DGIdb - ADORA1 Gene Record

ADORA1 134 Druggable Genome

Alternate Names:

134
ADENOSINE A1 RECEPTOR
ADORA1
RDC7
102775
262
ENSG00000163485
OTTHUMG00000042125
P30542
AA1R_HUMAN
ADENOSINE RECEPTOR A1
ADENOSINE A1 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P30542]
18
NP_000665
NM_000674
A<sub>1</sub> receptor
PA24583
T92072

Gene Info:

Interpro Short Name	7TM_GPCR_Rhodpsn
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR000276
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Type	Family
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Status	Swiss-Prot
GuideToPharmacology Gene Category Name	Adenosine receptors
GuideToPharmacology Gene Category ID	3
Target Main Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Transmembrane Helix Count	7
Target Class	Receptors
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Mustafa et al., 2006, Altered intravenous pharmacokinetics of topotecan in rats with acute renal failure (ARF) induced by uranyl nitrate: do adenosine A1 antagonists (selective/non-selective) normalize the altered topotecan kinetics in ARF?, Xenobiotica
Rieg et al., 2007, Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite., Eur. J. Pharmacol.
Wang, 2007, Caffeine facilitation of glutamate release from rat cerebral cortex nerve terminals (synaptosomes) through activation protein kinase C pathway: an interaction with presynaptic adenosine A1 receptors., Synapse
Listos et al., Adenosine receptor antagonists intensify the benzodiazepine withdrawal signs in mice., Pharmacol Rep
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Gaytan et al., 2006, Effect of postnatal exposure to caffeine on the pattern of adenosine A1 receptor distribution in respiration-related nuclei of the rat brainstem., Auton Neurosci
Aurelio L et al., 2009, 3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists., Bioorg Med Chem
Lerman, 1993, Response of nonreentrant catecholamine-mediated ventricular tachycardia to endogenous adenosine and acetylcholine. Evidence for myocardial receptor-mediated effects., Circulation
Yamamoto et al., 2003, Intrathecal adenosine A1 receptor agonist attenuates hyperalgesia without inhibiting spinal glutamate release in the rat., Cell. Mol. Neurobiol.
Ellenbogen et al., 2005, Trial to evaluate the management of paroxysmal supraventricular tachycardia during an electrophysiology study with tecadenoson., Circulation
Prystowsky et al., 2003, Termination of paroxysmal supraventricular tachycardia by tecadenoson (CVT-510), a novel A1-adenosine receptor agonist., J. Am. Coll. Cardiol.
Peterman et al., Tecadenoson: a novel, selective A1 adenosine receptor agonist., Cardiol Rev
Greenberg B et al., 2007, Effects of multiple oral doses of an A1 adenosine antagonist, BG9928, in patients with heart failure: results of a placebo-controlled, dose-escalation study., J Am Coll Cardiol
Vu CB et al., 2006, Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists., J Med Chem
Daly et al., 1987, Adenosine receptors: development of selective agonists and antagonists., Prog. Clin. Biol. Res.
Kim SH et al., 2009, Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma., Respir Med
Chang LC et al., 2006, 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists., J Med Chem
Nantwi et al., 2003, Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function 4 months after C2 hemisection., J Spinal Cord Med
Gaspar A et al., 2012, In search for new chemical entities as adenosine receptor ligands: development of agents based on benzo-γ-pyrone skeleton., Eur J Med Chem
Funakoshi et al., 2007, A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction., Circulation
Schenone et al., 2010, A1 receptors ligands: past, present and future trends., Curr Top Med Chem
Buenestado et al., 2010, The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages., Br. J. Pharmacol.
Ezeamuzie et al., 2007, The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages., Int. Immunopharmacol.
Haschemi et al., 2007, Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages., J. Immunol.
Trincavelli et al., 2010, Adenosine receptors: what we know and what we are learning., Curr Top Med Chem
Dungo R et al., 2013, Istradefylline: first global approval., Drugs

TRABODENOSON ADORA1

Interaction Score: 3.91

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name INO-8875

Mechanism of Interaction Adenosine A1 receptor agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
CAPADENOSON ADORA1

Interaction Score: 2.6

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
GS-9667 ADORA1

Interaction Score: 2.6

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Trial Name CVT-3619

Novel drug target Established target

Mechanism of Interaction Adenosine A1 receptor partial agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
SELODENOSON ADORA1

Interaction Score: 2.6

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CHEMBL207824 ADORA1

Interaction Score: 2.6

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16686529

Sources:
DTC
CHEMBL303124 ADORA1

Interaction Score: 2.6

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19751980

Sources:
DTC
TECADENOSON ADORA1

Interaction Score: 2.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A1 receptor agonist

Trial Name tecadenoson

PMIDs:
15956124 13678937 16230891

Sources:
TdgClinicalTrial ChemblInteractions
TONAPOFYLLINE ADORA1

Interaction Score: 1.95

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A1 receptor antagonist

Trial Name BG-9928

PMIDs:
17692744 17125265

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD
RPR749 ADORA1

Interaction Score: 1.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GW493838 ADORA1

Interaction Score: 1.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BAY1067197 ADORA1

Interaction Score: 1.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NAXIFYLLINE ADORA1

Interaction Score: 1.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHROMOCARB ADORA1

Interaction Score: 1.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22703703

Sources:
DTC
APAXIFYLLINE ADORA1

Interaction Score: 1.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PBF-680 ADORA1

Interaction Score: 1.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMP579 ADORA1

Interaction Score: 1.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
ROLOFYLLINE ADORA1

Interaction Score: 1.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor antagonist

Direct Interaction yes

Trial Name rolofylline, MK-7418, KW-3902

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD
ADENOSINE ADORA1

Interaction Score: 0.95

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? True

Direct Interaction? True

PMIDs:
17438146 20370661 20136829 17321471 17442976 20370662

Sources:
ChemblInteractions GuideToPharmacology
ISTRADEFYLLINE ADORA1

Interaction Score: 0.65

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
23700273

Sources:
GuideToPharmacology
DERENOFYLLINE ADORA1

Interaction Score: 0.65

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor antagonist

Direct Interaction yes

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
CHEMBL59532 ADORA1

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19751980

Sources:
DTC
FK453 ADORA1

Interaction Score: 0.65

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor antagonist

Direct Interaction yes

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
CAFFEINE ADORA1

Interaction Score: 0.48

Interaction Types & Directionality:

multitarget

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine receptor antagonist

Specific Action of the Ligand Antagonist

PMIDs:
17162470 17126319 17372967 17085856 11752352 16702031

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
CHEMBL136689 ADORA1

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
APADENOSON ADORA1

Interaction Score: 0.43

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ISOBUTYLMETHYLXANTHINE ADORA1

Interaction Score: 0.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL27508 ADORA1

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MEFLOQUINE ADORA1

Interaction Score: 0.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
OXTRIPHYLLINE ADORA1

Interaction Score: 0.39

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
3588607 14992338

Sources:
ChemblInteractions
AMINOPHYLLINE ADORA1

Interaction Score: 0.39

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
8425287 12735630

Sources:
ChemblInteractions
PICLIDENOSON ADORA1

Interaction Score: 0.33

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
THEOPHYLLINE ADORA1

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ADC4022, low-dose inhaled theophylline

Novel drug target Established target

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
3588607 14992338

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
BINODENOSON ADORA1

Interaction Score: 0.33

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
8-CYCLOPENTYLTHEOPHYLLINE ADORA1

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
VIPADENANT ADORA1

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CAFFEINE, CITRATED ADORA1

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRELADENANT ADORA1

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
ST1535 ADORA1

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
NAMODENOSON ADORA1

Interaction Score: 0.26

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ZM-241385 ADORA1

Interaction Score: 0.26

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
REGADENOSON ADORA1

Interaction Score: 0.26

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
N6-CYCLOPENTYLADENOSINE ADORA1

Interaction Score: 0.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
NECA ADORA1

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
THEOPHYLLINE SODIUM GLYCINATE ADORA1

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GS 6201 ADORA1

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL375293 ADORA1

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL285819 ADORA1

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PENTOXIFYLLINE ADORA1

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name pentoxifylline, EHT0201

Novel drug target Established target

PMIDs:
3588607

Sources:
TdgClinicalTrial
ASPIRIN ADORA1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19019667

Sources:
PharmGKB

Ensembl: ENSG00000163485
- Version: 101_38
Alternate Names:

ADORA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P30542
- Version: 11-September-2012
Alternate Names:

P30542 Uniprot Accession

ADORA1 Uniprot Gene Name

AA1R_HUMAN Uniprot Id

Gene Info:

Interpro Short Name 7TM_GPCR_Rhodpsn

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000163485
- Version: 26-July-2011
Alternate Names:

ADENOSINE A1 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P30542] Description

ENSG00000163485 Ensembl Gene Id

ADORA1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P30542
- Version: January-2014
Alternate Names:

ADORA1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
TEND: P30542
- Version: 01-August-2011
Alternate Names:

P30542 Uniprot Accession

134 Entrez Gene Id

AA1R_HUMAN Uniprot Id

Gene Info:

Target Main Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
GuideToPharmacology: 134
- Version: 29-September-2020
Alternate Names:

262 HUGO Gene ID

262 HUGO Gene Symbol

adenosine A1 receptor HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Adenosine receptors

GuideToPharmacology Gene Category ID 3

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
PharmGKB: ADORA1
- Version: 18-August-2020
Alternate Names:

PA24583 PharmGKB ID

Gene Info:

Publications:

Kim SH et al., 2009, Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma., Respir Med

DTC: ADORA1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Gaspar A et al., 2012, In search for new chemical entities as adenosine receptor ligands: development of agents based on benzo-γ-pyrone skeleton., Eur J Med Chem

Aurelio L et al., 2009, 3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists., Bioorg Med Chem

Chang LC et al., 2006, 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists., J Med Chem

ChemblInteractions: ADORA1
- Version: chembl_23
Alternate Names:

ADORA1 GENE_SYMBOL

Adenosine receptor A1 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000163485
- Version: 31-May-2017
Alternate Names:

ENSG00000163485 Gene Symbol

ADORA1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: ADORA1
- Version: 27-Jun-2013
Alternate Names:

134 Gene ID

RDC7 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Adenosine A1 receptor
- Version: 2020.06.01
Alternate Names:

ADORA1 TTD Gene Abbreviation

T92072 TTD Target ID

Gene Info:

Publications:

Novel drug target	Established target
Trial Name	INO-8875
Mechanism of Interaction	Adenosine A1 receptor agonist

Mechanism of Interaction	Adenosine A1 receptor partial agonist
Direct Interaction	yes

Trial Name	CVT-3619
Novel drug target	Established target
Mechanism of Interaction	Adenosine A1 receptor partial agonist

Direct Interaction	yes
Mechanism of Interaction	Adenosine A1 receptor antagonist
Trial Name	BG-9928

Specific Action of the Ligand	Agonist
Endogenous Drug?	True
Direct Interaction?	True

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Direct Interaction	yes
Mechanism of Interaction	Adenosine receptor antagonist
Specific Action of the Ligand	Antagonist

Trial Name	ADC4022, low-dose inhaled theophylline
Novel drug target	Established target
Mechanism of Interaction	Adenosine receptor antagonist

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Direct Interaction?	False

Trial Name	pentoxifylline, EHT0201
Novel drug target	Established target

P30542	Uniprot Accession
ADORA1	Uniprot Gene Name
AA1R_HUMAN	Uniprot Id

ADENOSINE A1 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P30542]	Description
ENSG00000163485	Ensembl Gene Id
ADORA1	Display Id

P30542	Uniprot Accession
134	Entrez Gene Id
AA1R_HUMAN	Uniprot Id

262	HUGO Gene ID
262	HUGO Gene Symbol
adenosine A1 receptor	HUGO Gene Name

ADORA1 Gene Record

ADORA1 134 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name INO-8875 Mechanism of Interaction Adenosine A1 receptor agonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A1 receptor partial agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Trial Name CVT-3619 Novel drug target Established target Mechanism of Interaction Adenosine A1 receptor partial agonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A1 receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16686529

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19751980

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adenosine A1 receptor agonist Trial Name tecadenoson

PMIDs: 15956124 13678937 16230891

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adenosine A1 receptor antagonist Trial Name BG-9928

PMIDs: 17692744 17125265

Sources: TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A1 receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A1 receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A1 receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine A1 receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22703703

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine A1 receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine A1 receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine A1 receptor antagonist Direct Interaction yes Trial Name rolofylline, MK-7418, KW-3902

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? True Direct Interaction? True

PMIDs: 17438146 20370661 20136829 17321471 17442976 20370662

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name INO-8875

Mechanism of Interaction Adenosine A1 receptor agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Trial Name CVT-3619

Novel drug target Established target

Mechanism of Interaction Adenosine A1 receptor partial agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
16686529

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19751980

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A1 receptor agonist

Trial Name tecadenoson

PMIDs:
15956124 13678937 16230891

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A1 receptor antagonist

Trial Name BG-9928

PMIDs:
17692744 17125265

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22703703

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor antagonist

Direct Interaction yes

Trial Name rolofylline, MK-7418, KW-3902

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? True

Direct Interaction? True

PMIDs:
17438146 20370661 20136829 17321471 17442976 20370662

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
23700273

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A1 receptor antagonist

Direct Interaction yes

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
19751980

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)