Eur. J. Pharmacol.
    Listos et al., Adenosine receptor antagonists intensify the benzodiazepine withdrawal signs in mice., Pharmacol Rep
    Wang, 2007, Caffeine facilitation of glutamate release from rat cerebral cortex nerve terminals (synaptosomes) through activation protein kinase C pathway: an interaction with presynaptic adenosine A1 receptors., Synapse
    Mustafa et al., 2006, Altered intravenous pharmacokinetics of topotecan in rats with acute renal failure (ARF) induced by uranyl nitrate: do adenosine A1 antagonists (selective/non-selective) normalize the altered topotecan kinetics in ARF?, Xenobiotica
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Aurelio L et al., 2009, 3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists., Bioorg Med Chem
    Yamamoto et al., 2003, Intrathecal adenosine A1 receptor agonist attenuates hyperalgesia without inhibiting spinal glutamate release in the rat., Cell. Mol. Neurobiol.
    Lerman, 1993, Response of nonreentrant catecholamine-mediated ventricular tachycardia to endogenous adenosine and acetylcholine. Evidence for myocardial receptor-mediated effects., Circulation
    Ellenbogen et al., 2005, Trial to evaluate the management of paroxysmal supraventricular tachycardia during an electrophysiology study with tecadenoson., Circulation
    Prystowsky et al., 2003, Termination of paroxysmal supraventricular tachycardia by tecadenoson (CVT-510), a novel A1-adenosine receptor agonist., J. Am. Coll. Cardiol.
    Peterman et al., Tecadenoson: a novel, selective A1 adenosine receptor agonist., Cardiol Rev
    Linden et al., 1999, Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells., Mol. Pharmacol.
    Greenberg B et al., 2007, Effects of multiple oral doses of an A1 adenosine antagonist, BG9928, in patients with heart failure: results of a placebo-controlled, dose-escalation study., J Am Coll Cardiol
    Vu CB et al., 2006, Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists., J Med Chem
    Daly et al., 1987, Adenosine receptors: development of selective agonists and antagonists., Prog. Clin. Biol. Res.
    Kim SH et al., 2009, Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma., Respir Med
    Bianchi et al., 1993, Defibrotide, a single-stranded polydeoxyribonucleotide acting as an adenosine receptor agonist., Eur. J. Pharmacol.
    Chang LC et al., 2006, 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists., J Med Chem
    Nantwi et al., 2003, Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function 4 months after C2 hemisection., J Spinal Cord Med
    Gaspar A et al., 2012, In search for new chemical entities as adenosine receptor ligands: development of agents based on benzo-γ-pyrone skeleton., Eur J Med Chem
    Fisone et al., 2004, Caffeine as a psychomotor stimulant: mechanism of action., Cell. Mol. Life Sci.
    Chou et al., 2003, Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues., Am. J. Vet. Res.
    Haschemi et al., 2007, Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages., J. Immunol.
    Schenone et al., 2010, A1 receptors ligands: past, present and future trends., Curr Top Med Chem
    Trincavelli et al., 2010, Adenosine receptors: what we know and what we are learning., Curr Top Med Chem
    Buenestado et al., 2010, The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages., Br. J. Pharmacol.
    Ezeamuzie et al., 2007, The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages., Int. Immunopharmacol.
    Funakoshi et al., 2007, A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction., Circulation
    Schwabe et al., 1985, Xanthine derivatives as antagonists at A1 and A2 adenosine receptors., Naunyn Schmiedebergs Arch. Pharmacol.
    Kralic et al., 2005, Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice., J. Clin. Invest.
    Zuchora et al., 2005, Adenosine A1 receptors and the anticonvulsant potential of drugs effective in the model of 3-nitropropionic acid-induced seizures in mice., Eur Neuropsychopharmacol
    Martins DF et al., 2015, Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor., J Peripher Nerv Syst
    De Vry et al., 2004, Pharmacological characterization of the chronic constriction injury model of neuropathic pain., Eur. J. Pharmacol.
    Dungo R et al., 2013, Istradefylline: first global approval., Drugs
    Gonca E et al., 2015, The effect of cannabidiol on ischemia/reperfusion-induced ventricular arrhythmias: the role of adenosine A1 receptors., J Cardiovasc Pharmacol Ther
    Abelaira HM et al., 2012, Lamotrigine treatment reverses depressive-like behavior and alters BDNF levels in the brains of maternally deprived adult rats., Pharmacol Biochem Behav
    Barakat A, 2019, Revisiting Tramadol: A Multi-Modal Agent for Pain Management., CNS Drugs
    Sawynok J et al., 2013, Spinal and peripheral adenosine A₁ receptors contribute to antinociception by tramadol in the formalin test in mice., Eur J Pharmacol
  • THEOBROMINE   ADORA1

    Interaction Score: 2.99

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    16702031 17126319 17085856 17372967 15095008 17162470 12602592 3588607


    Sources:
    DrugBank

  • TRABODENOSON   ADORA1

    Interaction Score: 2.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name INO-8875
    Mechanism of Interaction Adenosine A1 receptor agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD ChemblInteractions

  • CAPADENOSON   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor partial agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • NAXIFYLLINE   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    DrugBank ChemblInteractions

  • GS-9667   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Trial Name CVT-3619
    Novel drug target Established target
    Mechanism of Interaction Adenosine A1 receptor partial agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • SELODENOSON   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • CHEMBL207824   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16686529


    Sources:
    DTC

  • TECADENOSON   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A1 receptor agonist
    Trial Name tecadenoson

    PMIDs:
    15956124 13678937 16230891


    Sources:
    TdgClinicalTrial DrugBank ChemblInteractions

  • CHEMBL303124   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19751980


    Sources:
    DTC

  • TONAPOFYLLINE   ADORA1

    Interaction Score: 1.74

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Trial Name BG-9928

    PMIDs:
    17692744 17125265


    Sources:
    TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • ROLOFYLLINE   ADORA1

    Interaction Score: 1.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Direct Interaction yes
    Trial Name rolofylline, MK-7418, KW-3902

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • RPR749   ADORA1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GW493838   ADORA1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BAY1067197   ADORA1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHROMOCARB   ADORA1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22703703


    Sources:
    DTC

  • APAXIFYLLINE   ADORA1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PBF-680   ADORA1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMP579   ADORA1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • ADENOSINE   ADORA1

    Interaction Score: 0.82

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? True
    Direct Interaction? True

    PMIDs:
    17442976 20370661 20370662 20136829 17321471 17438146


    Sources:
    DrugBank GuideToPharmacology ChemblInteractions

  • ISTRADEFYLLINE   ADORA1

    Interaction Score: 0.75

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    23700273


    Sources:
    DrugBank GuideToPharmacology

  • DERENOFYLLINE   ADORA1

    Interaction Score: 0.5

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Direct Interaction yes
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • CHEMBL59532   ADORA1

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19751980


    Sources:
    DTC

  • FK453   ADORA1

    Interaction Score: 0.5

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Direct Interaction yes
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • DEFIBROTIDE   ADORA1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8405101


    Sources:
    DrugBank

  • OXTRIPHYLLINE   ADORA1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    14992338 3588607


    Sources:
    DrugBank ChemblInteractions

  • AMINOPHYLLINE   ADORA1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    12735630 8425287


    Sources:
    DrugBank ChemblInteractions

  • CHEMBL136689   ADORA1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • APADENOSON   ADORA1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL27508   ADORA1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MEFLOQUINE   ADORA1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ENPROFYLLINE   ADORA1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10496952


    Sources:
    DrugBank

  • CAFFEINE   ADORA1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    multitarget
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine receptor antagonist
    Specific Action of the Ligand Antagonist

    PMIDs:
    16702031 17126319 17085856 17372967 17162470 11752352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • PICLIDENOSON   ADORA1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BINODENOSON   ADORA1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • 8-CYCLOPENTYLTHEOPHYLLINE   ADORA1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • VIPADENANT   ADORA1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CAFFEINE, CITRATED   ADORA1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRELADENANT   ADORA1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ST1535   ADORA1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • THEOPHYLLINE   ADORA1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ADC4022, low-dose inhaled theophylline
    Novel drug target Established target
    Mechanism of Interaction Adenosine receptor antagonist

    PMIDs:
    14992338 3588607


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • DYPHYLLINE   ADORA1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2997628


    Sources:
    DrugBank

  • NAMODENOSON   ADORA1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ZM-241385   ADORA1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • REGADENOSON   ADORA1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • GABAPENTIN   ADORA1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    15765150 15572277 26456872 15140630


    Sources:
    DrugBank

  • N6-CYCLOPENTYLADENOSINE   ADORA1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • NECA   ADORA1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TRAMADOL   ADORA1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    stimulator (activating)

    Interaction Info:

    PMIDs:
    31004280 23872384


    Sources:
    DrugBank

  • THEOPHYLLINE SODIUM GLYCINATE   ADORA1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISOBUTYLMETHYLXANTHINE   ADORA1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • GS 6201   ADORA1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL375293   ADORA1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL285819   ADORA1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PENTOXIFYLLINE   ADORA1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name pentoxifylline, EHT0201
    Novel drug target Established target

    PMIDs:
    3588607


    Sources:
    TdgClinicalTrial DrugBank

  • LAMOTRIGINE   ADORA1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22306746


    Sources:
    DrugBank

  • CANNABIDIOL   ADORA1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    24853683


    Sources:
    DrugBank

  • ASPIRIN   ADORA1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19019667


    Sources:
    PharmGKB

  • Ensembl: ENSG00000163485

    • Version: 101_38

    Alternate Names:
    ADORA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P30542

    • Version: 11-September-2012

    Alternate Names:
    P30542 Uniprot Accession
    ADORA1 Uniprot Gene Name
    AA1R_HUMAN Uniprot Id

    Gene Info:
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000163485

    • Version: 26-July-2011

    Alternate Names:
    ADENOSINE A1 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P30542] Description
    ENSG00000163485 Ensembl Gene Id
    ADORA1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P30542

    • Version: January-2014

    Alternate Names:
    ADORA1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • TEND: P30542

    • Version: 01-August-2011

    Alternate Names:
    P30542 Uniprot Accession
    134 Entrez Gene Id
    AA1R_HUMAN Uniprot Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • GuideToPharmacology: 134

    • Version: 29-September-2020

    Alternate Names:
    262 HUGO Gene ID
    262 HUGO Gene Symbol
    adenosine A1 receptor HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Adenosine receptors
    GuideToPharmacology Gene Category ID 3

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • PharmGKB: ADORA1

    • Version: 18-August-2020

    Alternate Names:
    PA24583 PharmGKB ID

    Gene Info:

    Publications:
    Kim SH et al., 2009, Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma., Respir Med

  • DrugBank: BE0000013

    • Version: 5.1.7

    Alternate Names:
    ADORA1 DrugBank Gene Name
    P30542 UniProt Accession
    134 Entrez Gene Id

    Gene Info:

    Publications:
    Barakat A, 2019, Revisiting Tramadol: A Multi-Modal Agent for Pain Management., CNS Drugs
    Sawynok J et al., 2013, Spinal and peripheral adenosine A₁ receptors contribute to antinociception by tramadol in the formalin test in mice., Eur J Pharmacol
    Nantwi et al., 2003, Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function 4 months after C2 hemisection., J Spinal Cord Med

  • DTC: ADORA1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Gaspar A et al., 2012, In search for new chemical entities as adenosine receptor ligands: development of agents based on benzo-γ-pyrone skeleton., Eur J Med Chem
    Aurelio L et al., 2009, 3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists., Bioorg Med Chem
    Chang LC et al., 2006, 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists., J Med Chem

  • ChemblInteractions: ADORA1

    • Version: chembl_23

    Alternate Names:
    ADORA1 GENE_SYMBOL
    Adenosine receptor A1 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000163485

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000163485 Gene Symbol
    ADORA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: ADORA1

    • Version: 27-Jun-2013

    Alternate Names:
    134 Gene ID
    RDC7 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Adenosine A1 receptor

    • Version: 2020.06.01

    Alternate Names:
    ADORA1 TTD Gene Abbreviation
    T92072 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21