DGIdb - ACVRL1 Gene Record

ACVRL1 94 Druggable Genome

Alternate Names:

94
ACTIVIN A RECEPTOR LIKE TYPE 1
ACVRL1
ACVRLK1
ALK-1
ALK1
HHT
HHT2
ORW2
SKR3
TSR-I
601284
175
ENSG00000139567
OTTHUMG00000169507
ACTIVIN RECEPTOR-LIKE KINASE 1
ACTIVIN RECEPTOR-LIKE KINASE-1
TGF-B SUPERFAMILY RECEPTOR TYPE I
SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
P37023
SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3 PRECURSOR (EC 2.7.1.37) (SKR3) (ACTIVIN RECEPTOR-LIKE KINASE 1) (ALK-1) (TGF-B SUPERFAMILY RECEPTOR TYPE I) (TSR-I). [SOURCE:UNIPROT/SWISSPROT;ACC:P37023]
T36959

Gene Info:

Target Subclass	EC:2.7.11.30
Target Class	Receptors
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

CELL SURFACE
KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME

Publications:

Cunha SI et al., 2011, ALK1 as an emerging target for antiangiogenic therapy of cancer., Blood
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

ASCRINVACUMAB ACVRL1

Interaction Score: 46.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase receptor R3 inhibitor

Direct Interaction yes

PMIDs:
21467543

Sources:
ChemblInteractions TTD
DALANTERCEPT ACVRL1

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ACE-041

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial
PANULISIB ACVRL1

Interaction Score: 1.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase receptor R3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HESPERADIN ACVRL1

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC

Ensembl: ENSG00000139567
- Version: 101_38
Alternate Names:

ACVRL1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000139567

Version: 26-July-2011

Alternate Names:

SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3 PRECURSOR (EC 2.7.1.37) (SKR3) (ACTIVIN RECEPTOR-LIKE KINASE 1) (ALK-1) (TGF-B SUPERFAMILY RECEPTOR TYPE I) (TSR-I). [SOURCE:UNIPROT/SWISSPROT;ACC:P37023] Description

ENSG00000139567 Ensembl Gene Id

ACVRL1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P37023
- Version: January-2014
Alternate Names:

ACVRL1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass EC:2.7.11.30

Publications:
TTD: Activin receptor-like kinase-1
- Version: 2020.06.01
Alternate Names:

ACVRL1 TTD Gene Abbreviation

T36959 TTD Target ID

Gene Info:

Publications:

Cunha SI et al., 2011, ALK1 as an emerging target for antiangiogenic therapy of cancer., Blood
DTC: ACVRL1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
ChemblInteractions: ACVRLK1
- Version: chembl_23
Alternate Names:

ALK1 GENE_SYMBOL

ACVRL1 GENE_SYMBOL

Serine/threonine-protein kinase receptor R3 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000139567
- Version: 31-May-2017
Alternate Names:

ENSG00000139567 Gene Symbol

ACVRL1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: ACVRL1
- Version: 19.3
Alternate Names:

ENSG00000139567 Ensembl Gene ID

ACVRLK1 Human Protein Atlas Gene Synonym

ALK1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: ACVRL1
- Version: 01-February-2022
Alternate Names:

ACVRLK1 GO Gene Synonym

ALK1 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, SERINE THREONINE KINASE

Publications:
dGene: ACVRL1
- Version: 27-Jun-2013
Alternate Names:

94 Gene ID

ACVRLK1 dGene Synonym

ALK-1 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
Pharos: ACVRL1
- Version: 01-February-2022
Alternate Names:

Serine/threonine-protein kinase receptor R3 Gene Name

P37023 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
ClearityFoundationClinicalTrial: ACVRL1
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Mechanism of Interaction	Serine/threonine-protein kinase receptor R3 inhibitor
Direct Interaction	yes

SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3 PRECURSOR (EC 2.7.1.37) (SKR3) (ACTIVIN RECEPTOR-LIKE KINASE 1) (ALK-1) (TGF-B SUPERFAMILY RECEPTOR TYPE I) (TSR-I). [SOURCE:UNIPROT/SWISSPROT;ACC:P37023]	Description
ENSG00000139567	Ensembl Gene Id
ACVRL1	Display Id

ALK1	GENE_SYMBOL
ACVRL1	GENE_SYMBOL
Serine/threonine-protein kinase receptor R3	UNIPROT

Serine/threonine-protein kinase receptor R3	Gene Name
P37023	UniProt ID

Trial Name	ACE-041
Novel drug target	Novel Target

ACVRL1 Gene Record

ACVRL1 94 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

ASCRINVACUMAB ACVRL1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase receptor R3 inhibitor Direct Interaction yes

PMIDs: 21467543

Sources: ChemblInteractions TTD

DALANTERCEPT ACVRL1

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ACE-041 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial ClearityFoundationClinicalTrial

PANULISIB ACVRL1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase receptor R3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

HESPERADIN ACVRL1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19035792

Sources: DTC

Ensembl: ENSG00000139567

Alternate Names: ACVRL1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000139567

Alternate Names: SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3 PRECURSOR (EC 2.7.1.37) (SKR3) (ACTIVIN RECEPTOR-LIKE KINASE 1) (ALK-1) (TGF-B SUPERFAMILY RECEPTOR TYPE I) (TSR-I). [SOURCE:UNIPROT/SWISSPROT;ACC:P37023] Description ENSG00000139567 Ensembl Gene Id ACVRL1 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P37023

Alternate Names: ACVRL1 Gene Symbol

Gene Info: Target Class Receptors Target Subclass EC:2.7.11.30

Publications:

TTD: Activin receptor-like kinase-1

Alternate Names: ACVRL1 TTD Gene Abbreviation T36959 TTD Target ID

Gene Info:

Publications: Cunha SI et al., 2011, ALK1 as an emerging target for antiangiogenic therapy of cancer., Blood

DTC: ACVRL1

Alternate Names:

Gene Info:

Publications: Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

ChemblInteractions: ACVRLK1

Alternate Names: ALK1 GENE_SYMBOL ACVRL1 GENE_SYMBOL Serine/threonine-protein kinase receptor R3 UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000139567

Alternate Names: ENSG00000139567 Gene Symbol ACVRL1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: ACVRL1

Alternate Names: ENSG00000139567 Ensembl Gene ID ACVRLK1 Human Protein Atlas Gene Synonym ALK1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

GO: ACVRL1

Alternate Names: ACVRLK1 GO Gene Synonym ALK1 GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE, SERINE THREONINE KINASE

Publications:

dGene: ACVRL1

Alternate Names: 94 Gene ID ACVRLK1 dGene Synonym ALK-1 dGene Synonym

Gene Info:

Gene Categories: KINASE, SERINE THREONINE KINASE

Publications:

Pharos: ACVRL1

Alternate Names: Serine/threonine-protein kinase receptor R3 Gene Name P37023 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

ClearityFoundationClinicalTrial: ACVRL1

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase receptor R3 inhibitor

Direct Interaction yes

PMIDs:
21467543

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ACE-041

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase receptor R3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19035792

Sources:
DTC

Alternate Names:

ACVRL1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3 PRECURSOR (EC 2.7.1.37) (SKR3) (ACTIVIN RECEPTOR-LIKE KINASE 1) (ALK-1) (TGF-B SUPERFAMILY RECEPTOR TYPE I) (TSR-I). [SOURCE:UNIPROT/SWISSPROT;ACC:P37023] Description

ENSG00000139567 Ensembl Gene Id

ACVRL1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ACVRL1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass EC:2.7.11.30

Alternate Names:

ACVRL1 TTD Gene Abbreviation

T36959 TTD Target ID

Publications:

Cunha SI et al., 2011, ALK1 as an emerging target for antiangiogenic therapy of cancer., Blood

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Alternate Names:

ALK1 GENE_SYMBOL

ACVRL1 GENE_SYMBOL

Serine/threonine-protein kinase receptor R3 UNIPROT

Alternate Names:

ENSG00000139567 Gene Symbol

ACVRL1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000139567 Ensembl Gene ID

ACVRLK1 Human Protein Atlas Gene Synonym

ALK1 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

ACVRLK1 GO Gene Synonym

ALK1 GO Gene Synonym

Gene Categories:

CELL SURFACE, SERINE THREONINE KINASE

Alternate Names:

94 Gene ID

ACVRLK1 dGene Synonym

ALK-1 dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Alternate Names:

Serine/threonine-protein kinase receptor R3 Gene Name

P37023 UniProt ID

Gene Categories:

KINASE