DGIdb - ACHE Gene Record

ACHE 43 Druggable Genome

Alternate Names:

43
ACETYLCHOLINESTERASE (CARTWRIGHT BLOOD GROUP)
ACHE
ACEE
ARACHE
N-ACHE
YT
100740
108
ENSG00000087085
OTTHUMG00000157033
P22303
ACES_HUMAN
acetylcholinesterase
BE0000426
ACETYLCHOLINESTERASE PRECURSOR (EC 3.1.1.7) (ACHE). [SOURCE:UNIPROT/SWISSPROT;ACC:P22303]
2465
PA20
T30082
NM_015831
NP_056646

Gene Info:

Interpro Acc	IPR002018
Interpro Name	Carboxylesterase, type B
Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	CarbesteraseB
Target Main Class	Enzymes
Target Subclass	3.1.1.7
Target Class	Enzymes
Target Subclass	EC:3.1.1.7
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Acetylcholine turnover
GuideToPharmacology Gene Category ID	765
GuideToPharmacology Gene Category Name	Hydrolases
GuideToPharmacology Gene Category ID	799

(10 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUGGABLE GENOME
ENZYME

Publications:

Trevisani et al., 2000, Neostigmine: safe and effective treatment for acute colonic pseudo-obstruction., Dis. Colon Rectum
Naves et al., 2001, Repetitive nerve stimulation decreases the acetylcholine content of quanta at the frog neuromuscular junction., J. Physiol. (Lond.)
Beck et al., 2003, Stress interacts with peripheral cholinesterase inhibitors to cause central nervous system effects., Life Sci.
Takeuchi et al., 2000, Stimulation by nizatidine, a histamine H(2)-receptor antagonist, of duodenal HCO(3)(-)secretion in rats:relation to anti-cholinesterase activity., World J. Gastroenterol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Minic et al., 2003, Butyrylcholinesterase and acetylcholinesterase activity and quantal transmitter release at normal and acetylcholinesterase knockout mouse neuromuscular junctions., Br. J. Pharmacol.
Zhang et al., 2009, Neuromuscular blockade, reversal agent use, and operating room time: retrospective analysis of US inpatient surgeries., Curr Med Res Opin
Gottwald et al., 1999, Rivastigmine, a brain-region selective acetylcholinesterase inhibitor for treating Alzheimer's disease: review and current status., Expert Opin Investig Drugs
Naik et al., 2009, Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice., J Pharm Pharm Sci
Scacchi R et al., 2009, Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine., Am J Med Genet B Neuropsychiatr Genet
Lalli et al., 2008, Rivastigmine in Parkinson's disease dementia., Expert Rev Neurother
Greig et al., 2002, Butyrylcholinesterase: an important new target in Alzheimer's disease therapy., Int Psychogeriatr
Birks et al., 2009, Rivastigmine for Alzheimer's disease., Cochrane Database Syst Rev
Grossberg et al., 2000, Lack of adverse pharmacodynamic drug interactions with rivastigmine and twenty-two classes of medications., Int J Geriatr Psychiatry
Goldblum et al., 2000, Topical rivastigmine, a selective acetylcholinesterase inhibitor, lowers intraocular pressure in rabbits., J Ocul Pharmacol Ther
Stahl, 2000, The new cholinesterase inhibitors for Alzheimer's disease, Part 1: their similarities are different., J Clin Psychiatry
Onor et al., 2007, Rivastigmine in the treatment of Alzheimer's disease: an update., Clin Interv Aging
Kennedy et al., 1999, Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans., J Clin Psychopharmacol
Farlow, 2003, Update on rivastigmine., Neurologist
Pang et al., 2003, Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators., Chem. Biol.
da Costa et al., 2001, Short- and long-term influences of calcitonin gene-related peptide on the synthesis of acetylcholinesterase in mammalian myotubes., Br. J. Pharmacol.
Malatová et al., 1999, Depression of acetylcholinesterase synthesis following transient cerebral ischemia in rat: pharmacohistochemical and biochemical investigation., Gen. Physiol. Biophys.
Quistad et al., 2000, Phosphoacetylcholinesterase: toxicity of phosphorus oxychloride to mammals and insects that can be attributed to selective phosphorylation of acetylcholinesterase by phosphorodichloridic acid., Chem. Res. Toxicol.
Ashani et al., 1990, Differences in conformational stability between native and phosphorylated acetylcholinesterase as evidenced by a monoclonal antibody., Biochemistry
Cardoso CL et al., 2004, Indole glucoalkaloids from Chimarrhis turbinata and their evaluation as antioxidant agents and acetylcholinesterase inhibitors., J Nat Prod
Ki et al., 2010, Donepezil, a potent acetylcholinesterase inhibitor, induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells., Biol. Pharm. Bull.
Sugimoto, 2001, Donepezil hydrochloride: a treatment drug for Alzheimer's disease., Chem Rec
Kryger et al., 1999, Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs., Structure
Repantis et al., 2010, Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: a systematic review., Pharmacol. Res.
Jann, 2000, Rivastigmine, a new-generation cholinesterase inhibitor for the treatment of Alzheimer's disease., Pharmacotherapy
Shepherd et al., Donepezil overdose: a tenfold dosing error., Ann Pharmacother
Kosasa et al., 1999, Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats., Eur. J. Pharmacol.
Davis, 1999, Alzheimer's disease: seeking new ways to preserve brain function. Interview by Alice V. Luddington., Geriatrics
Huang L et al., 2014, Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease., Eur J Med Chem
Tuovinen et al., 1999, Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication., Toxicology
Nguyen et al., 1999, Maturation of neuromuscular transmission during early development in zebrafish., J. Neurophysiol.
Monnet-Tschudi et al., 2000, Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures., Toxicol. Appl. Pharmacol.
Blasina et al., 2000, Evidence for a noncholinergic function of acetylcholinesterase during development of chicken retina as shown by fasciculin., Cell Tissue Res.
Bolognesi et al., 2001, Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors., J. Med. Chem.
Papp et al., 2006, Similarities between CSF-brain extracellular transfer and neurofibrillary tangle invasion in Alzheimer's disease., Neurobiol. Aging
Bolognesi et al., 2003, Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors., Farmaco
Kenakin et al., 1985, Self-cancellation of drug properties as a mode of organ selectivity: the antimuscarinic effects of ambenonium., J. Pharmacol. Exp. Ther.
Hodge et al., 1992, Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities., Mol. Pharmacol.
Lockhart et al., 2001, Differential inhibition of [3H]-oxotremorine-M and [3H]-quinuclinidyl benzilate binding to muscarinic receptors in rat brain membranes with acetylcholinesterase inhibitors., Naunyn Schmiedebergs Arch. Pharmacol.
Webb, 1965, Affinity of benzoquinonium and ambenonium derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution., Biochim. Biophys. Acta
Du et al., 2004, Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease., Curr. Pharm. Des.
Wang et al., 1999, Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE., Neuroreport
Villarroya et al., 2004, New classes of AChE inhibitors with additional pharmacological effects of interest for the treatment of Alzheimer's disease., Curr. Pharm. Des.
Traykov et al., 1999, In vivo PET study of cerebral [11C] methyl- tetrahydroaminoacridine distribution and kinetics in healthy human subjects., Eur. J. Neurol.
Ahmed et al., 2006, Inhibition of two different cholinesterases by tacrine., Chem. Biol. Interact.
Marco et al., 2003, Recent developments in the synthesis of acetylcholinesterase inhibitors., Mini Rev Med Chem
Wang et al., 1998, Anticholinesterase effects of huperzine A, E2020, and tacrine in rats., Zhongguo Yao Li Xue Bao
Takatori, 2006, [Mechanisms of neuroprotective effects of therapeutic acetylcholinesterase inhibitors used in treatment of Alzheimer's disease]., Yakugaku Zasshi
Krustev et al., 2006, Calcium-independent tacrine-induced relaxation of rat gastric corpus smooth muscles., Can. J. Physiol. Pharmacol.
Bag S et al., 2013, Design, synthesis and biological activity of multifunctional α,β-unsaturated carbonyl scaffolds for Alzheimer's disease., Bioorg Med Chem Lett
Greenblatt et al., 1999, Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution., FEBS Lett.
Guillou et al., 2000, Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts., Bioorg. Med. Chem. Lett.
Woodruff-Pak DS et al., 2001, Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning., Proc Natl Acad Sci U S A
Lilienfeld, 2002, Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease., CNS Drug Rev
Olin et al., 2002, Galantamine for Alzheimer's disease., Cochrane Database Syst Rev
Lilienfeld et al., 2000, Galantamine: additional benefits to patients with Alzheimer's disease., Dement Geriatr Cogn Disord
Scott et al., 2000, Galantamine: a review of its use in Alzheimer's disease., Drugs
Tonkopiĭ et al., 1976, [Interaction of reversible inhibitors with the catalytic centers and allosteric sites of cholinesterases]., Biull Eksp Biol Med
Woodruff-Pak et al., 2002, Nicotinic cholinergic modulation: galantamine as a prototype., CNS Drug Rev
Hansen et al.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Blesa, 2000, Galantamine: therapeutic effects beyond cognition., Dement Geriatr Cogn Disord
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Sinha et al., 1975, Synthesis and biological activity of spin-labeled analogs of biotin, hexamethonium, decamethonium, dichlorisoproterenol, and propranolol., J. Med. Chem.
Hallek et al., 1988, Effects of some mono- and bisquaternary ammonium compounds on the reactivatability of soman-inhibited human acetylcholinesterase in vitro., Biochem. Pharmacol.
Wu et al., 1989, Tacrine protection of acetylcholinesterase from inactivation by diisopropylfluorophosphate: a circular dichroism study., Mol. Pharmacol.
Robaire et al., 1975, Effects of edrophonium, eserine, decamethonium, d-tubocurarine, and gallamine on the kinetics of membrane-bound and solubilized eel acetylcholinesterase., Mol. Pharmacol.
Seto et al., 1988, Structure-activity relationship of reversible cholinesterase inhibitors including paraquat., Arch. Toxicol.
Amenta et al., 2006, Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission., Mech. Ageing Dev.
Anzai, 2006, [Use of biosensors for detecting organophosphorus agents]., Yakugaku Zasshi
Alkondon et al., 2006, Subtype-specific inhibition of nicotinic acetylcholine receptors by choline: a regulatory pathway., J. Pharmacol. Exp. Ther.
Longobardi et al., 2005, Use of electrochemical biosensor and gas chromatography for determination of dichlorvos in wheat., J. Agric. Food Chem.
Durcan et al., 2006, Eosinophil-mediated cholinergic nerve remodeling., Am. J. Respir. Cell Mol. Biol.
Prasad et al., 2000, Interactions of bovine brain tubulin with pyridostigmine bromide and N,N'-diethyl-m-toluamide., Neurochem. Res.
Servatius et al., 2000, Effects of inescapable stress and treatment with pyridostigmine bromide on plasma butyrylcholinesterase and the acoustic startle response in rats., Physiol. Behav.
Ricordel et al., 2000, [Chemical weapons: antidotes. View about the real means, perspectives]., Ann Pharm Fr
Sinton et al., 2000, Stressful manipulations that elevate corticosterone reduce blood-brain barrier permeability to pyridostigmine in the Rat., Toxicol. Appl. Pharmacol.
Drake-Baumann et al., 1999, Effects of exposure to low-dose pyridostigmine on neuromuscular junctions in vitro., Muscle Nerve
Bartolucci C et al., 2006, Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819)., J Med Chem
Mazzucchelli M et al., 2003, Characterization of the effect of ganstigmine (CHF2819) on amyloid precursor protein metabolism in SH-SY5Y neuroblastoma cells., J Neural Transm (Vienna)
Keymer et al., 1999, Acetylcholinesterase and inhibitors: effects upon normal and regenerating nerves of the rat., Eur. J. Neurosci.
Ravelli et al., 1998, Static Laue diffraction studies on acetylcholinesterase., Acta Crystallogr. D Biol. Crystallogr.
Martín-Biosca et al., 2009, Screening of acetylcholinesterase inhibitors by CE after enzymatic reaction at capillary inlet., J Sep Sci
Luo et al., 1999, Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium., Biochemistry
Luo et al., 1999, Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime., Chem. Biol. Interact.
Huby et al., 1999, Role of acetylcholinesterase (AChE) secreted by parasitic nematodes on the growth of the cell line from epithelial origin HT29-D4., Parasitology
Hatip-Al-Khatib et al., 2005, Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats., Br. J. Pharmacol.
Ciesielski-Treska et al., 1975, Morphological, histochemical and chromosomal patterns of neuroblastoma parental and purine resistant lines., Neurobiology
Duarte et al., 2007, Privileged structures: a useful concept for the rational design of new lead drug candidates., Mini Rev Med Chem
Contreras et al., 1999, Aminopyridazines as acetylcholinesterase inhibitors., J. Med. Chem.
Klein, 2007, Phenserine., Expert Opin Investig Drugs
Greig et al., 2005, Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects., Curr Alzheimer Res
Ward et al., 2003, The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs., Vet Ophthalmol
Choung et al., 2007, A double-blind, randomized, placebo-controlled trial of itopride (100 and 200 mg three times daily) on gastric motor and sensory function in healthy volunteers., Neurogastroenterol. Motil.
Jokanović, 2009, Medical treatment of acute poisoning with organophosphorus and carbamate pesticides., Toxicol. Lett.
Jokanović et al., 2009, Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds., Curr. Med. Chem.
Kalisiak J et al., 2012, Nonquaternary reactivators for organophosphate-inhibited cholinesterases., J Med Chem
Kalisiak J et al., 2011, Amidine-oximes: reactivators for organophosphate exposure., J Med Chem
Kovacic, 2003, Mechanism of organophosphates (nerve gases and pesticides) and antidotes: electron transfer and oxidative stress., Curr. Med. Chem.
Wong et al., 2000, Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis., Biochemistry
Elsinghorst et al., 2007, First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor., J. Med. Chem.
Radić et al., 1999, The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases., Chem. Biol. Interact.
Bourgeois et al., 1978, [Effects of chronic paralysis of chick embryo by flaxedil on the development of the neuromuscular junction]., C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat.
Radić et al., 2001, Peripheral site ligands accelerate inhibition of acetylcholinesterase by neutral organophosphates., J Appl Toxicol
Ishitani et al., 1972, Studies on the ultrastructural distribution of H 3 -dimetacrine in rat cerebral cortex., Jpn. J. Pharmacol.
Golicnik et al., 2002, Acceleration of Drosophila melanogaster acetylcholinesterase methanesulfonylation: peripheral ligand D-tubocurarine enhances the affinity for small methanesulfonylfluoride., Chem. Biol. Interact.
Gupta et al., 1992, Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX., Neurotoxicology
Bianchi et al., 2005, Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors., Bioorg. Med. Chem. Lett.
Kari et al., 1985, Effects of the synthetic glucocorticoid betamethasone on the survival of neurons in fetal rabbit brain cell culture., Brain Res.
Nakamura et al., 1993, Characterization of esterases involved in the hydrolysis of dipivefrin hydrochloride., Ophthalmic Res.
Robinson et al., 1993, Prenatal exposure to methadone delays the development of striatal cholinergic neurons., Brain Res. Dev. Brain Res.
Tsakiris et al., The effect of galactose metabolic disorders on rat brain acetylcholinesterase activity., Z. Naturforsch., C, J. Biosci.
Zeitz et al., 1978, Effects of 6-aminonicotinamide on growth and acetylcholinesterase activity during differentiation of neuroblastoma cells in vitro., Naunyn Schmiedebergs Arch. Pharmacol.
Laine-Cessac P et al., 1993, Inhibition of cholinesterases by histamine 2 receptor antagonist drugs., Res Commun Chem Pathol Pharmacol
Aono M et al., 1986, Cholinergic effects of histamine-H2 receptor antagonists partly through inhibition of acetylcholinesterase., Gastroenterol Jpn
Kounenis G et al., 1986, The inhibition of acetylcholinesterase by ranitidine: a study on the guinea pig ileum., J Pharmacobiodyn
Petroianu GA et al., 2005, Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of ranitidine., J Appl Toxicol
Changeux JP et al., 1969, On the association of tyrocidine with acetylcholinesterase., Proc Natl Acad Sci U S A
He et al., 2007, Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B., Bioorg. Med. Chem.
Zangara, 2003, The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease., Pharmacol. Biochem. Behav.

NEOSTIGMINE ACHE

Interaction Score: 10.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of ACHE activity in human serum.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
10826417 11313435 12726885 11819669 11752352 12522088 19257799

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology
AMBENONIUM ACHE

Interaction Score: 9.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15982786 13679187 2857786 1588924 11752352 11330337 5833399

Sources:
TEND TdgClinicalTrial TTD DrugBank
EDROPHONIUM ACHE

Interaction Score: 5.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Details of the Assay for Interaction Using the chloride salt

PMIDs:
10103097 10089512 19472276 10433700 11752352 10421446 10363282

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology
RIVASTIGMINE ACHE

Interaction Score: 4.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
11139819 19470293 18780301 18671661 12636181 19370562 10713582 10673128 11078030 18044073 11752352 10587286 14587496

Sources:
TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
PRALIDOXIME ACHE

Interaction Score: 3.76

Interaction Types & Directionality:

activator (activating)

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of human recombinant AChE by modified Ellman's method.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
19651196 19519385 22206546 21438612 14529460 10801325

Sources:
DTC DrugBank GuideToPharmacology
GALANTAMINE ACHE

Interaction Score: 3.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name galantamine hydrobromide,Razadyne, Reminyl

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
23540646 10606746 10762042 11172080 12177686 12137632 10971048 11129124 1026294 12481195 11078030 20480924 10592235 11752352 10971049

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology
CHEMBL490866 ACHE

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL455333 ACHE

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL117651 ACHE

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL395280 ACHE

Interaction Score: 2.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10592235 12895686

Sources:
DrugBank
HUPERZINE B ACHE

Interaction Score: 2.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17126020

Sources:
DrugBank
GANSTIGMINE ACHE

Interaction Score: 2.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16913695 12898348

Sources:
DrugBank
ISOFLUROPHATE ACHE

Interaction Score: 2.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Acetylcholinesterase inhibitor

Direct Interaction yes

PMIDs:
12837382 11350858 10378121 10898598 11752352 1692236

Sources:
TTD DrugBank ChemblInteractions
TACRINE ACHE

Interaction Score: 2.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Specific Action of the Ligand Inhibition

PMIDs:
15544504 10208549 15544507 10210906 16860785 10513568 10024872 25282266 12871155 10375753 11752352 16880719 17218977

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology
CHEMBL1082738 ACHE

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1235106 ACHE

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL107316 ACHE

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL483716 ACHE

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
TYROTHRICIN ACHE

Interaction Score: 1.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
5257018

Sources:
DrugBank
GALACTITOL ACHE

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11098845

Sources:
NCI
DESOXYCORDIFOLINE ACHE

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15568781

Sources:
DTC
ZANAPEZIL ACHE

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15951830

Sources:
DrugBank
TURBINATINE ACHE

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15568781

Sources:
DTC
PHYSOSTIGMINE ACHE

Interaction Score: 1.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name physostigmine ,Xalieve

Specific Action of the Ligand Inhibition

PMIDs:
10403635 10368402 10873710 11752352 10741458 11141093

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
DEMECARIUM ACHE

Interaction Score: 1.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
12641839 11752352

Sources:
DrugBank
PYRIDOSTIGMINE ACHE

Interaction Score: 1.15

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
10685600 10869589 10669805 11752352 10814558 10366222

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology
PROPIDIUM ACHE

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
DONEPEZIL ACHE

Interaction Score: 1.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
20522977 11893059 10368299 20193764 10641971 10466911 10513568 10024872 25282266 11752352

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology
DONEPEZIL HYDROCHLORIDE ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Acetylcholinesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMOCARZINE ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DEMECARIUM BROMIDE ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Acetylcholinesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIMETACRINE ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
4539395

Sources:
DrugBank
EDROPHONIUM CHLORIDE ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Acetylcholinesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ITOPRIDE ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name itopride,Itax

Novel drug target Established target

PMIDs:
17300287

Sources:
TdgClinicalTrial DrugBank
AMBENONIUM CHLORIDE ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Acetylcholinesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ECHOTHIOPHATE IODIDE ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Acetylcholinesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRALIDOXIME CHLORIDE ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Acetylcholinesterase activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HEXAFLUORENIUM BROMIDE ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Acetylcholinesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ECHOTHIOPHATE ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
DECAMETHONIUM ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
239236 3345199 2913485 1207670 3190453

Sources:
DrugBank
ACOTIAMIDE ACHE

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name acotiamide hydrochloride, YM-443, Z-338

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
CHOLINE SALICYLATE ACHE

Interaction Score: 0.72

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
16297435 17139155 16565162 16302752 16456188

Sources:
DrugBank
CHEMBL1234669 ACHE

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
TUBOCURARINE ACHE

Interaction Score: 0.63

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11823003 10421444 1475066 15878275 11920914

Sources:
DrugBank
CHOLINE ACHE

Interaction Score: 0.63

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
16297435 17139155 16565162 16302752 16456188

Sources:
DrugBank
6-AMINONICOTINAMIDE ACHE

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
153476

Sources:
NCI
PHENSERINE ACHE

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Phenserine

PMIDs:
17594192 16248851

Sources:
TdgClinicalTrial DrugBank
GALLAMINE TRIETHIODIDE ACHE

Interaction Score: 0.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17944454 10421444 1207670 3190453 417864 11920914

Sources:
DrugBank
NEOSTIGMINE METHYLSULFATE ACHE

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Acetylcholinesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RIVASTIGMINE TARTRATE ACHE

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TACRINE HYDROCHLORIDE ACHE

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ACETYLCHOLINE ACHE

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
PYRIDOSTIGMINE BROMIDE ACHE

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Acetylcholinesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GALANTAMINE HYDROBROMIDE ACHE

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Acetylcholinesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
EPTASTIGMINE ACHE

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
RANITIDINE ACHE

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8095733 2874096 3559884 15669026

Sources:
DrugBank
DIPIVEFRIN ACHE

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8446367

Sources:
DrugBank
LADOSTIGIL ACHE

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MINAPRINE ACHE

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18045214 10052979

Sources:
DrugBank
CHEMBL1234276 ACHE

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
8-AZAGUANINE ACHE

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1207869

Sources:
NCI
BETAMETHASONE ACHE

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3896398

Sources:
NCI
SKIMMIANINE ACHE

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYLENE BLUE ACHE

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
MALATHION ACHE

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LATREPIRDINE ACHE

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Dimebon

PMIDs:
None found

Sources:
TdgClinicalTrial
THIOGUANINE ACHE

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1207869

Sources:
NCI
METHADONE ACHE

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8149590

Sources:
NCI

Ensembl: ENSG00000087085
- Version: 101_38
Alternate Names:

ACHE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000087085
- Version: 26-July-2011
Alternate Names:

ENSG00000087085 Ensembl Gene Id

ACHE Display Id

ACETYLCHOLINESTERASE PRECURSOR (EC 3.1.1.7) (ACHE). [SOURCE:UNIPROT/SWISSPROT;ACC:P22303] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P22303
- Version: 01-August-2011
Alternate Names:

P22303 Uniprot Accession

ENSG00000087085 Ensembl Gene Id

43 Entrez Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 3.1.1.7

Publications:
HopkinsGroom: P22303
- Version: 11-September-2012
Alternate Names:

ACHE Uniprot Gene Name

43 Entrez Gene Id

P22303 Uniprot Accession

Gene Info:

Interpro Acc IPR002018

Interpro Name Carboxylesterase, type B

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P22303
- Version: January-2014
Alternate Names:

ACHE Gene Symbol

Gene Info:

Target Subclass EC:3.1.1.7

Target Class Enzymes

Publications:
GuideToPharmacology: 43
- Version: 29-September-2020
Alternate Names:

108 HUGO Gene ID

108 HUGO Gene Symbol

acetylcholinesterase (Cartwright blood group) HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Acetylcholine turnover

GuideToPharmacology Gene Category ID 765

GuideToPharmacology Gene Category Name Hydrolases

Gene Categories:

ENZYME

Publications:

PharmGKB: ACHE

Version: 18-August-2020

Alternate Names:

PA20 PharmGKB ID

Gene Info:

Publications:

Scacchi R et al., 2009, Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine., Am J Med Genet B Neuropsychiatr Genet

DrugBank: BE0000426

Version: 5.1.7

Alternate Names:

ACHE DrugBank Gene Name

P22303 UniProt Accession

43 Entrez Gene Id

Gene Info:

Publications:

Rosenberry TL et al., 2008, Monitoring the reaction of carbachol with acetylcholinesterase by thioflavin T fluorescence and acetylthiocholine hydrolysis., Chem Biol Interact

Nakamura et al., 1993, Characterization of esterases involved in the hydrolysis of dipivefrin hydrochloride., Ophthalmic Res.

Elsinghorst et al., 2007, First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor., J. Med. Chem.

NCI: ACHE

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Ciesielski-Treska et al., 1975, Morphological, histochemical and chromosomal patterns of neuroblastoma parental and purine resistant lines., Neurobiology

Tsakiris et al., The effect of galactose metabolic disorders on rat brain acetylcholinesterase activity., Z. Naturforsch., C, J. Biosci.

Abou-Bedair et al., 2002, Comparison of hypoxic cell radiosensitizers, KIN-804, KIN-844, KIN-806 and TX-1877, on brain and liver metabolizing capacities in mice bearing Ehrlich ascites carcinoma., Biol. Pharm. Bull.

DTC: ACHE

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Cardoso CL et al., 2004, Indole glucoalkaloids from Chimarrhis turbinata and their evaluation as antioxidant agents and acetylcholinesterase inhibitors., J Nat Prod

Huang L et al., 2014, Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease., Eur J Med Chem

Kalisiak J et al., 2012, Nonquaternary reactivators for organophosphate-inhibited cholinesterases., J Med Chem

HingoraniCasas: ENSG00000087085
- Version: 31-May-2017
Alternate Names:

ENSG00000087085 Gene Symbol

ACHE Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ACHE
- Version: chembl_23
Alternate Names:

ACHE GENE_SYMBOL

Acetylcholinesterase UNIPROT

AChE UNIPROT

Gene Info:

Publications:
TTD: Acetylcholinesterase
- Version: 2020.06.01
Alternate Names:

AChE TTD Gene Abbreviation

T30082 TTD Target ID

Gene Info:

Publications:
GO: ACHE
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE

Publications:

Details of the Assay for Interaction	Inhibition of ACHE activity in human serum.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Trial Name	-
Novel drug target	Established target
Details of the Assay for Interaction	Using the chloride salt

Mechanism of Interaction	Cholinesterases; ACHE & BCHE inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

Details of the Assay for Interaction	Inhibition of human recombinant AChE by modified Ellman's method.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Trial Name	galantamine hydrobromide,Razadyne, Reminyl
Novel drug target	Established target
Specific Action of the Ligand	Inhibition

Mechanism of Interaction	Acetylcholinesterase inhibitor
Direct Interaction	yes

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Mechanism of Interaction	Acetylcholinesterase activator
Direct Interaction	yes

Trial Name	acotiamide hydrochloride, YM-443, Z-338
Novel drug target	Established target

activator (activating)
inhibitor (inhibitory)

ENSG00000087085	Ensembl Gene Id
ACHE	Display Id
ACETYLCHOLINESTERASE PRECURSOR (EC 3.1.1.7) (ACHE). [SOURCE:UNIPROT/SWISSPROT;ACC:P22303]	Description

P22303	Uniprot Accession
ENSG00000087085	Ensembl Gene Id
43	Entrez Gene Id

ACHE	Uniprot Gene Name
43	Entrez Gene Id
P22303	Uniprot Accession

108	HUGO Gene ID
108	HUGO Gene Symbol
acetylcholinesterase (Cartwright blood group)	HUGO Gene Name

ACHE	DrugBank Gene Name
P22303	UniProt Accession
43	Entrez Gene Id

ACHE Gene Record

ACHE 43 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of ACHE activity in human serum. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 10826417 11313435 12726885 11819669 11752352 12522088 19257799

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15982786 13679187 2857786 1588924 11752352 11330337 5833399

Sources: TEND TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Details of the Assay for Interaction Using the chloride salt

PMIDs: 10103097 10089512 19472276 10433700 11752352 10421446 10363282

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 11139819 19470293 18780301 18671661 12636181 19370562 10713582 10673128 11078030 18044073 11752352 10587286 14587496

Sources: TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: activator (activating) inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of human recombinant AChE by modified Ellman's method. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 19651196 19519385 22206546 21438612 14529460 10801325

Sources: DTC DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name galantamine hydrobromide,Razadyne, Reminyl Novel drug target Established target Specific Action of the Ligand Inhibition

PMIDs: 23540646 10606746 10762042 11172080 12177686 12137632 10971048 11129124 1026294 12481195 11078030 20480924 10592235 11752352 10971049

Sources: TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 10592235 12895686

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17126020

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16913695 12898348

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Acetylcholinesterase inhibitor Direct Interaction yes

PMIDs: 12837382 11350858 10378121 10898598 11752352 1692236

Sources: TTD DrugBank ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Specific Action of the Ligand Inhibition

PMIDs: 15544504 10208549 15544507 10210906 16860785 10513568 10024872 25282266 12871155 10375753 11752352 16880719 17218977

Sources: TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of ACHE activity in human serum.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
10826417 11313435 12726885 11819669 11752352 12522088 19257799

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15982786 13679187 2857786 1588924 11752352 11330337 5833399

Sources:
TEND TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Details of the Assay for Interaction Using the chloride salt

PMIDs:
10103097 10089512 19472276 10433700 11752352 10421446 10363282

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cholinesterases; ACHE & BCHE inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
11139819 19470293 18780301 18671661 12636181 19370562 10713582 10673128 11078030 18044073 11752352 10587286 14587496

Sources:
TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

activator (activating)

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of human recombinant AChE by modified Ellman's method.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
19651196 19519385 22206546 21438612 14529460 10801325

Sources:
DTC DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name galantamine hydrobromide,Razadyne, Reminyl

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
23540646 10606746 10762042 11172080 12177686 12137632 10971048 11129124 1026294 12481195 11078030 20480924 10592235 11752352 10971049

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
10592235 12895686

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17126020

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16913695 12898348

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Acetylcholinesterase inhibitor

Direct Interaction yes

PMIDs:
12837382 11350858 10378121 10898598 11752352 1692236

Sources:
TTD DrugBank ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Specific Action of the Ligand Inhibition

PMIDs:
15544504 10208549 15544507 10210906 16860785 10513568 10024872 25282266 12871155 10375753 11752352 16880719 17218977

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
5257018

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
11098845

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15568781

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15951830

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15568781

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name physostigmine ,Xalieve

Specific Action of the Ligand Inhibition

PMIDs:
10403635 10368402 10873710 11752352 10741458 11141093