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ACVRL1 Gene Record

  • Summary
  • Interactions
  • Claims
  • ACVRL1 94 Druggable Genome

    Alternate Names:

    94
    ACTIVIN A RECEPTOR LIKE TYPE 1
    ACVRL1
    ACVRLK1
    ALK-1
    ALK1
    HHT
    HHT2
    ORW2
    SKR3
    TSR-I
    601284
    175
    ENSG00000139567
    OTTHUMG00000169507
    ACTIVIN RECEPTOR-LIKE KINASE 1
    ACTIVIN RECEPTOR-LIKE KINASE-1
    TGF-B SUPERFAMILY RECEPTOR TYPE I
    SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3
    P37023
    SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3 PRECURSOR (EC 2.7.1.37) (SKR3) (ACTIVIN RECEPTOR-LIKE KINASE 1) (ALK-1) (TGF-B SUPERFAMILY RECEPTOR TYPE I) (TSR-I). [SOURCE:UNIPROT/SWISSPROT;ACC:P37023]
    T36959

    Gene Info:

    Target Subclass EC:2.7.11.30
    Target Class Receptors
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Cunha SI et al., 2011, ALK1 as an emerging target for antiangiogenic therapy of cancer., Blood
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
  • ASCRINVACUMAB   ACVRL1

    Interaction Score: 46.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase receptor R3 inhibitor
    Direct Interaction yes

    PMIDs:
    21467543


    Sources:
    ChemblInteractions TTD

  • DALANTERCEPT   ACVRL1

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ACE-041
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ClearityFoundationClinicalTrial

  • PANULISIB   ACVRL1

    Interaction Score: 1.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase receptor R3 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HESPERADIN   ACVRL1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • Ensembl: ENSG00000139567

    • Version: 101_38

    Alternate Names:
    ACVRL1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000139567

    • Version: 26-July-2011

    Alternate Names:
    SERINE/THREONINE-PROTEIN KINASE RECEPTOR R3 PRECURSOR (EC 2.7.1.37) (SKR3) (ACTIVIN RECEPTOR-LIKE KINASE 1) (ALK-1) (TGF-B SUPERFAMILY RECEPTOR TYPE I) (TSR-I). [SOURCE:UNIPROT/SWISSPROT;ACC:P37023] Description
    ENSG00000139567 Ensembl Gene Id
    ACVRL1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P37023

    • Version: January-2014

    Alternate Names:
    ACVRL1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass EC:2.7.11.30

    Publications:

  • TTD: Activin receptor-like kinase-1

    • Version: 2020.06.01

    Alternate Names:
    ACVRL1 TTD Gene Abbreviation
    T36959 TTD Target ID

    Gene Info:

    Publications:
    Cunha SI et al., 2011, ALK1 as an emerging target for antiangiogenic therapy of cancer., Blood

  • DTC: ACVRL1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

  • ChemblInteractions: ACVRLK1

    • Version: chembl_23

    Alternate Names:
    ALK1 GENE_SYMBOL
    ACVRL1 GENE_SYMBOL
    Serine/threonine-protein kinase receptor R3 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000139567

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000139567 Gene Symbol
    ACVRL1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: ACVRL1

    • Version: 19.3

    Alternate Names:
    ENSG00000139567 Ensembl Gene ID
    ACVRLK1 Human Protein Atlas Gene Synonym
    ALK1 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: ACVRL1

    • Version: 01-February-2022

    Alternate Names:
    ACVRLK1 GO Gene Synonym
    ALK1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, SERINE THREONINE KINASE

    Publications:

  • dGene: ACVRL1

    • Version: 27-Jun-2013

    Alternate Names:
    94 Gene ID
    ACVRLK1 dGene Synonym
    ALK-1 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • Pharos: ACVRL1

    • Version: 01-February-2022

    Alternate Names:
    Serine/threonine-protein kinase receptor R3 Gene Name
    P37023 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • ClearityFoundationClinicalTrial: ACVRL1

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21