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ADORA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • ADORA1 134 Druggable Genome

    Alternate Names:

    134
    ADENOSINE A1 RECEPTOR
    ADORA1
    RDC7
    102775
    262
    ENSG00000163485
    OTTHUMG00000042125
    P30542
    AA1R_HUMAN
    ADENOSINE RECEPTOR A1
    ADENOSINE A1 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P30542]
    PA24583
    T92072

    Gene Info:

    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000276
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Type Family
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot
    Target Main Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Transmembrane Helix Count 7
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Mustafa et al., 2006, Altered intravenous pharmacokinetics of topotecan in rats with acute renal failure (ARF) induced by uranyl nitrate: do adenosine A1 antagonists (selective/non-selective) normalize the altered topotecan kinetics in ARF?, Xenobiotica
    Rieg et al., 2007, Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite., Eur. J. Pharmacol.
    Wang, 2007, Caffeine facilitation of glutamate release from rat cerebral cortex nerve terminals (synaptosomes) through activation protein kinase C pathway: an interaction with presynaptic adenosine A1 receptors., Synapse
    Listos et al., Adenosine receptor antagonists intensify the benzodiazepine withdrawal signs in mice., Pharmacol Rep
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Gaytan et al., 2006, Effect of postnatal exposure to caffeine on the pattern of adenosine A1 receptor distribution in respiration-related nuclei of the rat brainstem., Auton Neurosci
    Aurelio L et al., 2009, 3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists., Bioorg Med Chem
    Lerman, 1993, Response of nonreentrant catecholamine-mediated ventricular tachycardia to endogenous adenosine and acetylcholine. Evidence for myocardial receptor-mediated effects., Circulation
    Yamamoto et al., 2003, Intrathecal adenosine A1 receptor agonist attenuates hyperalgesia without inhibiting spinal glutamate release in the rat., Cell. Mol. Neurobiol.
    Ellenbogen et al., 2005, Trial to evaluate the management of paroxysmal supraventricular tachycardia during an electrophysiology study with tecadenoson., Circulation
    Prystowsky et al., 2003, Termination of paroxysmal supraventricular tachycardia by tecadenoson (CVT-510), a novel A1-adenosine receptor agonist., J. Am. Coll. Cardiol.
    Peterman et al., Tecadenoson: a novel, selective A1 adenosine receptor agonist., Cardiol Rev
    Greenberg B et al., 2007, Effects of multiple oral doses of an A1 adenosine antagonist, BG9928, in patients with heart failure: results of a placebo-controlled, dose-escalation study., J Am Coll Cardiol
    Vu CB et al., 2006, Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists., J Med Chem
    Daly et al., 1987, Adenosine receptors: development of selective agonists and antagonists., Prog. Clin. Biol. Res.
    Kim SH et al., 2009, Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma., Respir Med
    Chang LC et al., 2006, 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists., J Med Chem
    Nantwi et al., 2003, Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function 4 months after C2 hemisection., J Spinal Cord Med
    Gaspar A et al., 2012, In search for new chemical entities as adenosine receptor ligands: development of agents based on benzo-γ-pyrone skeleton., Eur J Med Chem
    Funakoshi et al., 2007, A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction., Circulation
    Schenone et al., 2010, A1 receptors ligands: past, present and future trends., Curr Top Med Chem
    Buenestado et al., 2010, The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages., Br. J. Pharmacol.
    Ezeamuzie et al., 2007, The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages., Int. Immunopharmacol.
    Haschemi et al., 2007, Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages., J. Immunol.
    Trincavelli et al., 2010, Adenosine receptors: what we know and what we are learning., Curr Top Med Chem
  • TRABODENOSON   ADORA1

    Interaction Score: 5.98

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name INO-8875
    Mechanism of Interaction Adenosine A1 receptor agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • ROLOFYLLINE   ADORA1

    Interaction Score: 5.98

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Direct Interaction yes
    Trial Name rolofylline, MK-7418, KW-3902

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • CAPADENOSON   ADORA1

    Interaction Score: 3.99

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor partial agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • GS-9667   ADORA1

    Interaction Score: 3.99

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Trial Name CVT-3619
    Novel drug target Established target
    Mechanism of Interaction Adenosine A1 receptor partial agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • SELODENOSON   ADORA1

    Interaction Score: 3.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CHEMBL207824   ADORA1

    Interaction Score: 3.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16686529


    Sources:
    DTC

  • CHEMBL303124   ADORA1

    Interaction Score: 3.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19751980


    Sources:
    DTC

  • TECADENOSON   ADORA1

    Interaction Score: 3.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A1 receptor agonist
    Trial Name tecadenoson

    PMIDs:
    15956124 13678937 16230891


    Sources:
    TdgClinicalTrial ChemblInteractions

  • TONAPOFYLLINE   ADORA1

    Interaction Score: 2.49

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Trial Name BG-9928

    PMIDs:
    17692744 17125265


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • RPR749   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GW493838   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BAY1067197   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NAXIFYLLINE   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DERENOFYLLINE   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHROMOCARB   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22703703


    Sources:
    DTC

  • APAXIFYLLINE   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • FK453   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PBF-680   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMP579   ADORA1

    Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine A1 receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ADENOSINE   ADORA1

    Interaction Score: 1.75

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor agonist
    Direct Interaction yes

    PMIDs:
    17438146 20370661 20136829 17321471 17442976 20370662


    Sources:
    ChemblInteractions

  • CHEMBL59532   ADORA1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19751980


    Sources:
    DTC

  • CAFFEINE   ADORA1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    multitarget
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine receptor antagonist
    Trial Name -

    PMIDs:
    17162470 17126319 17372967 17085856 11752352 16702031


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • CHEMBL136689   ADORA1

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL27508   ADORA1

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OXTRIPHYLLINE   ADORA1

    Interaction Score: 0.6

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    3588607 14992338


    Sources:
    ChemblInteractions

  • AMINOPHYLLINE   ADORA1

    Interaction Score: 0.6

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    8425287 12735630


    Sources:
    ChemblInteractions

  • CAFFEINE, CITRATED   ADORA1

    Interaction Score: 0.5

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THEOPHYLLINE   ADORA1

    Interaction Score: 0.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ADC4022, low-dose inhaled theophylline
    Novel drug target Established target
    Mechanism of Interaction Adenosine receptor antagonist

    PMIDs:
    3588607 14992338


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • THEOPHYLLINE SODIUM GLYCINATE   ADORA1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOXIFYLLINE   ADORA1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name pentoxifylline, EHT0201
    Novel drug target Established target

    PMIDs:
    3588607


    Sources:
    TdgClinicalTrial

  • ASPIRIN   ADORA1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19019667


    Sources:
    PharmGKB

  • Ensembl: ENSG00000163485

    • Version: 101_38

    Alternate Names:
    ADORA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P30542

    • Version: 11-September-2012

    Alternate Names:
    P30542 Uniprot Accession
    ADORA1 Uniprot Gene Name
    AA1R_HUMAN Uniprot Id

    Gene Info:
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000163485

    • Version: 26-July-2011

    Alternate Names:
    ADENOSINE A1 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P30542] Description
    ENSG00000163485 Ensembl Gene Id
    ADORA1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P30542

    • Version: January-2014

    Alternate Names:
    ADORA1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • TEND: P30542

    • Version: 01-August-2011

    Alternate Names:
    P30542 Uniprot Accession
    134 Entrez Gene Id
    AA1R_HUMAN Uniprot Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • PharmGKB: ADORA1

    • Version: 18-August-2020

    Alternate Names:
    PA24583 PharmGKB ID

    Gene Info:

    Publications:
    Kim SH et al., 2009, Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma., Respir Med

  • DTC: ADORA1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Gaspar A et al., 2012, In search for new chemical entities as adenosine receptor ligands: development of agents based on benzo-γ-pyrone skeleton., Eur J Med Chem
    Aurelio L et al., 2009, 3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists., Bioorg Med Chem
    Chang LC et al., 2006, 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists., J Med Chem

  • ChemblInteractions: ADORA1

    • Version: chembl_23

    Alternate Names:
    ADORA1 GENE_SYMBOL
    Adenosine receptor A1 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000163485

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000163485 Gene Symbol
    ADORA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: ADORA1

    • Version: 27-Jun-2013

    Alternate Names:
    134 Gene ID
    RDC7 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Adenosine A1 receptor

    • Version: 2020.06.01

    Alternate Names:
    ADORA1 TTD Gene Abbreviation
    T92072 TTD Target ID

    Gene Info:

    Publications:

  • GO: ADORA1

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21